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Full-Text Articles in Entire DC Network
Ucf Prostate Patch Batch, Md Sanzid Bin Hossain, Yelena Piazza, Mujtaba Husain, Dexter Hadley
Ucf Prostate Patch Batch, Md Sanzid Bin Hossain, Yelena Piazza, Mujtaba Husain, Dexter Hadley
UCF Necropsy WSI
Pathologists diagnose biopsy samples with a stained specimen on the glass slide through a microscope. The entire specimen can be stored as a Whole Slide Image (WSI) for further analysis. However, managing and manually diagnosing hundreds of images is time-consuming and requires specific expertise. As a result, there is extensive ongoing research for computer-aided diagnosis of these digitally acquired pathology images. Deep learning has gained significant attention for its effectiveness with disease classification and segmentation of cancer cells from pathology images. For deep learning, a large number of annotated images are needed to build a robust and accurate model. However, …
Ucf Lung Patch Batch, Md Sanzid Bin Hossain, Yelena Piazza, Mujtaba Husain, Dexter Hadley
Ucf Lung Patch Batch, Md Sanzid Bin Hossain, Yelena Piazza, Mujtaba Husain, Dexter Hadley
UCF Necropsy WSI
Pathologists diagnose biopsy samples with a stained specimen on the glass slide through a microscope. The entire specimen can be stored as a Whole Slide Image (WSI) for further analysis. However, managing and manually diagnosing hundreds of images is time-consuming and requires specific expertise. As a result, there is extensive ongoing research for computer-aided diagnosis of these digitally acquired pathology images. Deep learning has gained significant attention for its effectiveness with disease classification and segmentation of cancer cells from pathology images. For deep learning, a large number of annotated images are needed to build a robust and accurate model. However, …
Sentimental Empiricism: Politics, Philosophy, And Criticism In Postwar France, Davide Panagia
Sentimental Empiricism: Politics, Philosophy, And Criticism In Postwar France, Davide Panagia
Politics
Sentimental Empiricism reconsiders the legacy of eighteenth and nineteenth century empiricism and moral sentimentalism for the intellectual formation of the generation of postwar French thinkers whose work came to dominate Anglophone conversations across the humanities under the guise of “French theory.” Panagia’s book first shows what was missed in the reception of this literature in the Anglophone academy by attending to how France’s pedagogical milieu plays out church and state relations in the form of educational debates around reading practices, the aesthetics of mimesis, French imperialism, and republican universalism. Panagia then shows how such thinkers as Jean Wahl, Simone de …
Primary Versus Secondary Psychosis In A Patient With Congenital Liver Disease, Sormeh Nourbakhsh, Stephen J. Ferrando
Primary Versus Secondary Psychosis In A Patient With Congenital Liver Disease, Sormeh Nourbakhsh, Stephen J. Ferrando
NYMC Faculty Publications
In this article we report the case of a man with congenital liver disease who later developed psychotic illness and was diagnosed with schizophrenia. We illustrate how decompensation in liver function was associated with the exacerbation of psychotic symptoms. We discuss differential diagnostic challenges, and the possible overlapping neuropathology in these two conditions that may converge on glutamate/N-methyl-D-aspartate dysfunction. This patient's case underscores the need for further research to elucidate the possible underlying mechanisms linking congenital liver disease and psychosis.
A Novel Treponema Pallidum Subspecies Pallidum Strain Associated With A Painful Oral Lesion Is A Member Of A Potentially Emerging Nichols-Related Subgroup, Maria Rosa Velasquez, Bridget D. De Lay, Diane G. Edmondson, Gary P. Wormser, Steven J. Norris, Kaitlin Cafferky, Eric Munzer, Ciril-Christian Rizk, Marina Keller
A Novel Treponema Pallidum Subspecies Pallidum Strain Associated With A Painful Oral Lesion Is A Member Of A Potentially Emerging Nichols-Related Subgroup, Maria Rosa Velasquez, Bridget D. De Lay, Diane G. Edmondson, Gary P. Wormser, Steven J. Norris, Kaitlin Cafferky, Eric Munzer, Ciril-Christian Rizk, Marina Keller
NYMC Faculty Publications
BACKGROUND: Early syphilitic lesions are typically painless; however, several recent case studies have included patients with tender lesions and no evidence of concurrent infections. Here we present the manifestations and serological and molecular findings of a patient from New York State with a painful tongue lesion. METHODS: The diagnosis of syphilis was based on a combination of physical examination, serologic, pathologic, and immunohistochemical findings. DNA obtained from a formalin-fixed, paraffin-embedded biopsy was used to characterize the infecting pathogen using polymerase chain reaction, multilocus sequence typing, and whole-genome sequencing methods. RESULTS: Polymerase chain reaction and multilocus sequence typing of the biopsy …
Loss-Of-Function G6pd Variant Moderated High-Fat Diet-Induced Obesity, Adipocyte Hypertrophy, And Fatty Liver In Male Rats, Shun Matsumura, Christina Signoretti, Samuel Fatehi, Bat Ider Tumenbayar, Catherine D'Addario, Erik Nimmer, Colin Thomas, Trisha Viswanathan, Alexandra Wolf, Victor Garcia, Petra Rocic, Yongho Bae, Sm Shafiqul Alam, Sachin A. Gupte
Loss-Of-Function G6pd Variant Moderated High-Fat Diet-Induced Obesity, Adipocyte Hypertrophy, And Fatty Liver In Male Rats, Shun Matsumura, Christina Signoretti, Samuel Fatehi, Bat Ider Tumenbayar, Catherine D'Addario, Erik Nimmer, Colin Thomas, Trisha Viswanathan, Alexandra Wolf, Victor Garcia, Petra Rocic, Yongho Bae, Sm Shafiqul Alam, Sachin A. Gupte
NYMC Faculty Publications
Obesity is a major risk factor for liver and cardiovascular diseases. However, obesity-driven mechanisms that contribute to the pathogenesis of multiple organ diseases are still obscure and treatment is inadequate. We hypothesized that increased , glucose-6-phosphate dehydrogenase (G6PD), the key rate-limiting enzyme in the pentose shunt, is critical in evoking metabolic reprogramming in multiple organs and is a significant contributor to the pathogenesis of liver and cardiovascular diseases. G6PD is induced by a carbohydrate-rich diet and insulin. Long-term (8 months) high-fat diet (HFD) feeding increased body weight and elicited metabolic reprogramming in visceral fat, liver, and aorta, of the wild-type …
Sustained Treatment Response And Global Improvements With Long-Term Valbenazine In Patients With Tardive Dyskinesia, Christoph U. Correll, Leslie Citrome, Carlos Singer, Jean-Pierre Lindenmayer, Celia Zinger, Grace Liang, Eduardo Dunayevich, Stephen R. Marder
Sustained Treatment Response And Global Improvements With Long-Term Valbenazine In Patients With Tardive Dyskinesia, Christoph U. Correll, Leslie Citrome, Carlos Singer, Jean-Pierre Lindenmayer, Celia Zinger, Grace Liang, Eduardo Dunayevich, Stephen R. Marder
NYMC Faculty Publications
PURPOSE/BACKGROUND: Using data from KINECT® 4, a phase 3, 48-week study of valbenazine, post hoc analyses were conducted to assess long-term outcomes that are relevant to the real-world management of tardive dyskinesia (TD). METHODS/PROCEDURES: Post hoc analyses of the participants of the KINECT 4 study who completed 48 weeks of open-label valbenazine (40 or 80 mg) treatment were conducted. Valbenazine effects on TD were evaluated using the Abnormal Involuntary Movement Scale (AIMS), Clinical Global Impression of Change-TD (CGI-TD), and Patient Global Impression of Change (PGIC). FINDINGS/RESULTS: Of 103 participants completing 48 weeks of treatment, 55% experienced clinically meaningful improvement (defined …
Obesity As A Risk Factor For Adverse Outcomes After Pedestrian Trauma Accidents In The Pediatric Population, Hannah Mulvihill, Katie Roster, Nisha Lakhi
Obesity As A Risk Factor For Adverse Outcomes After Pedestrian Trauma Accidents In The Pediatric Population, Hannah Mulvihill, Katie Roster, Nisha Lakhi
NYMC Faculty Publications
OBJECTIVE: The aim of the study is to determine whether overweight or obese children are at an increased risk for injury and adverse outcomes following pedestrian motor vehicle accidents. METHODS: We performed a retrospective study of patients between the ages of 2 and 17 who were pedestrians injured in a collision with a motorized vehicle, presenting to a level 1 trauma center, between January 1, 2010, to December 31, 2021. Patients with admission weights falling above the 90th percentile of the Centers for Disease Control and Prevention's sex-specific growth charts were identified as overweight/obese, those below the cutoff were categorized …
Genetic Counseling Access And Service Delivery In New York State Is Variable For Parents Of Infants With Complex Cftr Genotypes Conferring Uncertain Phenotypes, Denise M. Kay, Hossein Sadeghi, Catherine Kier, Maria Berdella, Joan K. Decelie-Germana, Zafer N. Soultan, Danielle M. Goetz, Michele Caggana, Christopher N. Fortner, Robert Giusti, Robert Kaslovsky, Colleen Stevens, Karen Voter, John J. Welter
Genetic Counseling Access And Service Delivery In New York State Is Variable For Parents Of Infants With Complex Cftr Genotypes Conferring Uncertain Phenotypes, Denise M. Kay, Hossein Sadeghi, Catherine Kier, Maria Berdella, Joan K. Decelie-Germana, Zafer N. Soultan, Danielle M. Goetz, Michele Caggana, Christopher N. Fortner, Robert Giusti, Robert Kaslovsky, Colleen Stevens, Karen Voter, John J. Welter
NYMC Faculty Publications
BACKGROUND: New York State (NYS) utilizes a three-tiered cystic fibrosis newborn screening (CFNBS) algorithm that includes cystic fibrosis transmembrane conductance regulator (CFTR) gene sequencing. Infants with >1 CFTR variant of potential clinical relevance, including variants of uncertain significance or varying clinical consequence are referred for diagnostic evaluation at NYS cystic fibrosis (CF) Specialty Care Centers (SCCs). AIMS: As part of ongoing quality improvement efforts, demographic, screening, diagnostic, and clinical data were evaluated for 289 CFNBS-positive infants identified in NYS between December 2017 and November 2020 who did not meet diagnostic criteria for CF and were classified as either: CFTR-related metabolic …
Long-Term Efficacy Of Liposomal Nanocarriers Of Preassembled Glycocalyx In Restoring Cerebral Endothelial Glycocalyx In Sepsis, Shinya Ishiko, An Huang, Dong Sun
Long-Term Efficacy Of Liposomal Nanocarriers Of Preassembled Glycocalyx In Restoring Cerebral Endothelial Glycocalyx In Sepsis, Shinya Ishiko, An Huang, Dong Sun
NYMC Faculty Publications
The endothelial glycocalyx (EG) undergoes early degradation in sepsis. Our recent work introduced a novel therapeutic approach involving liposomal nanocarriers of preassembled glycocalyx (LNPG) to restore EG in lipopolysaccharide (LPS)-induced sepsis model of mice. While short-term effects were promising, this study focuses on the long-term impact of LNPG on mouse cerebral microcirculation. Utilizing cranial window, we assessed the stability of vascular density (VD) and perfused boundary region (PBR), an index of EG thickness, over a five-day period in normal control mice. In septic groups (LPS, LPS + 1-dose LNPG, and LPS + 2-dose LNPG), the exposure of mice to LPS …
Twenty-Three-Year-Old Patient With Chronic Pain And Fainting Spells-A Clinical Vignette, Allegra N. Ploeg, Jacques Courseault, Anusha Lekshminarayanan
Twenty-Three-Year-Old Patient With Chronic Pain And Fainting Spells-A Clinical Vignette, Allegra N. Ploeg, Jacques Courseault, Anusha Lekshminarayanan
NYMC Faculty Publications
Care for and clinical presentation of patients with connective tissue disorders, specifically hypermobile Ehlers-Danlos syndrome, is poorly understood. Diagnosis can often take years, and comprehensive care can be difficult to coordinate for these patients. This vignette aims to show the clinical characteristics of a young female with Hypermobile Ehlers-Danlos, as well as the evaluation of her diagnostic presentation and subsequent treatment. The demographic data of this population are yet to be established, and as it can vary widely between individuals, it is important to recognize symptoms that distinguish this disorder from others with similar presentations. Education of physicians on this …
Cardiac Myosin Activator Omecamtiv Mecarbil: Novel Treatment For Systolic Heart Failure, Maat Mack, William H. Frishman
Cardiac Myosin Activator Omecamtiv Mecarbil: Novel Treatment For Systolic Heart Failure, Maat Mack, William H. Frishman
NYMC Faculty Publications
Systolic Heart failure is a complex clinical syndrome characterized by a decrease in cardiac contractility and a reduction in organ perfusion. Current pharmacologic inotropes attempt to improve contractility via indirect mechanisms but are limited in terms of safety and effectiveness. Omecamtiv mecarbil is a novel agent in a new class of drugs known as cardiac myosin activators; their unique mechanism of action involves directly activating the enzymatic pathway in the cardiac myocyte as a way to improve ventricular contraction. Preclinical and clinical trials have found that omecamtiv mecarbil improves cardiac contractility without increasing the risk of any of the harmful …
First Monte Carlo Beam Model For Ultra-High Dose Rate Radiotherapy With A Compact Electron Linac, Tianyuan Dai, Austin M. Sloop, Mahbubur R. Rahman, Jacob P. Sunnerberg, Megan A. Clark, Ralph Young, Sebastian Adamczyk, Philip Von Voigts-Rhetz, Chris Patane, Michael Turk, Lesley Jarvis, Brian W. Pogue, David J. Gladstone, Petr Bruza, Rongxiao Zhang
First Monte Carlo Beam Model For Ultra-High Dose Rate Radiotherapy With A Compact Electron Linac, Tianyuan Dai, Austin M. Sloop, Mahbubur R. Rahman, Jacob P. Sunnerberg, Megan A. Clark, Ralph Young, Sebastian Adamczyk, Philip Von Voigts-Rhetz, Chris Patane, Michael Turk, Lesley Jarvis, Brian W. Pogue, David J. Gladstone, Petr Bruza, Rongxiao Zhang
NYMC Faculty Publications
BACKGROUND: FLASH radiotherapy based on ultra-high dose rate (UHDR) is actively being studied by the radiotherapy community. Dedicated UHDR electron devices are currently a mainstay for FLASH studies. PURPOSE: To present the first Monte Carlo (MC) electron beam model for the UHDR capable Mobetron (FLASH-IQ) as a dose calculation and treatment planning platform for preclinical research and FLASH-radiotherapy (RT) clinical trials. METHODS: The initial beamline geometry of the Mobetron was provided by the manufacturer, with the first-principal implementation realized in the Geant4-based GAMOS MC toolkit. The geometry and electron source characteristics, such as energy spectrum and beamline parameters, were tuned …
The Impact Of Ipsilateral Implantable Cardioverter Defibrillator In Axillary Intra-Aortic Balloon Pump Support As Bridge To Heart Transplantation, Ameesh Isath, Rahim Hirani, Avi Levine, Gregg M. Lanier, Aroubah Iqbal, Junichi Shimamura, Alan L. Gass, David Spielvogel, Masashi Kai, Suguru Ohira
The Impact Of Ipsilateral Implantable Cardioverter Defibrillator In Axillary Intra-Aortic Balloon Pump Support As Bridge To Heart Transplantation, Ameesh Isath, Rahim Hirani, Avi Levine, Gregg M. Lanier, Aroubah Iqbal, Junichi Shimamura, Alan L. Gass, David Spielvogel, Masashi Kai, Suguru Ohira
NYMC Faculty Publications
BACKGROUND: The axillary artery (AX) access for intra-aortic balloon pump (IABP) as a bridge to heart transplant (HT) allows mobility while awaiting a suitable donor. As end-stage heart failure patients often have an implantable cardioverter defibrillator (ICD) on the left side, the left AX approach may be avoided due to the perception of difficult access and proximity of two devices. We aimed to evaluate the outcomes of patients bridged to HT with a left-sided AX IABP with or without ipsilateral ICDs. METHODS: We retrospectively reviewed HT candidates at our institution supported by left-sided axillary IABP from November 2019 to February …
Is Low Cortisol A Marker Of Long Covid?, Armin Alaedini, Stafford Lightman, Gary P. Wormser
Is Low Cortisol A Marker Of Long Covid?, Armin Alaedini, Stafford Lightman, Gary P. Wormser
NYMC Faculty Publications
No abstract provided.
Do Program Directors Of Anesthesiology Residency Programs Interpret Narrative Letters Of Recommendation As Intended?, Samantha R. Pianello, Joanna M. Abouezzi, Garret M. Weber, Elizabeth Drugge, Marvin S. Medow, Apolonia E. Abramowicz
Do Program Directors Of Anesthesiology Residency Programs Interpret Narrative Letters Of Recommendation As Intended?, Samantha R. Pianello, Joanna M. Abouezzi, Garret M. Weber, Elizabeth Drugge, Marvin S. Medow, Apolonia E. Abramowicz
NYMC Faculty Publications
Background Letters of recommendation (LORs) are an important part of the application process for medical residency programs with most specialties preferring a narrative format. Given the inherent subjectivity of narrative LORs, the current study sought to determine whether the intended messages of narrative LORs written for applicants to anesthesiology residency programs are accurately interpreted by readers. Methodology Anonymous online surveys were sent via the Qualtrics platform to program directors (PDs) of the Accreditation Council for Graduate Medical Education-accredited anesthesiology residency programs in the Mid-Atlantic region as designated by the Electronic Residency Application Service, which consists of the states of New …
More Investigations Needed For Enhanced Recovery After Anesthesia For Craniotomy, Sarah C. Smith, Apolonia Elisabeth Abramowicz
More Investigations Needed For Enhanced Recovery After Anesthesia For Craniotomy, Sarah C. Smith, Apolonia Elisabeth Abramowicz
NYMC Faculty Publications
No abstract provided.
Mobile Stroke Units In Acute Ischemic Stroke: A Comprehensive Systematic Review And Meta-Analysis Of 5 "T Letter" Domains, Abdulrahman Ibrahim Hagrass, Sarah Makram Elsayed, Mohamed Fahmy Doheim, Mohamed Abdelhady Mostafa, Mohamed Elfil, Mohammed Al-Kafarna, Bashar Khaled Almaghary, Aya Mamdouh Fayoud, Aboalmagd Hamdallah, Mohammed Tarek Hasan, Khaled Mohamed Ragab, Anas Zakarya Nourelden, Mohamed Sayed Zaazouee, Chaitanya Medicherla, Mackenzie Lerario, Alexandra L. Czap, Ji Chong, May Nour, Fawaz Al-Mufti
Mobile Stroke Units In Acute Ischemic Stroke: A Comprehensive Systematic Review And Meta-Analysis Of 5 "T Letter" Domains, Abdulrahman Ibrahim Hagrass, Sarah Makram Elsayed, Mohamed Fahmy Doheim, Mohamed Abdelhady Mostafa, Mohamed Elfil, Mohammed Al-Kafarna, Bashar Khaled Almaghary, Aya Mamdouh Fayoud, Aboalmagd Hamdallah, Mohammed Tarek Hasan, Khaled Mohamed Ragab, Anas Zakarya Nourelden, Mohamed Sayed Zaazouee, Chaitanya Medicherla, Mackenzie Lerario, Alexandra L. Czap, Ji Chong, May Nour, Fawaz Al-Mufti
NYMC Faculty Publications
Intravenous thrombolysis (IVT) may be administered to stroke patients requiring immediate treatment more quickly than emergency medical services if certain conditions are met. These conditions include the presence of mobile stroke units (MSUs) with on-site treatment teams and a computed tomography scanner. We compared clinical outcomes of MSU conventional therapy by emergency medical services through a systematic review and meta-analysis. We searched key electronic databases from inception till September 2021. The primary outcomes were mortality at 7 and 90 days. The secondary outcomes included the modified Rankin Scale score at 90 days, alarm to IVT or intra-arterial recanalization, and time …
Dual Antiplatelet Therapy Versus Intravenous Tissue Plasminogen Activator With Acute Minor Ischemic Stroke: A Systematic Review And Meta-Analysis Of Safety And Efficacy, Abdallah Abbas, Abdullah Ashraf Hamad, Mostafa Hossam El Din Moawad, Dalia Kamal Ewis, Rana Ahmed Youssef, Heba Hamouda, Malak A. Hassan, Mohammad Aladawi, Mohamed Elfil, Mostafa Meshref, Fawaz Al-Mufti
Dual Antiplatelet Therapy Versus Intravenous Tissue Plasminogen Activator With Acute Minor Ischemic Stroke: A Systematic Review And Meta-Analysis Of Safety And Efficacy, Abdallah Abbas, Abdullah Ashraf Hamad, Mostafa Hossam El Din Moawad, Dalia Kamal Ewis, Rana Ahmed Youssef, Heba Hamouda, Malak A. Hassan, Mohammad Aladawi, Mohamed Elfil, Mostafa Meshref, Fawaz Al-Mufti
NYMC Faculty Publications
OBJECTIVES: To compare the safety and efficacy of Dual Antiplatelet Therapy (DAPT) and Intravenous (IV) Tissue Plasminogen Activator (t-PA) in minor Acute Ischemic Stroke (AIS). MATERIALS AND METHODS: Following Cochrane and PRISMA guidelines, we analyzed observational studies and clinical trials comparing DAPT and IV t-PA in patients with minor AIS. Databases included PubMed, Scopus, and Web of Science. Data extraction included study characteristics, patient demographics, and analyzed outcomes. RevMan 5.3 and OpenMetaAnalyst 2021 were used to analyze the data and assess heterogeneity, respectively. The risk of bias was determined using RoB 2.0 and the Newcastle-Ottawa scale. RESULTS: This meta-analysis included …
Trainee Perspectives Regarding The Effect Of The Dobbs V. Jackson Women's Health Organization Supreme Court Decision On Obstetrics And Gynecology Training, Kate V. Meriwether, Shunaha Kim-Fine, Tova Ablove, Arthur Ollendorff, Lindsay E. Dale, Jamie W. Krashin, William D. Winkelman, Francisco Orejuela, Donna Mazloomdoost, Cara L. Grimes, A Jenna Beckham, Katie Propst, Maria E. Florian-Rodriguez, Jema K. Turk, Olivia H. Chang, Sarah Horvath, Stephanie T. Ros, Catrina C. Crisp, Timothy R. Petersen, Cheryl B. Iglesia
Trainee Perspectives Regarding The Effect Of The Dobbs V. Jackson Women's Health Organization Supreme Court Decision On Obstetrics And Gynecology Training, Kate V. Meriwether, Shunaha Kim-Fine, Tova Ablove, Arthur Ollendorff, Lindsay E. Dale, Jamie W. Krashin, William D. Winkelman, Francisco Orejuela, Donna Mazloomdoost, Cara L. Grimes, A Jenna Beckham, Katie Propst, Maria E. Florian-Rodriguez, Jema K. Turk, Olivia H. Chang, Sarah Horvath, Stephanie T. Ros, Catrina C. Crisp, Timothy R. Petersen, Cheryl B. Iglesia
NYMC Faculty Publications
We aimed to describe obstetrics and gynecology (OBGYN) trainees' anticipation of how the Dobbs v. Jackson Women's Health Organization (Dobbs) U.S. Supreme Court decision may affect their training. A REDCap survey of OBGYN residents and fellows in the United States from September 19, 2022, to December 1, 2022, queried trainees' anticipated achievement of relevant Accreditation Council for Graduate Medical Education (ACGME) training milestones, their concerns about the ability to provide care and concern about legal repercussions during training, and the importance of OBGYN competence in managing certain clinical situations for residency graduates. The primary outcome was an ACGME program trainee …
Potential Medicare Part D Savings On Ophthalmic Generic Drugs, David A. Collet, Matthew B. Urban, Abha Amin
Potential Medicare Part D Savings On Ophthalmic Generic Drugs, David A. Collet, Matthew B. Urban, Abha Amin
NYMC Faculty Publications
No abstract provided.
Cyanotic Congenital Heart Disease In Pregnancy: A Review Of Pathophysiology And Management, Klaudia J. Koziol, Ameesh Isath, Wilbert S. Aronow, William Frishman, Pragya Ranjan
Cyanotic Congenital Heart Disease In Pregnancy: A Review Of Pathophysiology And Management, Klaudia J. Koziol, Ameesh Isath, Wilbert S. Aronow, William Frishman, Pragya Ranjan
NYMC Faculty Publications
The advancement of medical treatment and surgical technique, along with the invention of cardiopulmonary bypass, has allowed for long-term survival of patients with cyanotic congenital heart disease (CHD)-with many women with CHD now reaching child-bearing age and wishing to become pregnant. Pregnancy in these women is a major concern as the physiologic adaptations of pregnancy, including an increased circulating volume, increased cardiac output, reduced systemic vascular resistance, and decreased blood pressure, place a substantial load on the cardiovascular system. These changes are essential to meet the increased maternal and fetal metabolic demands and allow for sufficient placental circulation during gestation. …
Healthcare Disparities In Cardiovascular Medicine, Tzvi Fishkin, Andy Wang, William H. Frishman, Wilbert S. Aronow
Healthcare Disparities In Cardiovascular Medicine, Tzvi Fishkin, Andy Wang, William H. Frishman, Wilbert S. Aronow
NYMC Faculty Publications
There are significant healthcare disparities in cardiovascular medicine that represent a challenge for cardiologists and healthcare policy-makers who wish to provide equitable care. Disparities exist in both the management and outcomes of hypertension, coronary artery disease and its sequelae, and heart failure. These disparities are present along the lines of race, gender, and socioeconomic status. Despite recent efforts to reduce disparity, there are knowledge and research gaps among cardiologists with regards to both the scope of the problem and how to solve it. Solutions include increasing awareness of disparities in cardiovascular health, increasing research for optimal treatment of underserved communities, …
Texas School Board And Ambition Replication Data, Kelly Bergstrand
Texas School Board And Ambition Replication Data, Kelly Bergstrand
Sociology & Anthropology Datasets
This data contains information on the demographics of Texas school board members and their ambition levels. (2024-06-20)
Supplementary Files For "Using Digitized Building And Weather Records To Improve The Accuracy Of Ground To Roof Snow Load Ratio Estimations", Gideon Parry, Brennan Bean
Supplementary Files For "Using Digitized Building And Weather Records To Improve The Accuracy Of Ground To Roof Snow Load Ratio Estimations", Gideon Parry, Brennan Bean
Browse all Datasets
Reliability targeted snow loads (RTLs) measure the weight in accumulated snow (i.e. snow load) that a roof is required to support to ensure the probability of failure is suf- ficiently low. This calculation has historically relied upon a probability distribution that characterizes the ratio between the annual maximum ground snow load to the annual max- imum roof snow load, a quantity referred to as Gr. The best available data for estimating Gr comes from Canadian case studies from the 1950s and 1960s. However, much of the data was never digitized, with only approximations of data being made available in scanned …
Efficiently Targeting Neuroblastoma With The Combination Of Anti-Ror1 Car Nk Cells And N-803 And In Nb Xenografts, Yaya Chu, Gaurav Nayyar, Meijuan Tian, Dean A. Lee, Mehmet F. Ozkaynak, Jessica Ayala-Cuesta, Kayleigh Klose, Keira Foley, Alyssa S. Mendelowitz, Wen Luo, Yanling Liao, Janet Ayello, Gregory K. Behbehani, Stanley Riddell, Tim Cripe, Mitchell S. Cairo
Efficiently Targeting Neuroblastoma With The Combination Of Anti-Ror1 Car Nk Cells And N-803 And In Nb Xenografts, Yaya Chu, Gaurav Nayyar, Meijuan Tian, Dean A. Lee, Mehmet F. Ozkaynak, Jessica Ayala-Cuesta, Kayleigh Klose, Keira Foley, Alyssa S. Mendelowitz, Wen Luo, Yanling Liao, Janet Ayello, Gregory K. Behbehani, Stanley Riddell, Tim Cripe, Mitchell S. Cairo
NYMC Faculty Publications
The prognosis for children with recurrent and/or refractory neuroblastoma (NB) is dismal. The receptor tyrosine kinase-like orphan receptor 1 (ROR1), which is highly expressed on the surface of NB cells, provides a potential target for novel immunotherapeutics. Anti-ROR1 chimeric antigen receptor engineered expanded peripheral blood natural killer (anti-ROR1 CAR exPBNK) cells represent this approach. N-803 is an IL-15 superagonist with enhanced biological activity. In this study, we investigated the and anti-tumor effects of anti-ROR1 CAR exPBNK cells with or without N-803 against ROR1 NB models. Compared to mock exPBNK cells, anti-ROR1 CAR exPBNK cells had significantly enhanced cytotoxicity against ROR1 …
Microbiology, Public Health, And The Murals Of Diego Rivera, Felipe C. Cabello, Henry P. Godfrey
Microbiology, Public Health, And The Murals Of Diego Rivera, Felipe C. Cabello, Henry P. Godfrey
NYMC Faculty Publications
Diego Rivera, an acclaimed Mexican painter active during the first half of the 20th century, painted multiple frescoes in Mexico and the United States. Some include depictions of bacteria, their interactions with human hosts, and processes related to microbiology and public health, including the microbial origin of life, diagnosis of infection, vaccine production, and immunization. Microbiological subjects in Rivera's murals at the Mexican Ministry of Health in Mexico City; the Detroit Institute of Art, Detroit; Rockefeller Center, New York/Palacio de Bellas Artes, Mexico City; Chapultepec Park, Mexico City; and the Institute of Social Security, Mexico City, span almost 25 years, …
Right To Higher Education Of Persons With Disabilities: Indian Scenario, Sanjay Jain
Right To Higher Education Of Persons With Disabilities: Indian Scenario, Sanjay Jain
Book Chapters
The Book "Disability: A Journey from Welfare to Right", is a collection of excellent pieces on disability laws and policies at the national and international level. This monumental work is a comprehensive exploration of the legal frameworks, policies, and jurisprudence surrounding disability rights.
Models Of Disability And Judicial Interpretation In India, Sanjay Jain
Models Of Disability And Judicial Interpretation In India, Sanjay Jain
Book Chapters
How disability is modeled or understood is determinative in the evolution of both Disability Studies and Disability Politics. By focusing on India, this chapter demonstrates that transformation and metamorphosis in the lives of persons with disabilities is contingent and predicated on the adoption of models to evolve conceptions of disability and disability rights. Upon the ratification of the United Nations Convention on the Rights of Persons with Disabilities 2006 by India, a presumption arose that the Indian legal order embraced the social and Human rights models of disability and that disability was no longer to be viewed through the prism …
Foxa2 Rewires Ap-1 For Transcriptional Reprogramming And Lineage Plasticity In Prostate Cancer, Zifeng Wang, Scott L. Townley, Songqi Zhang, Mingyu Liu, Muqing Li, Maryam Labaf, Susan Patalano, Kavita Venkataramani, Kellee R. Siegfried, Jill A. Macoska, Dong Han, Shuai Gao, Gail P. Risbridger, Renea A. Taylor, Mitchell G. Lawrence, Housheng Hansen He, Luke A. Selth, Changmeng Cai
Foxa2 Rewires Ap-1 For Transcriptional Reprogramming And Lineage Plasticity In Prostate Cancer, Zifeng Wang, Scott L. Townley, Songqi Zhang, Mingyu Liu, Muqing Li, Maryam Labaf, Susan Patalano, Kavita Venkataramani, Kellee R. Siegfried, Jill A. Macoska, Dong Han, Shuai Gao, Gail P. Risbridger, Renea A. Taylor, Mitchell G. Lawrence, Housheng Hansen He, Luke A. Selth, Changmeng Cai
NYMC Faculty Publications
FOXA family proteins act as pioneer factors by remodeling compact chromatin structures. FOXA1 is crucial for the chromatin binding of the androgen receptor (AR) in both normal prostate epithelial cells and the luminal subtype of prostate cancer (PCa). Recent studies have highlighted the emergence of FOXA2 as an adaptive response to AR signaling inhibition treatments. However, the role of the FOXA1 to FOXA2 transition in regulating cancer lineage plasticity remains unclear. Our study demonstrates that FOXA2 binds to distinct classes of developmental enhancers in multiple AR-independent PCa subtypes, with its binding depending on LSD1. Moreover, we reveal that FOXA2 collaborates …