Digital Commons Network^™

Utilization And Costs Of Home Hemodialysis, In-Center Hemodialysis, And Peritoneal Dialysis Among Patients With End-Stage Renal Disease (Esrd) In The United States, Andres Mauricio Garcia Sierra

Electronic Theses and Dissertations, 2020-

Chronic kidney disease (CKD) is a condition that requires access to renal replacement therapies (RRTs) to enable patients to live. The use of such therapies has been continuously researched due to the high cost to payers and their patients. This dissertation aimed to analyze the incidence, prevalence, and mortality of renal replacement therapies in patients with end-stage renal disease (ESRD), and document cost trends and analyze possible inequalities in access to these therapies. Based on an integrated health risk management (IHRM) model, this study examined patient characteristics associated with renal replacement therapies in ESRD patients through a pooled cross-sectional study …

Exploring Risk Factors Associated With Post-Traumatic Stress Disorder Symptomatology In Police, Lori Camacho

Electronic Theses and Dissertations, 2020-

Mental health outcomes, especially post-traumatic stress disorder (PTSD), in police have become more of a concern for law enforcement administrators, peers, family and friends. Using culture as a theoretical framework, the current cross-sectional, convergent mixed methods study explored the relationship between personal cumulative exposure to different types of critical incidents and likelihood of reporting PTSD symptoms in a sample of officers (n=71) from one municipal police department. This study also examined how personal cumulative exposure to different types of critical incidents and likelihood of reporting symptoms of PTSD may be moderated by the degree of perception of social support from …

A Digitally Enhanced Virtual Cognitive Behavior Skill Building Intervention To Reduce Parent Stress And Family Obesogenic Behaviors, Sharlene Smith

Electronic Theses and Dissertations, 2020-

Parental stress is associated with increased obesogenic family lifestyle behaviors contributing to childhood obesity. Novel interventions are needed to reduce parental stress and improve healthy lifestyle behaviors for preschool-age children and families. The primary study aim was to analyze preliminary effects of a digitally enhanced evidence-based cognitive- behavior skill-building (CBSB) intervention on parental stress and healthy lifestyle behaviors (diet and physical activity) among parents of preschool-age children. A secondary aim was to evaluate feasibility/acceptability of this school-based virtual intervention during the COVID-19 pandemic. The 12-week intervention involved text messaging and three pre-recorded CBSB educational video presentations accessed by parents of …

Role Of Vitamin D, Folate, And Cobalamin Deficiency In Mycobacterium Avium Paratuberculosis Infection And Inflammation, Joseph Vaccaro

Electronic Theses and Dissertations, 2020-

Vitamin D, folate, and cobalamin (vitamin B12) are crucial micronutrients in human physiology that are necessary for healthy calcium, phosphorus, and single-carbon metabolism. Recent studies have indicated that these vitamins also affect the inflammatory response in ways unrelated to their well-characterized deficiencies. Accordingly, analysis of their effect on chronic inflammatory diseases like Crohn's disease (CD) is warranted. This investigation examines the effects of vitamin deficiency on macrophages and intestinal epithelial cells upon exposure to Mycobacterium avium paratuberculosis (MAP,) a pathogen capable of triggering CD, to model the inflammatory response in clinical CD patients. ELISA analysis of CD patient plasma established …

Topographical Distribution And Morphology Of Sympathetic Postganglionic Innervation And Chronic Intermittent Hypoxia (Cih) Induced Remodeling Of The Whole Heart At Single Cell/Axon/Varicosity Scale, Ariege Bizanti

Electronic Theses and Dissertations, 2020-

The sympathetic nervous system is crucial for controlling multiple cardiac functions and its overactivity is associated with many cardiovascular diseases (CVD). Chronic intermittent hypoxia (CIH) is a current model for sleep apnea, which constitutes a major risk factor for CVD through sympathetic overactivity. However, a comprehensive neuroanatomical map of the sympathetic innervation of the heart is unavailable which impedes our understanding of the remodeling of this map in pathological conditions. First, we used a combination of state-of-the-art techniques, including flat-mount tissue processing, immunohistochemistry for tyrosine hydroxylase (TH, a sympathetic marker), confocal microscopy and Neurolucida 360 software to trace, digitize, and …

Exploring The Impact Of Cultural Background Among Asian And Non-Hispanic White Populations On Organ Donation, Doyoung Ahn

Honors Undergraduate Theses

Background: The demand for organ donation is increasing but there is always a lack of organ donor supply. To receive an organ donation, specific criteria must be met. Matching criteria between the donor and the recipient is critically important. The likelihood of having a capable organ increases when the donors and recipients have the same ethnicity. However, the number of organ donors differ significantly based on ethnicity.

Purpose: The purpose of this literature review was to explore the impact of cultural background and education among the Asian and non-Hispanic White population on organ donation and how it impacts individuals' decisions …

The Effect Of L-Citrulline Supplementation On Blood Pressure: An Updated Systematic Review And Meta-Analysis Of Randomized Controlled Trials, Vraj Amin

Honors Undergraduate Theses

Cardiovascular disease remains one of the most prevalent diseases in the United States and has remained as the leading cause of death. Large Mendelian randomization studies have found significant correlations between high blood pressure and cardiovascular disease (CVD). In fact, high blood pressure is the single most important independent risk factor for CVD. The purpose of this study was to determine the effect of L-citrulline on blood pressure to determine whether it could be advised as an effective treatment for high blood pressure. L-citrulline is a naturally occurring amino acid that readily converts to L-arginine within the human body. L-arginine …

Evaluating Digital Cognitive Biomarkers As A Noninvasive Diagnostic Tool For Alzheimer's Disease: Correlations With Classic Csf Biomarkers, Kasey Corripio

Honors Undergraduate Theses

Alzheimer's Disease (AD) is a neurodegenerative disorder affecting over 35 million people. Early diagnosis and intervention are crucial for improving outcomes. Digital Cognitive Biomarkers (DCBs) offer a promising approach for early detection and disease management, quantifying cognitive processes of encoding and retrieval through a hierarchical Bayesian cognitive processing model using wordlist memory tests. We hypothesize that DCBs will correlate with classic AD cerebrospinal fluid (CSF) biomarkers (Aβ42, T-tau, p-tau) in patients with varying cognitive decline levels compared to healthy elderly controls. Using Alzheimer's Disease Neuroimaging Initiative (ADNI) data and paired Pearson correlation coefficient analysis, our results support the hypothesis, indicating …

Understanding School Shootings Using Qualitatively-Informed Natural Language Processing, Quan K. Do

Honors Undergraduate Theses

Prior literature has investigated the connection between school shootings and factors of familial trauma and mental health. Specifically, experiences related to parental suicide, physical or sexual abuse, neglect, marital violence, or severe bullying have been associated with a propensity for carrying out a mass shooting. Given prior research has shown common histories among school shooters, it follows that a person's violent tendencies can be revealed by their previous communications with others, thus aiding in predicting an individual's proclivity for school shootings. However, previous literature found no conclusions were drawn from online posts made by the shooters prior to the mass …

Post-Intensive Care Syndrome In Survivors Of Acute Respiratory Distress Syndrome (Ards) And Covid-19 Ards: A Descriptive Study, Sara Hassan

Honors Undergraduate Theses

Background: Post-intensive care syndrome (PICS) is an umbrella term for the long-term physical, cognitive, and mental health conditions survivors live with long after an ICU discharge. Mental health conditions experienced by survivors include anxiety, depression, and post-traumatic stress disorder (PTSD). Survivors of acute respiratory distress syndrome (ARDS) and COVID ARDS who were on a ventilator are particularly at risk of developing long-term mental health conditions.

Study Purpose: The purpose of this study was to investigate the severity of anxiety, depression, and PTSD in adult survivors of these two ARDS conditions (COVID ARDS; ARDS) who were admitted to intensive care units …

Nursing Interventions To Decrease Depressive And Anxious Symptoms In Hispanic-American Youth, Vanessa C. Hernandez

Honors Undergraduate Theses

Introduction: Hispanic-American youth are less likely to receive mental health services despite being at increased risk for depression and anxiety. Having depression and anxiety at a young age can have detrimental long-term effects such as sexual risk behavior, delinquency, and suicide. Various kinds of nurses interact with this age group which can be a missed opportunity to intervene for the welfare of these youth. Interventions exist for depression and anxiety; however, they are not specific to nurses who care for young Hispanic-American patients. Methods: An integrative literature review was performed to identify nursing interventions for Hispanic American youth with depression …

Therapeutic Gardening And Its Effects On Depressive Symptoms In Dementia Care, Shannon E. Norton

Honors Undergraduate Theses

Aim: To present a literature review of the positive effects and overall reduction of depressive symptoms that an intervention such as therapeutic gardening has on individuals living within memory care facilities.

Background: As most humans age, they often lose abilities or skills that they have had for their entire lives (e.g. driving, grooming, toileting, seeing and/or hearing). By implementing programs that involve therapeutic garden therapy, individuals with dementia who are at greater risk for clinical depressive symptoms may find that this alternative approach improves their symptoms.

Methods: A comprehensive, electronic, literature search in the CINAHL database was completed and included …

Benefits Of A Family-Based Judo Program For Parents Of Children With Autism Spectrum Disorder, Jeslin George

Honors Undergraduate Theses

A diagnosis of Autism Spectrum Disorder (ASD) can impact the entire family. Parents of children with ASD reportedly have greater stress levels, family conflict, financial concerns, and poor health habits than parents of neurotypical (NT) children. While many parent-focused interventions have been developed, these interventions focus on parent training and child behavior outcomes rather than the health and well-being of the parents. Therefore, this study aimed to examine the effects of a 15-week family judo program on physical and psychosocial health in parents of children with ASD. A total of 18 parents of children with ASD participated in a weekly …

The Relationship Between Evening Screen Time Use And Objectively Measured Sleep Outcomes In U.S. College Students, Donya Sedaghat

Honors Undergraduate Theses

Research suggests that elevated levels of screen time in the evening can negatively impact sleep outcomes (sleep duration, quality, and latency). Yet, there is a lack of evidence exploring if this relationship exists in college students. The purpose of this study is to investigate the relationship between evening screen time use and objectively measured sleep outcomes in US college students. College students (N = 29) junior or senior standing in a Health Sciences major were recruited to participate in this cross-sectional study. Participants wore accelerometers on their wrist for 24hr/day for seven days to capture sleep duration, efficiency, awakenings, and …

Split Catalytic Probes For The Detection Of Monkeypox Virus, Jaehyun Ahn

Honors Undergraduate Theses

The COVID-19 outbreak highlighted the important role that diagnostic tests play in the healthcare system. To reduce the impact of infectious disease outbreaks, the development of rapid and cost-effective point-of-care-tests (POCTs) is crucial. With the dissemination of the Monkeypox (Mpox) virus, it became a necessity to produce POCTS that are inexpensive and easy to use. This work explored the construction of two colorimetric assays that aim to detect Mpox genetic signatures. One is based on the split-peroxidase-like deoxyribozyme probes (sPDz), while the other utilizes a cascade system of split RNA-cleaving deoxyribozyme (sDz) and peroxidase-like deoxyribozyme (PDz). Both rely on catalytic …

Time Until Subsequent Pregnancy After Intrauterine Fetal Demise And Early Infant Death Based On Grieving Strategies, Gertride Delhomme

Honors Undergraduate Theses

The purpose of this research is to evaluate the coping strategies of families and childbearing women after intrauterine fetal demise and early infant death. The secondary purpose is to examine the effect of grieving strategies after intrauterine fetal demise compared to early infant death on time until subsequent pregnancy in women of childbearing age. A literature review exploring parental grief and coping strategies to cope with loss and its effect on the subsequent pregnancy was conducted from various online databases. All reviewed articles in the analysis indicated that coping strategies consist of a diverse number of mechanisms during the bereavement …

The Mental And Dental Repercussions Of Obstructive Sleep Apnea And Its Treatments, Emily E. Mcgoohan

Honors Undergraduate Theses

The purpose of this study is to examine the relationship between dental and mental health. To dive deeper into seeing this connection, patients with sleep apnea will be asked to share their experiences with the treatments for sleep apnea and how it had affected their mental or dental health.

Effect Of Estrogen On Chondrogenesis In Female Articular Chondrocytes, Ebony R. Parsons

Honors Undergraduate Theses

As women age and transition into menopause they face a higher risk of developing osteoarthritis leading to total joint replacements. Estrogen is the primary female reproductive hormone. As a woman approaches menopause, estrogen production decreases by 100-fold. Previous research has shown that Estrogen Replacement Therapy (ERT) reduced joint replacements in post-menopausal women. However, there is a lack of research surrounding ERT's effect on chondrocyte proliferation and extracellular matrix production, particularly 3D culture extracellular matrix production. Chondrogenesis is a process of skeletal development resulting in the formation of cartilage. Chondrocytes, derived from mesenchymal progenitors, serve as the fundamental cellular component in …

The Relative Contribution Of Health-Care Points Of Service To Overall Patient Satisfaction At A University Health Center, Jay M. Parikh

Honors Undergraduate Theses

Throughout the process of receiving healthcare, a patient is affected by several factors and processes. To just name a few, how long a patient must wait at the clinic, how friendly the front desk is, how the nurse treats the patient, how effective the physician is with his or her communication, what the cost of a patient's healthcare is, and how clean the clinic is all affect the patient's experience. When clinics excel in these factors, it promotes a favorable relationship between the patient and the clinic. Patients trust the healthcare provider and desire to continue attending that clinic when …

Observing The Relationship Between Physical Activity, Overall Health, Anxiety, And Sleep, Brianna Chicas

Honors Undergraduate Theses

College students' mental health has been researched for some time. In particular, the correlation between physical activity and mental health symptoms has been researched. The study examines the relationship between physical activity and anxiety, sleep, and overall health. College undergraduate students at the University of Central Florida took an online survey that measured all of these variables. A Pearson's correlation coefficient was used to assess correlations. Positive correlations were found between anxiety and sleep, anxiety and social desirability, sleep and social desirability, and strength training and vigorous physical activity. Negative correlations were found between overall health and physical activity, overall …

Examining Academic Challenges And Mental Health Among First-Generation And Non-First-Generation Students, Cecilia Q. Bui

Honors Undergraduate Theses

First-generation students are individuals whose parents have not attended college. These students often face challenges such as academic pressures, lack of social support, and mental health problems. Research has found that first-generation students experience a culture shock when transitioning from high school to college. These factors can impact academic success and affect overall health. This quantitative, cross-sectional study examined the impact of stress on mental health among first-generation and non-first-generation students. The study also examined if social and emotional support had a buffering effect on levels of depression, anxiety, and academic stress among first-generation college students. A survey measuring these …

Characterization Of Multiphase Complex Coacervate Droplets, Lindsey Rush

Honors Undergraduate Theses

The intracellular environment of eukaryotic cells has been found to have membrane-less organelles, which form through liquid-liquid phase separation.^1,2 The membrane-less organelles within the cell can be modeled with multiphase complex coacervates that are formed through the combination of two liquid polyelectrolyte complex coacervates, which are individually made up of a pair of one positively charged polymer and one negatively charged polymer.^3,4 Membrane-less organelles in a eukaryotic cell have been found to aggregate from liquid to solid in neurological disorders and during the aging process⁵, and investigation into the factors affecting aggregation of multiphase complex coacervates …

The Effects Of Kangaroo Care On The Stress Levels Of Parents In The Nicu, Niyati Sishodia

Honors Undergraduate Theses

Background: Parents of NICU patients have high stress levels compared to other populations, which negatively impact their mental health. The kangaroo care (KC) method has been used for its numerous benefits for infants, but not as widely studied for its impacts on parental stress. The purpose of this integrative literature review is to examine and synthesize the existing evidence regarding kangaroo care and its impact on the stress levels of NICU parents.

Methods: A literature search was conducted utilizing CINAHL Plus with Full Text, MEDLINE, and APA PsychInfo databases to identify relevant articles. Articles were included if they were published …

Long Term Effects Analysis Of Children Exposed To Postpartum Depression, Asheria Foster

Honors Undergraduate Theses

The purpose of this study is to explore and understand any correlation between a mother having postpartum depression and her now college-level child having a mental illness. The research question posed for this study was: Is there a correlation between maternal postpartum depression and the development of mental illnesses in college students? Studies have shown that there is a correlation in early childhood development, but there are deficits when it comes to long-term follow-up. Data for this study was collected via online surveys on SONA UCF. The results from the Chi-square test imply a strong association (p = .007) at …

The Impact Of Telemedicine On Patient-Provider Communication At A University Student Health Center, Venkata Naga Sreelalitapriya Duvuuri

Honors Undergraduate Theses

Effective patient-provider communication (PPC) involves conveying sufficient information to a patient such that the treatment is agreed upon and implemented accurately. Furthermore, a patient must feel adequately involved in the treatment process. With the advent of the COVID-19 pandemic, many clinical visits were shifted online. Although telemedicine was successful in meeting pandemic-specific goals, such as lowering personal contact, it changes the communicative context. Both patients and providers get less input from body language (nonverbal communication) and rely more on verbal communication. Furthermore, the number of telemedicine visits conducted remains elevated over pre-pandemic levels. Much of what is known about effective …

Evaluation Of Sleep Benefits Following A 16-Week Judo Program For Children With Autism Spectrum Disorder, Neha R. Chittaluru

Honors Undergraduate Theses

Autism Spectrum Disorder is a neurodevelopmental disorder characterized by language and communication deficits, and difficulties with social interaction (Twisk, 2001). Research has shown that 80% of youth with ASD experience sleep challenges which can lead to sleep-related health issues, exacerbate problematic behaviors, and increase vulnerability to anxiety and depression (Wachob & Lorenzi, 2015; Williams et al., 2004; Richdale & Schreck, 2009). Sleep plays a central role in adaptive functioning, and insufficient sleep can hinder learning, memory, and neuroplasticity for children with ASD (Cohen et al., 2014). As these unhealthy behavior patterns can lead to more adverse long-term health consequences, it …

The Encapsulation Of Enzymes In Multiphase Complex Coacervates, Akash R. Rajaram

Honors Undergraduate Theses

Polyelectrolyte complex coacervates (PECCs) result from liquid-liquid phase separation (LLPS) in solutions containing oppositely charged polymers ¹. Multiphase polyelectrolyte complex coacervates (MPECCs) result from the combination of multiple, specific PECCs ². The encapsulation of proteins in PECCs can serve as promising vehicles for the effective delivery of protein-based therapeutics, which are notoriously difficult to deliver. The encapsulation of model proteins, such as Bovine Serum Albumin (BSA) ³ or Human Hemoglobin (Hb) ⁴ have illustrated the protein-encapsulating capabilities of these PECC systems. The encapsulation of proteins in MPECCs is a topic that has yet to be explored; however, it …

The Successful Characteristics That Contribute To Black Male Students Matriculating Into Medical School, Cedric Brown

Electronic Theses and Dissertations, 2020-

In 2019, individuals that identified as Black represented 13.4% of the U.S. population, 12.5% of the undergraduate student enrollment population and 7.1% of the medical school population. Subsequently, this has yielded a 5% Black physician population and workforce consisting of just 2.3% Black male physicians (AAMC, 2018). The disproportionately low Black physician representation contributes to greater healthcare disparity outcomes within the U.S. Black population. This study is centered on the post-positive characteristics of Black male medical students that have successfully overcome barriers to entry and matriculated into medical school. The phenomenological post-positive study was conducted through the lens of Self-Efficacy …

Role Of Endoplasmic Reticulum Stress Response In Parainfluenza Virus Acute To Persistent Infections, Lauren L. Abbitt

Honors Undergraduate Theses

Persistent viral infections are a major health concern, with persistently infected (PI) cells being a source of continued shedding of virus and generation of viral mutants. Here, we hypothesized that cells persistently infected with the enveloped virus parainfluenza virus 5 (PIV5) would show altered expression of endoplasmic reticulum (ER) stress proteins and increased resistance to death caused by drug-induced ER stress. To test this, lysates of mock-infected, PIV5 acute-infected, and PIV5 PI human lung A549 cells were collected and levels of ER stress proteins were compared. Western blotting revealed that immunoglobulin heavy chain binding protein (BiP/GRP78) was present in higher …

Examining The Association Between Covid-19 And Anxiety In College Students With Varying Personality Traits, Ridha Anjum

Honors Undergraduate Theses

The goal of this thesis was to examine the relationship between personality types (i.e., extraversion and neuroticism) and anxiety levels among college students during the height of the pandemic. Specifically, this study examined whether factors contributed to anxiety and whether differences in anxiety scores differed by personality trait. It was hypothesized that individuals who scored high in both extraversion and neuroticism would report an increase in anxiety during the height of COVID-19 pandemic. Neuroticism is linked to emotional responses to a negative event (e.g., such as COVID), which may play a role on anxiety levels. The level of extraversion that …