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Spirituality And Spiritual Self-Care: Expanding Self-Care Deficit Nursing Theory, Mary Louise White

Wayne State University Dissertations

The purpose of this study was to extend the theory of self-care deficit nursing by including specific constructs of religion, spirituality, and spiritual self-care practices within the structure suggested by Orem's self-care deficit nursing theory. Based on an extensive literature review, practice experience, and a discovery theory-building approach, a new mid-range theory called White's theory of spirituality and spiritual self-care (WTSSSC) was developed. To begin to test this mid-range theory, empirical indices of many of the main concepts were identified from prior studies and one new instrument (the Spiritual Self-Care Practice Scale) was developed. Hypothesized relationships among the main concepts …

Application Of Magnetic Resonance Imaging To Understanding The Pathogenesis Of The X-Linked Leukodystrophy Pelizaeus-Merzbacher Disease, Jeremy Jerome Laukka

Wayne State University Dissertations

Myelin is a multilamellar membrane structure surrounding axons in both the CNS and PNS that facilitates nerve conduction. In the CNS, myelin is synthesized by oligodendrocytes, while in the PNS, myelin is synthesized by Schwann cells. In the CNS, Proteolipid protein 1 (PLP1), an integral membrane protein, is the major protein component of myelin, constituting ~50% of myelin protein. Mutations of the PLP1 gene in man cause a spectrum of neurological disease, ranging from the severe Pelizaeus-Merzbacher disease (PMD), that typically begins during infancy with nystagmus, seizures and hypotonia and evolves into spastic quadriparesis, cognitive impairment and ataxia, to ¡¥pure¡¦ …

Effect Of Dietary Folate Restriction On Colon Carcinogenesis In Dna Polymerase Β Haploinsufficient Mice, Lisa F. Ventrella Lucente

Wayne State University Dissertations

The data presented in this research is central to establishing the role that the base excision repair pathway (BER) plays in the development and progression of colon cancer when dietary folate is deficient. Both cellular folate restriction and BER deficiencies have been shown to result in the accumulation of endogenous damage and lesions that could eventually develop into carcinogenesis. In this study, a dietary folate deficiency (FD) resulted in a significant increase in aberrant crypt foci (ACF) formation and triggered liver tumorogenesis in wildtype (WT) animals, as did a BER deficiency in DNA polymerase Β haploinsufficient (Β-pol+/-) mice exposed to …

The Influence Of Religion And Spirituality On Rehabilitation Outcomes Among Traumatic Brain Injury Survivors, Brigid Waldron-Perrine

Wayne State University Dissertations

The long-term consequences of traumatic brain injury affect millions of Americans, many of whom report using religion and spirituality to cope. Little research, however, has investigated how various elements of the religious and spiritual belief systems affect rehabilitation outcomes. The present study sought to assess the use of specifically defined elements of religion and spirituality as coping resources in a sample of traumatically brain injured adults. Furthermore, various mechanisms by which religion and spirituality may affect outcome were explored.

The sample included 88 adults with brain injury from 1 to 20 years post injury and their knowledgeable significant others (SOs). …

The Interictal State In Epilepsy And Behavior, Daniel Tice Barkmeier

Wayne State University Dissertations

Epilepsy is one of the most common neurological diseases, affecting up to 1% of the world population. Epilepsy remains poorly understood and there are currently no medications to cure it. Patients with epilepsy have both seizures as well as another type of abnormal activity between seizures, known as interictal spikes. Interictal spikes have thus far been poorly researched, yet growing evidence supports an important role for them in epilepsy. In this project, we first show the high variability between reviewers in marking interictal spikes on intracranial EEG, and then develop and test an automated detection method to solve this problem. …

Adaptive Radiation Therapy Of Prostate Cancer, Ning Wen

Wayne State University Dissertations

ART is a close-loop feedback algorithm which evaluates the organ deformation and motion right before the treatment and takes into account dose delivery variation daily to compensate for the difference between planned and delivered dose. It also has potential to allow further dose escalation and margin reduction to improve the clinical outcome. This retrospective study evaluated ART for prostate cancer treatment and radiobiological consequences. An IRB approved protocol has been used to evaluate actual dose delivery of patients with prostate cancer undergoing treatment with daily CBCT.

The dose from CBCT was measured in phantom using TLD and ion chamber techniques …

Examining The Relationship Between Spiritual Resources, Self-Efficacy, Life Attidues, Cognition, And Personal Characteristics Of Homeless African American Women, Jean Gash

Wayne State University Dissertations

African Americans comprise 12% of the American population and 45% of the homeless sheltered population (United States Department of Housing and Urban Development [HUD], 2007). The fastest growing segment is African American women and African American women with children. The purpose of this study was to examine the relationship between spiritual resources, self-efficacy, life attitudes, cognition, and personal characteristics (e.g., physical and mental health, age, marital status, number of children, number and length of times homeless and perceptions of being at risk for serious illness) of homeless African American women from 30 years of age and older who were trying …

Is Private Long-Term Care Insurance Affordable For Older Adults?, Nayoung Kim

Wayne State University Dissertations

Nationwide there are fewer than 7 million long-term care (LTC) insurance policies in force. Why do so few Americans buy private long-term care (LTC) insurance? Several theories have been offered as possible explanations, including the availability of Medicaid, misperceptions that Medicare or other policies cover LTC, beliefs that one's own risk of needing LTC services is small, or desires to simply rely on children and spouses for LTC. This study examines another possible explanation - that private LTC insurance is simply "unaffordable" for most older Americans, which may be why they don't buy it.

This study begins by investigating the …

Comparison Of Affective Analgesia And Conditioned Place Preference Following Cholinergic Activation Of, Elena Schifirnet

Wayne State University Dissertations

Activation of the dopaminergic mesolimbic reward circuitry that originates in the ventral tegmental area (VTA) is postulated to preferentially suppress affective reactions to noxious stimuli (affective analgesia, AA). VTA dopamine neurons are activated via cholinergic inputs, and we have observed that microinjections of the acetylcholine agonist carbachol suppressed vocalizations of rats that occur following administration of brief (1 sec) tail-shocks (vocalization afterdischarges = VAD). VADs are a validated rodent model of pain affect. In addition, the capacity of carbachol to support reinforcement appears to be regionally dependent within VTA. Ikemoto and Wise (2002) reported that carbachol was self-administered in the …

The Experience Of Chronic Pain As Described By African American Indigent Adults Attending An Urban Primary Care Clinic, Jamie Alexandra Crawley

Wayne State University Dissertations

Background: Inadequate chronic pain control has far-reaching implications including costs for missed time at work; utilization of health care resources and reduced quality of life. People at highest risk for inadequate pain control include indigent adults and minorities. Newman's theory health as expanding consciousness views the chronic pain experience as a life pattern within health. Qualitatively examining chronic pain from participants' perspectives may improve chronic pain care.

Purpose: The purpose of this study was to examine the experiences of chronic pain as described by African American indigent adults attending an urban, primary care clinic.

Methods: 13- participants (7 men and …

A Vignette Study Examining The Accuracy Of Diagnosis: The Role Of Patient And Practitioner Gender And Race Match, Kevin Johnson

Wayne State University Dissertations

ABSTRACT

DIAGNOSING MENTAL ILLNESS

By

KEVIN JOHNSON

2010

Advisor: Dr. Janet R. Hankin

Major: Medical Sociology

Degree: Doctor of Philosophy in Sociology

A convenience snowball sample of 228 mental health practitioners were surveyed and administered two vignettes of persons with mental illness and a 12-question survey that included occupational background and attitudinal questions about diagnosing mental illness. The gender and race of the patients were randomly altered, while the symptoms and characteristics of mental illness remained constant for each vignette. Each practitioner assigned a DSM-IV diagnostic label for axis I and axis II on both vignettes. The surveys were coded …

Physical Activity Levels In Obese And Non-Obese Women And Their Relationship With Body Mass Index, Perceived Self-Efficacy, Perceived Benefits And Barriers Of Exercise, And Commitment To A Plan Of Action, Rose Lange

Wayne State University Dissertations

The purpose of this descriptive correlational study was to examine relationships among selected variables and concepts within the Health Promotion Model (perceived benefits, perceived barriers to exercise, self-efficacy, commitment to plan of action) in non-obese and obese women with a focus on the behavioral outcome of physical activity (leisure & lifestyle). A group of 137 women, aged 18-50 participated in this study. BMI was found to be positively correlated to an individual's perceived barriers to action. Findings did not support the hypothesis that as BMI increases perceived benefits, self-efficacy, commitment to a plan of action and physical activity levels would …

Communicative Competence In Persons With Aphasia: The Impact Of Executive Function, Judy Marie Mikola

Wayne State University Dissertations

The purpose of this study was to examine the relationship between executive function and performance on selected linguistic tasks in persons with aphasia secondary to left frontal lesions.

A group of 15 persons with aphasia (PWA) completed three communication board tasks of varying levels of complexity and structure. The subject's functional use of the picture/word communication board was tested during a Story Retelling task. In addition, the PWA's executive function skills were examined using six nonverbal tests. The PWA group performance scores were compared to that of the neurologically healthy control group.

Results demonstrated that the control group performed significantly …

Development And Validation Of A Measurement Scale To Analyze The Environment For Evidence-Based Medicine Learning And Practice By Medical Residents, Fangqiong Mi

Wayne State University Dissertations

A growing number of residency programs are instituting curricula to include the component of evidence-based medicine (EBM) principles and process. However, these curricula may not be able to achieve the optimal learning outcomes, perhaps because various contextual factors are often overlooked when EBM training is being designed, developed, and implemented. The purpose of the study was to develop and validate an instrument, the EBM Environment Scale, to analyze the environment for EBM learning and practice as perceived by medical residents.

The development of the EBM Environment Scale underwent the process of content domain identification, item generation, review by content experts …

Drosophila Nicotinamidase And Sir2 In Longevity Regulation And Oxidative Stress Response, And The Implications For Aging Theory, Gregory Miller

Wayne State University Dissertations

The protein deacetylase Sir2 has been shown to increase lifespan in a variety of organisms, possibly through its ability to engender the effects of dietary restriction. The Drosophila nicotinamidase DNAAM increases lifespan in a Sir2 dependant manner, and may play a role in oxidative stress resistance. Oxidative damage that accumulates in cells during normal aging contributes to a variety of diseases and pathologies, and can result in an increase in age specific mortality. Accordingly, the oxidative stress theory of aging predicts that organisms with an increased tolerance to oxidative damage will have an increased longevity, while organisms with decreased tolerance …

2001 Michigan Hospital Cqi/Tqm Study, Colleen L. Croxall

Wayne State University Dissertations

In recent years, there has been significant interest in the application of total quality management/continuous quality improvement (TQM/CQI) within health care organizations. The health care industry, in its quest to improve outcomes with fewer resources, began to look at CQI/TQM as a possible solution. To date, the most comprehensive and enthusiastic response to efforts to improve quality while containing or lowering costs is reflected in hospitals' commitment to continuous quality improvement/total quality management (CQI/TQM). The health care industry, particularly hospitals, has embraced the concepts of CQI/TQM with the belief that adoption will lead to an improvement in both the quality …

Ethical Decision Making By Hospital Nurses (Work Alienation), Jonathon Lawrence Cox

Wayne State University Dissertations

The hospital nurse is required to make decisions that affect the lives of patients. The American Nurses Association Code for Nurses ought to be the framework used by nurses in making those ethical decisions. The Code is not the primary basis for ethical decision making as has been shown in this and previous research. In this research the role of hospital employer, personal and professional values of staff nurses has been examined for their influence on the ethical decisions made by nurses. The nurses completed the Health Care Work Powerlessness Scale, and the Nursing Dilemmas Test and Ethical Behavior Inventory. …