Digital Commons Network^™

Radiolabeled Nanohydroxyapatite As A Platform For The Development Of New Pet Imaging Agents, Stacy Lee Queern

Arts & Sciences Electronic Theses and Dissertations

Positron emission tomography (PET) imaging utilizes drugs labeled with positron emitters to target and evaluate different biological processes occurring in the body. Tailoring medicine to the individual allows for higher quality of care with better diagnosis and treatment and is a key purpose for advancing research into developing new platforms for PET imaging agents. A PET nuclide of high interest for the development of these agents is 89Zr. This can be attributed to the long half-life of 3.27 days and low positron energy of 89Zr.

In this work, we developed a production method for 89Zr using Y sputtered coins that …

Fast Objective Coupled Planar Illumination Microscopy, Cody Jonathan Greer

Arts & Sciences Electronic Theses and Dissertations

Among optical imaging techniques light sheet fluorescence microscopy stands out as one of the most attractive for capturing high-speed biological dynamics unfolding in three dimensions. The technique is potentially millions of times faster than point-scanning techniques such as two-photon microscopy. This potential is especially poignant for neuroscience applications due to the fact that interactions between neurons transpire over mere milliseconds within tissue volumes spanning hundreds of cubic microns. However current-generation light sheet microscopes are limited by volume scanning rate and/or camera frame rate. We begin by reviewing the optical principles underlying light sheet fluorescence microscopy and the origin of these …

Learning About Large Scale Image Search: Lessons From Global Scale Hotel Recognition To Fight Sex Trafficking, Abby Stylianou

McKelvey School of Engineering Theses & Dissertations

Hotel recognition is a sub-domain of scene recognition that involves determining what hotel is seen in a photograph taken in a hotel. The hotel recognition task is a challenging computer vision task due to the properties of hotel rooms, including low visual similarity between rooms in the same hotel and high visual similarity between rooms in different hotels, particularly those from the same chain. Building accurate approaches for hotel recognition is important to investigations of human trafficking. Images of human trafficking victims are often shared by traffickers among criminal networks and posted in online advertisements. These images are often taken …

Employee Perceptions Of Organizational Corporate Responsibility And Their Effect On Employee Organizational Commitment, Lisa R. Davis

UNLV Theses, Dissertations, Professional Papers, and Capstones

The debate over whether organizations play a part in society beyond economic profit has been a major focus of research in corporate social responsibility (CSR). These debates have been mainly looked at from the macro (societal) or the meso (institutional) level. Very little research has been done on the role of the firm and looking at CSR from the micro (individual) level. Questions regarding the role of work for employees, securing economic benefits or making a difference in the world, would vary greatly depending on the individual and the importance they place on these areas in their own lives. Scholars …

Studies Of Inner-Shell Chemistry Of Mercury Based Compounds At Extreme Conditions, Sarah Schyck

UNLV Theses, Dissertations, Professional Papers, and Capstones

It has been theoretically predicted that when mercury difluoride (HgF2) is pressurized to above 50 GPa in the presence of molecular fluorine, it will most likely transform into mercury tetrafluoride (HgF4), thus mercury will behave as a transition element at high pressure. However, there is no experimental evidence verifying this prediction yet. To begin with, the crystalline properties of pure HgF2 at high pressure were not experimentally established. In this thesis, the high pressure structural properties of HgF2 are investigated by means of synchrotron X-ray powder diffraction. Our results reveal that the predicted, ambient cubic structure of HgF2 with the …

Mechanisms Of Calcium Phosphate Mineralization On Biological Interfaces And Their Engineering Applications, Doyoon Kim

McKelvey School of Engineering Theses & Dissertations

All living organisms utilize phosphorus (P) as an essential component of their cell membranes, DNA and RNA, and adenosine triphosphate. Bones, in addition to bearing loads, play an important role in balancing P levels in our bodies. In bones, a network of collagen templates and calcium phosphate (CaP) nanocrystals builds hierarchical levels, from nano- to macroscale. Within this architecture, the thermodynamic properties of CaP minerals are influential. Despite the importance of nucleation, growth, and crystallization in collagen structures for tissue development, little kinetic study of these processes has been conducted due to the limited in situ techniques for monitoring these …

Improve The Low Energy Sensitivity Of The Hawc Observatory, Zhixiang Ren

Optical Science and Engineering ETDs

The high altitude water cherenkov gamma-ray observatory (HAWC) has been fully operational since March of 2015 in Mexico at 4,100 meters above sea level on the hillside of the Sierra Negra Volcano. It consists of an array of 300 water cherenkov detectors, each equipped with four photo-multiplier tubes. HAWC operates 24-hours per day with a wide field-of-view (FOV, ∼ 2 sr) and a high duty cycle (∼ 95%). These make it a powerful survey and monitoring experiment for mapping the gamma ray sky at very high energies (VHE, 100 GeV to 100 TeV) and to study sources with varying intensities. …

Syntheses Of A Tin (Iv) Meso-Tetra(4-Pyridyl) Porphyrin Dichloride-Tetrachlorobis (Bipy)2 Ruthenium (Ii) Complex And Studies Of Photophysical Properties Of 1-Nitropyrene, Phillip Sharp

Electronic Theses and Dissertations

Development of a photosensitizer that can work in both aerobic and anaerobic environments would increase the robustness of the cancer treatment known as photodynamic therapy. The development of a photosensitizer was first attempted by synthesizing a tin (IV) meso-tetra (4-pyridyl) porphyrin dichloride-tetrachlorobis (Bipy)₂ ruthenium (II) complex. The synthesize of the tin porphyrin was done by a method from literature and had a percent error of 31.58 and 37.31 when comparing the theoretical percentages of carbon (55.39) and nitrogen (12.92) meaning that photosensitizer was not synthesized.

The second type of chromophore that was studied was 1-nitropyrene do determine if it …

The Evolution Of Computational Propaganda: Trends, Threats, And Implications Now And In The Future, Holly Schnader

Senior Honors Projects, 2010-2019

Computational propaganda involves the use of selected narratives, social networks, and complex algorithms in order to develop and conduct influence operations (Woolley and Howard, 2017). In recent years the use of computational propaganda as an arm of cyberwarfare has increased in frequency. I aim to explore this topic to further understand the underlying forces behind the implementation of this tactic and then conduct a futures analysis to best determine how this topic will change over time. Additionally, I hope to gain insights on the implications of the current and potential future trends that computational propaganda has.

My preliminary assessment shows …

Influencing Hawai‘I Hotel Patrons To Use Reef-Safe Sunscreens, Rochelle Good

UNLV Theses, Dissertations, Professional Papers, and Capstones

The health of Hawaiian coral reefs is threatened by pollution from common sunscreen ingredients such as oxybenzone. Hawai‘i hotel patrons using sunscreens with harmful ingredients contaminate coral reefs when these products wash off while swimming or bathing. Reef-safe sunscreens are alternative sunscreens that provide effective sun protection while averting damage to coral reefs. The purpose of this research was to determine the dominant factors leading to the pro-environmental behavior of using reef-safe sunscreen and identify practices that Hawai‘i hotel operators could implement to influence patrons to engage in this behavior. This research applied an integrative conceptual framework to model pro-environmental …

Bayesian Model Comparisons In Planetary Science, John Henry Boisvert

UNLV Theses, Dissertations, Professional Papers, and Capstones

Model comparison in the modern era allows us to use statistical methods that were previously difficult with older machines. I present a state-of-the-art model comparison code that uses modern Bayesian statistics to measure the Bayes factor between two competing models. The Bayes factor is the ratio of the probability of the data given one model to the probability of the data given another model. My code was used to compare models in five problems in planetary science. The first three pertain to radial velocity exoplanet data. There is a degeneracy in the radial velocity exoplanet signal between a single planet …

Tunable Electronic And Optical Properties Of Low-Dimensional Materials, Shiyuan Gao

Arts & Sciences Electronic Theses and Dissertations

Two-dimensional (2D) materials with single or a few atomic layers, such as graphene, hexagonal boron nitride (h-BN) and transition metal dichalcogenides (TMDCs), and the heterostructures or one-dimensional (1D) nanostructures they form, have attracted much attention recently as unique platforms for studying many condensed-matter phenomena and holds great potentials for nanoelectronics and optoelectronic applications. Apart from their unique intrinsic properties which has been intensively studied for over a decade by now, they also allow external control of many degrees of freedom, such as electrical gating, doping and layer stacking. In this thesis, I present a theoretical study of the electronic and …

Optimization Of Useful Hard X-Ray Photochemistry, David Lewis Goldberger

UNLV Theses, Dissertations, Professional Papers, and Capstones

X-ray induced damage is generally considered a nuisance, but in the field of Useful Hard X-ray Photochemistry we harness the highly ionizing and penetrating properties of hard X-rays (> 7 keV) to initiate novel photochemical decomposition and synthesis at ambient and extreme conditions. Preliminary experiments suggest that the energy of irradiating photons and the sample pressure play roles in determining the nature of X-ray induced damage. Here, we present the X-ray energy dependence of damage induced in strontium oxalate, strontium nitrate, and barium nitrate, as well as the pressure dependence of X-ray induced damage of strontium oxalate. Our results indicate …

Design, Layout, And Testing Of Sige Apds Fabricated In A Bicmos Process, Dane Laurence Gentry

UNLV Theses, Dissertations, Professional Papers, and Capstones

This Thesis is concerned with the design, layout, and testing of avalanche photodiodes (APDs). APDs are a type of photodetector and, thus, convert light signals into electrical signals (current or voltage). APDs can be fabricated using silicon (Si). In this Thesis, however, three integrated circuit (IC) chips containing various silicon-germanium (SiGe) APDs with different sizes, structures, and geometries were designed, laid out, and fabricated using the Austriamicrosystems (AMS) 0.35μm SiGe BiCMOS (S35) process. This was done in order to compare SiGe APDs to Si only APDs and investigate the hypothesis that SiGe APDs are capable of detecting longer wavelengths than …

Nanopower Analog Frontends For Cyber-Physical Systems, Kenji Aono

McKelvey School of Engineering Theses & Dissertations

In a world that is increasingly dominated by advances made in digital systems, this work will explore the exploiting of naturally occurring physical phenomena to pave the way towards a self-powered sensor for Cyber-Physical Systems (CPS). In general, a sensor frontend can be broken up into a handful of basic stages: transduction, filtering, energy conversion, measurement, and interfacing. One analog artifact that was investigated for filtering was the physical phenomenon of hysteresis induced in current-mode biquads driven near or at their saturation limit. Known as jump resonance, this analog construct facilitates a higher quality factor to be brought about without …

Computational Explorations Of Information And Mechanism Design In Markets, Zhuoshu Li

McKelvey School of Engineering Theses & Dissertations

Markets or platforms assemble multiple selfishly-motivated and strategic agents. The outcomes of such agent interactions depend heavily on the rules, regulations, and norms of the platform, as well as the information available to agents. This thesis investigates the design and analysis of mechanisms and information structures through the ``computational lens'' in both static and dynamic settings. It both addresses the outcome of single platforms and fills a gap in the study of the dynamics of multiple platform interactions.

In static market settings, we are particularly interested in the role of information, because mechanisms are harder to change than the information …

Towards Engineering Advanced Nanomaterials: Elucidating Fundamental Particle Behavior In Water And Critical Sorption Dynamics, Changwoo Kim

McKelvey School of Engineering Theses & Dissertations

As advanced nanomaterials, inorganic-organic nano composites have received great interest as potential platform (nano) structures for sensor, catalyst, sorbent, and environmental applications. Here, my Ph.D. research has focused on the design, synthesis, and characterization of advanced water-stable engineered metal-oxide nanoparticles functionalized by organic frames for environmental applications. For the environmental applications, I have evaluated particleoptimized sorption processes for the remediation and separation of arsenic, chromium, and uranium under environmentally relevant conditions. More specifically, I have explored the critical role of organic coating on sorption mechanisms and performances using engineered iron oxide -based, manganese oxide -based, and manganese ferrite -based (core) …

Kcnq1/Kcne1 Interaction In The Cardiac Iks Channel And Its Physiological Consequences, Jiajing Xu

McKelvey School of Engineering Theses & Dissertations

Dynamic conformational changes of ion channel proteins during activation gating determine their function as carriers of current. The relationship between these molecular movements and channel function over the physiological timescale of the action potential (AP) has not been fully established due to limitations of existing techniques. We constructed a library of possible cardiac IKs protein conformations and applied a combination of protein segmentation and energy linearization to study this relationship computationally. Simulations reproduced the effects of the beta-subunit (KCNE1) on the alpha-subunit (KCNQ1) dynamics and function, observed in experiments. Mechanistically, KCNE1 increased the probability of “visiting” conducting pore conformations on …

Application Of Machine Learning Techniques In Credit Card Fraud Detection, Ronish Shakya

UNLV Theses, Dissertations, Professional Papers, and Capstones

Credit card fraud is an ever-growing problem in today’s financial market. There has been a rapid increase in the rate of fraudulent activities in recent years causing a substantial financial loss to many organizations, companies, and government agencies. The numbers are expected to increase in the future, because of which, many researchers in this field have focused on detecting fraudulent behaviors early using advanced machine learning techniques. However, the credit card fraud detection is not a straightforward task mainly because of two reasons: (i) the fraudulent behaviors usually differ for each attempt and (ii) the dataset is highly imbalanced, i.e., …

Estimation Of The Parameters In A Spatial Regressive-Autoregressive Model Using Ord's Eigenvalue Method, Sajib Mahmud Mahmud Tonmoy

UNLV Theses, Dissertations, Professional Papers, and Capstones

In this thesis, we study one of Ord's (1975) global spatial regression models.

Ord considered spatial regressive-autoregressive models to describe the interaction

between location and a response variable in the presence of several covariates. He also

developed a practical estimation method for the parameters of this regression model

using the eigenvalues of a weight matrix that captures the contiguity of locations.

We review the theoretical aspects of his estimation method and implement it in the

statistical package R.

We also implement Ord's methods on the Columbus, Ohio, crime data set from the

year 1980, which involves the crime rate of …

Mechanisms For The Incorporation And Distribution Of Radionuclides In Near-Surface Fallout, Marc Alan Fitzgerald

UNLV Theses, Dissertations, Professional Papers, and Capstones

Fallout is the radioactive glass formed from a mixture of vaporized anthropogenic materials with proximate environmental material. These glassy byproducts constitute a compositional record of environmental materials such as soil and vapor precursors that are responsible for chemical heterogeneity in the glasses. The work of this dissertation is to untangle these different sources of compositional heterogeneity, distinguishing low-abundance vaporized anthropogenic-rich material from natural compositions, in order examine soil behavior and chemical evolution during fallout formation. Unfortunately, mixing convolutes the multivariate elemental relationships in these melts due to overlapping element abundances that might distinguish different source materials and chemical behaviors, making …

Scheduling Two Machines With Dissimilar Costs, Madhurupa Moitra

UNLV Theses, Dissertations, Professional Papers, and Capstones

We consider two devices, which has states ON and OFF. In the ON state, the devices use their full power whereas in the OFF state the devices consume no energy but a constant cost is associated with switching back to ON. Such two devices are configured with different run and power-up costs on which a sequence of jobs must be processed. The object is to minimize the cost. Such systems are widely used to conserve energy, for example, to speed scale CPUs, to control data centers, or to manage renewable energy.

The problems are studied in the framework of online …

Combinatorial Ant Optimization And The Flowshop Problem, Tasmin Chowdhury

UNLV Theses, Dissertations, Professional Papers, and Capstones

Researchers have developed efficient techniques, meta-heuristics to solve many Combinatorial Optimization (CO) problems, e.g., Flow shop Scheduling Problem, Travelling Salesman Problem (TSP) since the early 60s of the last century. Ant Colony Optimization (ACO) and its variants were introduced by Dorigo et al. [DBS06] in the early 1990s which is a technique to solve CO problems. In this thesis, we used the ACO technique to find solutions to the classic Flow shop Scheduling Problem and proposed a novel method for solution improvement. Our solution is composed of two phases; in the first phase, we solved TSP using ACO technique which …

Uas-Based Object Tracking Via Deep Learning, Marc Dinh

UNLV Theses, Dissertations, Professional Papers, and Capstones

Tracking is the task of identifying an object of interest and detect its position over time, and has numerous applications like surveillance, security and traffic control. In present times, unmanned aerial vehicles (UAV) have been more and more common which provides us with a new and less explored domain, with an ideal vantage point for surveillance and monitoring applications.. Aerial tracking is a particularly challenging task as it introduces new environmental variables such as rapid motion in 3D space. We propose a new deep learned tracker architecture catered to aerial tracking.

First, a study of six state-of-the-art deep learned trackers …

Examining Environmental Hazards In Rental Homes And Habitability Laws In Clark County, Nevada, Jorge Luis Bertran

UNLV Theses, Dissertations, Professional Papers, and Capstones

It is well established that home conditions are linked to the health outcomes of occupants. There are over 880,000 housing units in Clark County, Nevada; nearly half of those are renter-occupied units (ROUs). Currently, there is limited research on the characteristics of environmental hazards found in Clark County ROUs and the strength of habitability statutes created to protect tenants from substandard housing. Understanding how renters in Clark County are affected by environmental hazards in ROUs and the processes by which landlords and tenants resolve grievances related to those hazards would benefit public health. It would enhance the ability to quickly …

Prokaryotic Diversity And Aqueous Geochemistry Of Subsurface Environments Of The Death Valley Regional Flow System, Joshua David Sackett

UNLV Theses, Dissertations, Professional Papers, and Capstones

This dissertation summarizes over four years of effort towards the completion of a Ph.D. in Biological Sciences. The work presented in this document covers a broad range of topics, but a central unifying theme is prokaryotic life in the continental subsurface. The work presented in each chapter relied heavily on cultivation-independent methods for assessing prokaryotic communities, including prokaryotic community structure reconstruction from high-throughput sequencing of 16S rRNA gene libraries and single-cell genome analysis of novel uncultivated bacteria.

Chapter 2 examines the aqueous geochemistry and prokaryotic diversity of Devils Hole, a cavernous limnocrene and sole natural habitat for the critically endangered …

Efficient And Practical Composition Of Lock-Free Data Structures, Neha Bajracharya

UNLV Theses, Dissertations, Professional Papers, and Capstones

A concurrent data object is lock-free if it guarantees that at least one, among all concurrent operations, finishes after a finite number of steps. In other words, a lock free technique guarantees that some thread always makes progress. Lock-free data objects offer several advantages over their blocking counterparts, such as being immune to deadlocks and priority inversion, and typically provide high scalability and performance, especially in shared memory multiprocessor architectures.

Composition of data structures is a powerful approach to combine simple data structures to create more complex ones. It works as a building block for many advanced useful data structures. …

Petrogenesis Of Enriched And Intermediate Poikilitic Shergottites: From Magmatic Source To Emplacement, Rachel Rahib

UNLV Theses, Dissertations, Professional Papers, and Capstones

Poikilitic shergottites, making up >20% of martian meteorites, likely represent a significant composition of the martian crust, as intrusive gabbroic rocks. To further constrain petrogenetic relationships amongst enriched and intermediate poikilitic shergottites, we utilize bulk rock trace element compositions, mineral major element compositions, phosphorus maps of olivine grains, oxygen fugacity (ƒO2) values, subsolidus equilibration temperatures, and quantitative textural analyses, of the most comprehensive suite of poikilitic shergottites yet (11 samples), including three newly recovered samples (Northwest Africa [NWA] 11065, NWA 11043, NWA 10961). Although petrographically light rare earth element (LREE) enriched and intermediate poikilitic shergottites are similar, distinct LREE abundances …

Photophysical Characterization And Wavelength Tuning Of Natural And Synthetic Oxobacteriochlorins And Biohybrids, Don Hood

Arts & Sciences Electronic Theses and Dissertations

ABSTRACT OF THE DISSERTATION

Photophysical Characterization and Wavelength Tuning of Natural and Synthetic Oxobacteriochlorins and Biohybrids

By

Donald L. Hood

Doctor of Philosophy in Chemistry

Washington University in St. Louis, 2018

Dr. Dewey Holten, Chairperson

Herein is discussed the theoretical and practical unpinnings of photophysical behaviors and kinetic constants for tetrapyrrole macrocycles, to wit, porphyrins, chlorins, and bacteriochlorins. Understanding the characteristic photophysical response of tetrapyrroles to changes in environment or substituents is important to designing synthetic chromophores with tunable absorption wavelengths and for preparing useful biohybrids of natural photosynthetic light antennas combined with unnatural chromophores attached to the light antenna …

Anodic Cyclization Reaction: Manipulation Of Reaction Pathway And Efforts To Radical Cation And Radical Intermediate, Ruozhu Feng

Arts & Sciences Electronic Theses and Dissertations

In recent years, synthetic chemists have been expressing significant interest in electro-organic synthetic methods. This interest is being fueled by the existence of an increasing number of successful methods in the literature and the availability of new electrochemical equipment that removes the barrier to attempting an electrolysis reaction for the first time. Yet while these developments have fueled growth in some areas of electro-organic synthesis (the recycling of chemical catalysts for example), other areas remain underdeveloped. One such area is the exploration of reactions that can be triggered directly as an electrode surface without the use of any chemical reagent. …