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Ischemia-Modified Albumin As A Predicting Biomarker Of Oxidative Stress In Males With Primary Infertility, Hanan A. Derbala, Mohammed A. Shoeib, Noha R. Bayomy, Reem A. Hassan
Ischemia-Modified Albumin As A Predicting Biomarker Of Oxidative Stress In Males With Primary Infertility, Hanan A. Derbala, Mohammed A. Shoeib, Noha R. Bayomy, Reem A. Hassan
Menoufia Medical Journal
Objectives To evaluate the serum ischemia-modified albumin (IMA) level in patients with primary infertility as a useful marker for assessing oxidative stress. Background Infertility is a condition affecting 15% of the world's population. IMA is calculated through the evaluation of the binding of cobalt to albumin. Patients and methods This prospective study was conducted on 40 male patients of primary infertility with completely normal partner and 40 apparently healthy volunteers as a control group. Every participant was subjected to laboratory tests (complete blood count, liver and renal functions, hemoglobin A1c, measurement of serum IMA by enzyme-linked immunosorbent assay, and semen …
Evaluation Of Superoxide Dismutase Enzyme In Patients With Melasma: A Clinical And Immunohistochemical Study, Abeer S. Refay, Asmaa G. Abdou, Hesham N. Khaled, Reem A.A Elaziz Hassan
Evaluation Of Superoxide Dismutase Enzyme In Patients With Melasma: A Clinical And Immunohistochemical Study, Abeer S. Refay, Asmaa G. Abdou, Hesham N. Khaled, Reem A.A Elaziz Hassan
Menoufia Medical Journal
Objective To evaluate the role of superoxide dismutase (SOD) enzyme in melasma. Background Melasma is one of the most common acquired disorders of hyperpigmentation. SOD enzyme is upregulated in the presence of oxidative stress and can be utilized to detect it. Even though many potential etiological factors have been proposed, there is still much to learn about the pathophysiology of melasma. Patients and methods A cross-sectional study was conducted on 50 patients presenting with melasma and 50 apparently normal individuals as a control group selected from the Outpatient Clinic, Dermatology, Andrology and Sexually Transmitted Diseases Department, Faculty of Medicine, Menoufia …
The Protective Effect Of Pumpkin Seed Oil On L-Thyroxine-Induced Rat Testicular Oxidative Stress, Fatma M. Shabana, Mostafa M. El-Habeby, Nader Galal Zaki, Neveen M. El-Sherif
The Protective Effect Of Pumpkin Seed Oil On L-Thyroxine-Induced Rat Testicular Oxidative Stress, Fatma M. Shabana, Mostafa M. El-Habeby, Nader Galal Zaki, Neveen M. El-Sherif
Menoufia Medical Journal
Objectives This work aimed to study the effect of exogenously administered L-thyroxine on adult rat testis and to clarify the possible protective effect of pumpkin seed oil. Background L-thyroxine is a manufactured form of the thyroid hormone thyroxine. It is used for the treatment of cases of thyroid hormone deficiency. Recently, infertility among men has become a major concern. Pumpkin is an annual herbaceous plant and has been safely used as a natural remedy in many countries. It has a wide range of pharmacological activities and a proposed antioxidant effect. Materials and methods A total of 42 adult male albino …
Evaluation Of Glutathione Peroxidase Enzyme In Patients With Melasma: A Clinical And Immunohistochemical Study, Asmaa G. Abdou, Hesham N. Khaled, Wesam S. A. El Ashkar
Evaluation Of Glutathione Peroxidase Enzyme In Patients With Melasma: A Clinical And Immunohistochemical Study, Asmaa G. Abdou, Hesham N. Khaled, Wesam S. A. El Ashkar
Menoufia Medical Journal
Objective To evaluate the role of glutathione peroxidase (GPX1) in melasma. Background Melasma is a common acquired disorder of hyperpigmentation. GPX1 is an intracellular enzymatic antioxidant, and its levels are used as a major parameter representing oxidative damage that occurs in melasma. However, the clear association between GPX1 expression and melasma remains unknown. Patients and methods This prospective case–control study was conducted on 20 cases having melasma and 20 normal age-matched and sex-matched healthy volunteers. All sections were immunohistochemically stained for GPX1 antibody. Results There was significant difference between melasma cases and normal skin as regards GPX1 epidermal distribution ( …
Antiamnestic Effect Of Co-Administration Of Losartan And Donepezil In L-Methionine-Induced Vascular Dementia In Rats, Aya G. Keshk, Dalia R. Alsharaky, Maha M. Elbatsh, Safa R. Elfiky
Antiamnestic Effect Of Co-Administration Of Losartan And Donepezil In L-Methionine-Induced Vascular Dementia In Rats, Aya G. Keshk, Dalia R. Alsharaky, Maha M. Elbatsh, Safa R. Elfiky
Menoufia Medical Journal
Objective This study aimed to investigate the antiamnestic effect of losartan and/or donepezil in a l-methionine model of vascular dementia (VaD). Background VaD is a major public health problem worldwide. It is the second most common cause of dementia after Alzheimer disease. Combination therapy involving an acetylcholinesterase inhibitor with other neuroprotective agents has shown better desirable effects in the prevention of dementia. Materials and Methods Rats were divided into five groups treated for 4 weeks as follows: control group, l-methionine group, which received l-methionine 1.7 g/kg/day orally to induce VaD, donepezil group, which received donepezil 2.5 mg/kg/day in addition to …
Quantification Of Serum Melatonin Level And Its Association With Erectile Dysfunction, Mohamed A. Gaber, Mohamed H. A. Ghoniem, Noha R. Bayomy, Reem A. Abdelaziz Hassan
Quantification Of Serum Melatonin Level And Its Association With Erectile Dysfunction, Mohamed A. Gaber, Mohamed H. A. Ghoniem, Noha R. Bayomy, Reem A. Abdelaziz Hassan
Menoufia Medical Journal
Objectives The work aimed to evaluate the role of melatonin in erectile dysfunction (ED) by measuring its level in the serum of these patients and correlating its level with the clinical data. Background One common issue is ED. It is the persistent inability to obtain or maintain a sufficient penile erection for satisfactory sexual performance. One of the hormones secreted from the pineal gland is melatonin. It has antioxidative and antiinflammatory effects. It plays a role in erectile function. In the etiology of ED, oxidative stress is an essential factor, and promising results have been obtained with melatonin treatment in …
Therapeutic Effect Of Sodium 2-Mercaptoethanesulfonate On Dextran Sulfate Sodium-Induced Ulcerative Colitis In Rats, Emad-Eldeen M. Elhenawy, Maha M. Elbatsh, Rehab M. Samaka, Samah M. Wadan
Therapeutic Effect Of Sodium 2-Mercaptoethanesulfonate On Dextran Sulfate Sodium-Induced Ulcerative Colitis In Rats, Emad-Eldeen M. Elhenawy, Maha M. Elbatsh, Rehab M. Samaka, Samah M. Wadan
Menoufia Medical Journal
Objective The aim of the study was to investigate the possible therapeutic effects of sodium 2-mercaptoethanesulfonate (MESNA) on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in rats. Background Incidence of UC is high worldwide and has started to increase more and more specifically in the middle-east in the past few years. The established treatment of UC is still unsatisfactory, so the authors seek to develop new therapeutic modalities for UC. Materials and methods A total of 40 adult rats were divided into five groups (n = 8). Group 1 (control) is vehicle-treated group. Group 2 (DSStreated) received DSS 5% …
Serum Paraoxonase-1 Levels As An Indicator Of Oxidative Stress In Patients With Vitiligo, Eman K. Farag, Naglaa M. Ghanayem, Shawky M. El-Farargy
Serum Paraoxonase-1 Levels As An Indicator Of Oxidative Stress In Patients With Vitiligo, Eman K. Farag, Naglaa M. Ghanayem, Shawky M. El-Farargy
Menoufia Medical Journal
Objective To evaluate the use of serum paraoxonase-1 (PON1) activity as an indicator of oxidative stress in patients with active generalized vitiligo. Background Vitiligo is an acquired cutaneous disorder of pigmentation, characterized by destruction of melanocytes. One of the major hypotheses in the pathogenesis of vitiligo is the oxidative stress hypothesis. In patients with vitiligo, lower levels of PON1 prevent lipoprotein peroxidation and oxidation of low-density lipoprotein and cholesterol. Patients and methods A case–control study was conducted on 40 patients: 20 patients with recent active generalized vitiligo and 20 age-matched and sex-matched healthy volunteers served as controls. All the included …
Copy Number Variation Of The Ncf1 Gene In Patients Of Acne Vulgaris, Lamiaa K. Shehata, Mohammed A. M. Shoeb, Ola A. Bakry, Shaimaa E. Soliman
Copy Number Variation Of The Ncf1 Gene In Patients Of Acne Vulgaris, Lamiaa K. Shehata, Mohammed A. M. Shoeb, Ola A. Bakry, Shaimaa E. Soliman
Menoufia Medical Journal
Objective The objective of this study was to evaluate the influence of neutrophil cytosolic factor 1 gene copy number variation (CNV) on acne vulgaris in a sample of Egyptian population to explore whether this CNV affects disease occurrence or increases its risk. Background Acne vulgaris is a common skin condition that affects the majority of the population during adolescence. Acne is characterized by a variable combination of comedones, pustules, inflammation, and scarring. Oxidative stress has been considered to play a role in acne. Neutrophil cytosolic factor 1 (NCF1) is a component of NADPH oxidase enzyme, which is responsible for the …
Nephroprotective Effect Of Coadministration Of Curcumin And Sildenafil In Adenine-Induced Chronic Renal Failure In Rats, Abd Elrahman A. Yassin, Emad Eldin M. Elhenawy, Maha M. El-Batsh, Rehab M. Samaka, Samar R. Elnaggar
Nephroprotective Effect Of Coadministration Of Curcumin And Sildenafil In Adenine-Induced Chronic Renal Failure In Rats, Abd Elrahman A. Yassin, Emad Eldin M. Elhenawy, Maha M. El-Batsh, Rehab M. Samaka, Samar R. Elnaggar
Menoufia Medical Journal
Background Chronic renal failure (CRF) is a major public health problem worldwide. The pathophysiological basis of the disease and its complication include inflammation and oxidative stress, which are similar in humans and animals. In this study, we seek to develop new therapeutic modalities for CRF. Objective This study aimed to investigate the nephroprotective effects of curcumin (CUR) and/or sildenafil in adenine (AD) model of CRF. Materials and methods Rats were divided into five groups as follows: control naive group, AD group received AD 200 mg/kg/day orally to induce CRF, CUR group received CUR 200 mg/kg/day in addition to AD, sildenafil …
Possible Protective Effects Of Quercetin On Doxorubicin-Induced Cardiotoxicity In Rats, Fatma E. R. Hashish, Maha M. Elbatsh, Mahmoud H. El-Odemi, Moshira M. Abdel-Wahed, Sherin S. El-Naidany
Possible Protective Effects Of Quercetin On Doxorubicin-Induced Cardiotoxicity In Rats, Fatma E. R. Hashish, Maha M. Elbatsh, Mahmoud H. El-Odemi, Moshira M. Abdel-Wahed, Sherin S. El-Naidany
Menoufia Medical Journal
Objective Our study aimed to investigate the possible protective effects of quercetin (QCT) on doxorubicin (DOX)-induced cardiotoxicity in rats. Background DOX is an antineoplastic drug that produces cardiotoxicity; it generates highly cytotoxic-free radicals that damage the cardiomyocytes. QCT is a plant flavonoid. QCT pretreatment reduces DOX-induced oxidative stress. Materials and methods Fifty-five adult rats were divided into four groups: group 1 (control) received saline (5 ml/kg) orally for 4 weeks; group 2 (DOX) received six doses of DOX intraperitoneally (2.5 mg/kg) on alternative days in the last 2 weeks; group 3 (QCT + DOX) received QCT orally (10 mg/kg once …
Total Antioxidant Capacity As An Aging Marker In Egyptian Patients With Alzheimer Disease, Ahmed A. Sonbol, Amr S. Shalaby, Dalia H. Abou-Elela, Mariam A. Fouaad, Rawhia H. El-Edel
Total Antioxidant Capacity As An Aging Marker In Egyptian Patients With Alzheimer Disease, Ahmed A. Sonbol, Amr S. Shalaby, Dalia H. Abou-Elela, Mariam A. Fouaad, Rawhia H. El-Edel
Menoufia Medical Journal
Objective This study aimed to evaluate the total antioxidant capacity (TAC) as an aging marker in patients with Alzheimer disease (AD). Background AD is a neurodegenerative disorder that affects elderly and is the most common type of dementia. Reactive oxygen species is a major risk factor of Alzheimer. Oxidative stress, the most important factor in the pathogenesis of Alzheimer, occurs when reactive oxygen species and reactive nitrogen species increase and/or antioxidant defense system decreases. TAC is a marker of DNA oxidation. These data will explain pathogenesis and prevention and help in the treatment of AD. Patients and methods This study …
8-Hydroxy-2-Deoxyguanosine As A New Biomarker Of Oxidative Stress In Patients With Acne Vulgaris, Eman F. Abd Elfadil Albarqi, Magda M. Hagag, Nesreen G. Elhelbawy
8-Hydroxy-2-Deoxyguanosine As A New Biomarker Of Oxidative Stress In Patients With Acne Vulgaris, Eman F. Abd Elfadil Albarqi, Magda M. Hagag, Nesreen G. Elhelbawy
Menoufia Medical Journal
Objectives To evaluate the serum level of 8-hydroxy-2-deoxyguanosine (8-OHdG) in patients with acne vulgaris and also to detect relation between serum level of 8-OHdG and acne vulgaris severity. Background Acne vulgaris is a chronic inflammatory disease of the pilosebaceous follicles, characterized mainly by comedones. The precise mechanisms of acne are not known. Oxidative stress within the pilosebaceous unit are considered an important initiating step in the pathogenesis of acne. 8-OHdG is considered to be one of the main biomarkers of oxidative stress. Patients and methods This cross-sectional study was carried out on 75 patients with mild, moderate, and severe acne …
Relationship Of Methylenetetrahydrofolate Reductase C677t Genetic Polymorphism And Oxidative Changes In Egyptian Patients With Β-Thalassemia Major, Alshimaa R. S. Elkholy, Emad F. Abdalhalim, Mohammad G. Alhelbawy, Rawhia H. El Edel
Relationship Of Methylenetetrahydrofolate Reductase C677t Genetic Polymorphism And Oxidative Changes In Egyptian Patients With Β-Thalassemia Major, Alshimaa R. S. Elkholy, Emad F. Abdalhalim, Mohammad G. Alhelbawy, Rawhia H. El Edel
Menoufia Medical Journal
Objectives To evaluate the genetic polymorphism of methylenetetrahydrofolate reductase (MTHFR) C677T among patients with beta-thalassemia major and its related oxidative changes. Background Accelerated oxidative damage is one of the hallmarks in beta-thalassemia major. Genetic polymorphism of MTHFR C677T has been shown to cause hyperhomocysteinemia, which acts as a prooxidant. Material and methods Genotyping for MTHFR C677T was evaluated by PCR-restriction fragment length polymorphism technique. Complete blood picture, hemoglobin electrophoresis, serum ferritin, and total antioxidant capacity (TAC) were determined in 60 patients with beta-thalassemia major and 20 controls of matched age and sex. Results MTHFR 677TT genotype was significantly higher among …
Determination Of Oxidative Stress In Vitiligo By Measuring Superoxide Dismutase Levels In Vitiliginous Skin, Eman Seliet, Mai A. Omar, Ola Bakry, Sally Elhefnawy
Determination Of Oxidative Stress In Vitiligo By Measuring Superoxide Dismutase Levels In Vitiliginous Skin, Eman Seliet, Mai A. Omar, Ola Bakry, Sally Elhefnawy
Menoufia Medical Journal
Objective This study was conducted to determine the association between oxidative stress and vitiligo by measuring antioxidant enzyme superoxide dismutase (SOD) in vitiliginous skin. Background Vitiligo is an acquired depigmenting disease characterized by milky white patches of skin due to local destruction and loss of the epidermal melanocytes. Complex genetic, immunological, neural and self-destructive mechanisms interplay in its pathogenesis. According to autocytotoxic hypothesis, oxidative stress has been suggested to be the initial pathogenic event in melanocyte degeneration. Oxidative stress is defined as a disruption of the delicate balance between the formation of reactive oxygen species and the antioxidant defense system, …
The Value Of Serum Zinc In Early Detection Of Nephropathy In Type 2 Diabetic Patients, Ahmed R. Tawfeek, Mahmoud A.E.A. Kora, Mahmoud A. Sakr
The Value Of Serum Zinc In Early Detection Of Nephropathy In Type 2 Diabetic Patients, Ahmed R. Tawfeek, Mahmoud A.E.A. Kora, Mahmoud A. Sakr
Menoufia Medical Journal
Objective The aim of this research was to study the value of serum zinc in early detection of nephropathy in patients with type 2 diabetes. Background Zinc is involved in multiple aspects of cellular metabolism. It is required for the catalytic activity of nearly 100 enzymes and it plays a major role in immunity, protein synthesis, wound healing, DNA synthesis, and cell division. Zinc is also important for normal growth and development during pregnancy, childhood, and adolescence, and is required for proper sense of taste and smell. A daily intake of zinc is required to keep a steady state because …
The Clinical Significance Of Serum Anti-Heat-Shock Protein 27 Antibody Levels In Β-Thalassemia Patients, Amira M. F. Shehata, Mahmoud A. El-Hawy, Seham M. Ragab, Shereen M. El-Shazly
The Clinical Significance Of Serum Anti-Heat-Shock Protein 27 Antibody Levels In Β-Thalassemia Patients, Amira M. F. Shehata, Mahmoud A. El-Hawy, Seham M. Ragab, Shereen M. El-Shazly
Menoufia Medical Journal
Objective The aim of this study was to measure serum anti-heat-shock protein 27 (HSP27) antibody levels in β-thalassemia patients and to assess the potential associations with the clinical and laboratory characteristics in these patients. Background β-Thalassemia syndromes are one of the most common quantitative hemoglobinopathies. HSP27 is a protein that is produced by the cells as a result of exposure to oxidative stress. Anti-HSP27 antibodies are formed as a result of autoimmune response against HSP27 and they are responsible for the pathogenesis of various disorders. Patients and methods In this study, we analyzed serum anti-HSP27 antibody levels in 60 β-thalassemia …
Effect Of Quercetin Treatment On Hyperuricemic Renal Dysfunctions And Hemodynamic Parameters, Gergess S. Youssef, Hayam A. El-Samea Aiad, Heba F. El-Domiaty, Safaa M. Al-Kotb, Sally S. Donia, Sohair A. El-Hamid Saleh
Effect Of Quercetin Treatment On Hyperuricemic Renal Dysfunctions And Hemodynamic Parameters, Gergess S. Youssef, Hayam A. El-Samea Aiad, Heba F. El-Domiaty, Safaa M. Al-Kotb, Sally S. Donia, Sohair A. El-Hamid Saleh
Menoufia Medical Journal
Objective The aim of this study was to assess the potential effect of quercetin treatment on hyperuricemic renal dysfunctions and hemodynamic changes in in vivo and in vitro published studies. Materials and methods Data were obtained from Medline databases (PubMed, Medscape, ScienceDirect.) and all materials available in the internet from 2001 to 2016. The initial search presented 170 articles, of which 47 met the inclusion criteria. The articles studied the effect of quercetin treatment on hyperuricemic renal dysfunctions and hemodynamic changes. If the studies did not fulfill the inclusion criteria, they were excluded. Study quality assessment included whether ethical approval …
Biochemical And Histopathological Changes In The Brain Of Albino Rats Treated With Profenofos And The Possible Protective Effect Of Vitamins C And E, Amira M. El-Seidy, Safaa A. Amine, Samy M. Badawy, Samy A. Hammad, Shireen R. Abdou Slima
Biochemical And Histopathological Changes In The Brain Of Albino Rats Treated With Profenofos And The Possible Protective Effect Of Vitamins C And E, Amira M. El-Seidy, Safaa A. Amine, Samy M. Badawy, Samy A. Hammad, Shireen R. Abdou Slima
Menoufia Medical Journal
Objective The aim of this study was to evaluate the changes in the brain of albino rats treated with profenofos and the possible protective effect of vitamins C and E against the acute effect of profenofos. Background During the last decades the use of pesticides has increased steadily in developing countries in an effort to increase food production and control vector-borne diseases in plants. Organophosphorus (OP) compounds are widely used in agriculture as insecticides. OP poisoning is common due to its wide availability. Profenofos is a widely used insecticide and has been classified as moderately hazardous. OP pesticides are known …
Early Detection Of Attention Deficit Hyperactivity Disorder And/Or Epilepsy By Oxidative Stress Biomarkers, Fawzy A. Ashour, Maathir K. Elshafie, Omnia Ameen, Sameh A. Abdelnabi, Yahya M. Naguib
Early Detection Of Attention Deficit Hyperactivity Disorder And/Or Epilepsy By Oxidative Stress Biomarkers, Fawzy A. Ashour, Maathir K. Elshafie, Omnia Ameen, Sameh A. Abdelnabi, Yahya M. Naguib
Menoufia Medical Journal
Objectives The objective of this study was early detection of attention deficit hyperactivity disorder (ADHD) and/or epilepsy by oxidative stress biomarkers. Background ADHD is a developmental disorder with an etiopathology not fully understood. According to the prevailing view, oxidative metabolism may be involved. Patients and methods The study sample consisted of 100 children. Children were equally divided into four groups (25 children/group): group I (control group); group II (ADHD group); group III (epilepsy group); and group IV (ADHD with epilepsy group). Each participant was subjected to a multidisciplinary clinical interview using a comprehensively devised semistructured sheet covering sociodemographics, psychiatric and …
The Potential Association Of Heat Shock Protein 70-2 + 1267 A/G Gene Polymorphism With Nephropathy In Type Ii Diabetic Patients, Maathir Kamel El-Shafie, Mona Salah El-Din Mahmoud Habib, Naglaa Mohammed Ghanayem, Rania Mohammed Azmy Mohammed El-Shazly, Said Sayed Ahmed Khamis, Yasser Abd El-Sattar El-Ghobashi
The Potential Association Of Heat Shock Protein 70-2 + 1267 A/G Gene Polymorphism With Nephropathy In Type Ii Diabetic Patients, Maathir Kamel El-Shafie, Mona Salah El-Din Mahmoud Habib, Naglaa Mohammed Ghanayem, Rania Mohammed Azmy Mohammed El-Shazly, Said Sayed Ahmed Khamis, Yasser Abd El-Sattar El-Ghobashi
Menoufia Medical Journal
Objective The aim of the study was to assess the association between heat shock protein (HSP) 70-2 + 1267 A/G polymorphism and diabetic nephropathy (DN) in type II diabetes mellitus. Background DN is a life-threatening microvascular complication of type II diabetes. Oxidative stress plays a main role in its pathogenesis. As a consequence, a cellular adaptive response occurs requiring functional chaperones, so that the induction of HSPs is a maintained response in counteracting this oxidative stress. HSP70-2 + 1267 A/G and HSP70-hom + 2437 T/C polymorphisms may play an important role in susceptibility to and/or progression of DN. Patients and …
Study Of Oxidative Stress In Common Neonatal Disorders And Evaluation Of Antioxidant Strategies, Mohamed H. Bahbah, Mohamed A. El-Shafie, Mohsen M. Deeb, Seham M. Ragab
Study Of Oxidative Stress In Common Neonatal Disorders And Evaluation Of Antioxidant Strategies, Mohamed H. Bahbah, Mohamed A. El-Shafie, Mohsen M. Deeb, Seham M. Ragab
Menoufia Medical Journal
Objectives The aim of this work is to study oxidative stress and the profile of antioxidant mechanisms in common neonatal disorders. These disorders are prematurity, neonatal hyperbilirubinemia, and perinatal asphyxia. This study also aimed to evaluate the effect of treatment of these disorders on oxidative stress. Background In a broad sense, oxidative stress may be considered an imbalance between prooxidant and antioxidant forces or between the amount of reactive oxygen species and antioxidant defenses. The term oxygen radical disease of neonatology has been suggested to designate diseases whose pathogenesis includes tissue aggression from free radicals and reactive oxygen species. However, …
Oxidants And Antioxidants Role In Acne Vulgaris, Amira Adel Mahmoud, Ashraf Abd El Raoof Dawood, Mohamed Abd El Wahed Gaber
Oxidants And Antioxidants Role In Acne Vulgaris, Amira Adel Mahmoud, Ashraf Abd El Raoof Dawood, Mohamed Abd El Wahed Gaber
Menoufia Medical Journal
Objectives The aim of the study was to determine the effects of oxidative stress in acne vulgaris by measuring the levels of an oxidant [malondialdehyde (MDA)] and an antioxidant [superoxide dismutase (SOD) enzyme] in acne patients. Background Acne vulgaris is one of the common dermatological diseases, and its pathogenesis is multifactorial. Materials and methods Twenty-seven consecutive acne patients and 10 controls were enrolled. The parameters of oxidative stress, such as serum SOD and MDA, were measured spectrophotometrically. Results There was significantly higher enzymatic level of SOD (P < 0.001) and MDA (P < 0.001) in blood of patient with acne compared with that of healthy control. There was significant positive correlation between serum SOD and serum MDA level. Conclusion Oxidative stress exists in acne patients.