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2020

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Thaw Publications, Carl Landwehr, David Kotz Dec 2020

Thaw Publications, Carl Landwehr, David Kotz

Computer Science Technical Reports

In 2013, the National Science Foundation's Secure and Trustworthy Cyberspace program awarded a Frontier grant to a consortium of four institutions, led by Dartmouth College, to enable trustworthy cybersystems for health and wellness. As of this writing, the Trustworthy Health and Wellness (THaW) project's bibliography includes more than 130 significant publications produced with support from the THaW grant; these publications document the progress made on many fronts by the THaW research team. The collection includes dissertations, theses, journal papers, conference papers, workshop contributions and more. The bibliography is organized as a Zotero library, which provides ready access to citation materials …


Supporting Teaching With Primary Sources At Dartmouth College: A Report Coordinated By Ithaka S+R, Morgan Swan, Myranda Fuentes, Daniel Abosso, Joshua Dacey Dec 2020

Supporting Teaching With Primary Sources At Dartmouth College: A Report Coordinated By Ithaka S+R, Morgan Swan, Myranda Fuentes, Daniel Abosso, Joshua Dacey

Dartmouth Library Staff Publications

No abstract provided.


Evaluating The Reproducibility Of Physiological Stress Detection Models, Varun Mishra, Sougata Sen, Grace Chen, Tian Hao, Jeffrey Rogers, Ching-Hua Chen, David Kotz Dec 2020

Evaluating The Reproducibility Of Physiological Stress Detection Models, Varun Mishra, Sougata Sen, Grace Chen, Tian Hao, Jeffrey Rogers, Ching-Hua Chen, David Kotz

Dartmouth Scholarship

Recent advances in wearable sensor technologies have led to a variety of approaches for detecting physiological stress. Even with over a decade of research in the domain, there still exist many significant challenges, including a near-total lack of reproducibility across studies. Researchers often use some physiological sensors (custom-made or off-the-shelf), conduct a study to collect data, and build machine-learning models to detect stress. There is little effort to test the applicability of the model with similar physiological data collected from different devices, or the efficacy of the model on data collected from different studies, populations, or demographics.

This paper takes …


Barriers And Facilitators In Implementing A Pilot, Pragmatic, Telemedicine-Delivered Healthy Lifestyle Program For Obesity Management In A Rural, Academic Obesity Clinic, John A. Batsis, Auden C. Mcclure, Aaron B. Weintraub, Diane Sette, Sivan Rotenberg, Courtney J. Stevens, Diane Gilbert-Diamond, David Kotz, Stephen Bartels, Summer B. Cook, Richard I. Rothstein Sep 2020

Barriers And Facilitators In Implementing A Pilot, Pragmatic, Telemedicine-Delivered Healthy Lifestyle Program For Obesity Management In A Rural, Academic Obesity Clinic, John A. Batsis, Auden C. Mcclure, Aaron B. Weintraub, Diane Sette, Sivan Rotenberg, Courtney J. Stevens, Diane Gilbert-Diamond, David Kotz, Stephen Bartels, Summer B. Cook, Richard I. Rothstein

Dartmouth Scholarship

Few evidence-based strategies are specifically tailored for disparity populations such as rural adults. Two-way video-conferencing using telemedicine can potentially surmount geographic barriers that impede participation in high-intensity treatment programs offering frequent visits to clinic facilities. We aimed to understand barriers and facilitators of implementing a telemedicine-delivered tertiary-care, rural academic weight-loss program for the management of obesity.


Using Natural Language Processing And Sentiment Analysis To Augment Traditional User-Centered Design: Development And Usability Study, Curtis L. Petersen, Ryan Halter, David Kotz, Lorie Loeb, Summer B. Cook, Dawna M. Pidgeon, Brock Christensen, John A. Batsis Aug 2020

Using Natural Language Processing And Sentiment Analysis To Augment Traditional User-Centered Design: Development And Usability Study, Curtis L. Petersen, Ryan Halter, David Kotz, Lorie Loeb, Summer B. Cook, Dawna M. Pidgeon, Brock Christensen, John A. Batsis

Dartmouth Scholarship

Background: Sarcopenia, defined as the age-associated loss of muscle mass and strength, can be effectively mitigated through resistance-based physical activity. With compliance at approximately 40% for home-based exercise prescriptions, implementing a remote sensing system would help patients and clinicians to better understand treatment progress and increase compliance. The inclusion of end users in the development of mobile apps for remote-sensing systems can ensure that they are both user friendly and facilitate compliance. With advancements in natural language processing (NLP), there is potential for these methods to be used with data collected through the user-centered design process.

Objective: This study aims …


Assessing Textbook Costs At A Small College, Stephen G. Krueger, Lewis Ward Jul 2020

Assessing Textbook Costs At A Small College, Stephen G. Krueger, Lewis Ward

Dartmouth Library Staff Publications

In recent years, the cost of textbooks has risen drastically, making it an important issue for everyone involved in higher education. Accurate and specific information on the cost of textbooks is needed to effectively address the situation. Over the summer of 2018, a librarian and an undergraduate student at a small liberal arts college assessed the textbook costs at their institution, using methodology developed by community colleges doing similar research. Based on course catalogs, bookstore records, and other resources, they calculated the costs for students in different disciplines over four years of study. These costs were impacted by major, courses …


Automatic Recognition, Segmentation, And Sex Assignment Of Nocturnal Asthmatic Coughs And Cough Epochs In Smartphone Audio Recordings: Observational Field Study, Filipe Barata, Peter Tinschert, Frank Rassouli, Claudia Steurer-Stey, Elgar Fleisch, Milo Puhan, Martin Brutsche, David Kotz, Tobias Kowatsch Jul 2020

Automatic Recognition, Segmentation, And Sex Assignment Of Nocturnal Asthmatic Coughs And Cough Epochs In Smartphone Audio Recordings: Observational Field Study, Filipe Barata, Peter Tinschert, Frank Rassouli, Claudia Steurer-Stey, Elgar Fleisch, Milo Puhan, Martin Brutsche, David Kotz, Tobias Kowatsch

Dartmouth Scholarship

Background: Asthma is one of the most prevalent chronic respiratory diseases. Despite increased investment in treatment, little progress has been made in the early recognition and treatment of asthma exacerbations over the last decade. Nocturnal cough monitoring may provide an opportunity to identify patients at risk for imminent exacerbations. Recently developed approaches enable smartphone-based cough monitoring. These approaches, however, have not undergone longitudinal overnight testing nor have they been specifically evaluated in the context of asthma. Also, the problem of distinguishing partner coughs from patient coughs when two or more people are sleeping in the same room using contact-free audio …


Intro To Oer For Library Employees, Stephen G. Krueger Jul 2020

Intro To Oer For Library Employees, Stephen G. Krueger

Dartmouth Library Workshops and Presentations

Open educational resources (OER) are materials, such as open textbooks, that are free for anyone to use and share. This session will provide library employees with basic information about OER from a library perspective. Attendees will learn what makes a resource open access, how OER can help students and faculty, and where to find open textbooks and other OER.


Trans Health And Information Access, Stephen G. Krueger, Elaina Vitale Jun 2020

Trans Health And Information Access, Stephen G. Krueger, Elaina Vitale

Dartmouth Library Workshops and Presentations

Trans people experience myriad barriers to appropriate healthcare; one of these is simple access to information. Where can providers and patients find reliable, up-to-date, freely available information on their transition and other healthcare issues? Stephen Krueger (Scholarly Publishing Librarian) and Elaina Vitale (Research & Education Librarian) will discuss these issues in the context of open access information.


Bio Circuits For Evolutionary Biotech, Camilo Toruno Jun 2020

Bio Circuits For Evolutionary Biotech, Camilo Toruno

ENGS 86 Independent Projects (AB Students)

The field of bioengineering has much promise for renewable chemical production, bioremediation, and of course medical applications. Developing new useful microorganisms is extremely time and capital intensive, typically taking 50 million USD and eight years. This is due in large part to the low throughput techniques that are characteristic of the field of metabolic engineering. Here we describe the modification of an existing synthetic biosensor to measure the pharmaceutical dopamine, and the use of a circuit simulator Cadence to predict improvements to the biosensor. This biosensor paired with directed evolution techniques could reach throughputs of 5 million cells per day …


Social Distancing Sensor: Devices That Use Ultrasound And Radio Frequency Communication To Facilitate Social Distancing, Namya Malik Jun 2020

Social Distancing Sensor: Devices That Use Ultrasound And Radio Frequency Communication To Facilitate Social Distancing, Namya Malik

ENGS 86 Independent Projects (AB Students)

The rapid transmission of COVID-19 has caused a global health crisis. One of the primary ways to reduce the spread of the virus is to practice social distancing. Specifically, it is important to stay at least six feet away from others. However, it is difficult to implement this, and people can often forget to maintain this distance when they are in a public place.

My solution is a Social Distancing Sensor. This system consists of multiple devices that communicate with each other through both ultrasonic (US) signals and radio frequency (RF) signals. The devices are programmed with the use of …


A Convolutional Neural Network For Fast Fluence Estimation In Complex Tissues, Nicholas Blasey, Geoffrey P. Luke Jun 2020

A Convolutional Neural Network For Fast Fluence Estimation In Complex Tissues, Nicholas Blasey, Geoffrey P. Luke

ENGS 88 Honors Thesis (AB Students)

Photoacoustic (PA) imaging is a non-invasive diagnostic imaging technique that gives images of photoabsorbers based on their absorption of optical energy. These optical absorption properties can then be linked to important tissue properties. For the method to be quantitative, however, it is necessary to have an accurate estimation of the light fluence in the tissue. The current gold standard in addressing the fluence estimation problem, a Monte Carlo Simulation, is costly in time and computation. In this work, we developed a deep neural network to quickly and accurately estimate light fluence in arbitrary tissue types and geometries. The network was …


Engineering An Er-Targeted Dynein-Anchoring Fusion Protein To Mediate Spindle And Nuclear Positioning In Budding Yeast, Dayle Wang Jun 2020

Engineering An Er-Targeted Dynein-Anchoring Fusion Protein To Mediate Spindle And Nuclear Positioning In Budding Yeast, Dayle Wang

ENGS 88 Honors Thesis (AB Students)

Current evidence suggests that, in Saccharomyces cerevisiae, the Num1 protein binds and anchors cytoplasmic dynein to the cell cortex, where dynein generates a pulling force that aligns the mitotic spindle during mitosis; however, the exact location where Num1 anchors dynein remains unclear. In this study, I genetically engineered fusions of the dynein-anchoring CC domain of Num1 to a resident ER protein, Tcb3. Through functional microscopy-based assays, I found that the fusion protein Tcb3-CC rescues the mitotic spindle alignment defect in num1Δ yeast, indicating that the cortical ER can serve as an anchoring platform for dynein.


Investigations Of Mycelium As A Low-Carbon Building Material, Kevin Yang Jun 2020

Investigations Of Mycelium As A Low-Carbon Building Material, Kevin Yang

ENGS 88 Honors Thesis (AB Students)

With the building industry being responsible for 39% of global carbon emissions, there is an imperative need for low-carbon solutions that can decarbonize the built environment. This thesis aimed to address whether mycelium, the hyphal body of fungi, can be used as a building material. The first part of research involved developing a protocol for creating and testing mycelium samples. Mycelium composites were created by inoculating strains of mycelium onto agricultural substrates such as walnut shells, rice hulls, and a commercially available mix from Ecovative Design LLC. Mechanical compression and tensile tests, as well as thermal conductivity and fire resistance …


Feasibility Of Electric Field Assisted Clogging Reduction In Cold Gas Spraying Nozzle, Hendric Tronsson Jun 2020

Feasibility Of Electric Field Assisted Clogging Reduction In Cold Gas Spraying Nozzle, Hendric Tronsson

ENGS 88 Honors Thesis (AB Students)

The relatively novel cold spraying process expands its range of applications constantly. In order to continue this trend, this process still has various hurdles that need to be overcome such as clogging. Clogging within the cold gas spraying process causes porous coatings with less material properties and lower durability; a solution is needed in order to reduce the clogging and so expand the cold gas spraying applications. This study aimed to explore the feasibility of using an electric field to reduce clogging. To do so a simplified channel was used to simulate charged particle trajectory shifts under the influence of …


Cup-Net: Compressed Ultrafast Photography Using Convolutional Neural Networks, Matthew Parker Jun 2020

Cup-Net: Compressed Ultrafast Photography Using Convolutional Neural Networks, Matthew Parker

ENGS 88 Honors Thesis (AB Students)

Compressed ultrafast photography (CUP) is a cutting-edge imaging technique that uses a variation of the traditional streak camera to obtain video at 100 billion frames per second with a single exposure. In order to achieve this level of temporal detail, CUP leverages compressed sensing (CS). Compressed sensing theory states that a compressed representation of an image can be directly acquired using a non-adaptive measurement matrix so long as the encoding matrix follows certain properties such as restrictive isometry and incoherence. This compressed representation of the original scene can later be reconstructed back into the original form. CUP applies CS by …


A Low Resource Instrumentation Package For Thermal Ion Sensors, Ruth Nordhoff Jun 2020

A Low Resource Instrumentation Package For Thermal Ion Sensors, Ruth Nordhoff

ENGS 88 Honors Thesis (AB Students)

This thesis details the redesign of a reproducible, low-resource instrumentation package for deployment on multipoint sensorcraft arrays. Distributed arrays of sensors allow for the collection of simultaneous multipoint data. This instrumentation package provides power, digitization, timing and telemetry for two suborbital auroral thermal ion sensors. This thesis addressed limitations of a previous design, including measurement synchronization, external interfaces, and customizability. Fabrication and integration procedures developed for the redesigned package were implemented throughout the fabrication of 29 devices built for NASA sounding rockets. Results are presented from the 2019 launch of Sub-Tec 8. Recommendations are made for future design iterations.


Utilizing Neural Networks And Wearables To Quantify Hip Joint Angles And Moments During Walking And Stair Ascent, Megan V. Mccabe Jun 2020

Utilizing Neural Networks And Wearables To Quantify Hip Joint Angles And Moments During Walking And Stair Ascent, Megan V. Mccabe

ENGS 88 Honors Thesis (AB Students)

Wearable sensors were leveraged to develop two methods for computing hip joint angles and moments during walking and stair ascent that are more portable than the gold standard. The Insole-Standard (I-S) approach replaced force plates with force-measuring insoles and achieved results that match the curvature of results from similar studies. Peaks in I-S kinetic results are high due to error induced by applying the ground reaction force to the talus. The Wearable-ANN (W-A) approach combines wearables with artificial neural networks to compute the same results. Compared against the I-S, the W-A approach performs well (average rRMSE = 18%, R2 …


On Session Languages, Prashant Anantharaman, Sean W. Smith May 2020

On Session Languages, Prashant Anantharaman, Sean W. Smith

Computer Science Technical Reports

The LangSec approach defends against crafted input attacks by defining a formal language specifying correct inputs and building a parser that decides that language. However, each successive input is not necessarily in the same basic language---e.g., most communication protocols use formats that depend on values previously received, or on some other additional context. When we try to use LangSec in these real-world scenarios, most parsers we write need additional mechanisms to change the recognized language as the execution progresses. This paper discusses approaches researchers have previously taken to build parsers for such protocols and provides formal descriptions of new sets …


Supporting Students With Open Textbooks, Stephen G. Krueger, Katie Harding May 2020

Supporting Students With Open Textbooks, Stephen G. Krueger, Katie Harding

Dartmouth Library Workshops and Presentations

Have you ever considered adopting an open textbook for your course? If you are concerned about your students' access to their assigned textbook or if you are interested in exploring what open textbooks exist in your field, this session is for you. You'll learn how to find and use free, high quality, digital textbooks.


Design And Analysis Of A Piezoelectric Pulse Wave Velocity Sensor, Haley Richards, Andrew Closson, John Xj Zhang Apr 2020

Design And Analysis Of A Piezoelectric Pulse Wave Velocity Sensor, Haley Richards, Andrew Closson, John Xj Zhang

ENGS 88 Honors Thesis (AB Students)

Pulse Wave Velocity (PWV) is strongly correlated with blood pressure and a valuable biomarker in assessing hypertension. This report evaluates the feasibility of noninvasive blood pressure determination from piezoelectric PWV measurements. A wearable piezoelectric prototype was developed to detect PWV in the radial artery, and a computational model of the sensor was designed to simulate a piezoelectric sensor response under ideal conditions. These methods provide insight into the relationship between PWV and blood pressure, and the ability of piezoelectric materials to detect blood flow characteristics. This work lays the groundwork for future device development in this field.


Distributed Iot Attestation Via Blockchain (Extended Version), Ira Ray Jenkins, Sean W. Smith Mar 2020

Distributed Iot Attestation Via Blockchain (Extended Version), Ira Ray Jenkins, Sean W. Smith

Computer Science Technical Reports

The growing number and nature of Internet of Things (IoT) devices makes these resource-constrained appliances particularly vulnerable and increasingly impactful in their exploitation. Current estimates for the number of connected "things" commonly reach the tens of billions. The low-cost and limited computational strength of these devices can preclude security features. Additionally, economic forces and a lack of industry expertise in security often contribute to a rush to market with minimal consideration for security implications. It is essential that users of these emerging technologies, from consumers to IT professionals, be able to establish and retain trust in the multitude of diverse …


The Application Of Digital Health To The Assessment And Treatment Of Substance Use Disorders: The Past, Current, And Future Role Of The National Drug Abuse Treatment Clinical Trials Network, Lisa A. Marsch, Aimee Campbell, Cynthia Campbell, Ching-Hua Chen, Emre Ertin, Udi Ghitza, Chantal Lambert-Harris, Saeed Hassanpour, August F. Holtyn, Yih-Ing Hser, Petra Jacobs, Jeffrey D. Klausner, Shea Lemley, David Kotz, Andrea Meier, Bethany Mcleman, Jennifer Mcneely, Varun Mishra, Larissa Mooney, Edward Nunes, Chrysovalantis Stafylis, Catherine Stanger, Elizabeth Saunders, Geetha Subramaniam, Sean Young Mar 2020

The Application Of Digital Health To The Assessment And Treatment Of Substance Use Disorders: The Past, Current, And Future Role Of The National Drug Abuse Treatment Clinical Trials Network, Lisa A. Marsch, Aimee Campbell, Cynthia Campbell, Ching-Hua Chen, Emre Ertin, Udi Ghitza, Chantal Lambert-Harris, Saeed Hassanpour, August F. Holtyn, Yih-Ing Hser, Petra Jacobs, Jeffrey D. Klausner, Shea Lemley, David Kotz, Andrea Meier, Bethany Mcleman, Jennifer Mcneely, Varun Mishra, Larissa Mooney, Edward Nunes, Chrysovalantis Stafylis, Catherine Stanger, Elizabeth Saunders, Geetha Subramaniam, Sean Young

Dartmouth Scholarship

The application of digital technologies to better assess, understand, and treat substance use disorders (SUDs) is a particularly promising and vibrant area of scientific research. The National Drug Abuse Treatment Clinical Trials Network (CTN), launched in 1999 by the U.S. National Institute on Drug Abuse, has supported a growing line of research that leverages digital technologies to glean new insights into SUDs and provide science-based therapeutic tools to a diverse array of persons with SUDs.

This manuscript provides an overview of the breadth and impact of research conducted in the realm of digital health within the CTN. This work has …


Apparatus For Securely Configuring A Target Device And Associated Methods, Timothy J. Pierson, Xiaohui Liang, Ronald Peterson, David Kotz Feb 2020

Apparatus For Securely Configuring A Target Device And Associated Methods, Timothy J. Pierson, Xiaohui Liang, Ronald Peterson, David Kotz

Other Faculty Materials

Apparatus and method securely transfer first data from a source device to a target device. A wireless signal having (a) a higher speed channel conveying second data and (b) a lower speed channel conveying the first data is transmitted. The lower speed channel is formed by selectively transmitting the wireless signal from one of a first and second antennae of the source device based upon the first data. The first and second antenna are positioned a fixed distance apart and the target device uses a received signal strength indication (RSSI) of the first signal to decode the lower speed channel …


Workshop On The Development And Evaluation Of Digital Therapeutics For Health Behavior Change: Science, Methods, And Projects, Alan J. Budney, Lisa A. Marsch, Will M. Aklin, Jacob T. Borodovsky, Mary F. Brunette, Andrew T. Campbell, Jesse Dallery, David Kotz, Ashley A. Knapp, Sarah E. Lord, Edward V. Nunes, Emily A. Scherer, Catherine Stanger, William C. Torrey Feb 2020

Workshop On The Development And Evaluation Of Digital Therapeutics For Health Behavior Change: Science, Methods, And Projects, Alan J. Budney, Lisa A. Marsch, Will M. Aklin, Jacob T. Borodovsky, Mary F. Brunette, Andrew T. Campbell, Jesse Dallery, David Kotz, Ashley A. Knapp, Sarah E. Lord, Edward V. Nunes, Emily A. Scherer, Catherine Stanger, William C. Torrey

Dartmouth Scholarship

The health care field has integrated advances into digital technology at an accelerating pace to improve health behavior, health care delivery, and cost-effectiveness of care. The realm of behavioral science has embraced this evolution of digital health, allowing for an exciting roadmap for advancing care by addressing the many challenges to the field via technological innovations. Digital therapeutics offer the potential to extend the reach of effective interventions at reduced cost and patient burden and to increase the potency of existing interventions. Intervention models have included the use of digital tools as supplements to standard care models, as tools that …


Best Practices For Student-Led Publishing, Victoria Corwin Jan 2020

Best Practices For Student-Led Publishing, Victoria Corwin

Dartmouth Library Staff Publications

The Dartmouth Library engages with student writers and editors to support and advise publications. This guide was written by Victoria Corwin, Edward Connery Lathem Digital Library Fellow, in June 2020 after extensive literature reviews, interviews, and personal experience as a student Editor in Chief for three years.

This document covers some best practices for many aspects of student publishing at Dartmouth, including starting a publication, finding support, securing funding, publishing content, increasing visibility, copyright advice, and much more. The resources listed here apply to all types of publications, such as literary magazines, science journals, newspapers, blogs, and zines. This guide …


What Is A Virus?, Hannah K. Margolis, Emily J. Morin Jan 2020

What Is A Virus?, Hannah K. Margolis, Emily J. Morin

Independent Student Projects and Publications

About our Book

Hi everyone! Hannah here. As college students, my friend Emily and I are studying from home. We realized you probably are working from home too, and might not quite know why. So we put together this book to try and explain viruses- the annoying buggers behind the coronavirus and even the common cold. We hope you enjoy it and learn some new things about science too!

Copyright © 2020 Hannah Margolis

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Permission is granted to distribute this publication in its entirety, without change and …


The Relationship Between Cusp Region Ion Outflows And East-West Magnetic Field Fluctuations At 4,000-Km Altitude, S. M. Hatch, T. Moretto, Kristina A. Lynch, K. M. Laundal, J. W. Gjerloev, E. J. Lund Jan 2020

The Relationship Between Cusp Region Ion Outflows And East-West Magnetic Field Fluctuations At 4,000-Km Altitude, S. M. Hatch, T. Moretto, Kristina A. Lynch, K. M. Laundal, J. W. Gjerloev, E. J. Lund

Dartmouth Scholarship

A number of interdependent conditions and processes contribute to ionospheric-origin energetic ( 10 eV to several keV) ion outflows. Due to these interdependences and the associated observational challenges, energetic ion outflows remain a poorly understood facet of atmosphere-ionosphere-magnetosphere coupling. Here we demonstrate the relationship between east-west magnetic field fluctuations ( ) and energetic outflows in the magnetosphere-ionosphere transition region. We use dayside cusp region FAST satellite observations made near apogee ( 4,180-km altitude) near fall equinox and solstices in both hemispheres to derive statistical relationships between ion upflow and spectral power as a function of spacecraft frame frequency bands between …


Sun, Sea, And Ice: Autonomous Observations Of Sea Ice Mass Balance And The Partitioning Of Solar Radiation In Arctic Sea Ice, Mary Tobin Jan 2020

Sun, Sea, And Ice: Autonomous Observations Of Sea Ice Mass Balance And The Partitioning Of Solar Radiation In Arctic Sea Ice, Mary Tobin

ENGS 88 Honors Thesis (AB Students)

Three optical sensors were integrated into the Seasonal Ice Mass Balance Buoy (SIMB) 3 to autonomously measure Arctic sea ice mass balance and solar radiation partitioning simultaneously to better understand how Arctic sea ice responds to environmental forces and amplifies climate change. Two pyranometers measure incoming and reflected solar irradiance and an underwater quantum sensor measures PAR and transmitted solar radiation. The optical sensor SIMB-3 was sent to the Beaufort Sea, Alaska, for deployment. Due to complications with Covid-19 and dynamic ice conditions, the device is now scheduled for deployment in spring 2021. The results section presents data from a …


Biological And Genetic Comparison Of X-Ray And Gamma Ray Radiation Effects, Shannon Kossmann Jan 2020

Biological And Genetic Comparison Of X-Ray And Gamma Ray Radiation Effects, Shannon Kossmann

ENGS 88 Honors Thesis (AB Students)

In this study MC38 (murine colon adenocarcinoma) and B16F10 (murine melanoma) cellular responses to equivalent gamma and x-ray radiation doses were examined. The results of colony forming assay survival fractions indicate MC38 cells are more sensitive to radiation than B16F10 cells. Additionally, MC38 cells are more susceptible to gamma radiation than x-ray radiation at any given dose, whereas the opposite is true for B16F10 cells indicating potentially important comparative differences (gamma vs x-ray) in cell survival. Western blot protein analysis and NanoString mRNA analysis for gamma radiation of B16F10 cells demonstrated small changes in the expression of cell death regulators.