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A Randomized Trial To Compare Switching To Very Low Nicotine Content Cigarettes Versus Reducing Cigarettes Per Day, Elias Mushabac Klemperer

Graduate College Dissertations and Theses

Smoking cigarettes is the most preventable cause of death in the US. Smokers are often unsuccessful at quitting because they are dependent. Reducing nicotine could be one way to reduce dependence. Currently, reducing cigarettes per day (CPD) is the most common strategy to reduce nicotine intake. However, some have proposed switching to very low nicotine content (VLNC) cigarettes to reduce nicotine and dependence. Both reducing CPD and switching to VLNC cigarettes aim to reduce nicotine but do so in different ways. I conducted a randomized trial to compare the degree to which switching to VLNC cigarettes vs reducing CPD 1) …

Evaluating The Utility Of The Modified Cigarette Evaluation Questionnaire And The Cigarette Purchase Task For Predicting Acute Relative Reinforcing Efficacy In Cigarettes Which Vary In Nicotine Content, Cecilia L. Bergeria

Graduate College Dissertations and Theses

Rationale: Nicotine is the addictive component in cigarettes which maintains cigarette smoking that subsequently leads to morbidity and mortality. There are growing regulatory efforts to lower the nicotine content in cigarettes so that they are minimally addictive. Valid methods for assessing the abuse liability of cigarettes are essential to these efforts. While subjective effect measures and hypothetical purchase tasks are appealing because they are far easier to administer, it is unclear whether these methods can be used to evaluate acute relative reinforcing, a critical component of abuse liability. This secondary analysis sought to evaluate the utility of one subjective effects …

Comparing The Effects Of Menthol Status On The Behavioral Pharmacology Of Smoking Reduced Nicotine Content Cigarettes, Danielle Davis

Graduate College Dissertations and Theses

Introduction: An active area of tobacco regulatory science research focuses on examining the effects of varying the nicotine content of cigarettes as part of a potential national policy to lower their nicotine content levels to reduce addiction potential. The present study examines differences in the behavioral effects of reduced nicotine content cigarettes related to their menthol status. Menthol is the only cigarette flavoring that is still legally permissible according to Food and Drug administration regulations.

Methods: Participants were 26 current adult smokers from three populations especially vulnerable to tobacco use and addiction (economically disadvantaged women, opioid-dependent individuals, individuals with affective …