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Release Of Cortisol From Lanolin Alcohol-Providone Films, Mahmud Sighayer Treki

University of the Pacific Theses and Dissertations

In this study, lanolin alcohol as well as lanolin alcohol-povidone films (1:1 . 5) were investigated as a potential drug delivery system. The in vitro drug release from these films was studied in terms of the effect of agitation, film thickness and drug concentration. The rate of release of Cortisol from lanolin alcohol films was not affected by the intensity of agitation. Moreover, the film matrix was found to remain essentially intact throughout the release process. Further analysis of the data revealed that Higuchi's diffusion-controlled granular matrix model explained the mechanism of Cortisol release from such films. The results of …

Pharmacognosy Of The Saururaceae : Microscopy Of Powdered Drugs, Prakash Vaman Mallya

University of the Pacific Theses and Dissertations

Plants of the family Sauruaceae are used in folk medicine in various parts of the world. Chemistry of some plants of this family and their chemotaxonomy has been investigated in our laboratory (12).

It is very difficult to establish identity and authenticity of commercially available crude drugs and powders of the Saururaceae because a detailed, collective study of microscopic features of these plants is not available. Original papers establishing plants of this family (see later) do not include microscopic features; they describe only gross morphologic and other classical features required for systematics. They are not useful for a pharmacologist in …

Clinical And Financial Evaluation Of Patients Within A Diagnosis Related Group, Osama M. Ibrahim

University of the Pacific Theses and Dissertations

The purpose of this study is to evaluate financial and clinical data of patients within a selected DRG. The data obtained from such analysis will be used to design a system whereby clinical pharmacists may improve the hospital's reimbursement potential.

Based upon Upton's proposed plan, this study is designed to evaluate all DRGs in a community hospital in an attempt to focus on those DRGs which represent the greatest financial pressure to the pharmacy department and, therefore, to the institution.

Clinical and financial data of patients within the expensive DRG, will be collected from their medical and financial records for …

The Synthesis Of Various Substituted 3-Amino-7-Hydroxy-2,2-Dimethyltetralins And Their Opioid-Related Activities, David Alan Lippman

University of the Pacific Theses and Dissertations

A series of aminotetralones and aminotetralins were synthesized from the common intermediate F, 3-amino-2,2-dimethyl-7-methoxy- 1-tetralone. The final compounds derived from F were simple substituted and/or reduced analogues. The products would allow a progressive structure activity relationship to be drawn based on pharmacological testing.

The common intermediate F was synthesized utilizing a six step procedure starting with p-methoxyphenylacetic acid. The overall yield from the precursor to the F:HC1 was 25%. Compound F was either O-demethylated to form 3-amino-2,2-dimethyl-7-hydroxy-l-tetralone (I) or was dimethylated on the amine and subsequently O-demethylated to yield the 3-dimethylamino-7-hydroxy-2,2-dimethyl-l-tetralone (J). The last major modification was the reduction of …

Computerized Formulation And Optimization Of Medicated Chewing Gum, Daniel J. Berky

University of the Pacific Theses and Dissertations

Sixty Four caffeinated chewing gum preparations were formulated by varying the amounts of (i) cinnamaldhyde, (0-0.75%), (ii) docusate (0-0.5%) and (iii) sucrose (40-60%). The gum base consisted of 33.33% yellow beeswax and 66.66% polyisobutylene MH, and was added, adjusting for a final weight of 2 grams per gum. The amount of caffeine was maintained at 100mg. The preparations were subjected to an in vivo release study as well as a hedonic survey with a panel of student volunteers.

Data were analyzed by using multiple linear regression on a mainframe computer. The resulting mathematical model was used to predict a theoretically …

The Nature Of Leukocytic Response To Mouse Mammary Tumor Implants In C3h/Hej Mice With And Without Anticoagulation, Melvin Earl Liter

University of the Pacific Theses and Dissertations

Cancer is the second leading cause of death in the United States. The risk of cancer development and subsequent death from the disease increases sharply in the population over 55 years of age(1). Coagulation problems also increase with age and have been implicated in increasing the metastatic spread of cancer. Although cancer treatment has improved constantly it still remains quite toxic and improvement are needed

Mouse mammary tumor is a common form of cancer used for experimental animal study. This investigation was designed to study the nature of leukocytic response to mouse mammary tumor implants in C3H/HeJ mice with and …

Exercise And Eating Habit Change In The Treatment Of Obesity, Michael D. Johnson

University of the Pacific Theses and Dissertations

A pretest-posttest control group design was used to compare the effectiveness of a behavioral caloric reduction/exercise increase treatment package with a caloric reduction approach. The participants consisted of 32 people selected from those responding to a community newspaper advertisement announcing the weight control program. The caloric reduction/exercise treatment group focused on energy expenditure methods for reducing weight and improving physical fitness along with procedures for controlling food intake patterns. The caloric reduction group concentrated on procedures for controlling food intake patterns only. The results indicated that weight loss was achieved by both the caloric reduction group and the combined caloric …

Comparison Of Selected Radiopharmaceutical Chromatographic Quality Control Procedures, Lawrence Ray Andreatta

University of the Pacific Theses and Dissertations

The purpose of this study was to compare the accuracy and reproducibility of two commercially available chromatography kits with Instant Thin Layer Chromatography-Silica Gel (ITLC-SG) and Whatman Chromatography Paper. The two commercial kits evaluated were the- MAC Klt- produced-General Radioisotopes Products, and the TECH Kit by Ackerman Nuclear.

The Effect Of Selected Adjuvants On The In Vitro Percutaneous Penetration Of Benzocaine, See-Yan Lam

University of the Pacific Theses and Dissertations

This research project was designed to test whether the in vitro percutaneous penetration of benzocaine through human cadaver skin could be enhanced by dimethyl sulfoxide (DMSO), urea, polyoxyethylene (20) isohexadecyl ether and 1-dodecylazacycloheptan-2-one (Azone) in propylene glycol/water systems. Solubility and partitioning of benzocaine in propylene glycol/water systems was investigated. The adjuvant effects were studied in a 60/40 (V/V) propylene glycol/water co-solvent system. The well known drug penetration enhancer dimethyl sulfoxide did not enhance the penetration of benzocaine at any concentration level of DMSO under the conditions of the experiment. This lack of enhancement effect was probably due to increased solubility …