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Acetate Metabolism: The Physiological Role Of Adp-Forming Acetyl-Coa Synthetase And Acetate Kinase In Entamoeba Histolytica, Thanh Dang
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Entamoeba histolytica is a protozoan parasite that causes amoebic colitis and liver abscess in approximately 90 million people each year, resulting in 50,000-100,000 fatalities. Even though Entamoeba poses a significant public health problem worldwide, research dedicated to understanding the biology of this unique protozoan has been limited. This amitochondriate parasite lacks many essential biosynthesis pathways including the tricarboxylic acid (TCA) cycle and oxidative phosphorylation. As a result, substrate level phosphorylation plays a necessary role in ATP production. Unlike the standard glycolytic pathway, E. histolytica glycolysis requires pyrophosphate (PPi) by replacing ATP - dependent phosphofructokinase and pyruvate kinase with PPi - …
Compensatory Changes In Cyp Expression In Three Different Toxicology Mouse Models: Car-Null, Cyp3a-Null, And Cyp2b9/10/13-Null Mice, Ramiya Kumar, Linda C. Mota, Elizabeth J. Litoff, John P. Rooney, W. Tyler Boswell, Elliott Courter, Charles M. Henderson, Juan P. Hernandez, J. Christopher Corton, David D. Moore, William S. Baldwin
Compensatory Changes In Cyp Expression In Three Different Toxicology Mouse Models: Car-Null, Cyp3a-Null, And Cyp2b9/10/13-Null Mice, Ramiya Kumar, Linda C. Mota, Elizabeth J. Litoff, John P. Rooney, W. Tyler Boswell, Elliott Courter, Charles M. Henderson, Juan P. Hernandez, J. Christopher Corton, David D. Moore, William S. Baldwin
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Targeted mutant models are common in mechanistic toxicology experiments investigating the absorption, metabolism, distribution, or elimination (ADME) of chemicals from individuals. Key models include those for xenosensing transcription factors and cytochrome P450s (CYP). Here we investigated changes in transcript levels, protein expression, and steroid hydroxylation of several xenobiotic detoxifying CYPs in constitutive androstane receptor (CAR)-null and two CYP-null mouse models that have subfamily members regulated by CAR; the Cyp3a-null and a newly described Cyp2b9/10/13-null mouse model. Compensatory changes in CYP expression that occur in these models may also occur in polymorphic humans, or may complicate interpretation of ADME studies performed …