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Regulation Of E(Spl) Gene Expression During Development, Morgan L. Maeder

Biology Honors Papers

The Notch pathway, a crucial developmental signaling system, acts to direct the fates of individual cells in many organisms and has also been implicated in a wide range of human diseases. Notch signaling plays a vital role in cell fate decisions in almost every tissue type ranging from the skin to the nervous and vascular systems. Aberrant Notch signaling has been implicated as a cause of many diseases, including a variety of cancers. Activation of the Notch receptor releases a Notch intracellular domain into the nucleus, where it binds with a transcription factor, Suppressor of Hairless (Su(H))to create an active …