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Crystal Growth And The Search For Highly Correlated Ternary Intermetallic Antimonides And Stannides, Evan Lyle Thomas Jan 2006

Crystal Growth And The Search For Highly Correlated Ternary Intermetallic Antimonides And Stannides, Evan Lyle Thomas

LSU Doctoral Dissertations

This dissertation describes the crystal growth, chemical structures, and efforts made towards the understanding of the physical properties of novel ternary rare-earth intermetallics, which may display signature behavior such as superconductivity, heavy fermion behavior, intermediate valence, and/or large magnetoresistance. To address the problem of correlating these characteristics with structural features, several ternary antimony- and tin-containing phases, Ln-T-X (Ln = lanthanide; T = Co, Ni, Pd; X = Sn, Sb), have been synthesized in single crystalline form by metallic flux-growth methods and characterized by X-ray diffraction. The antimonide compounds LnNi1-xSb2 (Ln = Y, Gd-Tb, Er, Yb), alpha, beta-LnNiSb3 (Ln = La, …


Ab Initio Molecular Dynamics Simulations Of Methylaluminoxane (Mao) Synthesis By Hydrolysis Of Trimethylaluminum, Lacramioara Negureanu Jan 2006

Ab Initio Molecular Dynamics Simulations Of Methylaluminoxane (Mao) Synthesis By Hydrolysis Of Trimethylaluminum, Lacramioara Negureanu

LSU Doctoral Dissertations

MAO is the co-catalyst in the metallocene catalytic systems, which are widely used in single site olefin polymerization due to their high stereoselectivity. To date, the precise structure of MAO, the particular compound or compounds catalytically active in MAO, have eluded researchers. MAO, a white amorphous powder, is not a good sample for a direct spectroscopic characterization, and its NMR spectra are broad and almost featureless. Many structural models have been proposed but none are generally accepted. In the first part of this work the MAO formation mechanism was addressed. Molecular dynamics simulations at MP2 configuration interaction theory level have …


Verification Of Direct Brachytherapy Dosimetry For A Single Seed Implant, Jabari Robinson Jan 2006

Verification Of Direct Brachytherapy Dosimetry For A Single Seed Implant, Jabari Robinson

LSU Master's Theses

A new technique using direct post-implant dosimetry, which does not depend explicitly on brachytherapy seed orientation or position, was explored for a prostate and a breast case. This technique, proposed by E Sajo and ML Williams (SW), uses trace amounts of positron emitters placed in the seed capsule and uses the positron emission tomography image in conjunction with a computed tomography image (PET-CT) to compute the therapeutic dose distribution in the patient. The SW technique could reduce errors in the post-implant dose computations associated with seed localization, seed shadowing and medium heterogeneity. Dose point kernels were obtained using Monte Carlo …


Development Of Analytical Techniques For The Analysis Of Submicron Particles And Protein Aggregates, Yohannes H. Rezenom Jan 2006

Development Of Analytical Techniques For The Analysis Of Submicron Particles And Protein Aggregates, Yohannes H. Rezenom

LSU Doctoral Dissertations

The goal of the research presented in this dissertation is to develop analytical techniques for the analysis of heterogeneous mixtures of submicron particles and protein aggregates. In Chapter 2, a simple and reproducible technique for constructing perfectly aligned gaps in fused-silica capillaries has been developed for postcolumn reagent addition with capillary electrophoresis (CE) to take advantage of laser-induced fluorescence (LIF) detection. This technique uses laser ablation with a Nd:YAG laser to create gaps of 14.0 ¡Ó 2.2 ƒÝm. These structures have been used for reagent addition for postcolumn derivatization with LIF detection and have been tested for the separation of …


Investigation Into The Dirhodium-Catalyzed Hydroformylation Of 1-Alkenes And Preparation Of A Novel Tetraphosphine Ligand, Alexandre R. Monteil Jan 2006

Investigation Into The Dirhodium-Catalyzed Hydroformylation Of 1-Alkenes And Preparation Of A Novel Tetraphosphine Ligand, Alexandre R. Monteil

LSU Doctoral Dissertations

The reaction of the tetraphosphine ligand rac-et,ph-P4 (et,ph-P4 = PEt2CH2CH2(Ph)PCH2P(Ph)CH2CH2PEt2) with 2 equiv. of [Rh(nbd)2]+ (nbd = norbornadiene) generates [rac-Rh2(nbd)2(et,ph-P4)]2+, which is the precursor to a highly active and regioselective hydroformylation catalyst system. The “key” catalyst species generated under H2/CO pressure has been proposed to be the dihydrido complex [rac-Rh2H2(ì-CO)2(et,ph-P4)]2+, and represents one of the most dramatic example of homobimetallic …


Simulating Protein Evolution Via Thermodynamic Models, Yanlong Xu Jan 2006

Simulating Protein Evolution Via Thermodynamic Models, Yanlong Xu

LSU Doctoral Dissertations

Natural proteins are results of evolution and they need to maintain certain thermodynamic stabilities in order to carry out their biological functions. By simulating protein evolution based on thermodynamic rules, we could reconstruct the evolution trajectory and analyze the evolutionary dynamics of a protein population, and further understand the protein sequence-structure-function relationship. In this study, we have used both a simplified lattice model and a high-resolution atomic model to simulate protein evolution processes. With the lattice model, we have investigated general theoretical questions about how protein structural designability would affect protein evolution, particularly how it would affect protein recombination and …


Spatial Distribution Of Heavy Metals In Louisiana Sediments And Study Of Factors Impacting The Concentrations, Suniti Bhattarai Jan 2006

Spatial Distribution Of Heavy Metals In Louisiana Sediments And Study Of Factors Impacting The Concentrations, Suniti Bhattarai

LSU Master's Theses

To identify the sites with elevated metal concentrations and factors impacting the concentrations, we studied 128 observations on heavy metals collected from the four inch deep sediments in Louisiana lakes and rivers. Use of Fe as a normalizing factor to interpret the site of metal enrichment was justified based on its high correlation with other heavy metals. The regression coefficients of metal/Fe came out to be significant for all the metals in both level and log versions. For the metals, where prediction exceeded upper 95% confidence interval, we mapped the site with factors such as number of industries located within …


Syntheses And Biological Evaluation Of Water Soluble Carboranylporphyrins For Application In Boron Neutron Capture Therapy, Vijay Gottumukkala Jan 2006

Syntheses And Biological Evaluation Of Water Soluble Carboranylporphyrins For Application In Boron Neutron Capture Therapy, Vijay Gottumukkala

LSU Doctoral Dissertations

The goal of the research presented in this dissertation is to develop novel water soluble carboranylporphyrins that can deliver therapeutic dosage of boron specifically to tumors for application in boron neutron capture therapy. In order to accomplish this goal novel water soluble tetra(nido-carboranyl)porphyrin and the octa(nido-carboranyl)porphyrin with high boron contents are synthesized by the condensation of the carborane substituted benzaldehyde with the pyrrole under acidic conditions. These porphyrins are made water soluble by the deboronation of the closo-carboranes to afford the corresponding amphiphilic nido-carborane cages. The low cytotoxicity, high cellular uptake and intracellular localization of these carboranylporphyrins in tumor cells …


Synthesis, Crystal Growth, Magnetic And Transport Properties Of Ln-M-X (Ln=Lanthanide, M=Transition Metal, X=In, Ga) Compounds, Willa Maria Williams Jan 2006

Synthesis, Crystal Growth, Magnetic And Transport Properties Of Ln-M-X (Ln=Lanthanide, M=Transition Metal, X=In, Ga) Compounds, Willa Maria Williams

LSU Doctoral Dissertations

ABSTRACT This dissertation focuses on the structural stability, magnetic and transport properties of ternary lanthanide compounds grown using indium and gallium flux. Single crystals of TbRhIn5 were synthesized using indium flux. TbRhIn5 is isostructural to the well known LnnMIn3n+2 (n = 1, 2, ∞; Ln = La, Ce; M = Rh, Ir) and adopts the HoCoGa5 structure type and crystallizes in the space group P4/mmm, Z = 1. Lattice parameters are a = 4.6000(6) Å and c = 7.4370(11) Å, V = 157.29(6) Å3. A sharp antiferromagnetic transition is observed at TN = 48 K for TbRhIn5. Single crystals of …


Porous Inorganic-Organic Materials Based On Beta-Diketone Ligands, Yixun Zhang Jan 2006

Porous Inorganic-Organic Materials Based On Beta-Diketone Ligands, Yixun Zhang

LSU Doctoral Dissertations

Synthesis and characterization of porous inorganic-organic materials have been studied mainly on two linear β-diketone multifunctional ligands: pyridine based pyacH and isocyanide based HacphNC. As a known ligand, the preparation of pyacH has been improved with higher yield. When pyacH reacts with Fe and Al metal salts, trigonal metal β-diketonate building blocks M(pyac)3 are produced. When pyacH reacts with zinc acetate, both trans and cis Zn(pyac)2 are produced, both isomers were isolated and characterized by single-crystal X-ray crystallography. Solutions of the trigonal building block Fe(pyac)3 generate various crystal structures on reaction with AgNO3 in CH3CN. When the concentration of AgNO3 …


Application Of Polymeric Microfluidic Devices For Separation Of Single-Stranded Dna, Shawn Llopis Jan 2006

Application Of Polymeric Microfluidic Devices For Separation Of Single-Stranded Dna, Shawn Llopis

LSU Doctoral Dissertations

Microsystems targeted for DNA sequencing, especially those focused on electrophoretic separations, are rapidly proving their viability to genomic research, mimicking the progress made when capillary electrophoresis developed from miniaturizing slab gel electrophoresis techniques. Being the more recent electrophoretic separation platform, the commercial availability of microchip electrophoresis devices remains relatively limited. To this extent, high-aspect ratio microstructures formed in thermo plastics have been developed using rapid fabrication methods from molding tools designed for mass replication of high-aspect ratio microfeatures. In this work, the choice and compatibility of poly(methylmethacrylate) (PMMA) – the primary substrate for DNA separations in this work – was …


Circuits And Structure In Matroids And Graphs, Brian Daniel Beavers Jan 2006

Circuits And Structure In Matroids And Graphs, Brian Daniel Beavers

LSU Doctoral Dissertations

This dissertation consists of several results on matroid and graph structure and is organized into three main parts. The main goal of the first part, Chapters 1-3, is to produce a unique decomposition of 3-connected matroids into more highly connected pieces. In Chapter 1, we review the definitions and main results from the previous work of Hall, Oxley, Semple, and Whittle. In Chapter 2, we introduce operations that allow us to decompose a 3-connected matroid M into a pair of 3-connected pieces by breaking the matroid apart at a 3-separation. We also generalize a result of Akkari and Oxley. In …


Structural Characterization Of Poly(Heterocycles) Formed Using Oxidative Methods, Rebecca Marie Brauch Jan 2006

Structural Characterization Of Poly(Heterocycles) Formed Using Oxidative Methods, Rebecca Marie Brauch

LSU Doctoral Dissertations

This research focused on elucidation of structural information for conducting polymer systems using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). The structure of conducting polymer systems has been found to directly influence their physical properties. Poly(pyrrole) and poly(thiophene) are two of the most widely studied conducting polymers due to their high electrical conductivity, stability in the doped state, low toxicity, and current/potential applications. The purpose of this research was to apply MALDI-TOF MS to heterocyclic conducting polymers, specifically those of pyrrole and thiophene, to investigate structural properties of these polymers, with the specific aim of determining end group and …


Effects Of Diesel-Fuel And Copper Contaminants On Benthic Microalgae, Soraya Silva Jan 2006

Effects Of Diesel-Fuel And Copper Contaminants On Benthic Microalgae, Soraya Silva

LSU Doctoral Dissertations

Salt marshes are dynamic, highly productive habitats and serve as nursery grounds for many commercially and economically important species. Benthic microalgae (BMA) are considered an important food source for benthos and provide the principal source of nutrition that fuels secondary production. Estuarine sediments around the world are a repository for many contaminants from anthropogenic sources. In particular, hydrocarbons and metals are ubiquitous contaminants in coastal systems. The primary goal of this study was to study the effects of diesel fuel and copper, alone and in combination, on the BMA assemblage from a coastal salt marsh. To achieve this objective, salt …


Numerical Techniques For Fresnel Diffraction In Computational Holography, Richard Patrick Muffoletto Jan 2006

Numerical Techniques For Fresnel Diffraction In Computational Holography, Richard Patrick Muffoletto

LSU Doctoral Dissertations

Optical holography can produce very realistic virtual images due to its capability to properly convey the depth cues that we use to interpret three-dimensional objects. Computational holography is the use of digital representations plus computational methods to carry out the holographic operations of construction and reconstruction. The large computational requirements of holographic simulations prohibit present-day existence of real-time holographic displays comparable in size to traditional two-dimensional displays. Fourier-based approaches to calculate the Fresnel diffraction of light provide one of the most efficient algorithms for holographic computations because this permits the use of the fast Fourier transform (FFT). The limitations on …


Factors Influencing The Participation In Environmental Stewardship Programs: A Case Study Of The Agricultural And Forestry Sectors In Louisiana, Carrie Castille Mendoza Jan 2006

Factors Influencing The Participation In Environmental Stewardship Programs: A Case Study Of The Agricultural And Forestry Sectors In Louisiana, Carrie Castille Mendoza

LSU Doctoral Dissertations

Considerable research has been conducted to evaluate the adoption of agricultural best management practices and their overall impact on improving environmental quality. However, limited studies have been conducted to evaluate the behavioral factors that influence the adoption of these practices in the context of educational programs The goal of this study is to determine the factors that influence farmer conservation behavior that might lead to an increased probability of improving agriculture and forestry watersheds. A conceptual model was developed to identify the: 1) identify landowner participation in watershed conservation projects, and 2) determine the factors influencing agriculture and forestry landowners …


Ontology-Based Methodology For Error Detection In Software Design, Allyson M. Hoss Jan 2006

Ontology-Based Methodology For Error Detection In Software Design, Allyson M. Hoss

LSU Doctoral Dissertations

Improving the quality of a software design with the goal of producing a high quality software product continues to grow in importance due to the costs that result from poorly designed software. It is commonly accepted that multiple design views are required in order to clearly specify the required functionality of software. There is universal agreement as to the importance of identifying inconsistencies early in the software design process, but the challenge is how to reconcile the representations of the diverse views to ensure consistency. To address the problem of inconsistencies that occur across multiple design views, this research introduces …


Security In Heterogeneous Wireless Networks, Vijay Bulusu Jan 2006

Security In Heterogeneous Wireless Networks, Vijay Bulusu

LSU Master's Theses

The proliferation of a range of wireless devices, from the cheap low power resource starved sensor nodes to the ubiquitous cell phones and PDA's has resulted in their use in many applications. Due to their inherent broadcast nature Security and Privacy in wireless networks is harder than the wired networks. Along with the traditional security requirements like confidentiality, integrity and non-repudiation new requirements like privacy and anonymity are important in wireless networks. These factors combined with the fact that nodes in a wireless network may have different resource availabilities and trust levels makes security in wireless networks extremely challenging. The …


Influence Of Surface Chemistry On The Aggregation Of Beta Amyloid Peptide, Mariah Joan Wooldridge Mcmasters Jan 2006

Influence Of Surface Chemistry On The Aggregation Of Beta Amyloid Peptide, Mariah Joan Wooldridge Mcmasters

LSU Doctoral Dissertations

Alzheimer's disease is a progressive neurological ailment affecting 4.5 million aging Americans. The disease is characterized by the presence in the brain of self-assembled fibrils consisting of beta amyloid protein (Aβ). Soluble Aβ protein is present in normal human cerebrospinal fluid, but it is unclear what makes the protein aggregate into insoluble plaques. There is evidence that the Aβ fibril assembly is affected by interactions with biological surfaces, such as neuronal membranes. Here, surfaces consisting of self-assembled alkanethiol monolayers with different end groups were used to test the effect of surface chemistry on the structure and morphology of aggregates formed …


Infrared Laser Desorption/Ionization Mass Spectrometry: Fundamental And Applications, Mark Little Jan 2006

Infrared Laser Desorption/Ionization Mass Spectrometry: Fundamental And Applications, Mark Little

LSU Doctoral Dissertations

This dissertation on infrared laser desorption/ionization mass spectrometry encompasses fundamental studies of the desorption/ionization process and direct-from-gel laser desorption/ionization applications. Understanding of the fundamentals behind desorption and ionization can lead to improvements in the technique and to new applications. Experiments aimed at advancing this goal are wavelength studies and two-laser infrared/ultraviolet matrix-assisted laser desorption/ionization experiments. The direct-from-gel laser desorption/ionization application in which infrared laser desorption/ionization of analytes directly ionized after gel electrophoretic separation will also be presented. Protein and peptide standards were used as test analytes and the infrared lasers used were a 10.6 micrometers carbon-dioxide laser and a mid-IR …


Ecology Of Lesser Scaup Amphipods In The Upper-Midwest: Scope And Mechanisms Of The Spring Condition Hypothesis And Implications For Migration Habitat Conservation, Michael Jason Anteau Jan 2006

Ecology Of Lesser Scaup Amphipods In The Upper-Midwest: Scope And Mechanisms Of The Spring Condition Hypothesis And Implications For Migration Habitat Conservation, Michael Jason Anteau

LSU Doctoral Dissertations

I tested the scope of the Spring Condition Hypothesis in explaining the continental population decline of lesser scaup (Aythya affinis; hereafter scaup) and explored potential mechanisms affecting female body condition to assist conservation efforts for population recovery. Lipid reserves of females currently are lower than historical values during spring migration throughout Iowa, Minnesota, and North Dakota; females catabolized lipids throughout this area (indexed by concentrations of plasma-lipid metabolites, which accounted for 75% of the variation in mass change). My results indicate that a large segment of the continental scaup population likely is affected by decreased lipid reserves, which could cause …


Limit Theorems For Weighted Stochastic Systems Of Interacting Particles, Jie Wu Jan 2006

Limit Theorems For Weighted Stochastic Systems Of Interacting Particles, Jie Wu

LSU Doctoral Dissertations

The goal of this dissertation is to (a) establish the weak convergence of empirical measures formed by a system of stochastic differential equations, and (b) prove a comparison result and compactness of support property for the limit measure. The stochastic system of size n has coefficients that depend on the empirical measure determined by the system. The weights for the empirical measure are determined by a further n-system of stochastic equations. There is a random choice among N types of weights. The existence and uniqueness of solutions of the interacting system, weak convergence of the empirical measures, and the identification …


Effects Of Fire On Habitat Associations, Abundance, And Survival Of Wintering Henslow's Sparrows (Ammodramus Henslowii) In Southeastern Louisiana Longleaf Pine Savannas, Erik Ivan Johnson Jan 2006

Effects Of Fire On Habitat Associations, Abundance, And Survival Of Wintering Henslow's Sparrows (Ammodramus Henslowii) In Southeastern Louisiana Longleaf Pine Savannas, Erik Ivan Johnson

LSU Master's Theses

The Henslow’s Sparrow (Ammodramus henslowii) is the fastest declining short-distance migrant and fastest declining grassland bird in North America. Declines in longleaf pine (Pinus palustris) savannas, its primary wintering habitat, have exceeded 97%. Other than basic habitat requirements, very little is known about its wintering ecology. I examined habitat associations of wintering Henslow’s Sparrows resulting from fire in longleaf pine savannas in southeastern Louisiana during two winters. Because it is important to understand the relative importance of habitat parameters, which include structure, species composition, and food availability, I measured these to determine their relative importance to Henslow’s Sparrow densities. I …


Self-Assembly And Its Inhibition In Bolaform Amphiphilic Dendrimers, Jirun Sun Jan 2006

Self-Assembly And Its Inhibition In Bolaform Amphiphilic Dendrimers, Jirun Sun

LSU Doctoral Dissertations

Self-assembly is scientifically interesting, technologically important, and sometimes life-threatening. A striking example: Alzheimer’s disease is caused by the self-assembly of the â-amyloid fragment of amyloid precursor protein. Such natural amphiphiles normally are very expensive and complicated to isolate. Synthetic mimics that are much cheaper and easier to prepare can facilitate the development of efficient characterization methods, even as they suggest new materials science applications. Two-directional arborols are synthetic bolaform amphiphilic dendrimers. They dissolve in hot water and form reversible gels at room temperature. Bundles of fibrils, which are made by self-assembly of arborols, are found in the gels. The properties …


Adaptive Scalable Protocols For Heterogeneous Wireless Networks, Vamsi Krishna Paruchuri Jan 2006

Adaptive Scalable Protocols For Heterogeneous Wireless Networks, Vamsi Krishna Paruchuri

LSU Doctoral Dissertations

The focus of this dissertation is to propose analytical models to study the impact of collisions and interference in heterogeneous wireless networks and propose simple scalable and lightweight protocols that use these models to adapt to network conditions thus increasing efficiency, decreasing energy consumption and prolonging network lifetime. The contributions of this dissertation are multifold and are summarized as follows: - Analytical models to study the impact of collisions and interference on both broadcast and unicast messages. These analytical models are incorporated into the proposed protocols to adapt to the prevailing network conditions to improve their performance. - Optimized Flooding …


Swamp Tours In Louisiana Post Hurricane Katrina And Hurricane Rita, Dawn Schaffer Jan 2006

Swamp Tours In Louisiana Post Hurricane Katrina And Hurricane Rita, Dawn Schaffer

LSU Master's Theses

Hurricanes Katrina and Rita made landfall in southern Louisiana during August and September 2005, respectively. Prior to these storms swamp tours were a popular nature-based tourism experience that entertained visitors while teaching them about local flora, fauna, and culture. The number of swamp tour businesses in the state was slowly increasing. The purpose of this study was to determine how many swamp tours were operating after the hurricanes, what type of damage they sustained, and how they repaired their businesses. Differences between those tours that remained open after the hurricanes and those that closed were also examined. A 3-phase mail …


Delineating Hurricane Vulnerable Populations In Orleans Parish, Louisiana, Stephanie Pedro Jan 2006

Delineating Hurricane Vulnerable Populations In Orleans Parish, Louisiana, Stephanie Pedro

LSU Master's Theses

Since settlement first began, equality issues between different social classes have been evident in the location of where residents settled in New Orleans. This research seeks to answer the question: What socioeconomic indicators are prevalent in the areas most-at-risk to flooding which could inhabit populations least able to evacuate? I will use Census 2000 block group data from the socioeconomic sample data (SF3) collected in 2000, along with other economic and GIS data from the New Orleans region to statistically represent the distribution of risk by selecting indicators predicted to be in flood zones from a classification tree analysis. Then, …


Resource Recovery Of Coal Bed Methane Formation Water, Catherine Elizabeth Bishop Jan 2006

Resource Recovery Of Coal Bed Methane Formation Water, Catherine Elizabeth Bishop

LSU Master's Theses

During the excavation of natural gas, petroleum hydrocarbon-polluted brine water, termed production water, is drawn from the coal bed methane formations (CBMF) along with the natural gas product. The water is drawn out in vast amounts and re-injected into the CBMF. In the Greater Rocky Mountain Region (GRMR) where water supplies are dwindling, the remediation of CBMF production water has become a high priority for maintaining agriculture, residential development and industrial expansion. The overall objective of this research was to demonstrate in laboratory and field pilot studies the efficacious merging of Immobilized Microbe BioReactor (IMBR) technologies for biodegradation/mineralization of organics …


High Harmonic Generation By Short Laser Pulses: Time-Frequency Behavior And Applications To Attophysics, Mitsuko Murakami Jan 2006

High Harmonic Generation By Short Laser Pulses: Time-Frequency Behavior And Applications To Attophysics, Mitsuko Murakami

LSU Doctoral Dissertations

High harmonic generation (HHG) is a process in which noble gas atoms excited by an intense laser field at frequency ω1 emit radiation of higher frequencies that are odd integer multiples of ω1. Driven by an infrared laser, high harmonic radiation can span from the optical into the extreme ultraviolet (XUV) frequency range. In this thesis, I study HHG using short laser pulses by solving the time-dependent Schrödinger equation (TDSE). In particular, I will focus on calculating and controlling the time-dependent instantaneous frequency (chirp) of high harmonics. The harmonic chirp is a direct consequence of the atom-field …


Integrating Micro-Scale Separations To Matrix Assisted Laser Desorption And Ioniation Time Of Flight Mass Spectrometry (Maldi-Tof-Ms) For Protein Analysis, Harrison K. Musyimi Jan 2006

Integrating Micro-Scale Separations To Matrix Assisted Laser Desorption And Ioniation Time Of Flight Mass Spectrometry (Maldi-Tof-Ms) For Protein Analysis, Harrison K. Musyimi

LSU Doctoral Dissertations

This dissertation describes the integration of micro-scale separations to matrix assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI TOF MS) for protein analysis. MALDI MS provides unsurpassed accurate mass measurements of intact bio-molecules, for example peptides and proteins, which in turn generate high molecular specificity enabling the identity, function and structure of these molecules to be characterized. However, in order to realize the full potential of MS in proteomic studies, integrated sample processing on automated and high throughput platforms is required to address the complexity, diversity and the dynamic range of proteomic analysis. The work described here contributes towards …