Digital Commons Network^™

Solid Phase Peptide Synthesis, John Gibson

Honors Theses

Solid phase peptide synthesis is a relatively new biochemical process for polymerization of amino acids. It involves the selection of amino acids, blocking groups, and resins. This procedure was first investigated by R. B. Merrifield in an attempt to simplify previous methods of peptide synthesis. Since other methods involved amino acids, peptide esters, and diketopiperazines, peptide synthesis had been limited by amino acid selection and a host of technical problems. Solid phase synthesis alleviates many of these difficulties and limitations by supplying a faster and simpler stepwise addition of a wide variety of naturally occurring and synthetically prepared amino acids …

Spectral Studies Of Esters Of 9 And 1 Anthroic Acid, Robert Fisch

Honors Theses

A comparison was made between spectral properties of several atomatic esters of 9- anthroic acid (9- COOAR) and the methyl ester (9-COOMe). The spectral properties observed were absorption spectra, fluorescence quantum yields (Øf) and Stokes shifts. Although all of the ester absorption spectra showed anthracene-like structure, the aromatic ester spectra were clearly more diffuse than the 9-COOMe spectrum. Certain electron delocalization pathways are available to 9-COOAR but not to 9-COOMe, thereby allowing greater carboxyl group-ring interaction for 9-COOAR, resulting in increased spectral diffuseness relative to 9-COOMe. Data are presented which show that the electronic absorption spectra of these esters are …

The Reconversion Of Ethylene Thioketals To Ketones, Jeffrey Paul Ginther

Honors Theses

Many aldehydes, ketones and other carbonyl-containing compounds react with 1, 2-ethanedithol to give highly stable cyclic thioacetals or thioketals. The problem lies in recovering the substituted 1, 3-dithiolanes to the carbonyl compound without altering the other substituents of the molecule. We propose a new direct method of exchange with formaldehyde to reconvert the 1, 3-dithiolane to the carbonyl compound. This was accomplished with 2, 2-diethyl-l, 3-dithiolane. Also, a mechanism is proposed involving the formation of a sulfonium ion intermediate. In preparation for the exchange study seven 1, 3-dithiolanes were synthesized.

A Comparison Of The Spectral Properties Of Anthracene-9-Carboxylic Acid And Anthracene-9,10-Carboxylic Acid, Gail Wendy Goodman

Honors Theses

Previous studies have shown that substitution of a single carboxyl group on the anthracene ring produces fluorescent quantum yields (Øf) and Stokes shifts that are highly solvent dependent. The effects of solvents on the spectral properties of anthracene-9, 10-dicarboxylic acid (9, 10-(COOH) 2) which has symmetrically distributed carboxyl groups, was studied. Comparison is made with spectral data for 9-methyl anthroate (9-C00Me) and anthracene-9, 10-dicarboxylic acid (9, 10-(COOH) 2) which has symmetrically distributed carboxyl groups, was studied. Comparison is made with spectral data for 9-methyl anthroate (9-COOMe) and anthracene-9-carboxylix acid (9-COOH). The absorption and fluorescence spectra of the unprotonated forms of …

Theories On Planetary Motions, Jerry Thomason

Honors Theses

Anyone who has gazed into the starry sky with awe and amazement has often wondered what holds things together, where space ends and if there is no end, what wonders are beyond. The planets that are contained in this solar system and the growth of theories of the causes of the motions of these bodies are just some of the many wonders that a person can research.

In this work, I have intended to trace more or less a history of man's theories that govern the motions of the planets. I must admit that I will not cover by far …

The Schmidt Site: A Geologic Report, Julie Stein

Honors Theses

The Schmidt Site (20 SA 192) is located in Saginaw County, south of the Cass River and just east of the Grand Trunk Railroad in the NE 1/4, sec. 19, T 11 N, R 4 E, of the Bridgeport Township (figs. 1, 2, 3). The area is a remnant of a glacial lake bottom. There is very little local relief. Higher elevation exists to the north that is called the Port Huron Moraine and to the southeast, the Juniata, Owosso and Flint Moraines. All of these systems are associated with the last advance of ice, namely the Valders Advance (fig. …

Intuitive Concepts In Elementary Topology, Gary Rothwell

Honors Theses

My hour special study in intuitive topology originated in a curiosity of what exactly topology was and how it might be related to physics, my field of interest. The book I used was, Intuitive Concepts in Elementary Topology, by B.H. Arnold. This book is designed as a sophomore-junior level three hour course. Needless to say, I didn't quite cover the whole book in an hour a week. I mainly stuck to the intuitive concepts. Intuitive topology is dealing with more physical objects where the point set topology involves set theory; their unions, intersections and subsets.