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Behavioral Economic Demand: Investigation Of Sex Differences In Four Core Genotype Model Of Oral Oxycodone Self-Administration, Michelle Elsmore, David Jentsch, Joshua Peck, Anushree Karkhanis
Behavioral Economic Demand: Investigation Of Sex Differences In Four Core Genotype Model Of Oral Oxycodone Self-Administration, Michelle Elsmore, David Jentsch, Joshua Peck, Anushree Karkhanis
Undergraduate Honors Theses
Opioid misuse has been identified to be related to problematic release of dopamine in the brain that is otherwise satiated by other alternative rewards. As mediated by patterns of positive and negative reinforcement, prolonged opioid use may transition into misuse and development of opioid use disorder. In human populations, men and women differ in their acquisition of drug use and escalation to drug misuse. Women quickly surpass their male counterparts in their transition from use to misuse in what is coined the telescoping effect. In this four core genotype model of oral oxycodone self administration, males were hypothesized to consume …
The Effects Of Environmental Switchovers Between Enrichment And Impoverishment On Brain And Behavior In Mice, Judith K. Ahroon
The Effects Of Environmental Switchovers Between Enrichment And Impoverishment On Brain And Behavior In Mice, Judith K. Ahroon
Graduate Dissertations and Theses
Rearing rodents or primates in environments that are comparatively enriched or impoverished results in often impressive physiological and anatomical changes after a certain period of exposure. However, the anatomical and biochemical characteristics that respond to environmental experience (Bennett, Diamond, Krech, & Rosenzweig, 1964; Greenough & Volkmar, 1973; Walsh, Budtz-Olsen, Penny, & Cummins, 1969) have been subjected to a more sophisticated level of analysis than have the less consistent changes in behavioral tendencies. The specific nature of environmentally induced modifications in behavioral tendencies must be better understood, if substantive predictions about brain-behavior relationships can be made. Furthermore, the long-term effects of …