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Investigating The Role Of Nf-Kb Inhibition On Müller Glia Proliferation Following Injury In The Zebrafish Retina, Danielle Baffa
Investigating The Role Of Nf-Kb Inhibition On Müller Glia Proliferation Following Injury In The Zebrafish Retina, Danielle Baffa
Celebration of Scholarship 2023
No abstract provided.
Notch3 Expression In Zebrafish With Inherited Degeneration Vs. Inflicted Damage, Meghan Graeca
Notch3 Expression In Zebrafish With Inherited Degeneration Vs. Inflicted Damage, Meghan Graeca
Celebration of Scholarship 2022
While mammals possess a limited capacity for retinal regeneration, teleosts such as Danio rerio (zebrafish) can recover from retinal injury or cell death through stimulation of glia to induce reprogramming into neural stem-like cells.
1 In zebrafish, retinal Müller glia engage in regeneration in response to an injury-derived signal. It was previously shown2,3 that the regenerative response to retinal damage in zebrafish is regulated by the Notch signaling pathway. Persistent Notch signaling causes Müller glia to remain in a quiescent state in the undamaged retina, and Notch signaling repression causes Müller glia to reenter the cell cycle3 , reprogramming them …