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Differences In Compulsive-Like Ethanol Consumption In Adolescent-Trained And Adult-Trained Rats Exposed To Acute Isolation Stressors, Maria J. Lopez
Differences In Compulsive-Like Ethanol Consumption In Adolescent-Trained And Adult-Trained Rats Exposed To Acute Isolation Stressors, Maria J. Lopez
Seton Hall University Dissertations and Theses (ETDs)
The Pavlovian Conditioned Approach (PCA) procedure is an experimental procedure used with animals to induce compulsive-like behaviors directed towards an object conditioned stimulus (CS) paired with a sucrose pellet unconditioned stimulus (US) presented in a nearby food tray (sign tracking). When the object CS is an alcohol-containing bottle, the rats demonstrate compulsive-like interactions with the bottle object (e.g., approach, contact, and licking) that also results in alcohol consumption (drinking) in most rats. Compulsive alcohol drinking in a sign-tracking procedure is a result of the combined effects of schedule-induced compulsive-like behavior and the intake of alcohol (Tomie & Sharma, 2013).
The …
The Immediate And Long-Lasting Cognitive Consequences Of Adolescent Chronic Sleep Restriction, Kerry Howard
The Immediate And Long-Lasting Cognitive Consequences Of Adolescent Chronic Sleep Restriction, Kerry Howard
Seton Hall University Dissertations and Theses (ETDs)
Adolescence is a critical developmental period. An important change that occurs in adolescence is the neurological maturation for adult-type cognitive abilities. Research has linked adequate sleep quantity to successful learning and memory capabilities. However, due to a shift in sleep timing drive in adolescence, in combination with early awakening for school, the adolescent population is experiencing chronic sleep restriction (CSR). What repercussions to long-term memory capabilities could CSR in adolescence have immediately and are the consequences long-lasting? The present study modeled human adolescent CSR in rats through four hours of sleep deprivation for five days, followed by two days of …
The Short And Long-Term Effects Of Chronic Ketamine During Adolescence On Object Recognition Memory In Rats, William Hardin
The Short And Long-Term Effects Of Chronic Ketamine During Adolescence On Object Recognition Memory In Rats, William Hardin
Seton Hall University Dissertations and Theses (ETDs)
Prior research has demonstrated that ketamine causes deficits in object recognition and location memory following both acute and chronic administration (Pitsikas & Boultadakis, 2009; Venãncio et al., 2011). Although it is well established that abuse of many different kinds of drugs during the critical developmental period of adolescence can lead to impairments in cognition later in adulthood (Gilpin et al., 2012; Wagner et al., 2010), no research has investigated the effects of chronic ketamine administration during adolescence and its effects on behavior in adulthood. With recent research establishing that chronic ketamine during adolescence produces late-onset alterations in electrophysiology during adulthood …