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A Bioecological Approach To Understanding The Interaction Of Environmental Stress And Genetic Susceptibility In Influencing Cortisol And Blood Pressure In African American Adults, Sandra Marie Coulon
A Bioecological Approach To Understanding The Interaction Of Environmental Stress And Genetic Susceptibility In Influencing Cortisol And Blood Pressure In African American Adults, Sandra Marie Coulon
Theses and Dissertations
African Americans are disproportionately affected by high blood pressure, a precursor to cardiovascular disease. Bioecological, biomedical, and gene-environment interaction theories were integrated to test the impact of environmental stress and genetic susceptibility on stress-related outcomes, including waking cortisol, perceived stress, and blood pressure in African-American adults. The primary aim of the study was to investigate the effects of neighborhood socioeconomic status (SES), neighborhood satisfaction, and neighborhood collective efficacy on waking cortisol, perceived stress, and blood pressure and to determine whether genetic risk for increased glucocorticoid receptor sensitivity moderated those relations in a gene-by-environment (GxE) interaction. A secondary aim was to …
Associations Between Hypothalamic-Pituitary-Adrenal Axis System Gene Variants And Cortisol Reactivity In Preschoolers: Main Effects And Gene-Environment Interactions, Haroon I. Sheikh
Electronic Thesis and Dissertation Repository
Exposure to stressful events during early development has consistently been shown to produce long lasting effects on the hypothalamic-pituitary-adrenal (HPA) axis, which may increase vulnerability to mood and anxiety disorders. Recently reported genetic association studies indicate that these disorders may be influenced, in part, by gene-environment interactions (GxE) involving polymorphisms within the corticotrophin-releasing hormone and monoaminergic system genes. However, little is known about how genetic variants and life stress work to shape children’s neuroendocrine reactivity and emerging symptoms. Therefore, the aim of this thesis is to examine main effects of candidate genes and GxE on the neuroendocrine stress response and …
The Impact Of Relationship Functioning On Cortisol In Married Couples: A Dyadic Exploration Of Sleep As A Potential Mediator, Benjamin D. Clark
The Impact Of Relationship Functioning On Cortisol In Married Couples: A Dyadic Exploration Of Sleep As A Potential Mediator, Benjamin D. Clark
Theses and Dissertations
Relationship functioning in couples has been linked to numerous health outcomes. The purpose of this study was to examine the association between 1) marital functioning and sleep dimensions, 2) marital functioning and cortisol, and 3) sleep dimensions and cortisol. The sample consisted of 108 heterosexual, married couples and was part of a larger marital intervention study. As predicted, poor marital functioning was related to negative sleep outcomes. However, these effects were only significant for wives. There was also evidence to suggest that poor marital functioning was associated with increased cortisol levels in husbands. These effects were independent of age and …
Modeling Dyadic Attunement: Physiological Concordance In Newly Married Couples And Alliance Similarity In Patient-Therapist Dyads, Holly Laws
Doctoral Dissertations
Mutual influence within relationships is theorized as central to human development and functioning across the lifespan. Multiple theories posit a process of progressive bidirectional influence that results in greater similarity between dyad members over time, termed attunement. Yet attunement processes, from dyadic synchrony in healthy child development to partner influence within romantic relationships, are difficult to measure and model. One difficulty is that capturing information from both members of a relationship pair, or dyad, requires statistical modeling that appropriately accounts for the interdependence between them. The present study addressed this issue by putting forward a framework for modeling attunement processes …
The Cortisol/Dhea Ratio And Sexual Function In Women With And Without A History Of Depression, Carolyn Marie Dundon
The Cortisol/Dhea Ratio And Sexual Function In Women With And Without A History Of Depression, Carolyn Marie Dundon
Graduate College Dissertations and Theses
The comorbidity between female sexual dysfunction (FSD) and major depressive disorder (MDD) is well documented; however, the mechanism(s) underlying the relationship between these disorders has not been defined. The literature has associated the adrenal hormones cortisol and dehydroepiandrosterone (DHEA) with FSD and MDD, suggesting a biological mechanism that may elucidate the comorbidity between these disorders. Based on evidence pointing to a high cortisol/DHEA ratio (C/D Ratio) in MDD and low DHEA in FSD, this study investigated if the potential association between a high C/D Ratio and FSD would be greater for women with a history of MDD when compared to …