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Release Of Cortisol From Lanolin Alcohol-Providone Films, Mahmud Sighayer Treki

University of the Pacific Theses and Dissertations

In this study, lanolin alcohol as well as lanolin alcohol-povidone films (1:1 . 5) were investigated as a potential drug delivery system. The in vitro drug release from these films was studied in terms of the effect of agitation, film thickness and drug concentration. The rate of release of Cortisol from lanolin alcohol films was not affected by the intensity of agitation. Moreover, the film matrix was found to remain essentially intact throughout the release process. Further analysis of the data revealed that Higuchi's diffusion-controlled granular matrix model explained the mechanism of Cortisol release from such films. The results of …