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Mobile Health Technology To Enhance Healthcare Service Delivery In Developing Nations (Saudi Arabia), Nawaf Khan

Electronic Theses and Dissertations, 2020-

Saudi Arabia is among the countries that have very high prevalence rates of diabetes and hypertension, with prevalence rates of almost 18% and 25%, respectively. The majority of patients with diabetes and hypertension fail to manage their diseases and to show up for their follow up appointments. Mhealth technology is among the interventions that have been recently adopted to overcome these issues and improve the quality of healthcare services. This study aims to evaluate the effectiveness of a mobile phone application named diabetes and hypertension application (DHA Tracking) to promote adherence for patients with diabetes and hypertension in Mecca, Saudi …

A Computational Biomechanical Model-Based Optimization Of Fulcrum Support In Orthosis Enabled Closed Reduction Of Developmental Dysplasia Of The Hip, Christopher Rose

Electronic Theses and Dissertations, 2020-

Hip abduction orthosis devices (HAOD) are used to reduce the hip joint of infants affected by developmental dysplasia of the hip (DDH). HAOD have been successful for mild cases of DDH and ineffective for severe cases. Efforts in understanding the biomechanics of lower limbs have been made to improve the success rate of current treatment methods, especially for Grade IV dislocations (G4). The aim of this dissertation is twofold: first, it proposes the use of a varying fulcrum point (FP) located below the leg to improve DDH treatment; and secondly, it defines the optimal FP (OP) location for a broad …

Single Cell Forensic Genomics - Dna Profiling Of Micromanipulated Single Spermatozoa, Haley Hardin

Electronic Theses and Dissertations, 2020-

Current U.S. National guidelines allow for the collection of sexual assault evidence up to 5 days after the incidence occurs. In these cases, the ability to obtain an autosomal STR (aSTR) profile of the male donor in these cases diminishes as the time interval increases. This inability to recover an aSTR profile from the semen donor is not due to a complete lack of sperm cells, as studies have frequently shown that sperm persists in the vaginal canal or cervix up to 10 days post coitus. Thus, the inability to recover an aSTR profile of the sperm donor is likely …

Early Host Defense Mechanisms Against La Crosse Virus Infection, Maria A. Cruz Zamora

Electronic Theses and Dissertations, 2020-

Given the importance of innate defense mechanisms in the skin, we have examined the interactions of the arbovirus La Crosse virus (LACV) with serum factors that serve as a first line of antiviral defense, and the outcome of LACV infection of human keratinocytes, one of the main cell types present at viral entry. Incubation of LACV derived from insect cells (I-LACV) with normal human serum in vitro did not result in neutralization, but instead stabilized LACV virions and enhanced infectivity. Enhanced infectivity was also seen with heat inactivated serum devoid of complement activity and with serum from a range of …

The Effect Of Interventions On Radiotherapy-Induced Skin Toxicity: A Systematic Review, Claudia R. Figueroa

Honors Undergraduate Theses

Various studies show a variety of interventions for radiotherapy-induced skin toxicity. Radiotherapy-induced skin toxicity is the most common side effect for women with breast cancer who undergo radiotherapy sessions. Intervention agents include topical creams, barrier films, oral agents, as well as laser therapy. However, despite the variety of intervention agents available, there is still a lack of accepted guidelines to manage radiotherapy-induced skin toxicity. This thesis aims to conduct a systematic review and meta-analysis of published randomized controlled trials with the primary purpose of exploring the available intervention methods to prevent radiotherapy-induced skin toxicity and evaluate the effects of different …

The Effects Of Modifiable And Non-Modifiable Risk Factors On The Severity Of Gastroparesis-Like Symptoms, Jonathon B. Nelson

Honors Undergraduate Theses

Gastroparesis (GP) is a clinical disorder recognized by measured delayed gastric emptying without mechanical obstruction, in addition to symptoms such as nausea, vomiting, chronic abdominal pain, heartburn, early satiety upon eating a regular-sized meal, and exaggerated postprandial fullness. While GP is considered a clinically rare disorder, there is much suspicion that a much larger number of patients experience GP-like symptoms without an official diagnosis. Furthermore, little work has been done to identify the causes and exacerbations of this gastrointestinal (GI) distress in the young adult population. This study's primary goal was to establish a relationship between modifiable and non-modifiable risk …

Social Stigma, Public Health, And Addiction In Albania, Ediola Malkouari

Honors Undergraduate Theses

Drug use is considered in many countries the plague of today's society. Researchers from medical, psychological and sociological fields, as well as lawmakers, are interested in finding more answers to this widespread phenomenon. All over the world there are known conflicts related to drug producing, transportation routes and distribution, that harm the economy and social standing of the involved communities or countries. Policies towards drug use vary from country to country, but this research focuses on how stigma affects the lives of individuals suffering from substance use disorder (SUD) in Albania. Substance use disorder is not often considered a disease, …

The Relationship Between Parent And Child Health Behaviors In Youth With Autism Spectrum Disorder, Elise M. Arnold

Honors Undergraduate Theses

Previous studies found that children with ASD tend to participate in lower amounts of physical activity (PA), accumulate greater hours of screen time (ST), and have poorer sleep quality (SQ), compared to typically developing (TD) youth. Unfortunately, these poor health behaviors put youth with ASD at a high risk for developing obesity, as well as other obesity-related conditions (e.g. Type 2 diabetes). In order to reduce this risk, it is critical to understand the factors that affect activity levels and sleep in youth with ASD. Several studies have demonstrated that parents may have a large influence on social behaviors in …

Determining The Advantageous Acute Migraine Treatment: Rimegepant And Lasmiditan Review Of Literature, Tiffany A. Johnson

Honors Undergraduate Theses

This research aims to evaluate two new pharmaceuticals on the market. Rimegepant and Lasmiditan target the trigeminovascular system and respectively, are characterized in the gepant and ditan classes of pharmaceuticals. Based on a review of studies, Rimegepant was determined to be the advantageous acute treatment. This is not conclusive due to inequivalent comparison in sample size and amount of research completed. It is encouraged for additional research to be imposed before a conclusive determination of the advantageous acute treatment can be distinguished.

Perceptions Of Oral Health Access Among Foreign-Born College Students, Rahema Khan

Honors Undergraduate Theses

Oral health plays an integral role in our general health, wellbeing, and quality of life. Practicing evidence-based oral hygiene behaviors prevent oral diseases and improve systemic health. The burden of preventable oral diseases persists worldwide and weighs particularly heavy on specific population groups. While many studies have explored oral health among those of advanced age, children, and minority groups, there are a very few exploring the oral health care needs of postsecondary students, specifically those born outside of the United States (U.S.). Recognizing this gap in the literature, this study sought to gain a better understanding of oral health access …

Detection Of A Peptide Hormone - Somatostatin - Label-Free Split-Aptameric Probes, Charles A. Dowis

Honors Undergraduate Theses

Peptide hormones are important biomolecules that transduce downstream effects such as cell proliferation, regulation, and gene expression. Their levels have been upregulated in various disorders such as cancer, yet detection methods are lacking. We designed two split aptamer-based assays for the detection of a peptide hormone – Somatostatin (SST) – with different signal readouts: fluorescent readout based on light-up aptamers and the colorimetric readout of ABTS peroxidation from a G-quadruplex. We used an already selected split-aptamer –SSTA5–for SST for our designs and we had expected the developed detection systems to exhibit detection and quantification capabilities that would hopefully allow their …

Hospital Footwear As A Vector For Organism Transmission, David J. Frederick

Honors Undergraduate Theses

In the United States healthcare system, nearly one in 31 patients contract a nosocomial infection. Footwear worn in these hospital settings are a factor that should be considered when determining contributing agents and methods for organism transmission. The purpose of this review is to synthesize the current research on hospital footwear as a vector for organism transmission. Eight studies were included in this review to examine the impact of wearable interventions on footwear-related contamination in the hospital setting and organism transfer as it relates to footwear and hospital environments. The link between the organism load and diversity on hospital worn …

The Effects Of Roundup On The Life History, Stress Response, And Immune Function Of The Yellow Fever Mosquito, Aedes Aegypti, Lindsay E. Martin

Honors Undergraduate Theses

Aedes aegypti mosquitoes, vectors for many human diseases, begin life as larvae developing in water, potentially exposed to runoff with herbicides and pesticides. This study serves as a novel investigation into the transstadial effects of exposure to Roundup on A. aegypti life history, immunity, and stress response and aims to account for these effects in an R0 model for vectorborne disease transmission. Prior work has shown that Roundup negatively affects mosquito life history. I hypothesized that larval exposure to the maximum sublethal dose of Roundup (7189µg/L) would negatively impact A. aegypti life history, immunity (candidate gene approach), and stress response …

Novel Roles Of Rip2 In Inflammation And Resolution, Michael Shehat

Electronic Theses and Dissertations, 2020-

Receptor-interacting protein 2 (RIP2) is a kinase which mediates signaling downstream of the bacterial peptidoglycan sensors Nucleotide-binding Oligomerization Domain (NOD) 1 and 2. Genetic loss or pharmaceutical inhibition of RIP2 has been shown to be beneficial in multiple inflammatory disease models with the effects largely attributed to reducing pro-inflammatory signaling downstream of peptidoglycan recognition. However, given the widespread expression of this kinase and its reported interactions with numerous other proteins, it is possible that RIP2 has many other unappreciated roles. In this work, we report the involvement of RIP2 in two novel pathways. First, we demonstrate a NOD2 dependent role …

Awareness Of The Unaware: Anosognosia As A Comorbidity In Mental Health Conditions, Tiffany L. Baula

Honors Undergraduate Theses

The primary purpose of this integrative review of the literature is to describe healthcare provider’s recognition of anosognosia in individuals with comorbid mental health disorders, as a differentiating diagnosis needing preeminent early intervention. The secondary purpose is to examine how anosognosia influences outcomes in the population of individuals with severe mental illness. It is expected that early recognition by clinicians and implementation of additional interventions to address anosognosia as the most influential comorbidity of schizophrenia, will decrease exacerbations and improve treatment and patient outcomes.

A literature review exploring clinician’s acknowledgement of anosognosia was performed using various databases. Search terms included: …

Professional Liability Insurance For Athletic Trainers: A Cross Sectional Study Of Athletic Trainers Who Do Per Diem Work, Kameelah J. Belgrave

Honors Undergraduate Theses

Context: Many secondary school athletic trainers (ATs) complete per diem work as a way to supplement their income. Working per diem means the AT provides services to events that are not part of their main employment. Since this type of work is not connected to their main employment, the AT may lack appropriate professional liability insurance (PLI). PLI is a type of insurance that protects healthcare professionals from bearing the entire cost of defending a malpractice claim made by a former or current patient. Anecdotally, many ATs believe that the PLI provided by their main employer covers all health care …

The Effects Of A Plant-Based Diet On Inflammation Of Patients With Cardiac Disease, Rachel L. Butcher

Honors Undergraduate Theses

Cardiac disease is the primary cause of death in the United States of America (CDC, 2017). Despite ongoing efforts and investments to improve cardiac health in the United States, most of the population will suffer from cardiovascular diseases. There is a multitude of research supporting that diet can contribute to cardiac disease, but it is less known that diet can greatly contribute to regulation and reversal of cardiovascular disease processes (Huang et al., 2012; Satija et al., 2017; Kim et al., 2019). Existing research supports the efficacy of plant-based diets to manage and reverse certain cardiac diseases (Tuso et al., …

The Effects Of Vaping On Oral Streptococci And Oral Inflammation, Matthew Caldwell

Honors Undergraduate Theses

E-cigarette (e-cig) use is rising, but much is unknown about the effects of its vapor. This vapor contains chemicals such as propylene glycol, a known antimicrobial, and nicotine, whose derivatives are carcinogenic. Here, we study the effects of vaping on resident bacteria of the oral cavity and on oral cell inflammation. Oral streptococci are major residents in the oral cavity, with S. mutans the primary cause of dental caries. Growth and biofilm formation have been shown to be enhanced upon exposure to traditional cigarette smoke in vitro. In this study, we analyzed the effects of e-cig vapor on growth …

"It’S Just A Bad Period" And Other Ways Of Dismissing Women's Pain: An Ethnographic Look Into The Experience Of Endometriosis, Selina Hays

Honors Undergraduate Theses

This thesis uses online ethnographic methods to analyze the impact of patriarchal values on the illness experiences of women with endometriosis. Current literature suggests that negative impact on patients with endometriosis with regard to cultural discourse surrounding menstruation and chronic illness. Utilizing a combination of critical discourse analysis and constructivist grounded theory, the results of this research demonstrate that patients engage in a form of performance that is reactive to normalization and dismissal of pain by doctors and wider social support due in part to cultural stigmas of menstruation and chronic pain, as well as the inherent power imbalance in …

Pestilence And Poverty: The Great Influenza Pandemic And Underdevelopment In The New South, 1918-1919, Andrew Kishuni

Honors Undergraduate Theses

This study examines the "Spanish" influenza pandemic of 1918-1919 in the U.S. South, using case-studies of Jacksonville, Savannah, New Orleans, and Nashville to sculpt a "Southern flu" more identical to the Global South and the developing world than the rest of the U.S. I examine poverty and political and economic paralysis in the years between the end of Reconstruction and 1918, and the poor results of political indifference on public health and disease control. I also analyze the social and institutional racism against persons of color that defined high infectious disease mortality in Southern cities.

I argue that Southerners faced …

The Relationship Between Community Health Worker Supply And The Rate Of Preventable Hospitalizations Of Rural Latinos With Diabetes, Danielle O. Mapp

Honors Undergraduate Theses

The ever-increasing prevalence of diabetes mellitus and its associated healthcare costs in the United States has led to our healthcare system's need for cost-effective health resources and chronic disease management. The interventions of Community Health Workers (CHWs) can cost-effectively improve population health and prevent the unnecessary utilization of some medical services especially in rural, low-income, minority populations, where there is often limited access to healthcare. The purpose of this study is to investigate the relationship between the number of total CHWs in rural counties and the mean diabetes-related preventable hospitalization rates in Latino patients diagnosed with diabetes in those rural …

Exploring The Impact Of Pre-Exposure Prophylaxis Related To Sexual Behavior In College Men, Dalton J. Poe

Honors Undergraduate Theses

Pre-exposure prophylaxis (PrEP) is an effective tool for preventing human immunodeficiency virus (HIV) acquisition in sexually active at-risk individuals such as men who have sex with men (MSM). The purpose of this study is to examine factors associated with intent to engage in risky sexual behavior among HIV-negative college aged (18-24) MSM who are currently adherent to PrEP or who have expressed interest in the future adoption of PrEP. A multiracial/ethnic sample of 31 men expressing interest in the adoption of PrEP and 6 men currently taking PrEP completed a quantitative survey identifying key themes regarding attitudes towards PrEP and …

Millennial Attitudes Toward Telehealth: An Integrative Literature Review, Hannah Gwyneth Y. Tabora

Honors Undergraduate Theses

Purpose: The primary purpose of this research was to explore individuals born in the millennial generation’s likelihood of using telehealth and virtual office visits as a replacement for face to face provider interactions. The secondary purpose was to examine the feasibility and access of treatable conditions and ailments in a virtual environment.

Methods: A literature review exploring millennials and telehealth was performed using various databases with search terms combined to include: ‘millennials*’, ‘telehealth*’, ‘telemed*’, ‘finance*’, ‘primary care*’, ‘healthcare*’, ‘health knowledge*’, ‘literacy*’, ‘education*’, ‘misinformation*’. The data was conformed into tables that synthesized the relationship between the millennial generation and their access …

Development Of A Sox9 Reporter Cell For High-Throughput Chondrogenic Assessment, Alyssa R. Mickle

Honors Undergraduate Theses

Osteoarthritis (OA) is a debilitating disease caused by the deterioration of articular cartilage and is a leading cause of disability in the United States and worldwide. Much current research into improved treatment for this disease is focused on tissue engineering through the growth of cartilage sheets made by articular chondrocytes. However, as chondrocytes proliferate in vitro, they also lose their ability to produce dense extracellular matrix, a necessary component of articular cartilage conferring mechanical strength. SOX9, a transcriptional activator, increases type II collagen expression, a key articular cartilage extracellular matrix component. Thus, SOX9 promotes an articular cartilage phenotype. Therefore, …

Promotion Of Neuronal Regeneration: Upregulation Of Intrinsic Neuronal Growth Capacity Versus Microtubule Stabilization, Cathy Le

Honors Undergraduate Theses

Central Nervous System (CNS) injury may lead to irreversible damage to cognitive and motor abilities when injured. This is due to the inability of axons to regenerate. This thesis focuses on two methods of promoting axonal regeneration: microtubule stabilization and upregulation of the intrinsic growth capacity of the neuron via the mechanistic target of rapamycin (mTOR) pathway. Both have shown promising results in potentially being a therapeutic treatment for CNS trauma. This research seeks to (1) test a combinatorial method of axonal regeneration utilizing both methods simultaneously and (2) compare microtubule stabilization and upregulation of the mTOR pathway as neuronal …

The Association Between Testicular Cancer And Female Reproductive Cancers: A Systematic Review, Alyssa Church

Honors Undergraduate Theses

The most common neoplasm found in young to middle-aged men is testicular cancer (TCa). This disease not only poses a risk of early death, but can also affect a male's fertility and testosterone levels and can diminish one's mental health and/or quality of life. One particular line of research that is emerging in the field is a possible genetic association of TCa with female reproductive cancers. We employed a systematic review to assess the methodological quality of articles that met the inclusionary criteria. To be selected for this review, articles had to go through a primary, secondary, and tertiary screening …

Evaluation Of Remote-Based Learning Of A Nutrition Program For Adolescents With Autism Spectrum Disorder: A Covid-19 Pilot Study, Riley H. Shurack

Honors Undergraduate Theses

Introduction: Adolescents with Autism Spectrum Disorder (ASD) demonstrate poor health-related behaviors, such as nutrition, compared to their typically developed (TD) counterparts. With the occurrence of the COVID-19 pandemic and mandatory stay-at-home orders, such health-related behaviors may be complicated and there is a need to focus on feasibility and acceptability of in-person and remote-based nutrition programs.

Methods: Eleven high school students with ASD were recruited to participate in a modified nutrition program utilizing Zoom software during COVID-19. The duration was once a week for four weeks, and concepts reviewed included shopping for healthy food on a budget, introducing non-perishable …

Gelsolin-Mediated Actin Filament Severing In Crowded Environments, James Heidings

Electronic Theses and Dissertations, 2020-

Actin is an essential cytoskeletal protein that plays key roles in several cellular functions such as phagocytosis and cell motility with the help of actin binding proteins (ABPs). Gelsolin is a calcium regulated ABP that severs and caps actin filaments. Gelsolin helps control actin filament assembly dynamics that are required for cell survival. Cleavage products of gelsolin lead to Familial Amyloidosis, Finnish type, and conformational changes to gelsolin are implicated in disease progression. The majority of in vitro studies of gelsolin and actin have been performed in dilute buffer conditions which do not simulate the molecular interactions occurring in the …

Prescription Drug Abuse Amongst The Elderly, Michael O'Blenis

Electronic Theses and Dissertations, 2020-

This thesis attempts to document and illuminate the growing issue of prescription drug abuse among the elderly population. The average elder in the U.S. takes at least one prescription drug per day, depending upon their health status. Likewise, elders that suffer from multiple chronic conditions are more likely to take multiple prescription drugs. As the lifespan of humankind grows well into their 90's and older, even more elders will be placed on prescription drugs. As part of this study, a narrative literature review was conducted to summarize the topic of prescription drug abuse amongst the elderly. The findings suggest that …

Monitoring Pathological Gene Expression And Studying Endogenous Epigenetic Architecture By Crispr/Cas9-Based Tool Development Using Alpha-Synuclein As A Model, Levi Adams

Electronic Theses and Dissertations, 2020-

Until recently, complete understanding of the endogenous activity of pathologically relevant genes was out of reach and research was confined to in situ work, plasmid-based constructs and artificial model systems. The development and expansion of the CRISPR/Cas9 genome editing technique has enabled us to explore the molecular underpinnings of gene activation using the cell's own endogenous regulatory environment. In this work, we report on the development of a novel tool to monitor the endogenous activity of a causative gene in Parkinson's disease, a-synuclein. We use CRISPR/Cas9 to insert a highly sensitive engineered luciferase at the C-terminal of a-synuclein and assessed …