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The Long-Term Impact Of Chemotherapy On Neurogenesis And The Potential Use Of Fluoxetine As Preventative Treatment, Margaret Ross
The Long-Term Impact Of Chemotherapy On Neurogenesis And The Potential Use Of Fluoxetine As Preventative Treatment, Margaret Ross
Honors College
The present study attempts to investigate a potential underlying mechanism that contributes to cognitive impairments associated with chemotherapy treatment. In addition, it looks to investigate the potential preventative treatment using an antidepressant agent (Fluoxetine) to reduce the effects observed by chemotherapy treatment. One proposed explanation for Chemo Brain is a reduction in the proliferation of new brain cells. This study was designed to investigate this mechanism and was conducted in a series of two experiments. In experiment 1, 37 C57BL/6J male mice were administered saline or one of two chemotherapy agents; Cyclophosphamide or Doxorubicin over the course of eight days. …