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Synthesis Of (2-Hydroxyl-3-Butoxyl) Propyl-Succinyl-Chitosan – An Amino Sugar Anionic Surfactant Under Microwave Irradiation And Its Application, P. S. Singh, Suraj N. Mali, N. R. Sangale, Amit P. Pratap
Synthesis Of (2-Hydroxyl-3-Butoxyl) Propyl-Succinyl-Chitosan – An Amino Sugar Anionic Surfactant Under Microwave Irradiation And Its Application, P. S. Singh, Suraj N. Mali, N. R. Sangale, Amit P. Pratap
The Thai Journal of Pharmaceutical Sciences
Introduction: Chitosan, a biopolymer with 97% degree of deacetylation, was used herein, to synthesize an amino sugar anionic surfactant of varied alkyl chain length, using a microwave-assisted synthesis. We were also examined their properties in aqueous form. Objectives: The objectives of the study were to increase the surface activity and water solubility of chitosan derivatives. Materials and Methods: Structural features and crystallinity were confirmed using Fourier transform infrared, ¹H-nuclear magnetic resonance, and X-ray diffraction. The chitosan by itself was found to have weak surface-active properties since it has no hydrophobic segment. Results: The microwave-assisted synthesized sugar amino-based anionic surfactant, synthesis …
Synthesis And Evaluation Of Poly(Ethylene Glycol) Diacrylate-Modified Chitosan As A Mucoadhesive Polymer, Kwanputtha Arunprasert, Chaiyakarn Pornpitchanarong, Nitjawan Sahatsapan, Praneet Opanasopit, Prasopchai Patrojanasophon
Synthesis And Evaluation Of Poly(Ethylene Glycol) Diacrylate-Modified Chitosan As A Mucoadhesive Polymer, Kwanputtha Arunprasert, Chaiyakarn Pornpitchanarong, Nitjawan Sahatsapan, Praneet Opanasopit, Prasopchai Patrojanasophon
The Thai Journal of Pharmaceutical Sciences
This study aimed to synthesize a poly(ethylene glycol) diacrylate-modified chitosan (CS-PEGDA) as a mucoadhesive polymer for transmucosal drug delivery. Chitosan-cysteine (Cys-CS) was synthesized by coupling chemistry. Cys-CS was then employed for the synthesis of CS-PEGDA through a thiol-ene click reaction between the thiol groups of Cys-CS and alkene groups of PEGDA using triethanolamine as an activator. The obtained structure of the synthesized polymer was proved using Fourier transform infrared (FT-IR) spectroscopy and nuclear magnetic resonance (NMR) spectroscopy. The mucoadhesive capability of the synthesized polymer was examined by an ex vivo mucoadhesion test using a texture analyzer. The toxicity of synthesized …
Formulation And Evaluation Of Fast Disintegrating Tablets Of Domperidone Using Chitosan-Glycine Conjugates As Superdisintegrant, Simran Kaur Zandu, Reena Kumari, Inderbir Singh
Formulation And Evaluation Of Fast Disintegrating Tablets Of Domperidone Using Chitosan-Glycine Conjugates As Superdisintegrant, Simran Kaur Zandu, Reena Kumari, Inderbir Singh
The Thai Journal of Pharmaceutical Sciences
Purpose: The present research was envisaged to employ chitosan-glycine conjugates as superdisintegrant for developing fast disintegrating tablets of domperidone. Materials and Methods: Chitosan-glycine conjugates were prepared by physical mixing and microwave-assisted technique. Micromeritic study, Fourier transform infrared, scanning electron microscopy, and X-ray diffraction methods were employed for characterizing the powdered conjugates. The formulated FDTs were evaluated for wetting time, water absorption ratio, disintegration time, in vitro drug release, and other tablet parametric tests. Results and Discussion: The effective pore radius of unadulterated chitosan was found to be 18.45±1.27 μm whereas the chitosan-glycine conjugates prepared by physical technique and microwave technique …
Preparation And Characterization Of Demineralized Bone Matrix/Chitosan Composite Scaffolds For Bone Tissue Engineering, Panudda Dechwongya, Korbtham Sathirakul, Baldur Kristjánsson, Suwabun Chirachanchai, Sittisak Honsawek
Preparation And Characterization Of Demineralized Bone Matrix/Chitosan Composite Scaffolds For Bone Tissue Engineering, Panudda Dechwongya, Korbtham Sathirakul, Baldur Kristjánsson, Suwabun Chirachanchai, Sittisak Honsawek
Chulalongkorn Medical Journal
Background: A propitious alternative to supply bone substitutes is to develop living tissue substitutes basedon biodegradable materials. Demineralized bone matrix (DBM) can support and promote osteogenesis; scaffold is also attractive for use in bone tissue engineering. Chitosan scaffold has been shown to possess biological and mechanical properties suitable for tissue engineering and clinical applications.Objectives: This study aimed to develop a novel DBM/chitosan composite scaffold and to investigate whetheror not it has the ability to support the attachment and proliferation of human periosteal cells in vitro for bonetissue engineering.Methods: Chitosan and DBM/chitosan scaffolds (ratios 1:1 and 1:2) were fabricated with a …
Preparation Of Doubly Crosslinked Chitosan By The Use Of Environmentally Friendly Crosslinkers For Enzyme Immobilization, Siripran Tidiarat, Tanasait Ngawhirunpat, Praneet Opanasopit, Theerasak Rojanarata
Preparation Of Doubly Crosslinked Chitosan By The Use Of Environmentally Friendly Crosslinkers For Enzyme Immobilization, Siripran Tidiarat, Tanasait Ngawhirunpat, Praneet Opanasopit, Theerasak Rojanarata
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Preliminary Formulation Study Of Cold Pressed Rice Bran Oil Mask, Jirapomchai Suksaeree, Laksana Charoenchai, Apirak Sakunpak, Chaowalit Monton, Tun Chusut, Worawan Saingam, Pathamaporn Pathompak
Preliminary Formulation Study Of Cold Pressed Rice Bran Oil Mask, Jirapomchai Suksaeree, Laksana Charoenchai, Apirak Sakunpak, Chaowalit Monton, Tun Chusut, Worawan Saingam, Pathamaporn Pathompak
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Development Of Lawsone Methyl Ether Loaded Chitosan-Dextran Sulfate Nanoparticles; Preliminary Study, Pattravee Niamprem, Pharkphoom Panichayupakaranant, Waree Tiyaboonchai
Development Of Lawsone Methyl Ether Loaded Chitosan-Dextran Sulfate Nanoparticles; Preliminary Study, Pattravee Niamprem, Pharkphoom Panichayupakaranant, Waree Tiyaboonchai
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Aligned Electrospun Chitosan/Poly S-Caprolactone Blended Scaffold: Anti-Inflammatory Effect, Natthan Charemsriwilaiwat, Louise Carney, Brendan Robb, Praneet Opanasopit, Theerasak Rojanarata, Sandra Downes
Aligned Electrospun Chitosan/Poly S-Caprolactone Blended Scaffold: Anti-Inflammatory Effect, Natthan Charemsriwilaiwat, Louise Carney, Brendan Robb, Praneet Opanasopit, Theerasak Rojanarata, Sandra Downes
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Application Of Titrimetric Indicator To The Estimation Of Polyplex Formation Ratio Between Chitosan Polymer And Plasmid Dna Used For Gene Delivery Formulation, Samarwadee Plianwong., Praneet Opanasopit, Tanasait Ngawhirunpat, Theerasak Rojanarata
Application Of Titrimetric Indicator To The Estimation Of Polyplex Formation Ratio Between Chitosan Polymer And Plasmid Dna Used For Gene Delivery Formulation, Samarwadee Plianwong., Praneet Opanasopit, Tanasait Ngawhirunpat, Theerasak Rojanarata
The Thai Journal of Pharmaceutical Sciences
No abstract provided.
Role Of Aluminum Monostearate On Heat Treated-Chitosan Sponges Properties, K. Yodkhum, T. Phaechamud
Role Of Aluminum Monostearate On Heat Treated-Chitosan Sponges Properties, K. Yodkhum, T. Phaechamud
Journal of Metals, Materials and Minerals
Heat treatment can be employed to modify properties such as biocompatibility and degradation rate of chitosan-based materials. However, heat treatment generally has effect on worsening of physical properties of the biomaterials. Our previous study indicated that fatty additive; aluminum monostearate (Alst), could improve thermal stability of chitosan sponges. Aim of this study is to investigate an effect of amount of Alst on physicochemical properties of chitosan sponges treated by different heat treatment methods. Two methods of heat treatment including moist heat (autoclave at 121°C, 15 psi for 5 minutes) and dry heat (vacuum heat at 110°C for 24 hours) were …
Preparation And Characterization Of Particles From Chitosan With Different Molecular Weights And Their Trimethyl Chitosan Derivatives For Nasal Immunization, W Boonyo, H E. Junginger, N Waranuch, A Polnok, T Pitaksuteepong
Preparation And Characterization Of Particles From Chitosan With Different Molecular Weights And Their Trimethyl Chitosan Derivatives For Nasal Immunization, W Boonyo, H E. Junginger, N Waranuch, A Polnok, T Pitaksuteepong
Journal of Metals, Materials and Minerals
According to previous studies, molecular weights (MW) of chitosan presented an influence on the level of immune response to model antigen when administering with chitosan through nasal route. Moreover, trimethyl chitosan (TMC) with a degree of quaternization (DQ) of 40%, chitosan derivatives, was also shown to be the most potent nasal OVA delivery platforms compared to TMC with DQ of 20% and 60% in mice model. The aims of this study were to prepare particles from chitosan with difference MW and their TMC derivatives (DQ = 40%) and to characterize size, zeta potential, loading efficiency and release profile in order …
Preparation Of N-Acetyl-D-Glucosamine Using Enzyme From Aspergillus Sp., P Setthakaset, R Pichyangkura, A Ajavakom, M Sukwattanasinitt
Preparation Of N-Acetyl-D-Glucosamine Using Enzyme From Aspergillus Sp., P Setthakaset, R Pichyangkura, A Ajavakom, M Sukwattanasinitt
Journal of Metals, Materials and Minerals
N-acetyl-D-glucosamine (GlcNAc) is one of the basic constituents of mammal cartilage, which is known to help repair deteriorating cartilage and relieve pain and inflammation in osteoarthritis patients. The preparation of GlcNAc from squid pen β-chitin by using Aspergillus sp. chitinase in enzymatic hydrolysis is studied. The cultivation of the fungus in colloidal chitin minimum media at pH 3.5 and 40°C for 5 days gives the highest chitinolytic activity of 3.1 U/mL. The crude enzyme obtained from the the cultivation is used in the hydrolysis of milled squid pen β-chitin (50μm) at pH 4 (acetic acid 2M) and 45°C using 22 …
Surface Modification Of Bricks By Chitosan Coatings, S Nilpairach, S T. Dubas
Surface Modification Of Bricks By Chitosan Coatings, S Nilpairach, S T. Dubas
Journal of Metals, Materials and Minerals
Bricks were successfully modified by application of a chitosan coating in order to provide their surface with a water repellant character. The chitosan coating was prepared by depositing solutions of variable chitosan concentration (1% or 2.5% w/w) onto the brick surface and let to dry under ambient condition. In order to improve the water repellant property, the films were cross-linked with a 1% solution of sodium citrate, sodium sulfate or sodium tri - polyphosphate. The effect of the chitosan concentration on the morphology of the coating at the brick surface was observed by scanning electron microscope (SEM). It was found …
Improved L-929 Cell Growth From Self Assembled Pdadmac/Gelatin Thin Films, P Kittitheeranun, P Potiyaraj, T Bunaprasert, N Sanchavanakit, S T. Dubas
Improved L-929 Cell Growth From Self Assembled Pdadmac/Gelatin Thin Films, P Kittitheeranun, P Potiyaraj, T Bunaprasert, N Sanchavanakit, S T. Dubas
Journal of Metals, Materials and Minerals
This article demonstrates the advantages of using PDADMAC/gelatin over chitosan/gelatin multilayer thin films to improve L-929 mouse fibroblast growth. Although chitosan-based materials are often preferred in cell culture, we put in evidence the problematic low stability and decomposition of chitosan based film under physiological pH. Two kinds of coating were assembled using either chitosan or Poly(diallyldimethylammonium chloride) (PDADMAC) as polycationic polyelectrolyte and gelatin as the anionic counterpart. The non-toxic nature of each coating was confirmed by MTT assay for cell viability and cell proliferation. Using optical microscopy, it was observed that the L-929 fibroblast spread preferentially on the PDADMAC/gelatin surface …
Development Of Flame Retardant Polyphosphoric Acid Coating Based On The Polyelectrolyte Multilayers Technique, K Srikulkit, C Iamsamai, S T. Dubas
Development Of Flame Retardant Polyphosphoric Acid Coating Based On The Polyelectrolyte Multilayers Technique, K Srikulkit, C Iamsamai, S T. Dubas
Journal of Metals, Materials and Minerals
Polyelectrolyte multilayer (PEM) thin films were deposited on silk by sequential deposition of Chitosan and polyphosphoric acid. This PEM composition takes advantage of synergetic effect of the phosphorus and the nitrogen to provide an efficient coating, which prevents fiber decomposition at high temperature. Prior to the PEM assembly on silk fibers, the growth of the film was initially monitored using an atomic force microscopy (AFM). Films formed on silicon wafer after 10, 20, 30, 40 and 60 layers showed somewhat linear increase, which is consistent with the PEM technique. A total thickness ranging from 10 to 107 nm for the …
Properties Of Collagen/Chitosan Scaffolds For Skin Tissue Engineering, C Tangsadthakun, S Kanokpanont, N Sanchavanakit, T Banaprasert, S Damrongsakkul
Properties Of Collagen/Chitosan Scaffolds For Skin Tissue Engineering, C Tangsadthakun, S Kanokpanont, N Sanchavanakit, T Banaprasert, S Damrongsakkul
Journal of Metals, Materials and Minerals
Biopolymer blends between collagen and chitosan have the potential to produce cell scaffolds with biocompatible properties. In this study, porous scaffolds were fabricated by freeze drying the solution of collagen and chitosan and crosslinked by dehydrothermal treatment (DHT). Various types of scaffolds were prepared by varying compositions of collagen and chitosan. The scaffolds were fully characterized by Fourier transform infrared (FT-IR) spectroscopy. The results proved that collagen and chitosan scaffolds in all blending compositions contained only physical but not chemical interaction in molecular level. The compressive modulus from a universal mechanical testing machine decreased with increasing the compositions of chitosan. …
Physical Properties And Release Characteristics Of Matrices Prepared From Co-Spray Dried Powders Of Propranolol Hydrochloride And Chitosan, Poj Kulvanich, Sasitom Prugmahachaikul, Krisana Kraisintu
Physical Properties And Release Characteristics Of Matrices Prepared From Co-Spray Dried Powders Of Propranolol Hydrochloride And Chitosan, Poj Kulvanich, Sasitom Prugmahachaikul, Krisana Kraisintu
The Thai Journal of Pharmaceutical Sciences
Chitosan was prepared by deacetylation of chitin from shrimp hulls at various reaction times to yield chitosans having different degrees of deacetylation. Chitosans obtained were employed to prepare co-spray dried powders of propranolol hydrochloride-chi...