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Effect Of Arm Spasticity Grade On Blood Pressure Measurement, Chia-Min Lin, Huei-Yu Lo, Wai-Keung Lee, Meng-Tai Chen

Rehabilitation Practice and Science

Objective: The arm spasticity in patients with stroke has been proved to affect blood pressure measurement. However, earlier studies showed inconsistent results of how the spasticity affected the measurement of blood pressure. In some cases, measurement of blood pressure in patients' involved arm is necessary, so the purpose of this study was to investigate the effect of spasticity grade on blood pressure measurement in patients with stroke.Methods: We recruited 50 patients with hemiplegia or hemiparesis after stroke. The grade of arm spasticity was assessed using the modified Ashworth scale (MAS), while the bilateral brachial artery pressure was measured using an …

Joint Effect Of Multiple Common Snps Predicts Melanoma Susceptibility, Shenying Fang, Jiali Han, Mingfeng Zhang, Li-E Wang, Qingyi Wei, Christopher I. Amos, Jeffrey E. Lee

Dartmouth Scholarship

Single genetic variants discovered so far have been only weakly associated with melanoma. This study aims to use multiple single nucleotide polymorphisms (SNPs) jointly to obtain a larger genetic effect and to improve the predictive value of a conventional phenotypic model. We analyzed 11 SNPs that were associated with melanoma risk in previous studies and were genotyped in MD Anderson Cancer Center (MDACC) and Harvard Medical School investigations. Participants with ≥15 risk alleles were 5-fold more likely to have melanoma compared to those carrying ≤6. Compared to a model using the most significant single variant rs12913832, the increase in predictive …

Kneeling Leg Curl With Internal Rotation Training Improves Agility In Patients With Anterior-Posterior Laxity Of Knee, Chih-Kuan Wu, Shu-Chun Huang, Kuan-Chou Chen, Cheng-Hsiu Lai, Chia-Hua Kuo, Shih-Wei Chou

Rehabilitation Practice and Science

Objective: Whether strengthening exercises emphasizing on internal rotators of the knee are more effective in improving shuttle-run agility of the knees with anterior-posterior laxity (AP laxity). Methods: Twenty men with AP laxity of knee were randomly assigned to the three experimental groups in different strengthening modes: plate-loaded squat press (SP), plate-loaded kneeling leg curl with internal rotation (KLCIR), and kneeling leg curl (KLC). Control group with stable knees received no training. Anterior-posterior laxity, shuttle-run agility, and isokinetic strength were evaluated before and after training. Results: Those with AP laxity of knee have poorer performance in the shuttle run test than …

The Relationships Between Using The Rating Of Perceived Exertion, Metabolic Equivalent And Maximum Heart Rate At Ventilatory Threshold Into Determine Appropriate Exercise Prescription For Intensity In Obese Diabetic Patients: A Preliminary Study, Yan-Wen Chen, Francois Liang, Sen-Wei Tsai, Shih-Yi Lin, I. T. Lee, Sheu-Chen Liu, Shin-Shan Lu

Rehabilitation Practice and Science

Background: The rating of perceived exertion (RPE), metabolic equivalent (MET) and maximum heart rate (HRmax) at ventilatory threshold (VT) are commonly used methods as physiological parameters for monitoring exercise intensity. However, the appropriate levels of training intensity for obese type 2 diabetic diabetes mellitus (type 2 DM) patients have not been established.Purpose: To examine the parameters in obese Type 2 DM patients at ventilatory threshold, the exercise capacity of obese Type 2 DM patients, and to determine the appropriate levels of exercise intensity for exercise prescription in obese type 2 DM patients was investigated.Methods: Twenty obese type 2 DM patients …

Sensory Integration Dysfunction Affects Effectiveness Of Speech Therapy On Children With Functional Articulation Disorders, Li-Chen Tung, Ching-I Hu, Chin-Kai Lin, Ching-Lin Hsieh, Daniel Chiung-Jui Su, Ching-Chi Chen

Rehabilitation Practice and Science

Purpose: To compare the efficacy of speech therapy on children with functional articulation disorder with and without sensory integration dysfunction. Method: 20 young children were divided into two groups, those without sensory integration dysfunction (normal group, 10 children) and those with it (abnormal group, 10 children). The Mandarin Consonant Articulation Test for Preschool Children was administered on the children before and after therapy for articulation function. The oral motor function was evaluated by the Riley Motor Problems Inventory Oral Motor Tasks. Total of treatment sessions was recorded after the therapy. Results: Differences between the two groups in terms of age, …

Exploring The Possible Effects Of Mountaineering Activities On Sports Injuries, Body Composition And Thigh Muscle Function, Yi-Ting Fang, Chen-Liang Chou, Yi-Cheng Chen, Hong-Jen Chiou, Jin-Jong Chen, Hsuci-Chen Lee, Yi-Fen Shih

Rehabilitation Practice and Science

Background: Mountaineering and hiking have become popular activities recently, but related research in Taiwan has focused mainly on physiological reactions, much more than on the musculoskeletal system. However, the results of studies from abroad cannot be directly transferred because of the unique mountain and forest environment in Taiwan. In addition, chronic mountaineering injuries and derivative benefits in terms of specific physical performances still await further study. Therefore, it is important to investigate the possible relationship between mountaineering activities and musculoskeletal or knee function changes. Purpose: This study seeks to compare the differences in sports injuries, body composition and thigh muscle …

Role Of Defensins In The Pathogenesis Of Chronic Lung Allograft Rejection, Venkataswarup Tiriveedhi, Babak Banan, Saini Deepti, Angaswamy Nataraju, Ramsey Hachem, Elbert Trulock, Patterson G. Alexander, Thalachallour Mohanakumar

Biology Faculty Research

Chronic rejection predominantly manifested as bronchiolitis obliterans syndrome (BOS), still remains a major problem affecting long-term outcomes in human lung transplantation (LTx). Donor specific antibodies (DSA) and infiltration of neutrophils in the graft have been associated with the development of BOS. This study determines the role of defensins, produced by neutrophils, and its interaction with α-1-antitrypsin (AAT) towards induction of airway inflammation and fibrosis which are characteristic hallmarks of BOS. Bronchoalveolar lavage (BAL) and serum from LTx recipients, BOS+ (n=28), BOS− (n=26) and normal healthy controls (n=24) were analyzed. Our results show that BOS+ LTx recipients had higher α-defensins (HNP1–3) …

Spatial Analysis Of Factors Influencing Long-Term Stress In The Grizzly Bear (Ursus Arctos) Population Of Alberta, Canada, Mathieu Bourbonnais, Trisalyn Nelson, Mark Cattet, Chris T. Darimont, Gordon Stenhouse

Physiology Collection

Non-invasive measures for assessing long-term stress in free ranging mammals are an increasingly important approach for understanding physiological responses to landscape conditions. Using a spatially and temporally expansive dataset of hair cortisol concentrations (HCC) generated from a threatened grizzly bear (Ursus arctos) population in Alberta, Canada, we quantified how variables representing habitat conditions and anthropogenic disturbance impact long-term stress in grizzly bears. We characterized spatial variability in male and female HCC point data using kernel density estimation and quantified variable influence on spatial patterns of male and female HCC stress surfaces using random forests. Separate models were developed for regions …

Men At Risk; A Qualitative Study On Hiv Risk, Gender Identity And Violence Among Men Who Have Sex With Men Who Report High Risk Behavior In Kampala, Uganda., Rachel King, Joseph Barker, Sylvia Nakayiwa, David Katuntu, George Lubwama, Danstan Bagenda, Tim Lane, Alex Opio, Wolfgang Hladik

Journal Articles: Epidemiology

In Uganda, men who have sex with men (MSM) are at high risk for HIV. Between May 2008 and February 2009 in Kampala, Uganda, we used respondent driven sampling (RDS) to recruit 295 MSM≥18 years who reported having had sex with another man in the preceding three months. The parent study conducted HIV and STI testing and collected demographic and HIV-related behavioral data through audio computer-assisted self-administered interviews. We conducted a nested qualitative sub-study with 16 men purposively sampled from among the survey participants based on responses to behavioral variables indicating higher risk for HIV infection. Sub-study participants were interviewed …

Food Advertisements In Two Popular U.S. Parenting Magazines: Results Of A Five-Year Analysis, Corey H. Basch, Rodney N. Hammond, Danna Ethan, Lalitha Samuel

Publications and Research

Obesity rates among American youth have prompted an examination of food advertisements geared towards children. Research indicates children’s high exposure to these advertisements and their influence on food preferences. Less is known about the presence of these advertisements in parenting magazines. This study’s objective was to examine prevalence of food advertisements in popular parenting magazines and identify products by USDA food category. We analyzed 116 issues of two popular U.S. parenting magazines across five years. All food and beverage advertisements for USDA Food Category were coded. Breakfast cereals were coded for nutritional quality. The coding took place at varied libraries …

The Effects Of Acute Post Exercise Consumption Of Two Cocoa-Based Beverages With Varying Flavanol Content On Indices Of Muscle Recovery Following Downhill Treadmill Running, Katelyn Peschek, Robert Pritchett, Ethan Bergman, Kelly Pritchett

All Faculty Scholarship for the College of the Sciences

Dietary flavanols have been associated with reduced oxidative stress, however their efficacy in promoting recovery after exercise induced muscle damage is unclear. This study examined the effectiveness of acute consumption of cocoa-flavanols on indices of muscle recovery including: subsequent exercise performance, creatine kinase, muscle tenderness, force, and self-perceived muscle soreness. Eight endurance-trained athletes (VO2max 64.4 ± 7.6 mL/kg/min) completed a downhill running protocol to induce muscle soreness, and 48-h later completed a 5-K (kilometer) time trial. Muscle recovery measurements were taken at PRE, 24 h-POST, 48 h-POST, and POST-5K. Participants consumed 1.0 g of carbohydrate per kilogram of body weight …

Dose Dependent Effects Of Caffeine On Cognitive Performance And Neuronal Activation, Stephan Albrecht, Helen Morris, Michelle Vieyra

Journal of the South Carolina Academy of Science

Many students assume that the more caffeine you drink, the better your cognitive performance. Over-consumption of caffeine has many negative effects, so if there are no dose related cognitive benefits to large amounts of caffeine, then college students should limit their intake. This study looked at whether ingesting a medium dose (200 mg) versus a lower dose (100 mg) of caffeine improved short term memory as measured by Flanker and n-back tests, compared to a control group. In addition, we looked at whether larger doses of caffeine produced a difference in neuronal activation during these tests as measured by functional …

Periprosthetic Joint Infection Increases The Risk Of One-Year Mortality., Benjamin Zmistowski, Joseph A. Karam, M.D., Joel B Durinka, David S Casper, Md, Javad Parvizi Md

Rothman Institute Faculty Papers

BACKGROUND: Periprosthetic joint infection continues to potentially complicate an otherwise successful joint replacement. The treatment of this infection often requires multiple surgical procedures associated with increased complications and morbidity. This study examined the relationship between periprosthetic joint infection and mortality and aimed to determine the effect of periprosthetic joint infection on mortality and any predictors of mortality in patients with periprosthetic joint infection.

METHODS: Four hundred and thirty-six patients with at least one surgical intervention secondary to confirmed periprosthetic joint infection were compared with 2342 patients undergoing revision arthroplasty for aseptic failure. The incidence of mortality at thirty days, ninety …

Perceptions And Experiences Of Intimate Partner Violence Among Hispanic College Students, Racquel Vera

FIU Electronic Theses and Dissertations

Intimate partner violence (IPV) is recognized as a serious, growing problem on college campuses. IPV rates among college students exceed estimates reported for the general population. Few studies have examined the impact of IPV among the Hispanic college student (HCS) population or explored how HCSs perceive and experience IPV.

Focusing on young adults (ages 18 to 25 years), this mixed methods study was designed to explore the perceptions and experiences of IPV focusing on levels of victimization and perpetration in relation to gender role attitudes and beliefs, exposure to parental IPV, acculturation, and religiosity. A sample of 120 HCSs was …

Reductions In Serum Igf-1 During Aging Impair Health Span, Zhenwei Gong, Oran Kennedy, Hui Sun, Yingjie Wu, Garry A. Williams, Laura Klein, Luis Cardoso, Ronald W. Matheny Jr, Gene B. Hubbard, Yuji Ikeno, Roger P. Farrar, Mitchell B. Schaffler, Martin L. Adamo, Radhika H. Muzumdar, Shoshana Yakar

Publications and Research

In lower or simple species, such as worms and flies, disruption of the insulin-like growth factor (IGF)-1 and the insulin signaling pathways has been shown to increase lifespan. In rodents, however, growth hormone (GH) regulates IGF-1 levels in serum and tissues and can modulate lifespan via/or independent of IGF- 1. Rodent models, where the GH/IGF-1 axis was ablated congenitally, show increased lifespan. However, in contrast to rodents where serum IGF-1 levels are high throughout life, in humans, serum IGF-1 peaks during puberty and declines thereafter during aging. Thus, animal models with congenital disruption of the GH/ IGF-1 axis are unable …

Primary Care And Youth Mental Health In Ireland: Qualitative Study In Deprived Urban Areas, Dorothy Leahy, Elisabeth Schaffalitzky, Claire Armstrong, Gerard Bury, Paula Cussen-Murphy, Rachel Davis, Barbara Dooley, Blanaid Gavin, Rory Keane, Eamon Keenan, Linda Latham, David Meagher, Pat Mcgorry, Fiona Mcnicholas, Ray O'Connor, Ellen O'Dea, Veronica O'Keane, Tom P. O'Toole, Edel Reilly, Patrick Ryan, Lena Sanci, Bobby P. Smyth, Walter Cullen

Faculty Publications

BACKGROUND: Mental disorders account for six of the 20 leading causes of disability worldwide with a very high prevalence of psychiatric morbidity in youth aged 15-24 years. However, healthcare professionals are faced with many challenges in the identification and treatment of mental and substance use disorders in young people (e.g. young people's unwillingness to seek help from healthcare professionals, lack of training, limited resources etc.) The challenge of youth mental health for primary care is especially evident in urban deprived areas, where rates of and risk factors for mental health problems are especially common. There is an emerging consensus that …

Improving An Outpatient Diabetes Program Telephone Follow-Up Process: Evaluating Its Impact On Glycosylated Hemoglobin Levels, Joan B. Niemczewski

Graduate Theses, Dissertations, and Capstones

Telephone follow-up for diabetes self-management is used to facilitate ongoing support for individuals striving to maintain a healthy lifestyle. With the use of telephone follow-up after Diabetes Self-Management Education (DSME), key concepts can be emphasized and goal reinforcement can occur. When successfully managed, improved glycemic control occurs, as evidenced by reductions in glycosylated hemoglobin (A1C) levels. A review of the literature surrounding this topic and description of a capstone scholarly project utilizing findings from the literature to create an evidence-based telephone follow-up pilot study are included. Findings from this study did not reveal statistically significant reductions in A1C levels with …

Assessing Quality Outcomes In A Behavioral Oncology Program: Capstone Project, Elizabeth M. Archer-Nanda

Graduate Theses, Dissertations, and Capstones

The landscape of cancer care has changed dramatically over the past several decades. An illness that was once often fatal, now represents both an acute life threatening illness and a chronic condition. While there have been tremendous advancements in the treatment of the physiological aspects of cancer, management of related psychosocial and emotional issues have not seen this same progress. Limited information exists related to both the evaluation and outcome metrics associated with the screening and management of psychiatric sequelae after referral to specialized psychiatric services in cancer patient populations. This capstone project focused on (a) implementation of consistent use …

Comparison Between Two Methodological Paradigms Of Conditioned Place Preference With Methlyphenidate., Bryce D. Watson

Undergraduate Honors Theses

The aim of this thesis is to examine the mechanisms of Methylphenidate (MPH) on Conditioned Place Preference (CPP), a behavioral test of reward. The psychostimulant MPH is therapeutically used in the treatment of ADHD, but has been implicated in many pharmacological actions related to drug addiction and is considered to have abuse potential. Past work in our lab and others have shown substantial sex-differences in the neuropharmacological profile of MPH. Here a discussion of the relevant mechanisms of action of MPH and its relationship to neurotrophins and CPP are reviewed. Furthermore, previous work is reviewed and a rationale for two …

Acl Tears: Their Cause And Prevention, Meredith Shephard

Mahurin Honors College Capstone Experience/Thesis Projects

There has been an increase in the prevalence of anterior cruciate ligament (ACL) tears among athletes in the recent years. This paper will seek to discover why ACL injury is so common and if there is any way to minimize these injuries. Research has shown a number of things that can lead to prevention of these injuries, including a correlation between the strength of the hip and thigh muscles and the stability of the ACL. Also many recent studies show that individuals most susceptible to ACL injuries often have difficulty performing gross motor skills such that the lower extremities move …

Hand Hygiene Perceptions Of Student Nurses., Brittany Berger

Undergraduate Honors Theses

Compliance with hand hygiene is widely recognized as the most important factor in preventing transmission of infection to patients in healthcare settings (Haas and Larson, 2007). Hand hygiene dramatically decreases the potential pathogens on hands and is considered the first measure for decreasing the risk of transmitting organisms to patients, healthcare professionals, and family members. Noncompliance with hand hygiene practices has been shown to increase healthcare-associated infections, costing hospitals $35.7-$45 billion each year (Centers for Disease Control and Prevention [CDC], 2012). Education about hand hygiene starts in school and should transfer into the real world of nursing. The purpose of …

Surveys Of Women With Hpv And Their Healthcare Experiences., Danielle Defayette

Undergraduate Honors Theses

Genital human papillomavirus infection is the most common sexually transmitted virus in the United States, with almost 20 million Americans currently infected and an additional 6.2 million becoming newly infected each year. Women rely strongly on their health care providers to educate and comfort them regarding this distressing diagnosis. This study will use an online, self-completion questionnaire to obtain women’s opinions regarding their health care providers’ performances concerning the initial consultation after learning of their HPV diagnosis. Findings from this study provided insight as to how women prefer receiving information from their health care providers concerning their diagnosis of HPV. …

Effects Of Wii Fit™ Plus Cardiovascular Exercises On Cognitive Function In Older Adults: Feasibility Study., Ifeanyichukwu Chinedozi

Undergraduate Honors Theses

Cognitive decline increasingly plague older adults. Although various studies have correlated aerobic exercises with decreased incidence of the development and progression of cognitive deterioration in older adults, there is no evidence as to whether or not the Wii Fit Plus Rhythm Kung-Fu, Hula-Hoop and the Wii Just Dance can improve the cognitive function of older adults as measured by the Standardized Mini Mental State Examination (SMMSE) instrument. A descriptive study design was used to explore the feasibility of implementing an aerobic exercise program for older adults in an assisted living facility using these Wii games, and evaluating whether or not …

Impact Of Oxidative Stress On Female Fertility., Tasha Harris

Undergraduate Honors Theses

This study examined nutritional status and fecundity of women and was approved for patient enrollment by the ETSU Institutional Review Board (IRB). Once enrolled, participants filled out two food frequency questionnaires (FFQ, fruit/vegetable intake, fat intake), self-reported anthropometric data, and had one 5 mL vacutainer of whole blood (EDTA) collected for measures of oxidative stress (OS), coenzyme Q10 level, and fatty acid profile of the red blood cell (RBC) membrane. Participants were either designated to the case group (13 women experiencing fertility problems and an anti-mullerian hormone level of 1 ng/ml or less (AMH, <1 ng/mL)) or the control group (13 women experiencing normal ovulation cycles and no evidence of polycystic disease). This study hypothesized that the case group would have poorer plasma antioxidant status, consume more dietary saturated fat and have lower levels of omega-3 and higher levels of omega-6 fatty acids in the RBC membrane. Results showed that case participants had significantly higher body mass index (BMI) when graduating from high school, BMI upon enrollment in the study, and trended to gain more weight since high school. Antioxidant status of the plasma tended to be higher for the case group. This result was surprising as case participants consumed significantly fewer servings of fruits and vegetables (sources of antioxidants) than control subjects. FFQ results indicated that case participants consumed significantly higher amounts of total fat (g), saturated fat (g), unsaturated fat (g), and their diets had a higher dietary fat percent. No significant differences were noted in the individual fatty acids isolated from the RBC membrane or in calculated ratios of fatty acid between case and control groups. The fatty acid profile from RBC membranes are in agreement with self-reported fat intake from FFQ data and may provide a rationale for no differences observed between the two groups.

Strengthening Immigrants' Health Access: Current Opportunities, Leighton C. Ku

Health Policy and Management Issue Briefs

This brief summarizes key opportunities helping the nation’s newcomers in gaining health insurance coverage and health access that are possible under the current law. Provisions of the Affordable Care Act (ACA) will help millions of legal immigrants gain access to affordable health insurance coverage. At the same time, however, immigrants will also face new responsibilities. Like citizens, lawfully present immigrants will be responsible for having health insurance coverage or paying a tax penalty, although some are exempt. Rules about immigrants’ access to health insurance benefits are often complicated because they depend on specific immigration categories, as well as eligibility for …

Innovative Approach To New Nurse Residency, Meaningful Use And Health Care Reform, Pamela V. Stanley

Doctor of Nursing Practice (DNP) Projects

The project’s aim was to examine the financial impact of replacing registered nurse (RN) travelers, RN registry and RN overtime with new graduate RNs. Newly graduated RNs are often viewed by hospital administrators as a more costly staffing resource. This project contributes knowledge regarding the potential cost savings with the utilization of a centralized float pool incorporating new graduates. In addition, it contributes a novel idea for reducing organizational costs of implementing an electronic medical record with the utilization of new graduates as super users.

A new graduate program, which incorporated the use of a formal preceptor and mentoring program, …

How Age Friendly Is This City? Strategies For Assessing Age-Friendliness, Michelle Dellamora

Electronic Thesis and Dissertation Repository

The Age-Friendly Cities framework, created by the World Health Organization (WHO), has emerged as a community-based response to the challenges of demographic aging and increasing urbanization. In 2010, London, Ontario, became the first city in Canada to join the WHO Global Network of Age-Friendly Communities. Network milestones require the measurement of the baseline age-friendliness of the community. The objectives of this thesis are: 1. Determine the best available assessment tools for measuring the age-friendliness of a community, and 2. Establish the baseline age-friendliness of London, Ontario. A scoping review was utilized to collect and assess available surveys and questionnaires. A …

The Impact Of Intrauterine Exposure To Gestational Diabetes Mellitus On Early Childhood Body Mass Index Trajectories, Aniq Anam

Electronic Thesis and Dissertation Repository

Background: Although gestational diabetes mellitus (GDM) has been linked to pediatric obesity, there is limited research on the impact of intrauterine exposure to GDM on trajectories of childhood growth. Objective: To assess the effect of prenatal GDM exposure on childhood body mass index (BMI) trajectories. Design: Analyses were conducted using data from cycles 2 to 6 (1994-2004; N=3412 children) of the National Longitudinal Survey of Children and Youth. Latent growth curve modelling (LGCM) was used to model BMI trajectories from age 2 to 10 years with prenatal exposure to GDM as a predictor. Effect modification by breastfeeding was assessed. Results: …

Factors Influencing Youth Self-Perceptions Of Overweight And Obesity, Caitlin Helen Sommers

Dissertations and Theses

This study sought to examine whether participation in physical activity affects the ability to correctly classify body size, based on body mass index classifications. Secondarily, this study determined whether adolescents who incorrectly classified their body size overestimated or underestimated their size. Self-report data from the Youth Risk Behavior Surveillance Survey collected by the Centers for Disease Control and Prevention were analyzed. Logistic regression was performed to examine relationships between self-perception of body size and physical activity, television viewing time, computer/video game use, physical education class time, and extracurricular sports activities. Significance was set to p<0.05. Physical activity was the only statistically significant independent variable (p=0.058, OR = 1.060). Although physical activity was shown to be statistically significant, it did not appear to meaningfully increase the ability of youth to correctly classify body size. Secondary analysis showed that adolescents who incorrectly classified their body size were more likely to underestimate their body size. Females more frequently underestimated their body size (females=673; males=384).

Mitigating Risk Factors For Disease Progression In Patients With Varus Gonarthrosis, Angelo Boulougouris

Electronic Thesis and Dissertation Repository

Knee osteoarthritis (OA) is a leading cause of disability worldwide. Its growing burden is related to an aging population, obesity and physical inactivity. The progression of knee OA involves both biomechanical and systemic mechanisms. Known risk factors that might be altered through interventions include lower limb alignment, the distribution of loads across the knee during walking, body composition and muscular strength. The overall purpose of this thesis was to evaluate the effects of multi-modal, rehabilitative and surgical interventions that target different risk factors for disease progression in patients with medial compartment knee OA and varus mal-alignment (varus gonarthrosis). The thesis …