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The Evaluation Of The Prokinetic Action Of A Luminally Restricted 5-Ht4 Receptor Agonist In Mice, Emma Schoeling
The Evaluation Of The Prokinetic Action Of A Luminally Restricted 5-Ht4 Receptor Agonist In Mice, Emma Schoeling
Graduate College Dissertations and Theses
Serotonin (5-HT) is a neurotransmitter mainly produced in the enteric nervous system (ENS) of the gastrointestinal (GI) system. Serotonin has widespread function throughout the body including regulating mood, cognition, sleep, sex, and appetite. In the context of the gut, the monoamine modulates vasodilation, mucus secretion, pain, and peristaltic reflexes for motility. The 5-HT4 receptor is expressed on enteric epithelial cells and nerve terminals in the intestinal mucosa. The agonists available to act on these receptors are a favorable target to promote epithelial healing, recovery from colitis or constipation, and epithelial cell proliferation. The non-absorbable, luminally restricted, 5-HT4R agonist (5HT4-LA1; Takeda …
Investigating The Effects Of Medroxy-Progesterone And Hormonal Birth Control On Habit Behavior In Female Rats, Sarah Charlotte Von Doepp
Investigating The Effects Of Medroxy-Progesterone And Hormonal Birth Control On Habit Behavior In Female Rats, Sarah Charlotte Von Doepp
Graduate College Dissertations and Theses
Recent research has shown that there is a significant sex difference in the rate of habit acquisition in rats, with intact females acquiring the behavior with fewer action-outcome reinforcer pairings than intact males. This difference is shown to be related to the presence of cyclic estrogen and progesterone during habit behavior acquisition training. Specifically, the presence of progesterone has been shown to be crucial in early habit acquisition. However, the mechanism of action through which progesterone is influencing this behavior is unknown. Additionally, this project explores the impacts of long-term hormonal (levonorgestrel - progestin based) birth control on habit behavior …
The Role Of Dentate Gyrus Pituitary Adenylate Cyclase Activating Polypeptide (Pacap) In Contextual Fear Discrimination, Samantha Kelly Moriarty
The Role Of Dentate Gyrus Pituitary Adenylate Cyclase Activating Polypeptide (Pacap) In Contextual Fear Discrimination, Samantha Kelly Moriarty
Graduate College Dissertations and Theses
When dysregulated, neural systems important for fear behaviors can contribute to mental health disorders such as anxiety, phobias, and post-traumatic stress disorder (PTSD). In PTSD, a myriad of symptoms is possible, but a hallmark feature of the disorder is generalizing fear. This occurs when fear is experienced inappropriately in relation to the environment or circumstances. To study this behavior in rodent models, contextual fear conditioning is used. Contextual fear conditioning is a learning theory preparation where rodents are conditioned with an aversive stimulus such as foot-shock in one distinct context (A), while concurrently being exposed to a safe context (B). …
The Effect Of Tryptamine Producing Bacteria On Gut Motility In Mice, Emilia Sofia Norberg
The Effect Of Tryptamine Producing Bacteria On Gut Motility In Mice, Emilia Sofia Norberg
Graduate College Dissertations and Theses
It has become increasingly clear that there is bidirectional communication between the microbes that exist in the lumen of the gastrointestinal (GI) tract and the nervous system. Research within the last 20 years has revealed GI bacterial metabolites to have a significant effect on gut motility, and some of these actions involve influencing serotonin signaling in the epithelial layer of the intestines. Serotonin, abbreviated as 5- HT, has many functions within the gut including propulsive and segmentation motility, vasodilation, and epithelial cell secretion. There are several bacterial species that have been discovered to synthesize one of 5-HT’s precursory molecules, including …
Quantifying Glial-Glial Interactions In Drosophila Using Automated Image Analysis, Gabriela Salazar Lopez
Quantifying Glial-Glial Interactions In Drosophila Using Automated Image Analysis, Gabriela Salazar Lopez
Graduate College Dissertations and Theses
Imaging is an immensely powerful tool in biomedical research. Technological advances in the last half century have led to the development of new tools for image analysis, with major strides being made in the last 20 years especially with machine and deep learning. However, researchers still often hit a bottleneck during the image analysis phase of their projects that often leads to delays and sometimes even limits the scope of their studies. In this thesis I demonstrate some of the issues that arise while quantifying images to answer a biological question by using a dataset of fly central nervous system …