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Simultaneous Determination Of Sitagliptin And Metformin In Pharmaceutical Preparations By Capillary Zone Electrophoresis And Its Application To Human Plasma Analysis, Mohamed Salim, Nahed El-Enany, Fathalah Belal, Mohomad Walash, Gabor Patonay
Simultaneous Determination Of Sitagliptin And Metformin In Pharmaceutical Preparations By Capillary Zone Electrophoresis And Its Application To Human Plasma Analysis, Mohamed Salim, Nahed El-Enany, Fathalah Belal, Mohomad Walash, Gabor Patonay
Chemistry Faculty Publications
A novel, quick, reliable and simple capillary zone electrophoresis CZE method was developed and validated for the simultaneous determination of sitagliptin (SG) and metformin (MF) in pharmaceutical preparations. Separation was carried out in fused silica capillary (50.0 cm total length and 43.0 cm effective length, 49 μm i.d.) by applying a potential of 15 KV (positive polarity) and a running buffer containing 60 mM phosphate buffer at pH 4.0 with UV detection at 203 nm. The samples were injected hydrodynamically for 3 s at 0.5 psi and the temperature of the capillary cartridge was kept at 25 °C. Phenformin was …
Di-Cationic Arylimidamides Act Against Neospora Caninum Tachyzoites By Interference In Membrane Structure And Nucleolar Integrity And Are Active Against Challenge Infection In Mice, Michelle Schorer, Karim Debache, Fabienne Barna, Thierry Monney, David Boykin, Chad E. Stevens, Andrew Hemphill
Di-Cationic Arylimidamides Act Against Neospora Caninum Tachyzoites By Interference In Membrane Structure And Nucleolar Integrity And Are Active Against Challenge Infection In Mice, Michelle Schorer, Karim Debache, Fabienne Barna, Thierry Monney, David Boykin, Chad E. Stevens, Andrew Hemphill
Chemistry Faculty Publications
Neospora caninum is considered to be the main cause of bovine abortion in Europe and the USA, leading to considerable financial impact. Losses are caused directly by abortions or indirectly through breeding of calves with impaired viability. Due to the lack of effective chemotherapy against bovine neosporosis, there is a need to develop new anti-protozoal compounds, which would either eliminate the parasite or avoid its transmission. In order to identify compounds of interest, the in vitro activities of 41 di-cationic pentamidine derivatives were studied employing a transgenic N. caninum clone expressing beta-galactosidase as a reporter gene. The arylimidamide DB745, previously …
Insight Into The Modulation Of Shaw2 Kv Channels By General Anesthetics: Structural And Functional Studies Of S4-S5 Linker And S6 C-Terminal Peptides In Micelles By Nmr, Jin Zhang, Xiaoguang Qu, Manuel Covarrubias, Markus W. Germann
Insight Into The Modulation Of Shaw2 Kv Channels By General Anesthetics: Structural And Functional Studies Of S4-S5 Linker And S6 C-Terminal Peptides In Micelles By Nmr, Jin Zhang, Xiaoguang Qu, Manuel Covarrubias, Markus W. Germann
Chemistry Faculty Publications
The modulation of the Drosophila Shaw2 Kv channel by 1-alkanols and inhaled anesthetics is correlated with the involvement of the S4–S5 linker and C-terminus of S6, and consistent with stabilization of the channel's closed state. Structural analysis of peptides from S4–S5 (L45) and S6 (S6c), by nuclear magnetic resonance and circular dichroism spectroscopy supports that an α-helical conformation was adopted by L45, while S6c was only in an unstable/dynamic partially folded α-helix in dodecylphosphocholine micelles. Solvent accessibility and paramagnetic probing of L45 revealed that L45 lies parallel to the surface of micelles with charged and polar residues pointing towards the …