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Regulation Of E(Spl) Gene Expression During Development, Morgan L. Maeder
Regulation Of E(Spl) Gene Expression During Development, Morgan L. Maeder
Biology Honors Papers
The Notch pathway, a crucial developmental signaling system, acts to direct the fates of individual cells in many organisms and has also been implicated in a wide range of human diseases. Notch signaling plays a vital role in cell fate decisions in almost every tissue type ranging from the skin to the nervous and vascular systems. Aberrant Notch signaling has been implicated as a cause of many diseases, including a variety of cancers. Activation of the Notch receptor releases a Notch intracellular domain into the nucleus, where it binds with a transcription factor, Suppressor of Hairless (Su(H))to create an active …
Analysis Of The Upstream Regulatory Region Of The Enhancer Of Split M7 Gene In Drosophila , Bryanne E. Robson
Analysis Of The Upstream Regulatory Region Of The Enhancer Of Split M7 Gene In Drosophila , Bryanne E. Robson
Biology Honors Papers
The Notch pathway is one of the vital signaling pathways used during Drosophila development. Present in many organisms and extensively studied in D. melanogaster, this pathway serves to transduce signals between neighboring developing cells and inhibits neuronal differentiation by lateral inhibition. The primary targets of Notch are the Enhancer of split (E(spl)) genes. Although the upstream regulatory regions of the E(spl) genes contain biding sites for Suppressor of Hairless, Proneural, and E(spl) proteins, their expression patterns are not identical. There is a hidden complexity in the regulatory regions of these genes that may help explain the conservation of the overall …