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An Invitation To The Study Of Brain Networks, With Some Statistical Analysis Of Thresholding Techniques, Mark Daley Jan 2014

An Invitation To The Study Of Brain Networks, With Some Statistical Analysis Of Thresholding Techniques, Mark Daley

Brain and Mind Institute Researchers' Publications

We provide a brief introduction to the nascent application of network theory to mesoscale networks in the human brain. Following an overview of the typical data-gathering, processing, and analysis methods employed in this field, we describe the process for inferring a graph from neural time series. A crucial step in the construction of a graph from time series is the thresholding of graph edges to ensure that the graphs represent physiological relationships rather than artifactual noise. We discuss the most popular currently employed methodologies and then introduce one of our own, based on the theory of random matrices. Finally, we …


Links Between White Matter Microstructure And Cortisol Reactivity To Stress In Early Childhood: Evidence For Moderation By Parenting., Haroon I Sheikh, Marc F Joanisse, Sarah M Mackrell, Katie R Kryski, Heather J Smith, Shiva M Singh, Elizabeth P Hayden Jan 2014

Links Between White Matter Microstructure And Cortisol Reactivity To Stress In Early Childhood: Evidence For Moderation By Parenting., Haroon I Sheikh, Marc F Joanisse, Sarah M Mackrell, Katie R Kryski, Heather J Smith, Shiva M Singh, Elizabeth P Hayden

Brain and Mind Institute Researchers' Publications

Activity of the hypothalamic-pituitary-adrenal axis (measured via cortisol reactivity) may be a biological marker of risk for depression and anxiety, possibly even early in development. However, the structural neural correlates of early cortisol reactivity are not well known, although these would potentially inform broader models of mechanisms of risk, especially if the early environment further shapes these relationships. Therefore, we examined links between white matter architecture and young girls' cortisol reactivity and whether early caregiving moderated these links. We recruited 45 6-year-old girls based on whether they had previously shown high or low cortisol reactivity to a stress task at …