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Faculty Notes, John Carroll University

Faculty Notes - John Carroll University

Spring 2023, Volume 16, Issue 1

The Effect Of Sleep Environment On Sleep Quality And Behavior In Firefighters, Erica Esper

Celebration of Scholarship 2023

Firefighting is a demanding profession with high physical and psychological demands. Additionally, shift work results in abnormal working hours, decreased work-life balance, and poor recovery, impacting sleep behaviors. Poor sleep has been associated with health issues such as increased cardiometabolic risk, mental health disorders, and reduced cognitive function. While this population is prone to disrupted sleep while on shift, little research exists describing the effect of the on-duty sleeping environment on sleep quality in firefighters. PURPOSE: Examine the effect of the sleep environment on sleep quality in firefighters. METHODS: Sixty-six firefighters (Age= 40.89±11.05; Body Mass Index = 29.01±3.84) enrolled in …

Prevention Research Center For Healthy Neighborhoods, Madeline Panus

Celebration of Scholarship 2023

No abstract provided.

The Effect Of S-Glutahionylation Of Keap-1/Nrf-2 And Caspase 3, Claire Greenless

Celebration of Scholarship 2023

S-glutathionylation is a form of post-translational modification where glutathione forms disulfide bonds with protein cysteine residues under oxidative conditions. The process of Sglutathionylation is important because it is a reversible process, regulates enzyme activity, and may link to disease development. In this work, under physiological conditions, KEAP-1 and NRF-2 bind together as a complex. Upon oxidative stress, NRF-2 dissociates from KEAP-1 and triggers an antioxidant response. However, the dissociation mechanism was not well studied. S-glutathionylation of KEAP-1 causes dissociation of NRF-2. This result demonstrates a possible dissociation mechanism of NRF-2. Caspase 3 is a cysteine containing protein and a key …

Investigating The Role Of Nf-Kb Inhibition On Müller Glia Proliferation Following Injury In The Zebrafish Retina, Danielle Baffa

Celebration of Scholarship 2023

No abstract provided.

Determination Of Taxonomic Placement Of Falsely-Branched Taxa In Soils Of San Nicolas Island And Reassessment Of The Tolypothrichaceae, Natalie Soliman

Celebration of Scholarship 2023

No abstract provided.

Feminist Mothering And The Needs-Focus Approach Of Writing Centers: A Literature Review, Sophia Wohlwend

Celebration of Scholarship 2023

Within academia, English fields have developed a reputation for being less professional or academically rigid compared to STEM. This undervaluation of English studies, particularly Writing Center work, poses many issues to the people who pursue these careers, specifically harming the women who decide to take these jobs. Typically, English fields are viewed as being nurturing and caring in a way that is deemed less respectable and coddling towards students. Thus, spaces like Writing Centers are branded as “domestic spaces” housing undesirable, feminine traits. As a result of these negative attitudes, this “women’s work” is judged as poorer in quality. According …

Hypoxia-Inducible Factor 1 Alpha Mediated Regulation Of Mitochondrial Function And Homeostasis In Normoxia, Matthew Lunkis

Celebration of Scholarship 2023

During normal levels of oxygenation, also known as normoxia, the transcription factor hypoxia-inducible factor (HIF) 1α is produced and broken down in a continuous manner. Previous studies of HIF1α function(s) in hypoxia demonstrate restricted oxygen uptake and decreased protein synthesis but data regarding this transcription factor in normoxia is limited. We determined the functional aspects of HIF1α in normoxia in differentiated myotubes and with transgenic mice. Higher expression of sirtuin 3 along with higher concentrations of many TCA cycle intermediates were identified in multiple studies. Additionally, phenotypic and morphological implications of HIF1α in normoxia were identified.

Disruption Of Minor Intron Splicing By Disease-Associated Mutations In U12 Snrna, Kyra Jancik

Celebration of Scholarship 2023

In eukaryotic gene expression, the removal of introns from pre-mRNA is an essential function carried out by spliceosomes. Human cells have two distinct spliceosomes: U2-dependent and U12-dependent. U2- dependent spliceosomes, or major spliceosomes, remove over 99% of introns, whereas U-12 dependent spliceosomes remove less than 0.5% of introns. Mutations in spliceosome machinery are a notable cause of human disease. In particular, mutations to components unique to the minor spliceosome demonstrate that it plays a vital role in human development. Mutations in the gene encoding the minor spliceosomal small nuclear RNA (snRNA) U12, RNU12, are associated with two rare developmental disorders: …

Faculty Notes, John Carroll University

Faculty Notes - John Carroll University

Fall 2022, Volume 15, Issue 2

Examining The Optical Properties Of Monosodium Urate For The Detection Of Gout Using A Magneto-Optical Device (Mod), Victoria Marino

Celebration of Scholarship 2022

The purpose of this research was to quantify the magnetooptical properties of monosodium urate (MSU) crystals that would allow for an easy diagnosis using a magneto-optical device (MOD). Characterization of these magnetic and optical properties was achieved by measuring the transmitted light intensity of a laser shining through a sample of monosodium urate with or without an applied (static) magnetic field. Using our theoretical model under the simplifying assumption that absorption is dominant, we determined that the extinction cross-section is σ𝑥 = 0.0127 cm3 /μg and we determined σ𝑧 using two different relationships which gave two distinctly different values. Due …

Classic Clinical Trial: A Methods Study In Unexplained Back Pain, Kathryn Bacik

Celebration of Scholarship 2022

Axial spondyloarthritis (AxSpA) is a type of inflammatory arthritis that primarily affects the spine including the sacroiliac (SI) joint located at the base of the spine. Over a lifetime, the AxSpA can lead to the fusion of the vertebrae and crippling effects on quality of life. This condition is

subdivided into two forms: ankylosing spondylitis (AS) and non- radiographic axial spondyloarthritis (nr-axSpA). While AS is usually

diagnosed using X-ray images that show irreversible bone damage, nr- AxSpA is more difficult to diagnose. In both cases, early detection of

disease will best prevent disease progression and preserve quality of life. An …

How Study And Test Formats Impact Foreign Language Vocabulary Learning: Pictures Vs. Words, Marie Pinzone

Celebration of Scholarship 2022

Background: The Revised Hierarchical Model suggests FL vocabulary acquisition is mediated and enhanced by native language vocabulary knowledge (Kroll & Stewart, 1994). The PSE, based on Paivio’s dual coding theory, holds that pictures are remembered better than words due to being encoded by both verbal and pictorial codes (Paivio & Csapo, 1973). Mixed evidence exists regarding whether the PSE obtains in FL vocabulary learning (Carpenter & Olson, 2012). Hockley (2008) found that the PSE for associative recognition occurs even when picture pairings are presented as words at test. Current Study: The present study seeks to replicate and extend …

Changes In Health Behaviors By Gender During A Global Pandemic, Anthony Costarella

Celebration of Scholarship 2022

As we emerge from Covid-19 pandemic, many people struggle to return to normal, leading us to ask what changes have occurred as a result of the virus and social distancing. We have observed 471 million people suffer with Covid-19, lost 6.08 million lives to the virus, and learned how the virus works as well as how to fight it, yet very little is known about the impact of the virus and its countermeasures on our health habits. PURPOSE: To examine the effect of gender on changes in health behaviors during the COVID-19 pandemic. METHODS: Eight hundred and sixty-six subjects (70.8% …

Cooperative Allosterism In Avidin And Streptavidin Upon Biotin Binding As Observed By Changes In Intrinsic Fluorescence, Alycia Murphy

Celebration of Scholarship 2022

Avidin is a homotetrameric protein known for its high binding affinity and specificity for biotin which gives it great functionality in many biotech applications. Prior research on the bacterial analog, streptavidin found cooperative allosterism exhibited in the binding process. This research was aimed at investigating whether this same cooperative allosterism accompanies the binding of biotin to avidin. This work measured intrinsic tryptophan fluorescence as biotin was titrated into avidin. A blueshift in the wavelength of maximum fluorescence as well as quenching of the overall fluorescence intensity, similar to the streptavidin was observed. The saturation point for 335 nm emission (tryptophans …

Notch3 Expression In Zebrafish With Inherited Degeneration Vs. Inflicted Damage, Meghan Graeca

Celebration of Scholarship 2022

While mammals possess a limited capacity for retinal regeneration, teleosts such as Danio rerio (zebrafish) can recover from retinal injury or cell death through stimulation of glia to induce reprogramming into neural stem-like cells.

1 In zebrafish, retinal Müller glia engage in regeneration in response to an injury-derived signal. It was previously shown2,3 that the regenerative response to retinal damage in zebrafish is regulated by the Notch signaling pathway. Persistent Notch signaling causes Müller glia to remain in a quiescent state in the undamaged retina, and Notch signaling repression causes Müller glia to reenter the cell cycle3 , reprogramming them …

Targeting Notch3 With Crispr-Cas9 Technology In Zebrafish Retinal Degeneration Models, Emily Januck

Celebration of Scholarship 2022

Teleost fish such as zebrafish (Danio rerio) have shown the ability to regenerate damaged photoreceptors due to the robust activity of Müller glia [1]. Interestingly, the Müller glia in retinal disease model zebrafish such as bbs2, cep290, and eys do not respond like those in normal zebrafish, making these genotypes a good model to study treatment options in humans [2, 3, 4]. The Notch signaling pathway is a highly conserved cell signaling pathway in many organisms that plays a role in determining cell fates in developmental processes [5]. Specifically, the notch3 gene has been studied and shown to have effects …

The Evolution Of Women In Business During The Covid-19 Pandemic And Beyond, Carleen Ellerbruch

Celebration of Scholarship 2022

I conducted a survey on the impact of COVID-19 on female professionals in their respective business industries. Respondents to the survey answered a multitude of different questions relating to the impact of COVID-19 on their professional work or their experience in business as a woman.

Any topic covering the pandemic is very new and has very little research or data to support it. The role of women in business continues to evolve and the pandemic is a major factor in its evolution. This survey allows us to gain insight into what will retain women longer, what new challenges needs to …

Faculty Notes, John Carroll University

Faculty Notes - John Carroll University

Spring 2022, Volume 15, Issue 1

Faculty Notes, John Carroll University

Faculty Notes - John Carroll University

Spring 2021, Volume 14, Issue 1

Faculty Notes, John Carroll University

Faculty Notes - John Carroll University

Fall 2021, Volume 14, Issue 2

Faculty Notes, John Carroll University

Faculty Notes - John Carroll University

Fall 2020, Volume 13, Issue 2

Faculty Notes, John Carroll University

Faculty Notes - John Carroll University

Spring 2020, Volume 13, Issue 1

Faculty Notes, John Carroll University

Faculty Notes - John Carroll University

Fall 2019, Volume 12, Issue 2

Faculty Notes, John Carroll University

Faculty Notes - John Carroll University

Spring 2019, Volume 12, Issue 1

Faculty Notes, John Carroll University

Faculty Notes - John Carroll University

Fall 2018, volume 11, issue 2

Faculty Notes, John Carroll University

Faculty Notes - John Carroll University

Spring 2018, volume 11, issue 1

Faculty Notes, John Carroll University

Faculty Notes - John Carroll University

Fall 2017, Volume 10, Issue 2

Faculty Notes, John Carroll University

Faculty Notes - John Carroll University

May 2017, Volume 10, Issue 1

Undergraduate Bulletin 2017-2019, John Carroll University

Undergraduate Bulletin

No abstract provided.