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A Bioecological Approach To Understanding The Interaction Of Environmental Stress And Genetic Susceptibility In Influencing Cortisol And Blood Pressure In African American Adults, Sandra Marie Coulon

Theses and Dissertations

African Americans are disproportionately affected by high blood pressure, a precursor to cardiovascular disease. Bioecological, biomedical, and gene-environment interaction theories were integrated to test the impact of environmental stress and genetic susceptibility on stress-related outcomes, including waking cortisol, perceived stress, and blood pressure in African-American adults. The primary aim of the study was to investigate the effects of neighborhood socioeconomic status (SES), neighborhood satisfaction, and neighborhood collective efficacy on waking cortisol, perceived stress, and blood pressure and to determine whether genetic risk for increased glucocorticoid receptor sensitivity moderated those relations in a gene-by-environment (GxE) interaction. A secondary aim was to …