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Sexually Dimorphic Effects Of Prenatal Stress On Cognition, Hormonal Responses, And Central Neurotransmitters, Rachel E. Bowman, Neil J. Maclusky, Yessenia Sarmiento, Maya Frankfurt, Marisa Gordon, Victoria N. Luine Aug 2004

Sexually Dimorphic Effects Of Prenatal Stress On Cognition, Hormonal Responses, And Central Neurotransmitters, Rachel E. Bowman, Neil J. Maclusky, Yessenia Sarmiento, Maya Frankfurt, Marisa Gordon, Victoria N. Luine

Psychology Faculty Publications

Exposure to stress during gestation results in physiological and behavioral alterations that persist into adulthood. This study examined the effects of prenatal stress on the postnatal expression of sexually differentiated cognitive, hormonal, and neurochemical profiles in male and female rats. Pregnant dams were subjected to restraint stress three times daily for 45 min during d 14-21 of pregnancy. The offspring of control and prenatally stressed dams were tested for anxiety-related and cognitive behaviors, stress and gonadal steroid hormone levels, as well as monoamines and metabolite levels in selected brain regions. Postnatal testosterone levels (measured at 1 and 5 d) did …


Why Distinctive Information Reduces False Memories: Evidence For Both Impoverished Relational-Encoding And Distinctiveness Heuristic Accounts, Amanda C. Gingerich, C. S. Dodson Jan 2004

Why Distinctive Information Reduces False Memories: Evidence For Both Impoverished Relational-Encoding And Distinctiveness Heuristic Accounts, Amanda C. Gingerich, C. S. Dodson

Scholarship and Professional Work - LAS

Two accounts explain why studying pictures reduces false memories within the Deese-Roediger-McDermott paradigm (J. Deese, 1959; H. L. Roediger & K. B. McDermott, 1995). The impoverished relational-encoding account suggests that studying pictures interferes with the encoding of relational information, which is the primary basis for false memories in this paradigm. Alternatively, the distinctiveness heuristic assumes that critical lures are actively withheld by the use of a retrieval strategy. When participants were given inclusion recall instructions to report studied items as well as related items, they still reported critical lures less often after picture encoding than they did after word encoding. …


Memory Matters Ii: Predictors Of Self-Care Behaviors In Young Adults With Type 1 Diabetes, Sari A. Soutor Jan 2004

Memory Matters Ii: Predictors Of Self-Care Behaviors In Young Adults With Type 1 Diabetes, Sari A. Soutor

Theses and Dissertations

Type 1 diabetes and associated hypoglycemia can result in verbal memory difficulties, yet the role of memory in daily diabetes self-care has not been evaluated for young adults. Subtests from two well-standardized memory measures were administered to 34 young adults with type 1 diabetes, aged 18-29, in this pilot study. Self-care behaviors were assessed through 24-hour diabetes care interviews, while HbAlc indicated metabolic control. Verbal associative memory uniquely accounted for 12% of the variance in blood glucose testing frequency (p p p p = .06. Single-trial verbal memory uniquely predicted 10% of the variance in metabolic control (p p < .05. Importantly, memory was the only significant predictor in each model, which indicates memory, rather than overall cognitive capacity or financial/educational resources, relates to self-care behaviors/health status. Memory, a novel factor not previously evaluated in the quest to better understand daily disease management for young adults with diabetes, is significantly related to central self-care behaviors and metabolic control. Memory predictors likely warrant additional research and clinical attention such that eventually, intervention studies might identify strategies or compensatory aids that could improve young adults' self-care behaviors and health status through facilitating better memory functioning.


Comparability Of Functional Mri Response In Young And Old During Inhibition, Kristy A. Nielson, Scott Aaron Langenecker, Thomas J. Ross, Hugh Garavan, Stephen M. Rao, Elliot Stein Jan 2004

Comparability Of Functional Mri Response In Young And Old During Inhibition, Kristy A. Nielson, Scott Aaron Langenecker, Thomas J. Ross, Hugh Garavan, Stephen M. Rao, Elliot Stein

Psychology Faculty Research and Publications

When using fMRI to study age-related cognitive changes, it is important to establish the integrity of the hemodynamic response because, potentially, it can be affected by age and disease. However, there have been few attempts to document such integrity and no attempts using higher cognitive rather than perceptual or motor tasks. We used fMRI with 28 healthy young and older adults on an inhibitory control task. Although older and young adults differed in task performance and activation patterns, they had comparable hemodynamic responses. We conclude that activation during cognitive inhibition, which was predominantly increased in elders, was not due to …


The Impact Of Hiv-Associated Neuropsychological Impairment On Everyday Functioning, Robert K. Heaton, Thomas D. Marcotte, Monica Rivera-Mindt, Joseph Sadek, David J. Moore, Heather Bentley, J Allen Mccutchan, Carla Reicks, Igor Grant, The Hnrc Group Jan 2004

The Impact Of Hiv-Associated Neuropsychological Impairment On Everyday Functioning, Robert K. Heaton, Thomas D. Marcotte, Monica Rivera-Mindt, Joseph Sadek, David J. Moore, Heather Bentley, J Allen Mccutchan, Carla Reicks, Igor Grant, The Hnrc Group

Psychology Faculty Publications

HIV-1 infection can be associated with neuropsychological (NP) deficits ranging from subtle to severe. The purpose of this study was to evaluate the functional, or “real-world” impact of HIV-associated NP impairment in a group of 267 HIV-infected participants. All participants received comprehensive NP, neuromedical, and standardized functional evaluations that included laboratory measures of shopping, cooking, financial management, medication management and vocational abilities. Compared to NP-normal participants, those with NP impairment performed significantly worse on all laboratory measures of everyday functioning. Multivariate analyses revealed that the NP ability domains of Abstraction/Executive Function, Learning, Attention/Working Memory and Verbal abilities most strongly and …


Visual Expectations: Using Machine Learning To Identify Patterns In Psychological Data, Skyler Place Jan 2004

Visual Expectations: Using Machine Learning To Identify Patterns In Psychological Data, Skyler Place

Honors Theses

The goal of this project was to utilize the tools of machine learning to evaluate the data obtained through experiments in psychology. Advanced pattern finding algorithms are an effective approach to analyzing large sets of data, from any domain of science. Consequently, we have a psychological question and hypothesis, and a separate machine learning technique to assess these claims. The realm of psychology that I focused on is visual cognition, and how an individual's knowledge affects how they see the world. This alteration of visual data is a part of perception -when the brain enhances the data coming in from …


The Effects Of Aniracetam Treatment On Cognitive Performance And Ampa Receptor Glur2 Subunit Expression After Moderate Fluid Percussion Injury In Rats, Anna Igorevna Baranova Jan 2004

The Effects Of Aniracetam Treatment On Cognitive Performance And Ampa Receptor Glur2 Subunit Expression After Moderate Fluid Percussion Injury In Rats, Anna Igorevna Baranova

Theses and Dissertations

In addition to the acute pathology produced by traumatic brain injury, there are chronic alterations that occur after the trauma, including a depressed state of neuronal activity (Feeney, 1991). This study included a preclinical testing of a novel treatment strategy focusing on increasing neuronal activity during the chronic hypofunctional posttraumatic stage. The present investigation tested the effects of repeated post-injury aniracetam administration on cognitive performance in the Morris water maze (MWM) and on the GluR2 - immunoreactivity and protein expression by Western blot analysis in the hippocampus. The first study examined the optimal dose of aniracetam in the MWM task. …