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The Effects Of Sglt2 Inhibitors In Patients With Metabolic Dysfunction-Associated Fatty Liver Disease; A Narrative Review, Mihaela Simona Popoviciu, Lorena Paduraru, Mominur Rahman, Fatema Akter Supti, Roxana Adriana Stoica, Delia Reurean Pintilei, Cristina Ioana Bica, Simona Cavalu

Journal of Mind and Medical Sciences

Worldwide, metabolic dysfunction-associated fatty liver disease (MAFLD) is a significant public health concern, especially since more than fifty percent of people with type 2 diabetes are affected by it. This pathological condition includes all states of fatty liver disease, from non-alcoholic fatty liver disease (NAFLD) to steatohepatitis (NASH). Prolonged evolutions can lead to cirrhosis and cancer, so treatment must be started early. Hepatic steatosis may be improved by sodium glucose co-transporter 2 inhibitors (SGLT2 inhibitors), which prevent glucose reabsorption in the proximal renal tubule and increase urinary excretion, thus lowering plasma glucose levels. Experimental studies in animal models have suggested …

Correlation Between Periodontal Status And Parkinson's Disease; A Literature Review, Dragos Nicolae Ciongaru, Anca Silvia Dumitriu, Bogdan Alexandru Dimitriu, Stana Paunica, Marina Cristina Giurgiu, Brandusa Florina Mocanu, George Alexandru Popescu, Silviu Mirel Pituru

Journal of Mind and Medical Sciences

This systematic review aims to explore the relationship between chronic inflammation of periodontal disease and neurodegenerative disorders (especially Parkinson's disease), focusing primarily on pathophysiological, clinical and immunological aspects. An exhaustive search on this topic was performed in several databases (including PubMed, Scopus and Web of Science) selecting articles published between 2006 and 2023. After reviewing the titles, abstracts and protocols of each study, 13 articles were extracted for detailed assessment. The main indicators in the study included clinical signs of gingival inflammation, bleeding on probing (BoP), bone loss (BL), periodontal probing depth (PPD), and clinical attachment loss (CAL). Additionally, levels …

The Role Of Inflammation In Diabetic Retinopathy In Patients With Type Ii Diabetes; Potential Therapeutic Perspectives, Adriana Georgescu, Ana Dascalu, Daniela Stana, Cristina Alexandrescu, Anca Bobirca, Bogdan Mihai Cristea, Geta Vancea, Crenguta Sorina Serboiu, Dragos Serban, Corneliu Tudor, Andreea Letitia Arsene, Laura Carina Tribus

Journal of Mind and Medical Sciences

Diabetic retinopathy is one of the major causes of visual impairment and blindness in adult population. The pathology is complex, the metabolic changes induced by the hyperglycemic environment leading to neurodegeneration, microvascular damage, with secondary ischemic and inflammatory changes in the retina. This review aims to update the literature data related to the role of inflammation in the onset and progression of diabetic retinopathy. Thus, the molecular and biochemical mechanisms triggered by excess glucose increase the expression of genes involved in inflammatory processes, which leads to the synthesis of inflammatory cytokines such as Il1, Il6, TNF alpha as well as …

Relationship Between C-Reactive Protein/Albumin Ratio And Mucocutaneous Symptom Frequency And Disease Severity In Behçet’S Disease, Erdal Pala, Mustafa Bayraktar

Turkish Journal of Medical Sciences

Background/aim: There is no specific marker that can be applied to determine the severity of Behçet’s disease. The aim of this study is to investigate the potential of C-reactive protein (CRP)/albumin (CAR) ratio as a tool for assessing the severity of Behçet’s disease.Materials and methods: A retrospective crosssectional study was conducted by examining hospital archives. The CRP and albumin levels of Behçet’s disease patients who presented to our dermatology clinic over a three-year period from February 2020 to February 2022 were included, along with the identical laboratory parameters in the control group. The CAR ratio was calculated and statistically compared …

Salivary C-Reactive Protein And Cortisol Analysis In Collegiate Female Lacrosse Athletes During A 2-Game Week, Kelsi R. Lambright, Stephanie Mathews, Jennifer A. Bunn

International Journal of Exercise Science: Conference Proceedings

Cortisol (CORT) and C-reactive protein (CRP) are two indicators of stress and are linked to tissue inflammation and illness. Increased stress and inflammation have been shown to decrease cognitive functioning, leading to diminished performance for athletes. Subjectively, athletes indicate fluctuations in stress, but few studies have assessed the physiological response of training and competition in elite female athletes. PURPOSE: The primary aim was to assess the acute response of CORT and CRP in Division I female lacrosse athletes during a high-stress week, including two games and three practices during the competitive season. The secondary aim was to assess the …

Short-Term Cd8+ T Cell Depletion Results In Blunted Liver Inflammation In Old Mice, Konner J. Terrebonne, David J. Buckley, Blessy Joseph, Sunita Sharma, Daniel W. Trott

International Journal of Exercise Science: Conference Proceedings

Advanced age is associated with an increase in basal inflammation of the organs. Previously we have found that T cells accumulate in the liver of old mice. A large proportion of these cells are CD8+ and produce inflammatory cytokines. We have previously demonstrated that CD8+ T cell depletion results in improved glucose tolerance in old mice. However, the mechanisms by which CD8+ depletion improves glucose tolerance is unclear. Therefore, we sought to determine whether pharmacologic CD8+ depletion would result in decreased liver specific inflammation in old mice compared to their old CD8+ intact counterparts. PURPOSE: To test the hypothesis …

Firefighters Versus Law Enforcement Officers: A Comparison Of Cardiovascular Disease Risk, Bethany C. Guerra, Hunter Martaindale, Steven E. Martin, Lisa C. Colvin, Drew E. Gonzalez, Matthew J. Mcallister

International Journal of Exercise Science: Conference Proceedings

Firefighters (FF) and law enforcement officers (LEO) have heightened cardiovascular disease (CVD) risk due to the stressful nature of their occupations. Data suggest that 45% of on-duty FF fatalities are related to CVD, while LEO have a 1.7 times higher CVD prevalence compared to the general public. To our knowledge, studies comparing FF to LEO, in terms of CVD risk factors, have not been published. This information is necessary to better understand differences in occupational disease risk, as well as to help bridge the gap between stress and CVD markers. PURPOSE: To compare CVD risk biomarkers, fitness, and body …

Role Of Inflammatory And Growth Factors In Diabetes Mellitus, Sayed Mohammed Firdous, Sourav Pal

Palestinian Medical and Pharmaceutical Journal

In diabetes mellitus, both inflammatory and growth factors play significant roles in the development and progression of the disease and its associated complications. Diabetics frequently show signs of chronic, low-grade inflammation. Insulin resistance and beta-cell dysfunction are exacerbated by the high levels of pro-inflammatory cytokines prevalent in diabetes, such as TNF-α and IL-6. High levels of the inflammatory marker C-reactive protein are linked to insulin resistance and an increased risk of cardiovascular disease. An upsurge in in diabetes is caused by NF-κB activation. Complications and pathological processes in diabetes may be exacerbated by a dysregulation of growth factors. The angiogenesis-related …

Leaky Gut And Inflammatory Biomarkers In A Medication Overuse Headache Model In Male Rats, Doğa Vuralli, Hale Gök Dağidir, Elif Abbasoğlu Topa, Hayrunnisa Bolay Belen

Turkish Journal of Medical Sciences

Medication overuse is common among chronic migraine patients and nonsteroidal antiinflammatory drugs (NSAIDs)are the most frequently overused drugs. The pathophysiological mechanisms underlying medication overuse headache (MOH) are notcompletely understood. Intestinal hyperpermeability and leaky gut are reported in patients using NSAIDs. The aim of the study is toinvestigate the role of leaky gut and inflammation in an MOH model MOH model in male rats.Methods: The study was conducted in male Sprague Dawley rats. There were two experimental groups. The first group was the chronicNSAID group in which the rats received mefenamic acid (n = 8) for four weeks intraperitoneally (ip) and …

High Amniotic Fluid Fractalkine And Mip-1Β Levels Are Associated With Intrauterine Growth Restriction: A Prospective Cohort Study, Şehmus Pala, Remzi Atilgan, Nevin İlhan

Turkish Journal of Medical Sciences

Proinflammatory chemokines have been shown to play crucial roles in implantation, spiral artery invasion, and thefetomaternal immunological response. In this context, we investigated the levels of fractalkine (CX3CL1) and chemokine CC motifligand 4 (CCL4 or MIP-1β) in maternal serum and amniotic fluids in pregnant women with intrauterine growth restriction (IUGR).Materials and methods: This prospective cohort study was carried out at Fırat University Obstetrics Clinic between January 1, 2022 andJuly 1, 2022. Group (G) 1: The control group consisted of 40 pregnant women who underwent elective cesarean section (CS) at 38–40weeks of gestation. G2: A total of 40 pregnant women with …

Effect Of Humic Acid On Oxidative Stress And Neuroprotection In Traumatic Spinal Cord Injury: An Experimental Study, Burak Kinali, Nail Özdemi̇r, Ali Karadağ, Özge Kaya Korkmaz, Ayşe Gülden Di̇ni̇z, Fatma Demet Arslan

Turkish Journal of Medical Sciences

Traumatic spinal cord injury (TSCI) is an important health problem, especially in developing countries withadditional socioeconomic loss. Humic acid (HA) usually has antioxidant, antiinflammatory, blood circulating, and antiviral effects.Hence, it was aimed herein to show the effect of HA on neuroprotection in a TSCI model.Materials and method: A TSCI model was used, in which 24 Wistar albino rats were divided into 4 groups: control group: subjectedto only laminectomy; sham group: subjected to laminectomy + TSCI; HA 5 mg/kg group: subjected to laminectomy + TSCI +intraperitoneal (IP) injection of 5 mg/kg of HA; and HA 10 mg/kg group: subjected to laminectomy …

Protective Effects Of Swimming Exercises And Metformin On Cardiac And Aortic Damage Caused By A High-Fat Diet In Obese Rats With Type 2 Diabetes, By Regulating The Bcl2/Bax Signaling Pathway, Ebru Özüdoğru, Emrah Atay, Mehtap Savran, Hali̇l Aşci, Özlem Özmen, Şenay Topsakal

Turkish Journal of Medical Sciences

Background/aim: Due to the increasing mortality and morbidity rates in diabetes mellitus (DM), which is one of the biggest health problems of our age, many treatment modalities are still being tried. The positive effects of metformin (MET) and physical exercise (EXE) on the pathophysiology of diabetes are well known. In this study, it was aimed to detail these positive effects of MET and EXE in combination on the basis of inflammation, apoptosis mechanisms, and endogen nesfatin-1 (NES-1) synthesis. Materials and methods: Twenty-seven type 2 DM (DM-2) male Wistar Albino rats were divided into 4 groups, as the high-fat diet (HFD), …

Different Roles Of Endothelial Cell-Derived Fibronectin And Plasma Fibronectin In Endothelial Dysfunction, Xiaoxin Luo, Weixiong Jian

Turkish Journal of Medical Sciences

MDABackground/ aim: Atherosclerosis is significantly influenced by endothelial cell activation and dysfunction. Studies have demonstrated the substantial presence of fibronectin (Fn) within atherosclerotic plaques, promoting endothelial inflammation and activation. However, cellular Fn (cFn) secreted by various cell types, including endothelial cells and smooth muscle cells, and plasma Fn (pFn) produced by hepatocytes. They are distinct forms of Fn that differ in both structure and function. The specific contribution of different types of Fn in promoting endothelial cell activation and dysfunction remain uncertain. Therefore, this study aimed to investigate the respective roles of pFn and endothelial cell-derived Fn (FnEC) in promoting …

The Evaluation Of Oxidative Stress And Inflammation Markers In Serum And Saliva Of The Patients With Temporomandibular Disorders, Di̇lara Kazan, Burcu Baş, Abdurrahman Aksoy, Enes Atmaca

Turkish Journal of Medical Sciences

Background/aim: Temporomandibular Disorders (TMD), as in the occurrence of many diseases, have been associated with oxidative stress (OS) resulting from the disruption of antioxidant mechanisms and the accumulation of reactive oxygen species in tissues. This study was designed to compare salivary and serum OS and inflammation markers of individuals with TMD and healthy subjects. Materials and methods: A prospective cross-sectional study was conducted. Twenty-seven TMD patients diagnosed with disc displacement (DD) according to Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) and 17 healthy subjects were enrolled in the study. Prior to any treatment, serum, and saliva samples were taken from …

The Effects Of Initiating A Fast With A High Fat Or A High Carbohydrate Shake On Mcp-1, Tnf-Alpha, And Il-6 Levels, Gage Jensen, Bruce Bailey

International Journal of Exercise Science: Conference Proceedings

Alzheimer’s disease, stroke, heart disease, and diabetes all rank among the leading causes of death in the United States, particularly among the elderly. While many behavioral and pharmacological strategies have been employed to reduce the incidence of these conditions, increasing evidence indicates that entering a mild to moderate state of ketosis through fasting or a very low carbohydrate diet can improve the prognosis for these conditions. PURPOSE: The purpose of this study was to evaluate the extent to which a high carbohydrate low fat (HC/LF) pre-fast meal altered MCP-1, TNF-alpha and IL-6 compared to a low carbohydrate high-fat pre-fast …

The Role Of Inflammation In Age-Related Macular Degeneration, Diana Florina Tricorache, Ana Maria Dascalu, Crenguta Serboiu, Anca Bobirca, Dragos Cretoiu, Dan Bratu, Corneliu Tudor, Laura Carina Tribus

Journal of Mind and Medical Sciences

Age-related macular degeneration (AMD) is a complex, chronic, and progressive disease which affects the macular area, being one of the leading causes of irreversible vision loss worldwide. Specific alterations of retinal structure occur at the macular level, which regarding its severity can range from the presence of drusen to the development of geographic atrophy or choroidal neovascularization. AMD has long been considered a degenerative disease, but new studies highlight the role of inflammation present both in the atrophic form and in the exudative form. The present review is based on comprehensive research on PubMed and Web of Science databases, and …

Homoeopathic Medicines Modulate Inflammatory Functions And Adhesion Receptor Expression In Human Blood Cells: An In Vitro Study, Nibedita Dalpati, Shubham Kumar Rai, Divya Singh, Shiba Prasad Dash, Sukanti S. Sarangi, Mahabahu Nayak, Pranita P. Sarangi

Indian Journal of Research in Homoeopathy

Background: Homoeopathic medicines are used extensively for the treatment of many human diseases and are shown to affect immune cell functions. However, our understanding of the immunomodulatory effects of such medicines and associated mechanisms of action remains limited. Objectives: The present study aims to investigate the immunomodulatory effects of Arsenic album, Rhus toxicodendron, Hepar sulphuris and Bryonia alba on lipopolysaccharide (LPS) induced peripheral blood neutrophils and monocytes. Materials and Methods: In this work, neutrophils and monocytes were treated with different homoeopathic dilutions of 30C potency separately, followed by stimulation with the LPS, to examine the immunomodulatory effects of these …

Systemic Inflammation Is Associated With Disease Extent And Survival In Oral Cavity Squamous Cell Carcinoma, Brendan Coutu, Dallin N. Christensen, Evan Ryan, Elizabeth Bradford Bell, Weining Zhen, Zafar Sayed

Graduate Medical Education Research Journal

Background: Although systemic immune-inflammation index (SII) correlates with patient survival in various solid malignancies limited information is available in the setting of oral cavity squamous cell carcinoma (OCSCC).

Methods: We retrospectively reviewed 222 patients who underwent a resection of curative intent for patients with OCSCC. SII was determined prior to surgical resection as platelet count × neutrophil count/lymphocyte count.

Results: At a median follow-up of 30.6 months, 2-year disease-free survival (DFS) and overall survival (OS) rates were 63.9% and 76.4%, respectively. A high SII (>1047) was associated with poor performance status and disease extent. A low SII was independently …

Peran Penting Inflamasom Nlrp3 Pada Aterosklerosis, Dewi Sukmawati

Jurnal Penyakit Dalam Indonesia

Cardiovascular diseases (CVDs) still contribute as the main cause of mortality and premature mortality worldwide. In Indonesia, CVDs contribute to 35% of the main cause of death in non-communicable diseases followed by diabetes at 6%. The ischemic heart disease and acute ischemic stroke is the main cause of death in Indonesia due to atherosclerosis. Atherosclerosis is a multifactorial cause, with chronic inflammation which causes myocardial infarction and acute ischemic stroke. Research demonstrated that one of the underlying mechanisms of atherosclerosis is inflammation. The current research suggested that inflammation could activate a complex of cytosol proteins, namely nucleotide-binding oligomerization domain-like receptor …

Management Of Pelvic Inflammatory Disease With Individualised Homoeopathic Medicine Natrum Muriaticum In Lm Potency: A Case Report, Lalit Tyagi, Shraddha Khanna

Indian Journal of Research in Homoeopathy

Introduction: Pelvic inflammatory disease is a group of disorders that affects the female genital tract having varied presentation, ranging from asymptomatic to symptoms of reproductive disability, infertility, ectopic pregnancy, etc. With the homoeopathic treatment, promising results have been seen in research on various clinical disorders but there is paucity of research in the field of pelvic inflammatory disorders. A case of pelvic inflammatory disease, treated with individualized homoeopathic medicine is presented. Further research is needed to confirm the role of homoeopathy in pelvic inflammatory disease.

Case summary: A 38-year-old woman presented with pain in the lower abdomen, discharge …

Hif-1 Activation And Inflammatory Responses To Hypoxia, Shazreen Shaharuddin, Nik Mohd Afizan Nik Abd Rahman, Mas Jaffri Masarudin, Mohammedarfat N Alamassi

International Journal of Aviation, Aeronautics, and Aerospace

Acute hypoxia is a significant physiological danger during high-altitude flying and military aircraft missions. The human brain requires a constant supply of oxygen to function properly, and is susceptible to settings with low availability of air oxygen. Hypoxia can influence inflammatory signalling, and both central and systemic responses can activate HIF pathway genes. HIFs are critical molecules that regulate inflammation andhypoxia, ensuring appropriate cell function and survival. Hypoxia is the condition in which insufficient oxygen reaches the body's tissues. It can be caused by a decrease in partial oxygen pressure (PO2) in the environment, problems with breathing and/or oxygen transport, …

Resveratrol Attenuated High Intensity Exercise Training-Induced Inflammation And Ferroptosis Via Nrf2/Fth1/Gpx4 Pathway In Intestine Of Mice, Zhe Xu, Xiaonan Sun, Bin Ding, Ming Zi, Yan Ma

Turkish Journal of Medical Sciences

Background/aim: Moderate exercise has beneficial effects for human health and is helpful for the protection against several diseases. However, high intensity exercise training caused gastrointestinal syndrome. Resveratrol, a plant extract, plays a vital role in protecting various organs. However, whether resveratrol protected mice against high intensity exercise training-induced intestinal damage remains unclear. In this study, our objective was to investigate the protective effects and mechanism of resveratrol in high intensity exercise training-treated mice. Materials and methods: Mice were treated with swimming exercise protocol and/or resveratrol (15 mg/kg/day) for 28 consecutive days. Then, the mice were sacrificed, and a series of …

The Effects Of Tarantula Cubensis Extract On Renal Ischemia Reperfusion Injury In Rats, Sai̇me Özbek Şebi̇n, Tuncer Nacar, Ayhan Tanyeli̇, Ersen Eraslan, Mustafa Can Güler, Erdem Toktay, Eli̇f Polat, Hati̇ce Tuğçe Gedi̇k

Turkish Journal of Medical Sciences

Background/aim: Renal ischemia-reperfusion (IR) related acute kidney injury (AKI) is an important health problem and has not yet been fully treated. Tarantula cubensis extract (TCE) is a homeopathic drug that has antiinflammatory and antioxidant effects. This study aimed to investigate the effects of TCE on renal ischemia-reperfusion injury in rats. Materials and methods: This study was carried out on 48 Spraque-Dawley male rats, which were divided into six groups. The first, second, and third groups were control, sham, and IR groups, respectively. Group four received IR and 0.2 mL of 96% ethanol. Group five and six received ischemia and reperfusion …

The Role Of Superb Microvascular Imaging In Detecting Low-Grade Inflammation Among Adults And Those With Chronic Kidney Disease: A Preliminary Study, Alaaddi̇n Nayman, Nusret Seher, Mehmet Öztürk, Hali̇l Özer, Gülperi̇ Çeli̇k

Turkish Journal of Medical Sciences

Background/aim: Pathophysiologic changes associated with chronic inflammation occur with aging and more prominently in patients with chronic kidney disease (CKD), and an association between chronic inflammation and muscle wasting has been identified. The microcirculation is extremely sensitive to the inflammatory process and actively participates in it. In a healthy adult, angiogenesis is a strictly controlled and rare occurrence. However, aberrant angiogenesis and the development of new tiny blood vessels are known in chronic inflammatory diseases. Superb microvascular imaging (SMI) is a noninvasive technique that can evaluate tiny vessels with low blood flow and provide quantitative data. Our goal was to …

Effects Of Acute Aerobic Exercise On Circulating Stlr And Srage Profiles In Normoglycemic And Insulin-Resistant Individuals, Ryan K. Perkins

International Journal of Exercise Science: Conference Proceedings

Impaired blood glucose regulation as a consequence of insulin resistance is linked to development of many clinical conditions, including cardiovascular disease, Alzheimer’s, and skeletal muscle wasting via inflammatory processes. Recent evidence suggests circulating solubilized Toll-Like Receptor (sTLR) and Receptor for Advanced Glycation Endproducts (sRAGE) originate from skeletal muscle and are related to glucose management and inflammation. PURPOSE: The purpose of this investigation was to explore 1) relationships among sTLR and sRAGE profiles and indices of metabolic health and 2) sTLR and sRAGE responses to an acute bout of aerobic exercise (AE) in normoglycemic (NG) and insulin-resistant (IR) individuals. We hypothesized …

Lessons From Sicilian Centenarians For Anti-Ageing Medicine. The Oxi-Inflammatory Status, Calogero Caruso, Giulia Accardi, Anna Aiello, Anna Calabrò, Mattia Emanuela Ligotti, Giuseppina Candore

Translational Medicine @ UniSa

Population ageing is a great achievement of humanity, but it also represents a challenge that the Western world is currently facing, as ageing is associated with increased susceptibility to age-related inflammatory diseases. Therefore, it is necessary to fully understand the mechanisms of healthy ageing to prevent the harmful aspects of ageing. The study of long living ndividuals (LLIs) is a great model for trying to achieve this goal. Accordingly, the oxy-inflammatory status of Sicilian LLIs was reviewed in the present paper. Based on the reported data, anti-inflammatory and anti-oxidative stress strategies have been discussed, useful for delaying or avoiding the …

Measuring Pro- And Anti-Inflammatory Biomarkers Among Low-Income Hispanic Adults: A Feasibility And Pilot Assessment, Charles F. Hodgman, Emily C. Lavoy, Craig Johnston, Ezemenari Obasi, Rosenda Murillo, Sandra Yan, Daniel P. O'Connor, Lorna Mcneill, Lorraine R. Reitzel, Daphne C. Hernandez

Health Behavior Research

Using the Orsmond and Cohen feasibility framework, the primary aim of this study was to assess the feasibility of the implementation of recruitment strategies, data collection procedures, and managerial resources needed to assess pro- and anti-inflammatory biomarkers from low-income, younger Hispanic adults. The secondary aim of this study was to describe the relationship between discrimination stress and inflammation as pilot work for future studies. Data were collected in a Houston-area community center from self-identifying Hispanic adults (ages 21–35) (August 2018). Inflammation was evaluated from blood samples, and interviewer-administered surveys in participants’ preferred language measured discrimination stress (Hispanic Stress Inventory-2 discrimination …

Obesity As A Risk Factor For Covid-19, Gabriela Hermes, Mir Saleem

Mako: NSU Undergraduate Student Journal

The coronavirus pandemic has presented a wide range of challenges for healthcare systems in the world. COVID-19 has infected millions of people, with approximately 90% of the population showing mild or no symptoms. The disease has some risk factors that increase its severity, such as obesity, age, diabetes, cardiovascular diseases, suppressed immune system, and pulmonary disorders. Obese individuals have higher chances of having symptomatic COVID-19 infection with excessive rates of hospitalization and ICU admission. Understanding the mechanisms defining the link between COVID-19 and obesity is necessary to develop preventive measures and therapeutic interventions for people with obesity. Patients with obesity …

The Effect Of Omega-3 As Diet-Enhanced Immunity On Sepsis Outcome In Critically Ill Patients, A Abd El Rhaman, Hatem A. Attallah, Marwa M. Taha, Wesam E. Salutan

Menoufia Medical Journal

Background Nutritional supplementation of omega-3 fatty acids has been proposed to modulate the balance of proinflammatory and anti-inflammatory mediators in sepsis and acute lung injury. Objectives To evaluate the effect of omega-3 fatty acids as diet-enhanced immunity on sepsis outcome in critically ill patients. Patients and methods Sixty patients with early sepsis were divided equally into two groups: group A who received high-dose omega-3 fatty acids for consecutive 7 days besides conventional sepsis treatment, group B: control group who received only conventional sepsis treatment. Both groups were followed up by inflammatory markers, sequential organ failure assessment score monitoring, need for …

Periodontal Disease And Covid-19, Zhaozhao Chen Dds, Ms, Phd, Laurie K. Mccauley Dds, Ms, Phd, Purnima S. Kumar Bds, Ms, Phd, Hom-Lay Wang Dds, Ms, Phd

The Journal of the Michigan Dental Association

As the gateway to the respiratory system, the oral cavity can play an essential role in SARS-CoV-2 invasion and transmission. Besides high expression of angiotensin‐converting enzyme 2 (ACE2), the oral cavity can harbor viral particles in saliva, gingival crevicular fluid, and the periodontal pocket. Microbial and inflammatory associations closely link periodontitis and COVID-19. In this review, we summarize the possible oral manifestations of COVID‐19, its association with periodontal diseases, the plausible underlying mechanisms of microbial and inflammatory crosstalk between COVID‐19 and periodontal diseases, and mitigation protocols during periodontal treatment.