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Spouse Violence In Case Of Police Officers In Puerto Rico: Violence In Police Families, Jorge Ismael Suarez

Theses and Dissertations

This applied dissertation was designed to explore the relationship between factors related to police work and whether these factors help predict domestic violence in a sample of officers of the Puerto Rico Police. The following factors were explored in this study: external burnout, alcohol abuse, department withdrawal, and authoritarian spillover. This study was based on a previous study by Johnson et al. (2005), which revealed that violence exposure and domestic violence among police officers are linked according to four mediation chains. The mediation chain was a model implemented by the authors to determine the influence of burnout, authoritarian spillover, alcohol …

Towards A Theory Of Sobriety Barriers: The Development Of A Novel Measure Of Alcohol Sobriety Barriers, Lindsay L. Arader

Theses and Dissertations

At present, there is no formal theory of barriers to sobriety from alcohol, and subsequently no standardized way to assess such barriers in the population. The goal of the current study was to formalize both a sobriety barriers theory and sobriety barriers measure via psychometric analysis. Researchers designed a sobriety barriers theory based on available literature, generated a multidimensional item-set representing this theory, administered the item-set to a sample of 1,187 respondents (56.4% female), and evaluated the extent to which the structure and contents of the item-set corresponded to the proposed theory using psychometric analysis. Structural analyses revealed a bifactor …

Perfectionism, Alcohol Intoxication, And Deliberate Self-Harm In Men And Women, Lissa N. Mandell

Theses and Dissertations

Previous research has demonstrated associations between deliberate self-harm (DSH) and perfectionism, although most of that research used retrospective self-report measures of DSH, which are prone to various cognitive biases. Although perfectionism has been associated with alcohol abuse, no research has examined how alcohol intoxication may moderate the relation between perfectionism and DSH. The aims of this experimental study were to determine if perfectionism is associated with a laboratory analogue of DSH (the Self-Aggression Paradigm) and examine the role of alcohol intoxication as a potential moderator. Using archival data, blood alcohol content (BAC) was manipulated by randomly assigning participants to reach …

The Relation Between Adhd Symptoms And Alcohol And Marijuana Use Outcomes Among College Students: The Mediating Role Of Experiential Avoidance, William Joshua Bradley

Theses and Dissertations

Individuals with attention-deficit/hyperactivity disorder (ADHD) are at significantly greater risk for alcohol and marijuana misuse and abuse compared to their peers. College students with ADHD may be particularly vulnerable to problematic alcohol and marijuana use, given the widespread use and abuse of these substances by college students generally and liability associated with ADHD specifically. Experiential avoidance, or avoidance of unwanted thoughts, feelings, and other internal experiences, is positively associated with ADHD symptoms and substance use problems. However, it is unclear what role experiential avoidance plays in the relation between ADHD and alcohol and marijuana use. This study examined whether experiential …

Alcohol And Other Addictive Behaviors Among Bariatric Surgery Patients, Rachel M. Arnold

Theses and Dissertations

Research has repeatedly highlighted a high rate of comorbidity of addictive behaviors in both clinical and non-clinical samples. While polydrug use has received significant attention in recent years, less is known about rates of comorbidity with behavioral addictions such as eating, work, exercise, or sex. Individuals with a history of bariatric surgery may provide a unique opportunity to examine the potential co-occurrence of addictive behaviors. High rates of food addiction symptoms and changes in alcohol use patterns post-surgically have highlighted a potential gap in our understanding of bariatric patients and their needs post-surgically. Using a composite measure of addictive behaviors, …

The Role Of Alcohol Use, Drinking Context, And Alcohol Expectancies In Sexual Assault Perpetration Among College Men, Joseph D. Censor

Theses and Dissertations

Sexual assault is a major public health and criminal justice problem in our society. The high prevalence rate of sexual assault victimization and perpetration among college students is even more disturbing. Additionally, the prevalence of alcohol use among college students is higher than in the general population, and alcohol use is associated with more than half of sexual assaults. The goal of the present study was to gain a deeper understanding of the role of various alcohol related factors in sexual assault perpetration among college men. Specifically, this study assessed the association of perpetration with general problematic alcohol use, general …

Genetics And Alcohol Interventions In Youth, Zoe E. Neale

Theses and Dissertations

Alcohol is the most commonly used substance among youth, and risky alcohol use is associated with harmful consequences such as accidents, academic consequences, and physical and emotional health problems. Alcohol use disorders are approximately 50% heritable, yet most efforts to prevent and intervene upon youth alcohol use focus only on environmental factors. Furthermore, current prevention and intervention programs tend to have modest effects and are not uniformly effective for all individuals. Gene-by-intervention (GxI) studies offer an opportunity to expand current understanding of interventions by examining whether underlying genetic risk may contribute to differential program effects. Much of the current GxI …

The Effects Of Alcohol On Bdnf And Cd5 Dependent Pathways, Andrew Jordan Payne

Theses and Dissertations

Alcohol represents the third leading cause of preventable death in the United States. Yet, despite its prevalent role in impeding human health, there is much to understand about how it elicits its effects on the body and how the body and brain change when an individual becomes physiologically dependent upon alcohol. The work presented herein represents an effort to elucidate the acute and chronic effects of alcohol on the nervous system. We investigate two specific protein pathways and their role in alcohol's effects on the body. The first begins with brain-derived neurotrophic factor (BDNF), which acts on TrkB, and ends …

Alcohol Affects The Reward Pathway Of The Brain Via A6-Containing Nicotinic Acetylcholine Receptors In The Nucleus Accumbens, Elizabeth Qiufeng Anderson

Theses and Dissertations

The prevailing view is that enhancement of dopamine (DA) transmission in the mesolimbic system consisting of DA neurons in the ventral tegmental area (VTA) that project to the nucleus accumbens (NAc) underlies the rewarding properties of ethanol (EtOH) and nicotine (NIC). Although the dogma is that EtOH enhancement of DA neural activity contributes to enhancement of DA transmission, DA neurons are not sensitive to rewarding levels of EtOH. However, VTA GABA neurons are sensitive to low-dose EtOH. We have shown previously that EtOH modulation of DA release in the NAc is mediated by α6-containing nicotinic receptors (α6*-nAChRs), that α6*-nAChRs mediate …

Aerobic Exercise Alters Opioid Receptors Following Chronic Alcohol Exposure, James N. Brundage

Theses and Dissertations

Opioid receptors have been a target of pharmacological manipulation in alcohol use disorder (AUD) recovery protocols for many years. Aerobic exercise, a common adjunct in AUD recovery, is known to modulate opioid receptors (ORs) both during both acute and long term exposure. The three subtypes of ORs: mu (MOR), delta (DOR), and kappa (KOR) are all expressed on neurons in the mesocorticolimbic circuitry. Kappa-opioid receptors are expressed directly on dopamine (DA) neuron terminals in the nucleus accumbens (NAc). Mu and Delta ORs are expressed on cholinergic interneurons (CINs) and GABA neurons in the NAc. In alcohol dependent rodents, KORs are …

The Effect Of Hurricane Sandy On Mental Health Outcomes Of New Yorkers, Kacper Perkowski

Theses and Dissertations

This study’s objective is to evaluate the effect of Hurricane Sandy on the long-term mental health of New Yorkers. Health data spanning from 2010-2014 was obtained through the Community Health Survey. Difference-in-differences regressions were employed to evaluate the relationship. The results show Hurricane Sandy had no statistically significant effect on any key mental health variables.

Attitudes About Date Rape: Context And Consent, Hannah Mae Strom

Theses and Dissertations

Sexual assault, and date rape specifically, is a prevalent problem among college students. Many factors influence students’ attitudes about these situations such as the closeness of the relationship and alcohol consumed at the time of the incident. These same factors similarly influence attitudes about reporting an assault. The development of mobile proximity-based dating applications (dating apps) has added a new, and largely under-researched, factor of influence to attitudes about perceptions of sexual consent. The current study used vignettes to examine college students’ perceptions of sexual consent and attitudes about reporting in a date rape scenario. The vignettes varied to explore …

Transcriptomic Profiling Of Postmortem Prefrontal Cortex And Nucleus Accumbens From Chronic Alcohol Abusers., Eric S. Vornholt

Theses and Dissertations

Alcohol use disorder (AUD) is a debilitating psychiatric illness that develops from a combination of genetic and environmental factors. While it is well documented that AUD is heritable, the shift from recreational alcohol use to abuse/dependence is poorly understood. In this dissertation, using postmortem brain tissue from individuals with alcohol dependence (AD), we profiled the genome-wide expression of circular RNA (circRNA), microRNA (miRNA), and messenger RNA (mRNA) to better understand the impact of gene expression on the development of AUD. To achieve this, we performed two independent studies that explore transcriptome differences between AD cases and controls. The first of …

Genome-Wide Systems Genetics Of Alcohol Consumption And Dependence, Kristin Mignogna

Theses and Dissertations

Widely effective treatment for alcohol use disorder is not yet available, because the exact biological mechanisms that underlie this disorder are not completely understood. One way to gain a better understanding of these mechanisms is to examine the genetic frameworks that contribute to the risk for developing this disorder. This dissertation examines genetic association data in combination with gene expression networks in the brain to identify functional groups of genes associated with alcohol consumption and dependence.

The first study took advantage of the behavioral complexity of human samples, and experimental capabilities provided by mouse models, by co-analyzing gene expression networks …

Baked And Buzzed: Investigating The Influence Of Co-Use Of Cannabis And Alcohol On White Matter Integrity In Emerging Adults, Natasha E. Wright

Theses and Dissertations

Objective: Growing evidence suggests alcohol and cannabis use independently alter neural structure and functioning, particularly during sensitive developmental time periods such as adolescence and emerging adulthood. However, there has been minimal investigation into the effects co-occurring use of these two substances, despite preliminary evidence of unique acute and psychopharmacological changes due to using alcohol and cannabis together.

Method: Data drawn from the IDEAA Consortium was utilized to assess white matter integrity as measured by FreeSurfer’s TRACULA in emerging adults (n=192; 16-27 years old). Timeline Follow-Back was used to calculate past month cannabis use, alcohol use, co-use days, binge alcohol episode, …

Neuroimmune-Mediated Alcohol Effects On Ventral Tegmental Area Microglia And Infiltrating Leukocytes, Travis Jonathan Clarke

Theses and Dissertations

Microglia are the primary immune cell in the central nervous system and are known as the “resident” macrophages in the central nervous system (CNS). While microglia are classically known as the immune cells of the CNS, their role has more recently been shown to extend far beyond immunity. The effects of ethanol on the brain are closely linked to neuroimmune responses mediated by microglia that are present in the healthy brain from the time of development. Though microglia have been classified as the “resident” immune cells of the CNS, new research suggests that other immune cells may be implicated in …

The Effects Of Instructors Discussing Alcohol In The Classroom On Student Perceptions Of Their Instructor, Nathaniel Swiech Brophy

Theses and Dissertations

This thesis is comprised of two studies. Study I is a qualitative exploratory analysis which attempts to uncover students’ experiences with instructors discussing alcohol in the university classroom and how the appropriateness of this behavior is determined. How this mention of alcohol affects the students’ perception of the instructor, as well as the relationship between perceived appropriateness of the behavior and change in perception, are also investigated. Study I found that students have experienced their instructors mentioning alcohol in the classroom as normative student behavior, part of the formal curriculum, and their instructor disclosing personal alcohol use. Participants determined appropriateness …

Neuroimmune-Mediated Alcohol Effects On Ventral Tegmental Area Neurons, Stephanie Bair Williams

Theses and Dissertations

Dopamine (DA) transmission is a key player in the rewarding aspects of ethanol as well as ethanol dependence. The current dogma is that DA transmission is increased during ethanol via the inhibition of ventral tegmental area (VTA) GABA neurons and that excitation of VTA GABA neurons during withdrawal results in decreased DA transmission. Microglia, the major neuroimmune effector in the brain, may be a key mediator in this process by releasing cytokines following activation. We evaluated the effect of ethanol on cytokine concentrations in the VTA and NAc using a cytometric bead array, and found that low dose ethanol (1.0 …

Concurrent Polysubstance Use In College Students: A Brief Social Norms Intervention To Abate Use, Jennifer Lynn Hernandez-Meier

Theses and Dissertations

Introduction: Many college students engage in marijuana and alcohol use, as well as concurrent and simultaneous polysubstance use of both of these substances (CPU, SPU). The literature on CPU and SPU in this population has not been comprehensively reviewed. It is also unclear whether when compared with concurrent users, simultaneous users experience increased risk of substance-related problems (problems), and if a brief normative feedback (NF) intervention is feasible for and can impact marijuana and alcohol use by concurrent users. Methods: This study involved: Paper 1) a narrative review of literature on marijuana and alcohol use and CPU and SPU in …

Evaluating A Brief Web-Based Prevention Intervention For Risky Alcohol Use Among College Students, Zoe Neale

Theses and Dissertations

The purpose of this study was to evaluate a brief, web-based alcohol prevention intervention program as a universal approach to addressing the range of alcohol behaviors present on college campuses. The sample of freshman college students recruited from Spit for Science (Dick et al., 2014) included 153 intervention participants, and 151 control participants matched on demographics and baseline alcohol variables. Hierarchical multiple regression, logistic regression, and moderated multiple regression were used to compare intervention and control participants on post-intervention alcohol variables. Treatment predicted lower alcohol use disorder (AUD) symptoms, particularly among baseline drinkers. For non-drinkers, the intervention was associated with …

Identifying Misconceptions Associated With Inaccurate Survey Reporting In The Combined Use Of Caffeine And Alcohol, Kathryn Polak

Theses and Dissertations

Research on college student use of caffeine combined with alcohol (CAC) and public health concern over such use has been hampered by the absence of psychometrically sound measures of caffeine and CAC use. The present study examined agreement between survey (CAS) and interview (TLFB) methods for collecting data on caffeine, alcohol and CAC use. Participants were N=50 college students randomized to complete CAS followed by TLFB or the reverse. Qualitative follow-up interviews with N=15 participants were used to identify factors contributing to CAS-TLFB discrepancies. Responses varied by method of administration, with largest discrepancy magnitudes found for CAC, followed …

Motivational Interviewing In Primary Care And General Health Care Settings: A Meta-Analysis, Michele Kathryn Olson

Theses and Dissertations

The rate of mortality and morbidity due to alcohol consumption warrants a comprehensive and evidence-based investigation exploring the efficacy of behavioral interventions within a general health care setting as a means of alcohol reduction. A particular type of intervention, known as Motivational Interviewing (MI; Miller, 1983) and Motivational Enhancement Therapy (MET; Miller, Sovereign, & Krege, 1988), both of which have seen surge in popularity, merits further inspection. Through electronic database searching, hand searching previous meta-analyses and systematic reviews, and searching the Motivational Network of Trainers bibliographic resource, 33 randomized controlled trials were located isolating the effect of motivational interviewing in …

“One More Drinkin’ Song”: A Longitudinal Content Analysis Of Country Music Lyrics Between The Years 1994 And 2013, Keith Mckay Evans

Theses and Dissertations

The lyrical content of pop music has rarely been studied, particularly for country music. The lyrics of the top 50 country songs for each year between 1994 and 2013 were coded for violent, sexual and substance use-related content. Violence had increased, as had sexual references, substance use, and substance use associated with sexual activity. Of particular note is the frequency of references to alcohol; 21% of the 1,000-song sampling frame contained alcoholic references, and the average for the final five-year period (2009-2013) was 1.01 references per song. This research should serve as a springboard into further studies about the lyrical …

Predicting Alcohol Consumption In Adolescent Rhesus Macaques (Macaca Mulatta), Andrea Nichole Sorenson

Theses and Dissertations

Numerous studies show that a low level of response to the intoxicating effects of alcohol is considered a risk factor for future alcoholism. However, assessing this sensitivity usually requires administering a controlled dose of alcohol, which has a number of inherent problems. Early observations in our lab suggest that the response to anesthetics that show cross tolerance with alcohol, like ketamine, are blunted in nonhuman primates at risk for high alcohol intake, and may be a viable measure of future alcohol consumption. This study was designed to test potential predictors of future alcohol consumption using the change in ketamine across …

Characterization Of The Hippocampal Acetylcholine System In A Rodent Model Of Fetal Alcohol Syndrome, Amy Elizabeth Perkins

Theses and Dissertations

Fetal alcohol spectrum disorders (FASD) are a major public health concern, as it is estimated that 2-5% of children are exposed to alcohol at some point during prenatal development. FASD have been shown to cause damage to multiple brain regions, but research shows that the hippocampus is especially sensitive to alcohol exposure. This damage to the hippocampus explains, in part, deficits in learning and memory that are hallmark symptoms of FASD. The acetylcholine neurotransmitter system plays a major role in learning and memory, and the hippocampus is one of its main targets. This experiment used a rodent model of Fetal …

Emotional Bond Between The Creator And The Avatar: Changes In Behavioral Intentions To Engage In Alcohol-Related Traffic Risk Behaviors, Hokyung Kim

Theses and Dissertations

The present study examines the joint impact of relationship with one's avatar and negative consequences to the avatar on changing behavioral intentions (CBI) in terms of alcohol-impaired driving. Avatars are users' visual self-representation in a virtual world, and play a major role to build the users' digital identity. One hundred eleven participants volunteered to participate in several experimental conditions where the degree of choice of avatar features and the degree of active control of the avatar were manipulated in Second Life, an immersive 3D virtual environment. Participants who were allowed to customize their avatar viewed their avatar more similar and …

Alcohol Biomarkers As Predictive Factors Of Rearrest In High Risk Repeat Offense Drunk Drivers, Brian Charles Kay

Theses and Dissertations

Alcohol biomarkers, or naturally occurring molecules which occur in response to one's alcohol consumption, are proving to be a value tool in objectively monitoring one's alcohol consumption. Coupling this assessment tool, with advances in computing power, new and powerful predictions are becoming evermore possible. In this retrospective study, data was first collected that consisted of a sample of 249 drivers convicted of driving under the influence charge and who monitored over the course of a year by biomarker blood tests. This data was then analyzed using machine learning methods. TwoStep cluster analysis showed distinct drinking groups within the drivers who …

Reducing Recidivism In Returning Offenders With Alcohol And Drug Related Offenses: Contracts For The Delivery Of Authentic Peer Based Recovery Support Services, Sarah Scarbrough

Theses and Dissertations

In collaboration with Sheriff C. T. Woody, the Deputies and other jail personnel, Kingdom Life Ministries (KLM) operates in the City of Richmond Jail. Aimed at serving individuals who suffer from alcoholism and other drug addictions, KLM’s programs offer peer-to-peer recovery support services; meaning people who are successful in their recovery deliver the recovery message. On any given day, rehabilitation and recovery services are provided to 120 men in what used to be the worst tier of the Richmond City Jail. A large portion of these men battle substance abuse disorders and have exhibited habitual criminal behavior over an extended …

Parent-Child Communication About Substance Use: Experiences Of Latino Emerging Adults, Kathryn Reid-Quiñones

Theses and Dissertations

The purpose of the current studies was to identify messages that Latino parents communicate to their offspring about the use of legal and illegal drugs and to determine associations between parental messages and substance use outcomes. Previous research has identified parent-child communication as protective against tobacco, alcohol, and other drug use. However, most of these studies have failed to examine the specific messages communicated and those that have focused almost exclusively on non-Hispanic Caucasians. Study 1 identified messages that Latino parents communicate to their offspring regarding legal and illegal drugs through two focus groups with Latino college students (N = …

Using The Timeline Followback To Identify Time Windows Representative Of Annual Posttreatment Drinking, Christopher J. Gioia

Theses and Dissertations

Using 12-month post treatment Timeline Followback drinking reports, data extrapolated from shorter time windows (e.g., 1 month, 6 months) were used to estimate total annual drinking. The objective was to determine whether data from a shorter time window would provide an estimate of annual drinking sufficiently consistent with the full year report such that it can be used in place of the full report. Data for this study were obtained from problem drinkers who voluntarily participated in a randomized controlled trial of a mail-based intervention. Complete follow-up data were obtained for 467 of the 825 participants who completed a 12-month …