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The Role Of Alexithymia In Memory And Executive Functioning Across The Lifespan, Anthony N. Correro, Elizabeth Rose Paitel, Steven J. Byers, Kristy A. Nielson

Psychology Faculty Research and Publications

Alexithymia is a personality trait characterised by difficulties identifying feelings (DIF), describing feelings (DDF), and externally oriented thinking (EOT). Alexithymia has been associated with poorer memory, at least for emotive materials, and recently, with executive and neural dysfunction. Aging is also accompanied by poorer memory and executive functioning (EF), neural dysfunction, and increasing alexithymia. Thus, the hypothesis of a general cognitive impairment in alexithymia, particularly in elders, needs investigation. Three large, independent, cross-sectional experiments (n = 296, 139 and 121, respectively) investigated memory and EF in healthy adults, ranging from young to old adulthood, with age, sex, and the …

The Effects Of Alexithymia And Age On Inhibitory Control, Anthony Correro

Dissertations (1934 -)

Alexithymia is a stable personality trait typified by externally oriented thinking and difficulties identifying and describing feelings. It is associated with cognitive-affective deficits such as poorer memory for emotional and neutral information as well as executive dysfunction. Relatedly, aging is accompanied by executive dysfunction and increasing alexithymia. Because executive functions comprise multiple cognitive skills, it is essential to demarcate which are impacted by aging and alexithymia. While age-related deficits in inhibitory control are well established, there is a dearth of literature examining inhibition in alexithymia. Thus, this study aimed to examine the effect of alexithymia on inhibition and to interrogate …

Examining The Effects Of Stress And Age On Neural Reward Processing: Considerations For The Role Of Individual Differences In Autonomic Reactivity, William Mccuddy

Dissertations (1934 -)

Acute stress is unavoidable and may hinder basic reward processing underlying adaptive decision-making. Additionally, older adults may be at an increased risk of poor decision-making after exposure to acute stress due to age-related changes in cognitive and autonomic functioning. The current study assessed the influence of acute stress, autonomic reactivity, and age on a simple behavioral task during fMRI. Specifically, old and young adults completed a basic reward processing paradigm (i.e., where participants received monetary rewards and punishments) after exposure to acute stress (i.e., social evaluative cold pressor) or control procedure between-subjects. In the young group, differential responses for monetary …

Resting Cerebral Blood Flow After Exercise Training In Mild Cognitive Impairment, Alfonso J. Alfini, Lauren R. Weiss, Kristy A. Nielson, Matthew D. Verber, J. Carson Smith

Psychology Faculty Research and Publications

Background:

Exercise training has been associated with greater cerebral blood flow (CBF) in cognitively normal older adults (CN). Alterations in CBF, including compensatory perfusion in the prefrontal cortex, may facilitate changes to the brain’s neural infrastructure.

Objective:

To examine the effects of a 12-week aerobic exercise intervention on resting CBF and cognition in CN and those with mild cognitive impairment (MCI). We hypothesized individuals with MCI (vs. CN) would exhibit greater whole brain CBF at baseline and that exercise would mitigate these differences. We also expected CBF changes to parallel cognitive improvements.

Methods:

Before and after a 12-week exercise intervention, …

Motor Timing Intraindividual Variability In Amnestic Mild Cognitive Impairment And Cognitively Intact Elders At Genetic Risk For Alzheimer’S Disease, Christina D. Kay, Michael Seidenberg, Sally Durgerian, Kristy A. Nielson, J. Carson Smith, John L. Woodard, Stephen M. Rao

Psychology Faculty Research and Publications

Introduction: Intraindividual variability (IIV) in motor performance has been shown to predict future cognitive decline. The apolipoprotein E-epsilon 4 (APOE-ε4) allele is also a well-established risk factor for memory decline. Here, we present novel findings examining the influence of the APOE-ε4 allele on the performance of asymptomatic healthy elders in comparison to individuals with amnestic MCI (aMCI) on a fine motor synchronization, paced finger-tapping task (PFTT).

Method: Two Alzheimer’s disease (AD) risk groups, individuals with aMCI (n = 24) and cognitively intact APOE-ε4 carriers (n = 41), and a control group consisting of cognitively intact APOE-ε4 noncarriers ( …

Exercise Training And Functional Connectivity Changes In Mild Cognitive Impairment And Healthy Elders, Theresa J. Chirles, Katherine Reiter, Lauren R. Weiss, Alfonso J. Alfini, Kristy A. Nielson, J. Smith Carson

Psychology Faculty Research and Publications

Background: Effective interventions are needed to improve brain function in mild cognitive impairment (MCI), an early stage of Alzheimer’s disease (AD). The posterior cingulate cortex (PCC)/precuneus is a hub of the default mode network (DMN) and is preferentially vulnerable to disruption of functional connectivity in MCI and AD. Objective: We investigated whether 12 weeks of aerobic exercise could enhance functional connectivity of the PCC/precuneus in MCI and healthy elders. Methods: Sixteen MCI and 16 healthy elders (age range = 60–88) engaged in a supervised 12-week walking exercise intervention. Functional MRI was acquired at rest; the PCC/precuneus was used as a …

Improved Cardiorespiratory Fitness Is Associated With Increased Cortical Thickness In Mild Cognitive Impairment, Katherine Reiter, Kristy A. Nielson, Theresa J. Smith, Lauren R. Weiss, Alfonso J. Alfini, J. C. Smith

Psychology Faculty Research and Publications

Cortical atrophy is a biomarker of Alzheimer’s disease (AD) that correlates with clinical symptoms. This study examined changes in cortical thickness from before to after an exercise intervention in mild cognitive impairment (MCI) and healthy elders. Thirty physically inactive older adults (14 MCI, 16 healthy controls) underwent MRI before and after participating in a 12-week moderate intensity walking intervention. Participants were between the ages of 61 and 88. Change in cardiorespiratory fitness was assessed using residualized scores of the peak rate of oxygen consumption (V̇O_2peak) from pre- to post-intervention. Structural magnetic resonance images were processed using FreeSurfer v5.1.0. …

Genetic Risk For Alzheimer's Disease Alters The Five-Year Trajectory Of Semantic Memory Activation In Cognitively Intact Elders, Stephen M. Rao, Aaron Bonner-Jackson, Kristy A. Nielson, Michael Seidenberg, J. Carson Smith, John L. Woodard, Sally Durgerian

Psychology Faculty Research and Publications

Healthy aging is associated with cognitive declines typically accompanied by increased task-related brain activity in comparison to younger counterparts. The Scaffolding Theory of Aging and Cognition (STAC) (Park and Reuter-Lorenz, 2009; Reuter-Lorenz and Park, 2014) posits that compensatory brain processes are responsible for maintaining normal cognitive performance in older adults, despite accumulation of aging-related neural damage. Cross-sectional studies indicate that cognitively intact elders at genetic risk for Alzheimer's disease (AD) demonstrate patterns of increased brain activity compared to low risk elders, suggesting that compensation represents an early response to AD-associated pathology. Whether this compensatory response persists or declines with the …

Predicting Cognitive Decline In Older Adults Through Multi-Voxel Pattern Analysis, Nathan Hantke

Dissertations (1934 -)

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is associated with cognitive and structural decline beyond what is seen in normal, healthy aging. Functional magnetic resonance imaging (fMRI) research indicates that prior to the onset of measureable cognitive impairment, individuals at-risk for AD demonstrate different patterns of neural activation than individuals at lower risk. Thus, differences in task-activated fMRI may be beneficial in predicting cognitive decline at a "pre-symptomatic" stage. The present study utilizes multi-voxel pattern analysis (MVPA) of baseline fMRI task-related activation to predict cognitive decline, with the hypothesis that famous and non-famous name task activation will discriminate …

Motor Variability During Sustained Contractions Increases With Cognitive Demand In Older Adults, Marnie Lynn Vanden Noven, Hugo M. Pereira, Tejin Yoon, Alyssa A. Stevens, Kristy A. Nielson, Sandra K. Hunter

Psychology Faculty Research and Publications

To expose cortical involvement in age-related changes in motor performance, we compared steadiness (force fluctuations) and fatigability of submaximal isometric contractions with the ankle dorsiflexor muscles in older and young adults and with varying levels of cognitive demand imposed. Sixteen young (20.4 ± 2.1 year: 8 men, 9 women) and 17 older adults (68.8 ± 4.4 years: 9 men, 8 women) attended three sessions and performed a 40 s isometric contraction at 5% maximal voluntary contraction (MVC) force followed by an isometric contraction at 30% MVC until task failure. The cognitive demand required during the submaximal contractions in each session …

Muscle Tension Induced After Learning Enhances Long-Term Narrative And Visual Memory In Healthy Older Adults, Kristy A. Nielson, Laura L. Wulff, Timothy J. Arentsen

Psychology Faculty Research and Publications

Arousing events are better remembered than mundane events. Indeed, manipulation of arousal, such as by muscle tension, can influence memory even when it occurs shortly after learning. Indeed, our founding study showed this approach can raise delayed memory performance in older adults to a level comparable to that of unaided young adults. Yet, systematic studies, especially those investigating different modalities or types of memory, have not been done. This study investigated the effects of a brief bout of isometric exercise via handgrip on narrative and visuospatial episodic memory in healthy elders. Forty-seven participants completed the Logical Memory subtest of the …

Comparison Of Semantic And Episodic Memory Bold Fmri Activation In Predicting Cognitive Decline In Older Adults, Nathan Hantke, Kristy A. Nielson, John L. Woodard, Leslie M. Guidotti Breting, Alissa Butts, Michael Seidenberg, J. Carson Smith, Sally Durgerian, Melissa A. Lancaster, Monica Matthews, Michael Sugarman, Stephen M. Rao

Psychology Faculty Research and Publications

Previous studies suggest that task-activated functional magnetic resonance imaging (fMRI) can predict future cognitive decline among healthy older adults. The present fMRI study examined the relative sensitivity of semantic memory (SM) versus episodic memory (EM) activation tasks for predicting cognitive decline. Seventy-eight cognitively intact elders underwent neuropsychological testing at entry and after an 18-month interval, with participants classified as cognitively “Stable” or “Declining” based on ≥1.0 SD decline in performance. Baseline fMRI scanning involved SM (famous name discrimination) and EM (name recognition) tasks. SM and EM fMRI activation, along with Apolipoprotein E (APOE) ε4 status, served as predictors of cognitive …

Prediction Of Cognitive Decline In Healthy Older Adults Using Fmri, John L. Woodard, Michael Seidenberg, Kristy A. Nielson, J Carson Smith, Piero Antuono, Sally Durgerian, Leslie Guidotti, Qi Zhang, Alissa Butts, Nathan Hantke, Melissa A. Lancaster, Stephen M. Rao

Psychology Faculty Research and Publications

Few studies have examined the extent to which structural and functional MRI, alone and in combination with genetic biomarkers, can predict future cognitive decline in asymptomatic elders. This prospective study evaluated individual and combined contributions of demographic information, genetic risk, hippocampal volume, and fMRI activation for predicting cognitive decline after an 18-month retest interval. Standardized neuropsychological testing, an fMRI semantic memory task (famous name discrimination), and structural MRI (sMRI) were performed on 78 healthy elders (73% female; mean age = 73 years, range = 65 to 88 years). Positive family history of dementia and presence of one or both apolipoprotein …

Semantic Knowledge For Famous Names In Mild Cognitive Impairment, Michael Seidenberg, Leslie Guidotti, Kristy A. Nielson, John L. Woodard, Sally Durgerian, Qi Zhang, Amelia Gander, Piero Antuono, Stephen M. Rao

Psychology Faculty Research and Publications

Person identification represents a unique category of semantic knowledge that is commonly impaired in Alzheimer's disease (AD), but has received relatively little investigation in patients with mild cognitive impairment (MCI). The current study examined the retrieval of semantic knowledge for famous names from three time epochs (recent, remote, and enduring) in two participant groups: 23 amnestic MCI (aMCI) patients and 23 healthy elderly controls. The aMCI group was less accurate and produced less semantic knowledge than controls for famous names. Names from the enduring period were recognized faster than both recent and remote names in both groups, and remote names …

Age-Related Functional Recruitment For Famous Name Recognition: An Event-Related Fmri Study, Kristy A. Nielson, Kelli Douville, Michael Seidenberg, John L. Woodard, Sarah K. Miller, Malgorzata Franczak, Piero Antuono, Stephen M. Rao

Psychology Faculty Research and Publications

Recent neuroimaging research shows that older adults exhibit recruitment, or increased activation on various cognitive tasks. The current study evaluated whether a similar pattern also occurs in semantic memory by evaluating age-related differences during recognition of Recent (since the 1990s) and Enduring (1950s to present) famous names. Fifteen healthy older and 15 healthy younger adults performed the name recognition task with a high and comparable degree of accuracy, although older adults had slower reaction time in response to Recent famous names. Event-related functional MRI showed extensive networks of activation in the two groups including posterior cingulate, right hippocampus, temporal lobe …

Comparability Of Functional Mri Response In Young And Old During Inhibition, Kristy A. Nielson, Scott Aaron Langenecker, Thomas J. Ross, Hugh Garavan, Stephen M. Rao, Elliot Stein

Psychology Faculty Research and Publications

When using fMRI to study age-related cognitive changes, it is important to establish the integrity of the hemodynamic response because, potentially, it can be affected by age and disease. However, there have been few attempts to document such integrity and no attempts using higher cognitive rather than perceptual or motor tasks. We used fMRI with 28 healthy young and older adults on an inhibitory control task. Although older and young adults differed in task performance and activation patterns, they had comparable hemodynamic responses. We conclude that activation during cognitive inhibition, which was predominantly increased in elders, was not due to …

Frontal Recruitment During Response Inhibition In Older Adults Replicated With Fmri, Scott Aaron Langenecker, Kristy A. Nielson

Psychology Faculty Research and Publications

Recent research has explored age-related differences in multiple areas of cognitive functioning using fMRI, PET, and SPECT. However, because these studies used different tasks, subjects, and methods, little is known about whether the results of these studies are generalizable or repeatable. The present study replicated a previous study [Psychol. Aging 17 (2002) 56] using the same Go/No-go task with a subset of 11 of the original older adult subjects, and using the same fMRI scanner and imaging methods. A direct comparison was made between these participants at Time 1 and Time 2 for both behavioral and functional data. These participants …

The Progression Of Β-Amyloid Deposition In The Frontal Cortex Of The Aged Canine, Takao Satou, Brian J. Cummings, Elizabeth Head, Kristy A. Nielson, Fletcher F. Hahn, Norton W. Milgram, Peter Velazquez, David H. Cribbs, Andrea J. Tenner, Carl W. Cotman

Psychology Faculty Research and Publications

Brains from 41 aged canines (≥10 years of age) were examined immunohistochemically to characterize the laminar distribution and age-related progression of β-amyloid (Aβ) in frontal cortex. We classified the Aβ patterns into four distinct types. Type I was characterized by small, faint deposits of Aβ in deep cortical layers. Type II consisted of diffuse deposits of Aβ mainly in layers V and VI. Type III had both dense plaques in superficial layers, and diffuse deposits in deep layers. Finally, Type IV had solely dense plaques throughout all layers of cortex. We compared the A …