Open Access. Powered by Scholars. Published by Universities.®
- Institution
-
- Thomas Jefferson University (39)
- University of Kentucky (22)
- Dartmouth College (20)
- Children's Mercy Kansas City (13)
- Western University (13)
-
- University of Nebraska Medical Center (11)
- Edith Cowan University (10)
- Selected Works (4)
- The Texas Medical Center Library (4)
- University of South Carolina (4)
- University of Wollongong (3)
- Himmelfarb Health Sciences Library, The George Washington University (2)
- Mississippi State University (2)
- Rowan University (2)
- Cedarville University (1)
- Old Dominion University (1)
- Philadelphia College of Osteopathic Medicine (1)
- Providence (1)
- University of Nevada, Las Vegas (1)
- University of South Florida (1)
- University of the Pacific (1)
- Publication
-
- Dartmouth Scholarship (20)
- Manuscripts, Articles, Book Chapters and Other Papers (13)
- Research outputs 2013 (10)
- Brain and Mind Institute Researchers' Publications (9)
- Rothman Institute Faculty Papers (8)
-
- Department of Surgery Faculty Papers (4)
- Epidemiology and Environmental Health Faculty Publications (4)
- Faculty Publications (4)
- Journal Articles (4)
- Journal Articles: Biochemistry & Molecular Biology (4)
- Yizhen Wu (4)
- Department of Emergency Medicine Faculty Papers (3)
- Department of Medicine Faculty Papers (3)
- Illawarra Health and Medical Research Institute (3)
- Internal Medicine Faculty Publications (3)
- Journal Articles: Epidemiology (3)
- Medical Biophysics Publications (3)
- Behavioral Science Faculty Publications (2)
- Department of Cancer Biology Faculty Papers (2)
- Department of Neuroscience Faculty Papers (2)
- Department of Pathology, Anatomy, and Cell Biology Faculty Papers (2)
- Nursing Faculty Publications (2)
- Sanders-Brown Center on Aging Faculty Publications (2)
- All Dugoni School of Dentistry Faculty Articles (1)
- Articles, Abstracts, and Reports (1)
- CRVAW Faculty Journal Articles (1)
- Cardeza Foundation for Hematologic Research (1)
- Center for Oral Health Research Faculty Publications (1)
- College of Arts and Sciences Publications and Scholarship (1)
- College of Population Health Faculty Papers (1)
- Publication Type
Articles 151 - 156 of 156
Full-Text Articles in Entire DC Network
Long-Term Persistency And Costs Associated With The Use Of Iron Chelation Therapies In The Treatment Of Sickle Cell Disease Within Medicaid Programs., Edward P Armstrong, Grant H Skrepnek, Medha Sasane, Susan M Snodgrass, Samir K. Ballas
Long-Term Persistency And Costs Associated With The Use Of Iron Chelation Therapies In The Treatment Of Sickle Cell Disease Within Medicaid Programs., Edward P Armstrong, Grant H Skrepnek, Medha Sasane, Susan M Snodgrass, Samir K. Ballas
Department of Medicine Faculty Papers
OBJECTIVE: This retrospective study evaluated iron chelating therapy (ICT) discontinuation and costs in Sickle cell disease (SCD) Medicaid recipients using healthcare claims from 2006-2010.
METHODS: Patients with ≥1 SCD diagnosis claim, ≥2 claims for deferoxamine (DFO) or deferosirox (DFX), and continuous enrollment ≥6 months prior to and 18 months following ICT initiation were included. Outcomes included treatment discontinuation, persistence (i.e., refill gaps ≥6 weeks), and total healthcare costs.
RESULTS: The average age among 404 SCD patients meeting study inclusion criteria was 18.7 (±11.0) years, with 45.8% being males and 66.7% being Blacks. Switches or combinations from DFO at index occurred …
Ash2 Acts As An Ecdysone Receptor Coactivator By Stabilizing The Histone Methyltransferase Trr., Albert Carbonell, Alexander Mazo, Florenci Serras, Montserrat Corominas
Ash2 Acts As An Ecdysone Receptor Coactivator By Stabilizing The Histone Methyltransferase Trr., Albert Carbonell, Alexander Mazo, Florenci Serras, Montserrat Corominas
Department of Biochemistry and Molecular Biology Faculty Papers
The molting hormone ecdysone triggers chromatin changes via histone modifications that are important for gene regulation. On hormone activation, the ecdysone receptor (EcR) binds to the SET domain-containing histone H3 methyltransferase trithorax-related protein (Trr). Methylation of histone H3 at lysine 4 (H3K4me), which is associated with transcriptional activation, requires several cofactors, including Ash2. We find that ash2 mutants have severe defects in pupariation and metamorphosis due to a lack of activation of ecdysone-responsive genes. This transcriptional defect is caused by the absence of the H3K4me3 marks set by Trr in these genes. We present evidence that Ash2 interacts with Trr …
A Genome-Wide Methylation Study On Essential Hypertension In Young African American Males., Xiaoling Wang, Bonita Falkner, Haidong Zhu, Huidong Shi, Shaoyong Su, Xiaojing Xu, Ashok Kumar Sharma, Yanbin Dong, Frank Treiber, Bernard Gutin, Gregory Harshfield, Harold Snieder
A Genome-Wide Methylation Study On Essential Hypertension In Young African American Males., Xiaoling Wang, Bonita Falkner, Haidong Zhu, Huidong Shi, Shaoyong Su, Xiaojing Xu, Ashok Kumar Sharma, Yanbin Dong, Frank Treiber, Bernard Gutin, Gregory Harshfield, Harold Snieder
Department of Medicine Faculty Papers
OBJECTIVE: There is emerging evidence from animal studies suggesting a key role for methylation in the pathogenesis of essential hypertension. However, to date, very few studies have investigated the role of methylation in the development of human hypertension, and none has taken a genome-wide approach. Based on the recent studies that highlight the involvement of inflammation in the development of hypertension, we hypothesize that changes in DNA methylation of leukocytes are involved in the pathogenesis of hypertension.
METHOD & RESULTS: We conducted a genome-wide methylation analysis on 8 hypertensive cases and 8 normotensive age-matched controls aged 14-23 years and performed …
Lead-Based Paint Awareness, Work Practices, And Compliance During Residential Construction And Renovation, James D. Blando, Nickita Antoine, Daniel Lefkowitz
Lead-Based Paint Awareness, Work Practices, And Compliance During Residential Construction And Renovation, James D. Blando, Nickita Antoine, Daniel Lefkowitz
Community & Environmental Health Faculty Publications
The U.S. Environmental Protection Agency recently implemented the Renovation, Repair and Painting (RRP) rule that applies to pre-1978 residences because of the potential presence of lead-based paint. Enforcement of this rule may be difficult and therefore it is crucial to understand the awareness and beliefs of contractors and the general public because these will likely be major determinants of exposures resulting from residential renovation work. The study described in this article utilized two mailed surveys: one directed to the general public and the other directed to contractors. The surveys were conducted in New Jersey and Virginia. Field observations were also …
A Phase 1b Study Of Humanized Ks-Interleukin-2 (Huks-Il2) Immunocytokine With Cyclophosphamide In Patients With Epcam-Positive Advanced Solid Tumors., Joseph P Connor, Mihaela C Cristea, Nancy L Lewis, Lionel D Lewis, Philip B Komarnitsky, Maria R Mattiacci, Mildred Felder, Sarah Stewart, Josephine Harter, Jean Henslee-Downey, Daniel Kramer, Roland Neugebauer, Roger Stupp
A Phase 1b Study Of Humanized Ks-Interleukin-2 (Huks-Il2) Immunocytokine With Cyclophosphamide In Patients With Epcam-Positive Advanced Solid Tumors., Joseph P Connor, Mihaela C Cristea, Nancy L Lewis, Lionel D Lewis, Philip B Komarnitsky, Maria R Mattiacci, Mildred Felder, Sarah Stewart, Josephine Harter, Jean Henslee-Downey, Daniel Kramer, Roland Neugebauer, Roger Stupp
Kimmel Cancer Center Faculty Papers
BACKGROUND: Humanized KS-interleukin-2 (huKS-IL2), an immunocytokine with specificity for epithelial cell adhesion molecule (EpCAM), has demonstrated favorable tolerability and immunologic activity as a single agent.
METHODS: Phase 1b study in patients with EpCAM-positive advanced solid tumors to determine the maximum tolerated dose (MTD) and safety profile of huKS-IL2 in combination with low-dose cyclophosphamide. Treatment consisted of cyclophosphamide (300 mg/m2 on day 1), and escalating doses of huKS-IL2 (0.5-4.0 mg/m2 IV continuous infusion over 4 hours) on days 2, 3, and 4 of each 21-day cycle. Safety, pharmacokinetic profile, immunogenicity, anti-tumor and biologic activity were evaluated.
RESULTS: Twenty-seven patients were treated …
Willingness To Undergo A Repeat Liver Biopsy Among Hiv/Hepatitis C Virus-Coinfected And Hepatitis C Virus-Monoinfected Patients, Valerianna K Amorosa, Omowunmi Aibana, Norah J Shire, Zachariah Dorey-Stein, Thomas Ferrara, Joanne Gilmore, Jay R Kostman, Vincent Lo Re
Willingness To Undergo A Repeat Liver Biopsy Among Hiv/Hepatitis C Virus-Coinfected And Hepatitis C Virus-Monoinfected Patients, Valerianna K Amorosa, Omowunmi Aibana, Norah J Shire, Zachariah Dorey-Stein, Thomas Ferrara, Joanne Gilmore, Jay R Kostman, Vincent Lo Re
Journal Articles
BACKGROUND: Guidelines for chronic hepatitis C virus (HCV) management have recommended that a liver biopsy be repeated at 3-year intervals for HIV/HCV-coinfected patients and 5-year intervals for those with HCV monoinfection to assess fibrosis progression. However, it is unclear if patients are willing to repeat this procedure.
OBJECTIVE: To determine the prevalence and factors, particularly HIV coinfection, associated with willingness to repeat a liver biopsy.
METHODS: A questionnaire was administered to 235 HCV-infected patients (113 with HIV coinfection) between January 2008 and June 2011 who previously underwent liver biopsy. The main outcome was self-reported willingness to repeat the biopsy. The …