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Communicative Competence In Persons With Aphasia: The Impact Of Executive Function, Judy Marie Mikola Jan 2010

Communicative Competence In Persons With Aphasia: The Impact Of Executive Function, Judy Marie Mikola

Wayne State University Dissertations

The purpose of this study was to examine the relationship between executive function and performance on selected linguistic tasks in persons with aphasia secondary to left frontal lesions.

A group of 15 persons with aphasia (PWA) completed three communication board tasks of varying levels of complexity and structure. The subject's functional use of the picture/word communication board was tested during a Story Retelling task. In addition, the PWA's executive function skills were examined using six nonverbal tests. The PWA group performance scores were compared to that of the neurologically healthy control group.

Results demonstrated that the control group performed significantly …


Development And Validation Of A Measurement Scale To Analyze The Environment For Evidence-Based Medicine Learning And Practice By Medical Residents, Fangqiong Mi Jan 2010

Development And Validation Of A Measurement Scale To Analyze The Environment For Evidence-Based Medicine Learning And Practice By Medical Residents, Fangqiong Mi

Wayne State University Dissertations

A growing number of residency programs are instituting curricula to include the component of evidence-based medicine (EBM) principles and process. However, these curricula may not be able to achieve the optimal learning outcomes, perhaps because various contextual factors are often overlooked when EBM training is being designed, developed, and implemented. The purpose of the study was to develop and validate an instrument, the EBM Environment Scale, to analyze the environment for EBM learning and practice as perceived by medical residents.

The development of the EBM Environment Scale underwent the process of content domain identification, item generation, review by content experts …


Drosophila Nicotinamidase And Sir2 In Longevity Regulation And Oxidative Stress Response, And The Implications For Aging Theory, Gregory Miller Jan 2010

Drosophila Nicotinamidase And Sir2 In Longevity Regulation And Oxidative Stress Response, And The Implications For Aging Theory, Gregory Miller

Wayne State University Dissertations

The protein deacetylase Sir2 has been shown to increase lifespan in a variety of organisms, possibly through its ability to engender the effects of dietary restriction. The Drosophila nicotinamidase DNAAM increases lifespan in a Sir2 dependant manner, and may play a role in oxidative stress resistance. Oxidative damage that accumulates in cells during normal aging contributes to a variety of diseases and pathologies, and can result in an increase in age specific mortality. Accordingly, the oxidative stress theory of aging predicts that organisms with an increased tolerance to oxidative damage will have an increased longevity, while organisms with decreased tolerance …