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Minimal Detectable Change And Responsiveness Of The 5-Item Barthel Index In Patients With Stroke, Wen-Shian Lu, Ya-Chen Lee, Fuh-Chour Twu, Ching-Lin Hsieh

Rehabilitation Practice and Science

Background and Purpose: A concise measurement tool can be easily accepted by clinicians. The 5-item Barthel Index (BI-5) has only 5 items and thus the potential to be used routinely in clinical settings. However, the minimal detectable change (MDC) and responsiveness of the BI-5 have not been verified sufficiently, limiting the interpretability of the change scores of the BI-5. The purposes of this study were to investigate the MDC and responsiveness of the BI-5 in patients with stroke and to compare the MDC and responsiveness of the BI-5 to those of the original BI.Methods: This study used secondary data analysis. …

Exploring The Possible Effects Of Mountaineering Activities On Sports Injuries, Body Composition And Thigh Muscle Function, Yi-Ting Fang, Chen-Liang Chou, Yi-Cheng Chen, Hong-Jen Chiou, Jin-Jong Chen, Hsuci-Chen Lee, Yi-Fen Shih

Rehabilitation Practice and Science

Background: Mountaineering and hiking have become popular activities recently, but related research in Taiwan has focused mainly on physiological reactions, much more than on the musculoskeletal system. However, the results of studies from abroad cannot be directly transferred because of the unique mountain and forest environment in Taiwan. In addition, chronic mountaineering injuries and derivative benefits in terms of specific physical performances still await further study. Therefore, it is important to investigate the possible relationship between mountaineering activities and musculoskeletal or knee function changes. Purpose: This study seeks to compare the differences in sports injuries, body composition and thigh muscle …

Pengaruh Latihan Fartlek Dengan Treadmill Dan Lari Di Lapangan Terhadap Daya Tahan Kardiorespirasi, Maya Kurnia, B.M. Wara Kushartanti

Jurnal Keolahragaan

Tujuan penelitian ini untuk mengungkapkan pengaruh dari latihan fartlek dengan treadmill, latihan fartlek dengan lari di lapangan, dan kapasitas vital paru terhadap daya tahan kardiorespirasi. Penelitian ini menggunakan desain eksperimen faktorial 2 x 2. Data dikumpulkan menggunakan tes daya tahan kardiorespirasi (tes Cooper 12 menit), dihitung jarak maksimal yang dapat ditempuh dalam waktu 12 menit tersebut. Hasil penelitian adalah sebagai berikut: (1) Ada perbedaan daya tahan kardiorespirasi antara kelompok latihan fartlek dengan treadmill dan kelompok latihan fartlek dengan lari di lapangan. Daya tahan kardiorespirasi kelompok latihan fartlek dengan lari di lapangan menunjuk-kan pengaruh lebih baik dibandingkan kelompok latihan fartlek …

Effectiveness Of Resistance (Strength) Training For Patients With Chronic Heart Failure, Yan-Wen Chen

Rehabilitation Practice and Science

The recent advancements in cardiac disease treatments have remarkably enhanced the survival rate of patients with chronic heart failure. In patients with exercise intolerance, the accompanied peripheral myopathy plays an important role. Resistance training is beneficial for musculoskeletal function in patients with chronic heart failure. However, the left ventricular myocardial remodeling progression and the hemodynamic response are controversial. Some studies showed that for those with stable heart failure (New York Heart Association functional classes I to III level), the adequate resistance training was beneficial in improvement of aerobic capacity, muscle histology, metabolic function, and left ventricular ejection fraction. In this …

Lipoma Arborescens On Mr Imaging And The Associated Lesions: A Reviewarticle Of 78 Cases, Cheng-Yuan Lin, Cheng-Ming Chiu, Tsung-Ching Lin, Shun-Lung Li, Chia-Yi Shang, Yu-Chiang Chen

Rehabilitation Practice and Science

Objective: To identify the different morphologic patterns of lipoma arborescens (LA) and the associated lesions on magnetic resonance (MR) imaging and to evaluate their clinical implication.Methods: We conducted a retrospective reviewarticle of the MR images and medical records of 78 patients diagnosed with LA of the knee (n=73) and shoulder (n=5). The diagnosis of LA was confirmed by the histologic findings in two cases and by the characteristic MR imaging features in the other 76.Results: A typical pattern of villous lipomatous proliferation of the synovium was identified on MR imaging in all cases, as a typical frond-like pattern in 38% …

Compressive Femoral Neuropathy Caused By Iliopsoas Muscle Hematoma: A Casereport, Szu-Hung Tsao, Yu-Ting Hsieh, Tai-Yi Wu, Shu-Hua Lin

Rehabilitation Practice and Science

Femoral neuropathy is uncommon compared with other mononeuropathies. We report a case of femoral neuropathy in a 53-year-old man who has cardiovascular disease and took Coumadin for 8 years. He has left lower extremity pain and weakness because of femoral nerve and lumbar plexus compression caused by an iliopsoas hematoma, which resulted from a period of prolonged bleeding. The patient’s condition improved after surgery and rehabilitation. We also reviewarticle the anatomy and pathophysiology of the femoral nerve, the clinical presentation of femoral neuropathy, the diagnostic tools used, the treatment method, and the prognosis.

Early Physical Therapy Intervention For A Child With Williams-Beuren's Syndrome And Presenting With Icf Model For Individual Activity And Participation: A Casereport, Shin-Mei Liu, Feng-Yin Lien, Shin-Tsu Chang, Heng-Yi Chu

Rehabilitation Practice and Science

Williams-Beuren's syndrome (W-B syndrome) is one of the genetic diseases, often comes with cardiovascular disease, abnormality of facial and teeth structure, poor motor control, delayed development of cognition and spatial sense. Here we present one child with W-B syndrome who underwent early intervention since she was 7 months old. After 20-month training, the child has made impressive progress in motor function and abilities of carrying ADL. Furthermore, by giving the parents instructions and guidelines for home programs, the relationship between the child and her parents also improved a lot. As the matter of fact, this casereport showed that the early …

台灣復健醫學雜誌通訊繼續教育測驗題, The Editors

Rehabilitation Practice and Science

No abstract provided.

Loss Of Atrx Does Not Confer Susceptibility To Osteoarthritis, Lauren A. Solomon, Bailey A. Russell, David Makar, Nathalie G. Bérubé, Frank Beier

Paediatrics Publications

The chromatin remodelling protein ATRX is associated with the rare genetic disorder ATR-X syndrome. This syndrome includes developmental delay, cognitive impairment, and a variety of skeletal deformities. ATRX plays a role in several basic chromatin-mediated cellular events including DNA replication, telomere stability, gene transcription, and chromosome congression and cohesion during cell division. We have used a loss-of-function approach to directly investigate the role of Atrx in the adult skeleton in three different models of selective Atrx loss. We specifically targeted deletion of Atrx to the forelimb mesenchyme, to cartilage and to bone-forming osteoblasts. We previously demonstrated that loss of ATRX …

The Public Health Pbrn Program: A Summative Report, Glen P. Mays

Glen Mays

This report provides a six-year summary of the work of the Public Health Practice-Based Research Networks Program, supported by the Robert Wood Johnson Foundation.

What's Happening: December 30, 2013, Maine Medical Center

What's Happening

No abstract provided.

Novel And Predominant Pathogen Responsible For The Enterovirus-Associated Encephalitis In Eastern China, Lei Zhang, Jie Yan, David M. Ojcius, Huakun Lv, Ziping Miao, Yin Chen, Yanjun Zhang, Jvying Yan

All Dugoni School of Dentistry Faculty Articles

Enteroviruses (EV) have been increasingly identified as the causative agent for unknown etiological encephalitis in many parts of the world, but the long period surveillance for enterovirus-associated encephalitis (EAE) was not reported in China. From 2002-2012 in Zhejiang, Coxsackieviruses A9, B1, B2, B3, B4, B5; and echoviruses 3, 4, 6, 9, 14, 25, 30 were detected from the unknown etiological encephalitis cases, with coxsackievirus B4 been identified here for the first time. From 2002-2004 and 2010-2012, echovirus 30 was found to be the periodically predominant serotype for in the EAE. The molecular typing results showed that all the EV isolates …

The Public Health Pbrn Program: A Summative Report, Center For Public Health Systems And Services Research

UKCPHSSR Research Briefs and Reports

This program seeks to expand the volume and quality of evidence on how best to organize, finance, and deliver public health services by: (1) helping to organize and develop practice-based research networks (PBRNs) comprised of public health agencies and skilled research institutions; (2) selecting grantees to receive funding and technical assistance for PBRN research projects; and (3) facilitating the successful development, implementation, and translation of research projects through PBRNs by providing technical assistance, fostering peer learning, and leading selected multi-network research activities.

Jefferson Digital Commons Quarterly Report: October-December 2012, Daniel G. Kipnis, Msi

Jefferson Digital Commons Reports

Jefferson Digital Commons quarterly report includes statistics, top 10 most downloaded items and new assets added to the collection.

Sphingosine-1-Phosphate-Mediated Mobilization Of Hematopoietic Stem/Progenitor Cells During Intravascular Hemolysis Requires Attenuation Of Sdf-1-Cxcr4 Retention Signaling In Bone Marrow, Kasia Mierzejewska, Yuri M. Klyachkin, Janina Ratajczak, Ahmed Abdel-Latif, Magda Kucia, Mariusz Z. Ratajczak

Saha Cardiovascular Research Center Faculty Publications

Sphingosine-1-phosphate (S1P) is a crucial chemotactic factor in peripheral blood (PB) involved in the mobilization process and egress of hematopoietic stem/progenitor cells (HSPCs) from bone marrow (BM). Since S1P is present at high levels in erythrocytes, one might assume that, by increasing the plasma S1P level, the hemolysis of red blood cells would induce mobilization of HSPCs. To test this assumption, we induced hemolysis in mice by employing phenylhydrazine (PHZ). We observed that doubling the S1P level in PB from damaged erythrocytes induced only a marginally increased level of mobilization. However, if mice were exposed to PHZ together with the …

Role Of Defensins In The Pathogenesis Of Chronic Lung Allograft Rejection, Venkataswarup Tiriveedhi, Babak Banan, Saini Deepti, Angaswamy Nataraju, Ramsey Hachem, Elbert Trulock, Patterson G. Alexander, Thalachallour Mohanakumar

Biology Faculty Research

Chronic rejection predominantly manifested as bronchiolitis obliterans syndrome (BOS), still remains a major problem affecting long-term outcomes in human lung transplantation (LTx). Donor specific antibodies (DSA) and infiltration of neutrophils in the graft have been associated with the development of BOS. This study determines the role of defensins, produced by neutrophils, and its interaction with α-1-antitrypsin (AAT) towards induction of airway inflammation and fibrosis which are characteristic hallmarks of BOS. Bronchoalveolar lavage (BAL) and serum from LTx recipients, BOS+ (n=28), BOS− (n=26) and normal healthy controls (n=24) were analyzed. Our results show that BOS+ LTx recipients had higher α-defensins (HNP1–3) …

Trypanosomatid Aquaporins: Roles In Physiology And Drug Response, Goutam Mandal, Jose F. Orta, Mansi Sharma, Rita Mukhopadhyay

HWCOM Faculty Publications

In the class Kinetoplastida, we find an order of parasitic protozoans classified as Trypanosomatids. Three major pathogens form part of this order, Trypanosoma cruzi, Trypanosoma brucei, and Leishmania, which are responsible for disease and fatalities in millions of humans worldwide, especially in non-industrialized countries in tropical and sub-tropical regions. In order to develop new drugs and treatments, the physiology of these pathogenic protozoans has been studied in detail, specifically the significance of membrane transporters in host parasites interactions. Aquaporins and Aquaglyceroporins (AQPs) are a part of the major intrinsic proteins (MIPs) super-family. AQPs are characterized for their ability to facilitate …

Spatial Analysis Of Factors Influencing Long-Term Stress In The Grizzly Bear (Ursus Arctos) Population Of Alberta, Canada, Mathieu Bourbonnais, Trisalyn Nelson, Mark Cattet, Chris T. Darimont, Gordon Stenhouse

Physiology Collection

Non-invasive measures for assessing long-term stress in free ranging mammals are an increasingly important approach for understanding physiological responses to landscape conditions. Using a spatially and temporally expansive dataset of hair cortisol concentrations (HCC) generated from a threatened grizzly bear (Ursus arctos) population in Alberta, Canada, we quantified how variables representing habitat conditions and anthropogenic disturbance impact long-term stress in grizzly bears. We characterized spatial variability in male and female HCC point data using kernel density estimation and quantified variable influence on spatial patterns of male and female HCC stress surfaces using random forests. Separate models were developed for regions …

Primary Care-Based Educational Interventions To Decrease Risk Factors For Metabolic Syndrome For Adults With Major Psychotic And/Or Affective Disorders: A Systematic Review, Cynthia Nover, Sarah S. Jackson

Epidemiology Faculty Publications

Background

Individuals with major psychotic and/or affective disorders are at increased risk for developing metabolic syndrome due to lifestyle- and treatment-related factors. Numerous pharmacological and non-pharmacological interventions have been tested in inpatient and outpatient mental health settings to decrease these risk factors. This review focuses on primary care-based non-pharmacological (educational or behavioral) interventions to decrease metabolic syndrome risk factors in adults with major psychotic and/or affective disorders.

Methods

The authors conducted database searches of PsychINFO, MEDLINE and the Cochrane Database of Systematic Reviews, as well as manual searches and gray literature searches to identify included studies.

Results

The authors were …

Beyond Perceptual Expertise: Revisiting The Neural Substrates Of Expert Object Recognition, Assaf Harel, Dwight J. Kravitz, Chris I. Baker

Psychology Faculty Publications

Real-world expertise provides a valuable opportunity to understand how experience shapes human behavior and neural function. In the visual domain, the study of expert object recognition, such as in car enthusiasts or bird watchers, has produced a large, growing, and often-controversial literature. Here, we synthesize this literature, focusing primarily on results from functional brain imaging, and propose an interactive framework that incorporates the impact of high-level factors, such as attention and conceptual knowledge, in supporting expertise. This framework contrasts with the perceptual view of object expertise that has concentrated largely on stimulus-driven processing in visual cortex. One prominent version of …

Men At Risk; A Qualitative Study On Hiv Risk, Gender Identity And Violence Among Men Who Have Sex With Men Who Report High Risk Behavior In Kampala, Uganda., Rachel King, Joseph Barker, Sylvia Nakayiwa, David Katuntu, George Lubwama, Danstan Bagenda, Tim Lane, Alex Opio, Wolfgang Hladik

Journal Articles: Epidemiology

In Uganda, men who have sex with men (MSM) are at high risk for HIV. Between May 2008 and February 2009 in Kampala, Uganda, we used respondent driven sampling (RDS) to recruit 295 MSM≥18 years who reported having had sex with another man in the preceding three months. The parent study conducted HIV and STI testing and collected demographic and HIV-related behavioral data through audio computer-assisted self-administered interviews. We conducted a nested qualitative sub-study with 16 men purposively sampled from among the survey participants based on responses to behavioral variables indicating higher risk for HIV infection. Sub-study participants were interviewed …

Inflammatory Cytokine Gene Expression In Mesenteric Adipose Tissue During Acute Experimental Colitis, William Conan Mustain, Marlene E. Starr, Joseph Daniel Valentino, Donald A. Cohen, Daiki Okamura, Chi Wang, B. Mark Evers, Hiroshi Saito

Markey Cancer Center Faculty Publications

BACKGROUND: Production of inflammatory cytokines by mesenteric adipose tissue (MAT) has been implicated in the pathogenesis of inflammatory bowel disease (IBD). Animal models of colitis have demonstrated inflammatory changes within MAT, but it is unclear if these changes occur in isolation or as part of a systemic adipose tissue response. It is also unknown what cell types are responsible for cytokine production within MAT. The present study was designed to determine whether cytokine production by MAT during experimental colitis is depot-specific, and also to identify the source of cytokine production within MAT.

METHODS: Experimental colitis was induced in 6-month-old C57BL/6 …

The Toxoplasma Gondii Cyst Wall Protein Cst1 Is Critical For Cyst Wall Integrity And Promotes Bradyzoite Persistence, Tadakimi Tomita, David J. Bzik, Yan Fen Ma, Barbara A. Fox

Dartmouth Scholarship

Toxoplasma gondii infects up to one third of the world's population. A key to the success of T. gondii as a parasite is its ability to persist for the life of its host as bradyzoites within tissue cysts. The glycosylated cyst wall is the key structural feature that facilitates persistence and oral transmission of this parasite. Because most of the antibodies and reagents that recognize the cyst wall recognize carbohydrates, identification of the components of the cyst wall has been technically challenging. We have identified CST1 (TGME49_064660) as a 250 kDa SRS (SAG1 related sequence) domain protein with a large …

Food Advertisements In Two Popular U.S. Parenting Magazines: Results Of A Five-Year Analysis, Corey H. Basch, Rodney N. Hammond, Danna Ethan, Lalitha Samuel

Publications and Research

Obesity rates among American youth have prompted an examination of food advertisements geared towards children. Research indicates children’s high exposure to these advertisements and their influence on food preferences. Less is known about the presence of these advertisements in parenting magazines. This study’s objective was to examine prevalence of food advertisements in popular parenting magazines and identify products by USDA food category. We analyzed 116 issues of two popular U.S. parenting magazines across five years. All food and beverage advertisements for USDA Food Category were coded. Breakfast cereals were coded for nutritional quality. The coding took place at varied libraries …

Simulation And Optimization Modeling For Drive-Through Mass Vaccination – A Generalized Approach, Aman Gupta, Gerald W. Evans, Sunderesh S. Heragu

Aman Gupta

Proper planning and execution of mass vaccination at the onset of a pandemic outbreak is important for local health departments. Mass vaccination clinics are required to be setup and run for naturally occurring pandemic outbreaks or even in response to terrorist attacks, e.g., anthrax attack. Walk-in clinics have often been used to administer vaccines. When a large percentage of a population must be vaccinated to mitigate the ill-effects of an attack or pandemic, drive-through clinics appear to be more effective because a much higher throughput can be achieved when compared to walk-in clinics. There are other benefits as well. For …

Table Of Contents, Michele Harmon

Journal of the South Carolina Academy of Science

No abstract provided.

A Mechanism Linking Id2-Tgfβ Crosstalk To Reversible Adaptive Plasticity In Neuroblastoma, Lina Chakrabarti, Bi-Dar Wang, Norman H. Lee, Anthony D. Sandler

Pharmacology and Physiology Faculty Publications

The ability of high-risk neuroblastoma to survive unfavorable growth conditions and multimodal therapy has produced an elusive childhood cancer with remarkably poor prognosis. A novel phenomenon enabling neuroblastoma to survive selection pressure is its capacity for reversible adaptive plasticity. This plasticity allows cells to transition between highly proliferative anchorage dependent (AD) and slow growing, anoikis-resistant anchorage independent (AI) phenotypes. Both phenotypes are present in established mouse and human tumors. The differential gene expression profile of the two cellular phenotypes in the mouse Neuro2a cell line delineated pathways of proliferation in AD cells or tyrosine kinase activation/ apoptosis inhibition in AI …

What's Happening: December 23, 2013, Maine Medical Center

What's Happening

No abstract provided.

Community Health News, Georgia Southern University

Community Health Department News (2011-2018)

• Rural Women’s Exercise Self-efficacy

Regulation Of Pten Inhibition By The Pleckstrin Homology Domain Of P-Rex2 During Insulin Signaling And Glucose Homeostasis, Cindy Hodakoski, Benjamin D. Hopkins, Douglas Barrows, Sarah M. Mense, Megan Keniry, Karen E. Anderson, Philip A. Kern, Phillip T. Hawkins, Len R. Stephens, Ramon Parsons

Clinical and Translational Science Faculty Publications

Insulin activation of phosphoinositide 3-kinase (PI3K) signaling regulates glucose homeostasis through the production of phosphatidylinositol 3,4,5-trisphosphate (PIP3). The dual-specificity phosphatase and tensin homolog deleted on chromosome 10 (PTEN) blocks PI3K signaling by dephosphorylating PIP3, and is inhibited through its interaction with phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 (P-REX2). The mechanism of inhibition and its physiological significance are not known. Here, we report that P-REX2 interacts with PTEN via two interfaces. The pleckstrin homology (PH) domain of P-REX2 inhibits PTEN by interacting with the catalytic region of PTEN, and the inositol polyphosphate 4-phosphatase domain of P-REX2 provides high-affinity binding to the postsynaptic …