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Articles 1 - 30 of 362
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Characterization And Haplotype Study Of 6 Novel Str Markers Related To The Kcnq1 Gene In Heterogeneous Cardiovascular Disorders In The Iranian Population, Azam Amirian, Zahra Zafari, Zohre Sharifi, Alireza Kordafshari, Morteza Karimipoor, Sirous Zeinali
Characterization And Haplotype Study Of 6 Novel Str Markers Related To The Kcnq1 Gene In Heterogeneous Cardiovascular Disorders In The Iranian Population, Azam Amirian, Zahra Zafari, Zohre Sharifi, Alireza Kordafshari, Morteza Karimipoor, Sirous Zeinali
Turkish Journal of Medical Sciences
No abstract provided.
Urinary Phytate Concentration And Risk Of Fracture Determined By The Frax Index In A Group Of Postmenopausal Women, Angel Arturo Lopez Gonzalez, Felix Grases, Bartolome Mari, Matias Tomas-Salva, Adrian Rodriguez
Urinary Phytate Concentration And Risk Of Fracture Determined By The Frax Index In A Group Of Postmenopausal Women, Angel Arturo Lopez Gonzalez, Felix Grases, Bartolome Mari, Matias Tomas-Salva, Adrian Rodriguez
Turkish Journal of Medical Sciences
Background/aim: This study was designed to evaluate the relationship between urinary phytate concentration and risk of fracture at 10 years, determined by using the FRAX model, in women who had undergone menopause within 5 years of the time of enrollment. Materials and methods: Of the 212 postmenopausal women evaluated, 69 were excluded because they had urinary phytate concentrations between 0.51 and 0.99 mg/L. Of the remaining 143 women, 91 had low (≤0.50 mg/L) and 52 had high (≥1.0 mg/L) urinary phytate concentrations. The 10-year risk of fracture was calculated by using the FRAX model.Results: The risks of major osteoporotic fracture …
The Distribution Of Mefv Mutations In Turkish Fmf Patients: Multicenter Study Representing Results Of Anatolia, Nazi̇fe Şule Yaşar Bi̇lge, İsmai̇l Sari, Di̇lek Solmaz, Abdurrahman Soner Şenel, Hakan Emmungi̇l, Levent Kiliç, Si̇bel Yilmaz Öner, Fati̇h Yildiz, Sedat Yilmaz, Emi̇ne Duygu Ersözlü, Müge Aydin Tufan, Sema Yilmaz, Veli̇ Yazisiz, Yavuz Pehli̇van, Cemal Bes
The Distribution Of Mefv Mutations In Turkish Fmf Patients: Multicenter Study Representing Results Of Anatolia, Nazi̇fe Şule Yaşar Bi̇lge, İsmai̇l Sari, Di̇lek Solmaz, Abdurrahman Soner Şenel, Hakan Emmungi̇l, Levent Kiliç, Si̇bel Yilmaz Öner, Fati̇h Yildiz, Sedat Yilmaz, Emi̇ne Duygu Ersözlü, Müge Aydin Tufan, Sema Yilmaz, Veli̇ Yazisiz, Yavuz Pehli̇van, Cemal Bes
Turkish Journal of Medical Sciences
Background/aim: The distribution of Mediterranean fever (MEFV) gene mutations in Turkish familial Mediterranean fever (FMF) patients varies according to geographic area of Turkey. There is a need for highly representative data for Turkish FMF patients. The aim of our study was to investigate the distribution of the common MEFV mutations in Turkish FMF patients in a nationwide, multicenter stu dy.Materials and methods: Data of the 2246 FMF patients, from 15 adult rheumatology clinics located in different parts of the country, were evaluated retrospectively. The following mutations have been tested in all patients: M694V, M680I, M694I, V726A, and E148Q.Results: There were …
Glutamate Transporter Slc1a1 Is Associated With Clear Cell Renal Cell Carcinoma, Sercan Ergün, Sezgi̇n Güneş, Recep Büyükalpelli̇, Oğuz Aydin
Glutamate Transporter Slc1a1 Is Associated With Clear Cell Renal Cell Carcinoma, Sercan Ergün, Sezgi̇n Güneş, Recep Büyükalpelli̇, Oğuz Aydin
Turkish Journal of Medical Sciences
Background/aim: This study aimed to comparatively analyze the expression levels of the SLC1A1 gene in renal specimens from tumors and adjacent healthy kidney tissues of patients with clear cell renal cell carcinoma (ccRCC).Material and methods: Nineteen patients diagnosed with ccRCC were included in the study. The expression levels of the SLC1A1 and GAPDH genes were measured in tumor and formalin-fixed paraffin-embedded (FFPE) tissue specimens from the adjacent healthy kidney of each subject. Via the GEPIA database, the distribution of SLC1A1 gene expressions in ccRCC and healthy kidney tissues was obtained. The relative expression of SLC1A1 was evaluated for the association …
The Efficacy And Safety Of Targeted Narrowband Uvb Therapy: A Retrospective Cohort Study, Kübra Esen Salman, İlknur Altunay, Andaç Salman
The Efficacy And Safety Of Targeted Narrowband Uvb Therapy: A Retrospective Cohort Study, Kübra Esen Salman, İlknur Altunay, Andaç Salman
Turkish Journal of Medical Sciences
Background/aim: Phototherapy is a safe and effective treatment modality for numerous dermatological conditions. Recently, targeted phototherapy modalities have gained importance due to their advantages over conventional phototherapy.This retrospective study aimed to evaluate the safety and efficacy of targeted narrowband UVB phototherapy in patients with dermatological disorders.Materials and methods: This single-center study included 173 patients who were treated with targeted narrowband UVB phototherapy. Demographic features, phototherapy parameters, and adverse effects were evaluated in all patients, and the treatment response was assessed in patients who attended at least one follow-up visit. Results: A total of 173 patients (102 females; 71 males) with …
Assessment Of Cardiac And Vessel Functions In Childhood Psoriasis, Berna Şaylan Çevi̇k, Fi̇gen Akalin, Eli̇f Erolu, Di̇lek Seçki̇n Gençosmanoğlu, Safi̇ye Atlas Tüli̇n Ergun
Assessment Of Cardiac And Vessel Functions In Childhood Psoriasis, Berna Şaylan Çevi̇k, Fi̇gen Akalin, Eli̇f Erolu, Di̇lek Seçki̇n Gençosmanoğlu, Safi̇ye Atlas Tüli̇n Ergun
Turkish Journal of Medical Sciences
Background/aim: Psoriasis is a chronic inflammatory disease. The effect of psoriasis on the cardiovascular system has not been studied in children before. We studied ventricular strain and vascular functions to assess early cardiovascular effects of psoriasis during childhood. Materials and methods: The study population consisted of 20 psoriatic and 20 age- and sex-matched control subjects. Two-dimensional echocardiography images, longitudinal and global strain, and carotid and brachial ultrasound studies were performed. Results: The mean age of psoriatic children was 14 ± 0.89 years and that of the controls was 14.05 ± 0.88. There were significant increases in terms of interventricular septum …
Optimum Recording Time Of Routine Electroencephalogram For Adults With Epilepsy*, Kemal Tutkavul, Yilmaz Çeti̇nkaya
Optimum Recording Time Of Routine Electroencephalogram For Adults With Epilepsy*, Kemal Tutkavul, Yilmaz Çeti̇nkaya
Turkish Journal of Medical Sciences
Background/aim: This study aimed to reveal the optimum recording time of routine electroencephalogram (EEG) for adults with epilepsy.Materials and methods: In this clinical observational study we investigated features of paroxysms that emerged in EEGs recorded for 45 min in adults with epilepsy.Results: Paroxysms were detected in 38.14% of 97 patients. The probability of occurrence of paroxysm during the first 10 min was found to be statistically significantly low in comparison to the first 30 and 45 min (respectively P = 0.004, P = 0.0001). This probability was found to increase insignificantly when comparing the first 20 min with the first …
Efficacy Of Chemical Shift Mri For Differentiating Diffuse Red Bone Marrow Reconversion And Hematological Malignancies, Burcu Akman, Hati̇ce Ayça Ata Korkmaz, Ahmet Sari
Efficacy Of Chemical Shift Mri For Differentiating Diffuse Red Bone Marrow Reconversion And Hematological Malignancies, Burcu Akman, Hati̇ce Ayça Ata Korkmaz, Ahmet Sari
Turkish Journal of Medical Sciences
Background/aim: The main purpose of our study was to determine the efficacy of chemical shift imaging (CSI) for differentiating diffuse red bone marrow reconversion (RBMR) and hematological malignancies. We also aimed to calculate the cut-off value for these entities with similar imaging features in routine magnetic resonance (MR) sequences.Materials and methods: A total of 54 patients were included: 17 patients (31.4%) with hematological malignancies (group 1), 16 patients (29.6%) with RBMR (group 2), and 21 patients (38.0%) with no clinical and hematological malignancies (control group). Patients with no pathological data or completed two-year follow-up and children were excluded from the …
The Impact Of Jak/Stat Inhibitor Ruxolitinib On The Genesis Of Lymphoproliferative Diseases, Can Türk, Müfi̇de Okay, Seyhan Türk, Eli̇f Sena Temi̇rci̇, Osama Jawad, Sali̇h Aksu, Ni̇lgün Sayinalp, İbrahi̇m Celaletti̇n Haznedaroğlu
The Impact Of Jak/Stat Inhibitor Ruxolitinib On The Genesis Of Lymphoproliferative Diseases, Can Türk, Müfi̇de Okay, Seyhan Türk, Eli̇f Sena Temi̇rci̇, Osama Jawad, Sali̇h Aksu, Ni̇lgün Sayinalp, İbrahi̇m Celaletti̇n Haznedaroğlu
Turkish Journal of Medical Sciences
Background/aim: Ruxolitinib, a JAK/STAT signaling pathway inhibitor targeted drug, has been approved for the controlling of disease symptoms and splenomegaly in patients with myeloproliferative neoplastic diseases. Recently, it has been proposed that ruxolitinib-induced JAK/STAT pathway inhibition in myelofibrosis is associated with an elevated frequency of aggressive B-cell lymphomas. However, the biological basis and significance of this pharmacobiological adverse event is unknown. The aim of this bioinformatics study is to detect any possible confounding effects of ruxolitinib on the genesis of lymphoproliferative disorders. Materials and methods: The gene expression data were retrieved from the E-MTAB-783 Cancer Genome Project database. Gene expression …
Antibiotic Resistance Pattern And Spa Types Of Staphylococcus Aureus Strains Isolated From Food Business And Hospital Kitchen Employees In Çanakkale, Turkey, Nesri̇n Çakici, Alper Akçali, Nükhet Ni̇lüfer Zorba
Antibiotic Resistance Pattern And Spa Types Of Staphylococcus Aureus Strains Isolated From Food Business And Hospital Kitchen Employees In Çanakkale, Turkey, Nesri̇n Çakici, Alper Akçali, Nükhet Ni̇lüfer Zorba
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to determine antibiotic resistance profiles and spa types of Staphylococcus aureus strains isolated from food business employees in Çanakkale, Turkey.Materials and methods:S.aureus isolates were collected from hand and nasal swabs of 300 individuals working in 17 food businesses and 9 hospital kitchens. All S. aureus isolates obtained from each carrier were typed by staphylococcal protein A (spa) typing method.Staphylococcal cassette chromosome mec (SCCmec) and multilocus sequence typing (MLST) of MRSA were performed by sequencing method.Results: Of the 300 individuals, 125 (41.6%) were found to be carriers of S. aureus, 215 isolates of which …
A Pilot Study On The Beneficial Effects Of Additional Selenium Supplementation To Methimazole For Treating Patients With Graves' Disease, Bin Xu, Di Wu, Hong Ying, Ying Zhang
A Pilot Study On The Beneficial Effects Of Additional Selenium Supplementation To Methimazole For Treating Patients With Graves' Disease, Bin Xu, Di Wu, Hong Ying, Ying Zhang
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to assess the effect of a combination use of methimazole (MMI) and selenium (Se) in the treatment of Graves' disease (GD). Materials and methods: A total of 103 newly diagnosed hyperthyroidism patients were randomized to MMI and MMI + Se combination groups. After treatment for 6 months, the levels of triiodothyronine (FT3), free thyroxine (FT4), thyrotropin receptor antibody (TRAb), thyroid peroxidase antibody (TPOAb), and thyroglobulin antibody (TGAb) were observed. An in vitro culture model of thyroid cells was established and the protein expression and mRNA levels of TRAb, TPOAb, and TGAb were determined …
Validity And Reliability Of The Turkish Version Of The Modified Yale Preoperative Anxiety Scale, Zehra Hati̇poğlu, Oğuzhan Kirdök, Di̇lek Özcengi̇z
Validity And Reliability Of The Turkish Version Of The Modified Yale Preoperative Anxiety Scale, Zehra Hati̇poğlu, Oğuzhan Kirdök, Di̇lek Özcengi̇z
Turkish Journal of Medical Sciences
Background/aim: The modifiedYa l ePreoperative Anxiety Scale (m-YPAS) is widely used to measure children's anxiety levels. The aim of this study was to translate the m-YPAS into Turkish and test its validity and reliability in Turkish children.Materials and methods: The English version of the m-YPAS was translated into Turkish using the forward-back-forward translation technique. This study enrolled 120 children. The m-YPAS was administered to 120 children who were recorded on video. The State-Trait Anxiety Inventory for Children (STAIC) was used for only 30 of 120 children. The videotapes were evaluated by two experienced observers [an anesthesiologist, ObA(an), and a psychologist, …
The Effectiveness Of Renal Nephrometry Score In Ablated Renal Tumors Via Radiofrequency Ablation Or Cryoablation, Seda Aladağ Kurt, Cem Yücel, Suna Özhan Oktar, Gonca Erbaş, Tevfi̇k Si̇nan Sözen, Ali̇ Yusuf Öner
The Effectiveness Of Renal Nephrometry Score In Ablated Renal Tumors Via Radiofrequency Ablation Or Cryoablation, Seda Aladağ Kurt, Cem Yücel, Suna Özhan Oktar, Gonca Erbaş, Tevfi̇k Si̇nan Sözen, Ali̇ Yusuf Öner
Turkish Journal of Medical Sciences
Background/aim: This study aimed to evaluate the clinical efficacy of radiofrequency ablation (RFA) and cryotherapy and to scrutinize the therapeutic success of the RENAL (radius, exophytic/endophytic, nearness to collecting system, anterior/posterior, and location) nephrometry score in terms of possible complications and the predictive status of oncological results.Materials and methods: Forty-five patients with biopsy-proven renal cell carcinomas (32 males, 13 females) treated with RFA and cryotherapy were included. Patients were 22-90 years old (average: 59.2 years). Statistical analyses were performed using SPSS for Windows. Results: A total of 79 lesions with dimensions varying between 0.9 and 4.5 cm (average: 2.2 cm) …
Clinical Significance Of Progastrin-Releasing Peptide, Neuron-Specific Enolase, Chromogranin A, And Squamous Cell Cancer Antigen In Pulmonary Neuroendocrine Tumors, Nuri̇ Tutar, Nur Aleyna Yetki̇n, Cevat Yazici, Ömer Önal, Olgun Kontaş, Fahretti̇n Keleştemur
Clinical Significance Of Progastrin-Releasing Peptide, Neuron-Specific Enolase, Chromogranin A, And Squamous Cell Cancer Antigen In Pulmonary Neuroendocrine Tumors, Nuri̇ Tutar, Nur Aleyna Yetki̇n, Cevat Yazici, Ömer Önal, Olgun Kontaş, Fahretti̇n Keleştemur
Turkish Journal of Medical Sciences
Background/aim: It is not always easy to diagnose pulmonary neuroendocrine tumors (PNETs). The aim of the present study is to make a differential diagnosis by studying the same markers in patients with non-small-cell lung carcinoma (NSCLC), patients with benign lung disease (chronic obstructive pulmonary disease and pneumonia), and healthy volunteers to determine the roles of these markers in pulmonary neuroendocrine tumor diagnosis and to identify their power. Materials and methods: A total of 100 participants including 23 PNET patients and 28 NSCLC patients who were pathologically di-agnosed but not yet treated, 25 participants with benign disease, and 24 healthy volunteers …
Use Of Traditional And Complementary Medicine For Musculoskeletal Diseases, Güli̇s Kavadar, Sali̇ha Eroğlu Demi̇r, Ebru Ayteki̇n, Yildiz Akbal
Use Of Traditional And Complementary Medicine For Musculoskeletal Diseases, Güli̇s Kavadar, Sali̇ha Eroğlu Demi̇r, Ebru Ayteki̇n, Yildiz Akbal
Turkish Journal of Medical Sciences
Background/aim: We aimedto determine the prevalence of traditional and complementary medicine (TCM) use among patients with musculoskeletal disorders (MSDs) and to examine the methods used, frequency, and experienced benefits of therapies; the reasons for using TCM; and the sources of information about therapies. We also compared demographic characteristics of users and nonusers of TCM.Materials and methods: The descriptive study was conducted with 839 patients who attended the physical therapy and rehabilitation units of 3 public hospitals between September 2014 and March 2015. A self-administered questionnaire including demographic characteristics, medical history, and details of TCM use was applied. Results: Of the …
Viral Prevalence, Clinical Profiles And Comparison Of Severity Scores For Predicting The Mortality Of Adults With Severe Acute Respiratory Infections, Hakan Aydin, Hali̇l Doğan, Doğaç Ni̇yazi̇ Özüçeli̇k, Mehmet Koçak, Osman Avşar Gül
Viral Prevalence, Clinical Profiles And Comparison Of Severity Scores For Predicting The Mortality Of Adults With Severe Acute Respiratory Infections, Hakan Aydin, Hali̇l Doğan, Doğaç Ni̇yazi̇ Özüçeli̇k, Mehmet Koçak, Osman Avşar Gül
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to determine the accuracy of severity scores for predicting the 28-day mortality among adults with severe acute respiratory infection (SARI) admitted to the emergency department.Materials andmethods: This study included 159 consecutive adult patients with SARI admitted to the emergency department of a tertiary hospital. A standard form was filled out in order to record demographic information, clinical parameters, laboratory tests, and radiographic findings of the patients. CURB-65, PSI, SIRS, qSOFA, SOFA and APACHE II scores were compared between the survivor and nonsurvivor groups. Results: Of 159 patients included in the study, 38.4% were …
Evaluation Of Cancer Risk In Patients With Periodontal Diseases, Deni̇z Can Güven, Ömer Di̇zdar, Abdullah Cevdet Akman, Ayşe Ezel Berker, Emre Yekedüz, Furkan Ceylan, Batuhan Başpinar, Ilgin Akbiyik, Burak Yasi̇n Aktaş, Deni̇z Yüce, Mustafa Erman, Kadi̇r Mutlu Hayran
Evaluation Of Cancer Risk In Patients With Periodontal Diseases, Deni̇z Can Güven, Ömer Di̇zdar, Abdullah Cevdet Akman, Ayşe Ezel Berker, Emre Yekedüz, Furkan Ceylan, Batuhan Başpinar, Ilgin Akbiyik, Burak Yasi̇n Aktaş, Deni̇z Yüce, Mustafa Erman, Kadi̇r Mutlu Hayran
Turkish Journal of Medical Sciences
Background/aim: In this study, we aimed to assess the cancer risk among patients with periodontal disease.Materials and methods: Patients diagnosed with periodontal diseases at Hacettepe University between 2007 and 2012 were included and data on the diagnosis of any cancer after periodontal disease were collected from patient files. The age- and sex-standardized incidence rates (SIRs) were calculated using Turkish National Cancer Registry 2013 data.Results: A total of 5199 patients were included. Median follow-up was 7.2 years. Patients with periodontal diseases had 17% increased risk of cancer compared with the expected counts for the corresponding age and sex groups (SIR: 1.17; …
Therapeutic Plasma Exchange In Hypertriglyceridemic Patients, Ilgin Yildirim Şi̇mşi̇r, Utku Erdem Soyaltin, Banu Pinar Şarer Yürekli̇, Mehmet Erdoğan, Şevki̇ Çeti̇nkalp, Lütfi̇ye Füsun Saygili, Ayhan Dönmez, Ahmet Gökhan Özgen
Therapeutic Plasma Exchange In Hypertriglyceridemic Patients, Ilgin Yildirim Şi̇mşi̇r, Utku Erdem Soyaltin, Banu Pinar Şarer Yürekli̇, Mehmet Erdoğan, Şevki̇ Çeti̇nkalp, Lütfi̇ye Füsun Saygili, Ayhan Dönmez, Ahmet Gökhan Özgen
Turkish Journal of Medical Sciences
Background/aim: High triglyceride (TG) levels are associated with increases in atherosclerotic cardiovascular disease (CVD), hepatic steatosis, and pancreatitis. Acute pancreatitis is a condition with high mortality. Therapeutic plasma exchange (TPE) in the treatment of hypertriglyceridemic pancreatitis (HTGP) is a rapid and effective treatment modality. In this study, the results of TPE were evaluated and the frequency of lipoprotein lipase (LPL) mutation in these patients was determined.Materials and methods: TPE was performed in 31 patients with HTGP at the Adult Therapeutic Apheresis Center.Results: A TG level under 500 mg/dL was achieved by applying apheresis at a median of 2 times (IQR …
Evaluation Of Malignancy With Thyroid Imaging Reporting And Data System (Ti-Rads) In Thyroid Nodules With Persistent Nondiagnostic Cytology, Hüsni̇ye Başer, Oya Topaloğlu, Sevgül Faki, Afra Alkan, Mustafa Ömer Yazicioğlu, Hayri̇ye Tatli Doğan, İbrahi̇m Kilinç, Reyhan Ersoy, Beki̇r Çakir
Evaluation Of Malignancy With Thyroid Imaging Reporting And Data System (Ti-Rads) In Thyroid Nodules With Persistent Nondiagnostic Cytology, Hüsni̇ye Başer, Oya Topaloğlu, Sevgül Faki, Afra Alkan, Mustafa Ömer Yazicioğlu, Hayri̇ye Tatli Doğan, İbrahi̇m Kilinç, Reyhan Ersoy, Beki̇r Çakir
Turkish Journal of Medical Sciences
Background/aim: We aimed to evaluate the utility of thyroid imaging reporting and data system (TI-RADS) in prediction of malignancy in thyroid nodules with persistent nondiagnostic (ND) cytology. Materials and methods: A total of 246 thyroid nodules which were surgically removed and had at least two fine-needle aspirations (FNAs) with ND cytology were included in this study. Ultrasonography features and TI-RADS scores were recorded. Results: Of 246 nodules, 218 (88.6%) had benign and 28 (11.4%) had malignant final histopathology. Frequencies of taller than wide shape, solidity, hypoechogenicity, microcalcifications, and presence of irregular borders were similar between benign and malignant nodules (P …
Three Dimensional Printing And Biomaterials In The Repairment Of Bone Defects; Hydroxyapatite Pla Filaments, İsmai̇l Kaya, Meryem Cansu Şahi̇n, İlker Deni̇z Ci̇ngöz, Nevi̇n Aydin, Murat Atar, Ceren Kizmazoğlu, Sali̇h Kavuncu, Hasan Emre Aydin
Three Dimensional Printing And Biomaterials In The Repairment Of Bone Defects; Hydroxyapatite Pla Filaments, İsmai̇l Kaya, Meryem Cansu Şahi̇n, İlker Deni̇z Ci̇ngöz, Nevi̇n Aydin, Murat Atar, Ceren Kizmazoğlu, Sali̇h Kavuncu, Hasan Emre Aydin
Turkish Journal of Medical Sciences
Background/aim: Application fields of bone tissue engineering studies continue to expand. New biocompatible materials aimed to improve bone repairment and regeneration of implants are being discovered everyday by scientists, engineers, and surgeons. Our objective in this study is to combine polylactic acid which is a polymer with hydroxyapatite in the repairment of bone defects considering the increased need by medical application fields. Materials and methods: After 750 g of PLA with a diameter of 2.85 mm was granulated into minimum particles, these particles were homogenously mixed with hydroxyapatite prepared in laboratory environment. Using this mixture, HA-PLA filament with a diameter …
Mitoxantrone-Melphalan Conditioning Regimen For Autologous Stem Cell Transplantation In Relapsed/Refractory Lymphoma, Müfi̇de Okay, Yahya Büyükaşik, Haluk Demi̇roğlu, Ümi̇t Yavuz Malkan, Rafi̇ye Çi̇ftçi̇ler, Eli̇fcan Aladağ Karakulak, Sali̇h Aksu, İbrahi̇m Celaletti̇n Haznedaroğlu, Ni̇lgün Sayinalp, Osman İlhami̇ Özcebe, Hakan Göker
Mitoxantrone-Melphalan Conditioning Regimen For Autologous Stem Cell Transplantation In Relapsed/Refractory Lymphoma, Müfi̇de Okay, Yahya Büyükaşik, Haluk Demi̇roğlu, Ümi̇t Yavuz Malkan, Rafi̇ye Çi̇ftçi̇ler, Eli̇fcan Aladağ Karakulak, Sali̇h Aksu, İbrahi̇m Celaletti̇n Haznedaroğlu, Ni̇lgün Sayinalp, Osman İlhami̇ Özcebe, Hakan Göker
Turkish Journal of Medical Sciences
Background/aim: High-dose chemotherapy followed by autologous stem cell transplantation (ASCT) has become the standard approach for patients with relapsed/refractory Hodgkin's lymphoma (HL) or non-Hodgkin's lymphoma (NHL). In this study, we report the outcome of the mitoxantrone-melphalan conditioning regimen for lymphoma. Materials and methods: The study group included 53 patients who were relapsed/refractory HL (n = 14) and NHL (n = 39) and received mitoxantrone and melphalan followed by ASCT. The transplant regimen consisted of mitoxantrone (60 mg/m2) and melphalan (180 mg/m2) followed by peripheral blood stem cell infusion (PBSC). Results: Prior to high-dose chemotherapy, 37.7% of the patients were in …
Effect Of 4 Weeks Of Frankincense Consumption On Explicit Motor Memory And Serum Bdnf In Elderly Men, Elham Asadi, Mohammad Reza Shahabi Kaseb, Rasool Zeidabadi, Mohammad Reza Hamedinia
Effect Of 4 Weeks Of Frankincense Consumption On Explicit Motor Memory And Serum Bdnf In Elderly Men, Elham Asadi, Mohammad Reza Shahabi Kaseb, Rasool Zeidabadi, Mohammad Reza Hamedinia
Turkish Journal of Medical Sciences
Background/aim: Memory is a mechanism for coding, storing, and recalling information. Weak memory and learning disability are common psychological problems in the elderly. The aim of this study was to investigate the effect of 4 weeks of frankincense consumption on explicit motor memory and serum BDNF in the elderly.Materials and methods: Twenty elderly men (mean age of 60.2 ± 1.7 years) were randomly divided into two groups: experimental (n = 12) and placebo (n = 8). The first blood samples were collected 24 h before the pretest. Then both groups participated in a 4-week exercise program based on the protocol …
Evaluation Of The Correlation Between Quantitative Measurement Of The Foveal Avascular Zone And Retinal Vessel Density And Outer Retinal Disruptions In Diabetic Patients, Nagi̇han Uğurlu, Ayşe Güzi̇n Taşlipinar Uzel, Ahmet Şengün, Fatma Yülek, Demet Özdaş, Abbas Ali̇ Tam, Reyhan Ersoy, Beki̇r Çakir
Evaluation Of The Correlation Between Quantitative Measurement Of The Foveal Avascular Zone And Retinal Vessel Density And Outer Retinal Disruptions In Diabetic Patients, Nagi̇han Uğurlu, Ayşe Güzi̇n Taşlipinar Uzel, Ahmet Şengün, Fatma Yülek, Demet Özdaş, Abbas Ali̇ Tam, Reyhan Ersoy, Beki̇r Çakir
Turkish Journal of Medical Sciences
Background/aim: The aim of the current study was to evaluate the correlation between the integrity of the outer retinal layers on optical coherence tomography (OCT) and objective parameters of retinal microvascular perfusion on optical coherence tomography angiography (OCTA).Materials and methods: A total of 105 eyes of 54 diabetic patients were included in the study. Integrity of the outer retinal layers including the external limiting membrane (ELM), ellipsoid zone (EZ), and interdigitation zone (IZ) was assessed by spectral-domain optical coherence tomography. The foveal avascular zone (FAZ) area and vessel density (VD) measurements in the superficial capillary plexus (SCP) and deep capillary …
The Association Between Levels Of Inflammatory Markers In Autistic Children Compared To Their Unaffected Siblings And Unrelated Healthy Controls, Loai Alzghoul, Sultan Abdelhamid, Ahmad Yanis, Yasmeen Qwaider, Mohammad Aldahabi, Suzan Albdour
The Association Between Levels Of Inflammatory Markers In Autistic Children Compared To Their Unaffected Siblings And Unrelated Healthy Controls, Loai Alzghoul, Sultan Abdelhamid, Ahmad Yanis, Yasmeen Qwaider, Mohammad Aldahabi, Suzan Albdour
Turkish Journal of Medical Sciences
Background/aim: Autism spectrum disorder (ASD) describes a range of neurodevelopmental disabilities that impair behavior and communication. Although it is relatively prevalent, the pathophysiology is still subject to speculation and debate. The aim of this study is to identify a possible association between interleukin-6, -8, -9, and -10 and tumor necrosis factor alpha (TNF- ∝) in autism among Jordanian children by comparing the plasma levels of these cytokines in autistic children with those of their unaffected siblings and unrelated healthy controls. Materials andmethods: In this study, 80 Jordanian children under the age of 12 with diagnosed autism were selected. For comparison, …
Relationship Between Sirt1 Gene Expression Level And Disease In Age-Related Cataract Cases, Ni̇hat Buğra Ağaoğlu, Nuray Varol, Sali̇ha Handan Yildiz, Cem Karaosmanoğlu, Rahmi̇ Duman, Müjgan Özdemi̇r Erdoğan, Mustafa Solak
Relationship Between Sirt1 Gene Expression Level And Disease In Age-Related Cataract Cases, Ni̇hat Buğra Ağaoğlu, Nuray Varol, Sali̇ha Handan Yildiz, Cem Karaosmanoğlu, Rahmi̇ Duman, Müjgan Özdemi̇r Erdoğan, Mustafa Solak
Turkish Journal of Medical Sciences
Background/aim: Age-related cataract is the most important visual impairment all over the world. Epigenetic modifications, especially overexpression of histone deacetylases, have become the focus of interest for cataract development in recent years. Sirtuin 1 (SIRT1), a class II histone deacetylase and a member of the sirtuin family, is one of the best-characterized histone deacetylases and has a pivotal role in age-related diseases. However, the association of SIRT1 with age-related cataracts has not yet been fully elucidated. Therefore, we aimed to determine the expression of SIRT1 in age-related cataract patients.Materials and methods: Expressions of SIRT1 were evaluated by quantitative polymerase chain …
The Effect Of Technical Details Of Percutaneous Catheter Drainage On The Clinical Outcomes Of Infected Necrotizing Pancreatitis Patients, Zhi-Hua Zhang, Yi-Xuan Ding, Yu-Duo Wu, Chong-Chong Gao, Fei Li
The Effect Of Technical Details Of Percutaneous Catheter Drainage On The Clinical Outcomes Of Infected Necrotizing Pancreatitis Patients, Zhi-Hua Zhang, Yi-Xuan Ding, Yu-Duo Wu, Chong-Chong Gao, Fei Li
Turkish Journal of Medical Sciences
Background/aim: This study aimed to investigate the effect of technical details of percutaneous catheter drainage (PCD) on the clinical outcomes of patients with infected necrotizing pancreatitis (INP).Materials and methods: A total of 44 INP patients treated in our hospital from October 2013 to October 2015 were included. The correlations of the first PCD treatment data and the clinical outcomes were analyzed.Results: The number of catheters was positively correlated with hospital readmission (r = 0.335, P = 0.032). Receiver operating characteristic curve analysis showed that patients with ? 3 catheters were more likely to have hospital readmission. Patients with pleural effusion …
Reference Values And Prediction Equation For The 6-Minute Walk Test In Healthy Children Aged 6?12 Years Old, Buse Özcan Kahraman, Ertuğrul Yüksel, Abdurrahman Nalbant, Umut Zi̇ya Koçak, Bayram Ünver
Reference Values And Prediction Equation For The 6-Minute Walk Test In Healthy Children Aged 6?12 Years Old, Buse Özcan Kahraman, Ertuğrul Yüksel, Abdurrahman Nalbant, Umut Zi̇ya Koçak, Bayram Ünver
Turkish Journal of Medical Sciences
Background/aim: The 6-minute walk test (6MWT) is the most commonly used and well-established test to measure functional exercise capacity in research and clinical settings. Country-specific reference values are important to interpret the results of 6MWT. However, no reference values have been reported for healthy Turkish children aged between 6 and 12 years old. The aim of this study was to determine normal reference values for the 6MWT test of healthy Turkish children aged between 6 and 12 years old. Materials and methods: Two hundred and sixty-two healthy children aged between 6 and 12 years old were included in this cross-sectional …
Comparison Of Inferior Vena Cava Collapsibility, Distensibility, And Delta Indices At Different Positive Pressure Supports And Prediction Values Of Indices For Intravascular Volume Status, Aykut Saritaş, Çi̇ler Zi̇nci̇rci̇oğlu, Peli̇n Uzun Saritaş, Uğur Uzun, Işil Güldoğan, Ni̇met Şenoğlu
Comparison Of Inferior Vena Cava Collapsibility, Distensibility, And Delta Indices At Different Positive Pressure Supports And Prediction Values Of Indices For Intravascular Volume Status, Aykut Saritaş, Çi̇ler Zi̇nci̇rci̇oğlu, Peli̇n Uzun Saritaş, Uğur Uzun, Işil Güldoğan, Ni̇met Şenoğlu
Turkish Journal of Medical Sciences
Background/aim: To compare the inferior vena cava (IVC) indices, identify their variation rates at positive pressure values and accurate predictive values for the volume status in patients with spontaneous respiration receiving different positive pressure support.Material and methods: The study included 100 patients who were divided into 4 pressure support groups, according to the different pressure supports received, and 3 volume groups according to their CVP values. Ultrasonography was applied to all of the patients to define their IVC diameters at different pressure supports. Dynamic parameters were derived from the ultrasonographic assessment of the IVC diameter [collapsibility (CI-IVC), distensibility (dIVC), and …
Determination Of Liver Fibrosis Stages In Egyptian Chronic Hepatitis B Patients By A Noninvasive Tool, Waleed Serag, Magdy Mahmoud, Basem Eysa, Sara Mahmoud
Determination Of Liver Fibrosis Stages In Egyptian Chronic Hepatitis B Patients By A Noninvasive Tool, Waleed Serag, Magdy Mahmoud, Basem Eysa, Sara Mahmoud
Turkish Journal of Medical Sciences
Background/aim: Hepatitis B virus (HBV) infection is the leading cause of liver fibrosis (LF). The prognosis and management of patients with chronic hepatitis B virus depend on the amount and progression of liver fibrosis. Angiopoietin-like protein 2 (Angptl2) is not only a chronic inflammatory mediator, but also a tissue-remodeling factor. The aim of this study is to explore the predictive value of Angptl2 in different fibrosis stages in patients chronically infected with HBV. Materials and methods: Eighty patients with chronic HBV infection undergoing Fibroscan were included. Serum concentrations of Angptl2 were detected using a commercial ELISA kit.Results: Angptl2 levels were …
Intensive Care Psychological Assessment Tool (Ipat): Turkish Validity And Reliability Study, Berker Duman, Zeynep Kotan, Vahap Ozan Kotan, Nevzat Mehmet Mutlu, Beyza Doğanay Erdoğan, Damla Sayar Akaslan, Safi̇ye Zeynep Tatli, Hakan Kumbasar
Intensive Care Psychological Assessment Tool (Ipat): Turkish Validity And Reliability Study, Berker Duman, Zeynep Kotan, Vahap Ozan Kotan, Nevzat Mehmet Mutlu, Beyza Doğanay Erdoğan, Damla Sayar Akaslan, Safi̇ye Zeynep Tatli, Hakan Kumbasar
Turkish Journal of Medical Sciences
Background/aim: It is of crucial importantance to be able to detect acute psychological distress in patients. The Intensive Care Psychological Assessment Tool (IPAT) was developed for this purpose in intensive care units. This study aims to evaluate the validity and reliability of the Turkish version of IPAT.Materials and methods: In total, 98 patients were included. To assess concurrent validity, the Intensive Care Experiences Scale (ICES) and the Hospital Anxiety Depression Scale were performed. Cronbach?s alpha coefficient was used to estimate internal consistency. Interitem and item-total score correlations were also performed. Sensitivity and specificity were derived for concurrent anxiety and depression.Results: …