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Role Of Cortisol In The Development Of Post-Traumatic Stress And Dysphoria, Devi Jayan
Role Of Cortisol In The Development Of Post-Traumatic Stress And Dysphoria, Devi Jayan
Dissertations (1934 -)
Exposure to a traumatic event is a significant predictor for the development of posttraumatic stress disorder (PTSD) and depression. Identification of specific risk factors for PTSD and depression after trauma exposure has been challenging due to comorbid and heterogeneous presentations of these conditions. Pre-existing research demonstrates reduced cortisol response (hypocortisolism) in chronic PTSD and an exaggerated cortisol response (hypercortisolism) in depression. The current longitudinal study examined cortisol response following a traumatic injury as a potential biomarker for deciphering specific risk for PTSD, depression, and PTSD depression comorbidity. Saliva samples for cortisol assay (post-injury cortisol) were collected from 172 trauma survivors …
Treatment Of Dual Diagnosis Post Traumatic Stress Disorder And Substance Use Disorders: A Meta-Analysis, Joshua Dolan
Treatment Of Dual Diagnosis Post Traumatic Stress Disorder And Substance Use Disorders: A Meta-Analysis, Joshua Dolan
Dissertations (1934 -)
The dual diagnosis of post-traumatic stress disorder and substance use disorders affects a large number of people. Various treatments have been used for addressing these co-occurring disorders and have now been empirically tested. These treatments can be divided into two categories: sequential and integrated. The goal of this study was to meta-analytically examine the effectiveness of these treatments and compare these two categories of treatment. Secondary objectives included the exploration of potential moderator variables and the symptom interplay between the two disorders after treatment. The results of the study suggested that treatment for the dual diagnosis of posttraumatic stress disorder …
Long Term Effects Of Chronic Variable Stress Administered During Different Developmental Stages In Mice, Henry Boeh
Long Term Effects Of Chronic Variable Stress Administered During Different Developmental Stages In Mice, Henry Boeh
Dissertations (1934 -)
A number of studies have suggested that the occurrence of past trauma can increase an individual's chance of developing PTSD from a new traumatic experience later in life. Trauma that occurs during childhood appears to have a particularly strong effect on this risk increase. Furthermore, conditioned fear responses have been shown to incubate over extended periods of time in animal models. To further investigate the role these phenomena play in the development of PTSD, this study exposed juvenile and adult mice to 7 days of chronic variable stress (CVS). One month later, a Pavlovian delay fear conditioning procedure was used …