Digital Commons Network^™

Rebalancing Shared Mobility Systems By User Incentive Scheme Via Reinforcement Learning, Matthew Brian Schofield

Theses and Dissertations

Shared mobility systems regularly suffer from an imbalance of vehicle supply within the system, leading to users being unable to receive service. If such imbalance problems are not mitigated some users will not be serviced. There is an increasing interest in the use of reinforcement learning (RL) techniques for improving the resource supply balance and service level of systems. The goal of these techniques is to produce an effective user incentivization policy scheme to encourage users of a shared mobility system to slightly alter their travel behavior in exchange for a small monetary incentive. These slight changes in user behavior …

Using Molecular Dynamics Simulations To Understand Receptor-Complex Communication And Signaling, Hannah Margaret Hoag

Theses and Dissertations

The overarching purpose of this document is to use Computer-aided drug design and Molecular dynamic simulations to better understand elusive drug-receptor interactions, as well as various types of inter-receptor signaling. Chapter One introduces the theory and importance of Computer-aided drug design and the methodology used in both Chapters Two and Three.

Chapter Two uncovers the relationship between the well-studied ABCB1 transporter and a newly identified drug known as Xanthohumol (XN). XN is compared to a commonly used drug, Doxorubicin (DOX), in this chapter. If the ABCB1 transporter can be properly inhibited, cancer-fighting drugs will be able to stay within the …

Lorawan Device Security And Energy Optimization, John A. Stranahan Jr.

Theses and Dissertations

Resource-constrained devices are commonly connected to a network and become "things" that make up the Internet of Things (IoT). Many industries are interested in cost-effective, reliable, and cyber secure sensor networks due to the ever-increasing connectivity and benefits of IoT devices. The full advantages of IoT devices are seen in a long-range and remote context. However, current IoT platforms show many obstacles to achieve a balance between power efficiency and cybersecurity. Battery-powered sensor nodes can reliably send data over long distances with minimal power draw by adopting Long-Range (LoRa) wireless radio frequency technology. With LoRa, these devices can stay active …

Synthesis And Cytotoxicity Of Trisubstituted Imidazoles, Venkata Agasthya Kasibotla

Theses and Dissertations

Aza heterocyclic compounds are an important class of organic compounds that play a major role in medicinal chemistry. Majority of the heterocyclic motifs such as imidazoles, triazoles, piperazines etc. act as building blocks for synthesizing active pharmaceutical ingredients. Several pharmaceutical drugs include these motifs due to their varying physicochemical properties, which enable them to exhibit wide range of pharmacological activities ranging from anti-fungal, anti-neoplastic, anti-helmintic, anti-microbial etc. Owing to their electron rich ring system, imidazole and piperazine based motifs have become an attractive target for design and development of novel chemical structures as new drugs. In the current study, we …