Digital Commons Network^™

Effect Of Urokinase Plasminogen Activator Receptor (Cd87) On Patients With De-Novo Acute Myeloid Leukemia, Arwa Abd El Hamed Hijii, Ghada E. Soliman, Iman A. Ahmedy, Samia H. Kandil

Menoufia Medical Journal

Objectives The objective of this study was to study the role and the prognostic value of urokinase-type plasminogen activator receptor (uPAR) (CD87) expression in patients with de-novo acute myeloid leukemia (AML). Background The physiological function of the uPAR (CD87) is concerned in various biological processes and signal transduction such as cancer metastasis, angiogenesis, cell migration, and wound healing. The uPAR is expressed in most solid cancer and in several hematological malignancies including myeloproliferative disease, acute leukemia (AML, acute lymphocytic leukemia), and multiple myeloma. Patients and methods This study was conducted on 52 newly diagnosed patients with AML and 20 age-matched …

Study Of Lung Ultrasonography As A Diagnostic Tool In Childhood Pneumonia, Ghada M. Elmashad, Mostafa M. Shalaby, Wael A. Bahbah, Waleed A. Mousa, Mahmood D. Al-Mendalawi

Menoufia Medical Journal

Objective

The aim of this study was to compare chest ultrasonography with chest radiography (CXR) in the diagnosis of children with pneumonia. Background

In Egypt, pneumonia and other acute respiratory infections were the causes of death in ∼19% of children younger than 5 years. According to current guidelines, pneumonia is diagnosed by clinical history, respiratory rate, fever, respiratory signs, and symptoms. Patients and Methods

A cross-sectional study was conducted on 60 patients with fever and signs of respiratory distress, and they were divided in two groups: group I with pneumonia, which included 45 patients who were finally diagnosed as having …

Screening Intelligence Of Primary School Children Using 'Draw-A-Person Test' In Mansoura District, Al Dakahlia Governorate, Ali M. El-Shafie, Dalia M. El Lahony, Mohamed A. M. Dagher, Zein A. Omar

Menoufia Medical Journal

Objective The aim was to screen the intelligence level among primary school children using 'draw-a-person (DAP) test' in Dakahlia Governorate. Background For more than 100 years, clinicians and psychologists have studied children's drawing as a measure of one's cognitive ability. In 1926, Florence Goodenough developed a drawing test called the DAP test. The DAP test consists of having a child draw -a whole person on a piece of paper that is scored via a list of items that are commonly present in the drawings. It showed that a child's drawing is a reflection of one's intellectual skills and development. Participants …

Endothelin-1 Gene Polymorphism In Egyptian Patients With Vitiligo, Douaa S. Alsaadany, Mohammed A. Shoeib, Ola A. Bakry, Sally M. El-Hefnawy

Menoufia Medical Journal

Objective The aim was to investigate the association between endothelin-1 (ET-1) gene polymorphism and vitiligo occurrence or increased vitiligo risk in Egyptian population. Background ET-1 is a keratinocyte-derived cytokine, which also has been defined as a strong mitogen and melanogen for human melanocytes and a potent stimulant of melanocyte proliferation, melanogenesis, and migration, implying a link with vitiligo. Patients and methods This study was conducted on 60 female patients with vitiligo. Their ages ranged from 6 to 70 years Overall, 54 cases presented with nonsegmental vitiligo and six cases presented with segmental vitiligo. Moreover, 40 age-matched and sex-matched …

A Study Of Dna Damage In Epileptic Children Treated With Valproic Acid Or Carbamazepine, Ahmed T. Mahmoud, Dina Abd El-Aziz Hammad, Maha A. Tawfik, Sameh A. Abd-El-Naby

Menoufia Medical Journal

Objective The aim of this study was to determine DNA damage in epileptic children due to seizures and/or due to the most widely used antiepileptic drugs (valproic acid or carbamazepine). Background Epilepsy is a common neurological disease that requires early diagnosis and treatment. However, long-term use of antiepileptic drugs has been shown to cause oxidative damage to protein and DNA. Patients and methods We enrolled 15 epileptic patients receiving valproic acid monotherapy, 15 epileptic patients receiving carbamazepine monotherapy, 10 epileptic children with no treatment, and 10 control healthy children. Blood samples were collected from a peripheral vein into heparinized tubes …

Evaluation Of Serum Amyloid A Protein As A Marker In Neonatal Sepsis, Eman A. Badr, Ghada M. Elmashad, Hanan M. Elsayed, Osama M. Omran, Zein A. Omar

Menoufia Medical Journal

Objective To evaluate the serum amyloid A (SAA) as an early and accurate diagnostic marker in neonatal sepsis. Background The early and efficient diagnosis of neonatal sepsis in high-risk neonates remains a difficult task as the clinical signs are nonspecific, complete blood count parameters and C-reactive protein (CRP) have low sensitivity, also difficulty of its diagnosis may be due to decreased positive values of blood culture and long time which is needed for detection of blood culture results. The SAA protein level in the blood increases earlier and up to 1000-fold in response to inflammation. Participants and methods A case–control …

Relationship Between Thyroid Nodule Size And Incidence Of Thyroid Cancer, Ahmed S. El-Gammal, Kareem M. Zahran, Mohammed A. E-Balshy

Menoufia Medical Journal

Objective The aim of this study was to study the size of thyroid nodule as a risk factor of thyroid malignancy. Background The nodular thyroid lesions are of interest to surgeons and patients since the major differential diagnosis is cancer. These thyroid lesions are present as solitary or multiple nodules. Patients and methods This study was carried out on 330 patients aged from 13 to 65 years, every patient included in the study were subjected to history taking, physical examination, preoperative investigations (thyroid function test and routine investigations and ultrasonography on thyroid gland to detect the size of lobes and …

Late-Onset Congenital Diaphragmatic Hernia, Misdiagnosed As Hydropneumothorax: A Case Report, Aditya P. Singh, Arun K. Gupta, Dinesh K. Barolia, Ramesh Tanger

Menoufia Medical Journal

Congenital diaphragmatic hernia (CDH) is herniation of bowels and abdominal solid organs in the thoracic cavity, causing pulmonary hypoplasia with decreased pulmonary vasculature and dysfunction of the surfactant system. In severe cases, left ventricular hypoplasia is also observed. Usually CDH present in the neonatal period. Late-onset CDH is a rare anomaly with misleading symptoms and signs. We present here a case of late presentation of congenital diaphragmatic hernia misdiagnosed as hydropneumothorax in an 11-month-old male child.

The Role Of Osteopontin In Dermatological Diseases, Alaa H. Marea, Amany M. Mohsen, Sally M. El-Hefnawy, Wafaa A. Shehata

Menoufia Medical Journal

Objective The aim of this study was to study the role of osteopontin (OPN) in dermatological diseases through a meta-analysis study. Data sources Previous literatures, reviews, and studies as well as medical websites (PubMed, Medscape and Science Direct), all material available in the internet from 2014 to 2017, and scientific journals databases were searched from the start date of each database. Study selection The initial search presented 10 articles of which five met the inclusion criteria. Selection was done by supervisors for studying the role of OPN in dermatological diseases. Data extraction If the studies did not fulfill the inclusion …

Role Of Functional Mri In Assessment Of Voice, Language, And Speech Disorders, Eman Ezzat, Hossam El-Dessouky, Marwa G A El-Hameed, Mohamed Baraka

Menoufia Medical Journal

Objective The objective of this study was to review the role of functional MRI (fMRI) in assessment of voice, language, and speech disorders. Materials and Methods Medline databases (PubMed, Medscape, and ScienceDirect) and all materials available in the Internet from 1993 to 2017 were the sources of data. The initial search presented 267 articles of which 62 met the inclusion criteria. The articles studied the role of fMRI in assessment of communication disorders as regards voice, language, and speech. If the studies did not fulfill the inclusion criteria, they were excluded. Study quality assessment included whether ethical approval was gained, …

Role Of Hepcidin In Iron Metabolism And Pathophysiology Of Different Types Of Anemia, Fady M. El Gendy, Mahmoud A. El-Hawy, Nehal K. El Shennawy

Menoufia Medical Journal

Objectives The study aimed to demonstrate the critical role of hepcidin in regulation of iron metabolism in various types of anemia. Data sources Medline databases (PubMed, Science Direct, Medscape) and all materials available in the Internet from 2007 to 2017 were searched. Study selection The initial search presented 38 articles, of which 11 met the inclusion criteria. The articles studied the relation between hepcidin and iron homeostasis in various types of anemia. Data extraction If the studies did not fulfill the inclusion criteria, they were excluded. Study quality assessment included whether ethical approval was gained, eligibility criteria specified, appropriate controls …

Notch Signaling In Dermatology, Heba Allah S K Bazid, Iman A. Seleit, Mohammed A. Basha, Ola A. Bakry, Rehab M. Samaka

Menoufia Medical Journal

Objective The aim of this study was to assess the role of Notch signaling in both health skin and pathogenesis and management of skin diseases. Materials and methods PubMed and all materials on the internet from 2000 to 2017 were searched. The initial search presented 101 articles, of which 49 met the inclusion criteria: clinical trial types II and III, published in English language, published in peer-reviewed journals, and focusing on Notch in different skin diseases. If the studies did not fulfill the inclusion criteria, they were excluded. Study quality assessment included whether ethical approval was obtained, eligibility criteria specified, …

Severity Of Atherosclerotic Coronary Artery Disease In Relation To Glycated Hemoglobin Level In Diabetic Patients, Abdullah M. Kamal, Ahmed A. Mostafa, Bayoumi M. Bayoumi

Menoufia Medical Journal

Objective The aim of this work was to assess the relationship between the level of glycated hemoglobin (HbA1c) and the severity of coronary artery disease (CAD) among diabetic patients and perform a comparison with nondiabetic patients. Background Diabetes mellitus and coronary heart disease are closely associated and generally coexist. The severity CAD is directly related to the quality of glucose control in diabetic patients. Patients and methods This study included 150 patients referred to coronary angiography. In addition to the routine evaluation, assessment of HbA1c level, transthoracic echocardiogram, and coronary angiography were performed and the Gensini score (GS) was calculated. …

Pharmacological Conversion Of Recent-Onset Atrial Fibrillation: A Randomized Study Of Propafenone And Amiodarone, Abdallah M. Kamal, George S. Kamil, Naglaa F. Ahmed

Menoufia Medical Journal

Aim The aim of this study was to compare the efficacy and rapidity of recent-onset atrial fibrillation (AF) conversion by oral propafenone versus an intravenous infusion of amiodarone. Background Amiodarone and propafenone are the most widely used drugs in Egypt for the pharmacological cardioversion of AF. Patients and methods Fifty patients with recent-onset AF – within less than 48 h – were investigated. The patients were divided randomly into two groups: the first group (group A) included 25 patients in whom amiodarone was administered and the second group (group B) included 25 patients in whom propafenone was administered. Results 88% …

Subendocardial Systolic Dysfunction In Hypertensive Patients With Strain St-T Changes On Ecg By Speckle Tracking, Gerges R. Thabet, Mahmoud A. Soliman, Morad B. Mena

Menoufia Medical Journal

Objective The aim of this study was to evaluate longitudinal strain by speckle tracking in hypertensive patients with strain ST-T on ECG. Background Hypertension causes ST-T changes on ECG which may predict subclinical systolic dysfunction detected by two-dimensional speckle tracking. Patients and methods Longitudinal strain analysis was done in 82 hypertensive patients, who were divided into three groups: the first group included 30 hypertensive patients with echocardiographic evidence of left ventricular hypertrophy (LVH) and strain ST-T changes on ECG (group 1), the second included 31 hypertensive patients with echocardiographic evidence of LVH but without changes on ECG (group 2), and …

The Role Of Color Doppler Ultrasonography In Evaluation Of Hemodialysis Graft Dysfunction, Aya H. El-Sabbagh, Mohammed S. El-Zawawi, Yasmin H. Hemida

Menoufia Medical Journal

Objective To evaluate role of duplex Doppler ultrasound in assessing arteriovenous graft (AVG) function, detecting complications and analyzing the resistance index (RI) and flow in the afferent artery. Background End-stage renal disease causes serious health problems all over the world. The numbers of patients requiring dialysis have grown. In Egypt, it is the cause of 1.3% of all deaths, with much more incidence in later years of life. A well-functioning dialysis access is the lifeline for those patients. Patients and methods This study included 20 patients (male/female: 11/9) with end-stage renal disease and on regular hemodialysis using AVG. The prospective …

Study Of Interleukin-6 And Its Role In Hepatic Encephalopathy In Patients With Liver Cirrhosis, Abdalaziz M M Salama, Ahmed Abd El-Rahman Sonbol, Ehab A. Abd El-Atty, El-Sayed I. El Shayeb

Menoufia Medical Journal

Objective The aim of this work was to study the role of interleukin-6 (IL-6) in hepatic encephalopathy (HE) in patients with liver cirrhosis. Background IL-6 is an interleukin that acts as both proinflammatory response and anti-immune response. Patients and methods This study included 80 patients divided into three groups: group I represents the control group (20 healthy individuals), group II included patients with liver cirrhosis 'without HE' (30 patients), and group III included patients with liver cirrhosis and HE of different grades (30 patients). Full history taking, clinical examination, and investigations for all cases were done. Results There was significant …

Noninvasive Methods For Fibrosis Assessment In Chronic Hepatitis C Virus Infection, Ehab A. Abd El-Atty, El-Sayed I. El-Shayb, Mohammed O. Belal

Menoufia Medical Journal

Objective The objective of this study is to compare several noninvasive methods of fibrosis assessment (platelet count, the aspartate aminotransferase/platelet ratio index, the Lok score, and the fibrosis-4 score) versus percutaneous liver biopsy (LB) in chronic hepatitis C virus infection. Background Noninvasive methods for assessment of hepatic fibrosis are increasingly needed. LB is an invasive procedure and includes a risk of complications, such as pain, pneumothorax, puncture of other viscera, and hemorrhage. In addition to the added cost, LB cannot be performed universally in all patients with impaired hemostasis of any origin. Patients and methods Our study included 500 patients …

Mean Platelet Volume And Its Correlation With Cardiovascular Risk In Type 2 Diabetic Patients, Heba Adel Saleh Omar Saeed, Mohamed A. El-Said, Mohamed A. Abd El-Hafeez, Nabil A. El-Kafrawy

Menoufia Medical Journal

Objective To evaluate the mean platelet volume (MPV) and its correlation with cardiovascular risk in type 2 diabetic patients. Background Platelet functions have important roles in the development of vascular complications in diabetic patients. Platelets with increased volume have increased activity compared to smaller ones, therefore, MPV is used as a marker for platelet activity. Patients and methods A cross-sectional analytical study was done on a group of 60 type 2 diabetic patients divided into group I, included 23 cases without cardiovascular disease, group II, included 37 cases with cardiovascular disease, and group III, included 20 healthy people as the …

Study Of Cd14+ And Cd16+ Peripheral Blood Monocytes In Asthmatic Patients, Ahmed A. Sonbol, Laila M. Montaser, Mohammed A. Agha, Mona A. Ibrahim

Menoufia Medical Journal

Objective This study aimed to investigate the enhanced frequencies of CD14⁺⁺ CD16 + peripheral blood monocytes in asthmatic patients. Background CD16 + monocytes are increased in inflammatory conditions. It was reported that CD16 + monocytes can be divided into two subsets with different potential of modulating inflammatory responses: CD14⁺⁺ CD16 + and CD14 + CD16 + monocytes. CD14⁺⁺ CD16 + and CD14 + CD16 + monocyte subsets are quantified in asthmatic patients regarding severity of disease and glucocorticoids treatment options. Patients and methods CD14⁺⁺ CD16 + was examined in 20 cases of completely controlled asthma, 20 …

Fibroblast Growth Factor 23: A Novel Biomarker Of Phosphate Retention In Patients With Chronic Kidney Disease, Asmaa A. A. Sabik, Rasha I. Noor El-Din, Seham Ahmed Zaky Khodair, Yassin S. Yassin

Menoufia Medical Journal

Objective The objective of this study was to evaluate fibroblast growth factor 23 (FGF23) expression in patients with chronic kidney disease (CKD) and its effect on diagnosis, grading, and prognosis of patients. Background CKD is recognized as a major public health problem in which there is progressive loss in renal function over a period of months or years. FGF23 is a protein that in humans is encoded by the FGF23 gene. FGF23 is a member of the FGF family which is responsible for phosphate metabolism. Patients and methods This study was conducted on 73 patients with CKD (with …

Human Chitinase-3-Like Protein Amarker Of Hepatic Fibrosis In Chronic Hepatitis C Virus Infection, Ayman A. Alghoraieb, Gehan K. El-Saeed, Hanan A. Ahmed, Rasha I. Noreldin

Menoufia Medical Journal

Objective The aim was to evaluate the level of human chitinase-3-like protein (YKL-40) in patients with hepatitis C virus infection and observe its level in hepatic fibrosis. Background Hepatic fibrosis results from long-standing liver damage, and it represents a major health care burden worldwide. In recent years, there has been increasing interest in identifying and describing hepatic fibrosis through the use of noninvasive markers. The serum YKL-40 level has been evaluated as a noninvasive marker of various chronic inflammatory and fibrotic liver diseases, including chronic hepatitis C, chronic hepatitis B, and alcoholic liver disease. Participants and methods This study case–control …

Use Of Azacytidine In Differentiation Of Mesenchymal Stem Cells, Iman A. Ahmedy, Rasha A. El Morsy, Shaimaa M. Motawe, Waled M. Fathy

Menoufia Medical Journal

Objective We aimed to study the differentiation of mesenchymal stem cells (MSCs) into cardiomyocytes using azacytidine. Background Ischemic injury of cardiomyocytes results in heart failure, as cardiomyocytes do not have the ability to regenerate after death. This has prompted interest in identifying cells capable of replacing the injured myocardium with healthy cells. The ideal candidate for cellular cardiomyoplasty is a less committed cell that can undergo full cardiogenic differentiation which can be found in the adult bone marrow (BM). Now it is believed that the adherent population of cells isolated from BM and expanded in vitro are a potential source …

Clinical And Angiographic Predictors Of Success In Chronic Total Occlusion Coronary Angioplasty, Ahmad M. Mahmoud Elsheikh, Ahmed A E Emara, Ahmed M. Elkersh, Alaa-Eldeen A. Hataba

Menoufia Medical Journal

Objective The aim of this study was to define the preinterventional parameters for procedural success of chronic total occlusion (CTO) coronary angioplasty. Background CTOs are encountered in 15–30% of patients undergoing coronary angiography. Compared with failed CTO angioplasty, successful CTO angioplasty has been associated with improvement in angina and left ventricular function and increased survival. Compared with intervention of nonoccluded stenoses, the recanalization of CTOs requires expert operator skills, increased procedural time, and increased radiation exposure to the patient, physician, and catheterization laboratory staff. Materials and methods This prospective study was conducted from April 2014 to March 2015 in Kobry …

The Role Of Diffusion-Weighted Mri On The Differentiation Of Complex Adnexal Masses, El-Sayed M. El-Sayed, Hamed G. Ali, Mohmad S. Abdullah

Menoufia Medical Journal

Background Conventional MRI has an established role in gynecologic imaging. However, increasing clinical demand for improved lesion characterization and disease mapping to optimize patient management has resulted in the incorporation of newer sequences, such as diffusion-weighted imaging (DWI), into routine protocols for pelvic MRI. DWI provides functional information on the microenvironment of water in tissues, hence augmenting the morphologic information derived from conventional MRIs. Objective The objective of this study was to highlight the role of DWI in differentiating benign from malignant complex adnexal masses. Patients and methods Twenty-five patients with adnexal masses underwent conventional MRI and DWI and the …

Decreased Expression Of Microrna-451 Is Associated With Imatinib Mesylate Resistance In Patients With Chronic Myeloid Leukemia, Amira M. F. Shehata, Khaled A. Khalifa, Omaima M. Abbas, Raafat M. Abdlfattah, Sally S. Mandour Esawy, Suzan A. El-Hassanein

Menoufia Medical Journal

Objectives To measure the expression levels of microRNA-451 (miR-451) in patients with chronic myeloid leukemia (CML) and to correlate miR-451 expression levels with response to imatinib mesylate (IM)-based therapeutic protocol. Background miRNAs are regulatory RNAs that have been classified as crucial players of cancer initiation and progression. Recent studies have illustrated an association between certain hematological malignancies and dysregulated miRNAs expressions; other studies have focused on the utilization of miRNAs as molecular biomarkers of cancer detection, outcome, and response to therapy. Patients and methods Real-time quantitative PCR technique was used to estimate the plasma miR-451 expression levels of 10 newly …

Evaluation Of Serum Kisspeptin In Infertile Men With Severe Oligospermia, Abdalla M. Attia, Bilal A. El-Mohsen Montaser, Hossam A. El Hamid Yassien, Mohammed M. El-Meligi

Menoufia Medical Journal

Objective The aim of this study was to determine whether an abnormality in the serum levels of kisspeptin is associated with oligospermia and male infertility. Background The study of kisspeptin has yielded a new concept on the physiology of the hypothalamic–pituitary–testicular axis and thus the sexual and reproductive functions of men. Patients and methods Our case–control study included 44 male participants aged 20–45 years divided into two groups: a case group composed of 22 infertile men with severe oligospermia and with normal serum levels of testosterone, luteinizing hormone, follicle-stimulating hormone, and prolactin and an age-matched control group composed of 22 …

Effect Of Ursodeoxycholic Acid On Indirect Hyperbilirubinemia In Neonates Treated With Phototherapy, Eman El-Sayed Al Kafory, Fady M. El-Gendy, Wael A. Bahbah

Menoufia Medical Journal

Objective The aim was to evaluate the role of ursodeoxycholic acid (UDCA) on neonatal indirect hyperbilirubinemia treated with phototherapy. Background Hyperbilirubinemia is a common neonatal problem. The present study aimed to investigate the role of UDCA on neonatal hyperbilirubinemia treated with phototherapy. Participants and methods This randomized controlled clinical trial was conducted on 100 full-term neonates with unconjugated hyperbilirubinemia, who received phototherapy in the neonatal ICU of Menoufia University Hospital, and they were randomly divided into two groups: group 1, which is the case group (n = 50), received ursofalk (250 mg capsule) in dose of 10 mg/kg/day divided …

Laparoscopic Cystic Duct Exploration, Ehab S. A. Mahmoud, Hatem M. Soltan, Mohammed S. Ammar, Mohammed A. El Balshy

Menoufia Medical Journal

Objective To evaluate the benefits of routine cystic duct exploration during laparoscopic cholecystectomy (LC). Background The era of LC has been established as it decreases postoperative pain, shortens the hospital stay, and returns the patient to full activity within 1 week. Cystic duct stones (CDS) especially in patients with multiple tiny gallbladder are implicated in postcholecystectomy pain, failure of insertion of transcystic intraoperative cholangiography catheter, and the subsequent development of common bile duct (CBD) stones. Patients and methods This was a prospective study that included 30 patients with chronic calcular cholecystitis with multiple tiny stones. The patients were operated at …

Left Ventricular Strain In Pediatric Patients With End-Stage Renal Disease, Ahmed A. Khattab, Fahima M. Hassan, Mahmoud A. Soliman, Marwa G S Feteih, Rania S. El-Zayat

Menoufia Medical Journal

Objective To evaluate left ventricular function using speckle tracking echocardiography (STE) in pediatric patients with end-stage renal disease (ESRD) with preserved left ventricular ejection fraction. Background ESRD is considered a leading cause of cardiovascular morbidity and mortality in pediatric patients. With the help of newer echocardiographic modalities such as two-dimensional (2D) STE, an early diagnosis of the cardiac involvement through the detection of subclinical myocardial dysfunction might be possible in pediatric patients with ESRD. Patients and methods This study was carried out on 35 children under regular hemodialysis for at least 3 days weekly owing to ESRD who were followed …