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Effects Of Exercise On The Cardiovascular Health Of Adolescents And Young Adults With Down Syndrome, Samarth Gupta

Rowan-Virtua Research Day

Introduction: It is known that the incidence of Down Syndrome has increased over time and that this condition is associated with congenital heart defects, lower cardiorespiratory capacity, and increased rates of obesity and type 2 diabetes. It has been shown that individuals who have congenital heart defects but not Down Syndrome have increased cardiorespiratory function after engaging in exercise. Unfortunately, the role of exercise in improving cardiovascular health outcomes among individuals with DS is not yet fully understood.

Results: Exercise has been found to improve several health outcomes among individuals with Down Syndrome. For example, moderate to vigorous treadmill exercises …

Unraveling The Gender Disparity: Investigating The Factors Behind Women’S Higher Acl Injury Risk, Kylie Smith

Research Days

No abstract provided.

Evaluation Of Botanical Extracts For Cytochrome P450 Inhibition Mediated Drug Interactions, Angela I. Calderón, Zarna Raichura, Kabre Heck, Jaewoo Choi, Mikah Brandes, Cody Neff, Claudia Maier, Amala Soumyanath, Robert Arnold

Oxford ICSB

There has been remarkable growth in consumption of botanical dietary supplements (BDS), making it important to understand the safety profile of BDS with respect to the pharmacokinetic properties for any potential of botanical-drug interactions. One such botanical interactions which has gained significant attention involves inhibition of cytochrome P450 (CYP450) enzymes by co-administered drugs. Our study involved examining two widely used botanicals, ashwagandha and açaí for any potential inhibition of CYP450. Four different ashwagandha extracts were tested, resulting in inhibition of CYP2B6 with IC50 < 100 µg/ml of extract and showed potential of time-dependent inhibition for CYP2C9 and CYP2D6 with an IC50 ~ 200 µg/ml of extract. In the case of açaí, seven different extracts were tested and only CYP2C9 was inhibited. The acidic methanol extract of açaí formulation showed an IC50 of 0.3 µg/ml of extract indicating potent inhibition of CYP2C9, while the methanol (IC50 ~ 91.75 µg/ml) & ethanol extracts of Mountain Rose açaí powder showed weak inhibitory effect with an IC50 < 100 µg/ml of extract for CYP2C9. The results reflect that both botanical extracts showed potential of CYP450 inhibition, suggesting that compounds in BDS can prolong the half-lives of medications leading to extended action or toxicity. Next step involves, testing subfractions of these extracts to identify the compounds responsible for the observed inhibition.

Chemistry, Biology, And Safety Of Volatile Organics From Aromatic And Medicinal Plants, Nicole Stevens

Oxford ICSB

Introduction Sleep is an important foundation of health, yet the U.S. Centers for Disease Control (CDC) notes that about 30% of adults to not get the recommended minimum of 7 hours’ sleep per night. Prescription treatments may help, but they carry risks such as side-effects, dependency, and medication interaction. Natural botanical extracts are a therapeutic possibility for improving sleep quality, but additional research is needed on their efficacy and safety. A system of natural products based on lavender was developed and tested in a human clinical study to evaluate effect on sleep, blood and safety markers, and gene expression modulation …

Development And Evaluation Of Trauma Informed Care Education For Licensed Nurses, Kristina O'Meara

Epsilon Sigma at-Large Research Conference

Trauma informed care nursing education is crucial. Trauma informed care is a method of providing health care which understands the likelihood of past and present traumatic events in patients and families. The experience of past or present trauma often led to chronic diseases, substance abuse disorder, fragmented health care, fears surrounding health care, chronic stress, and other negative health consequences. The purpose of this project is to increase licensed nurses’ awareness and ability to practice trauma informed care in clinical practice, as well as promote policy initiation within the health care facilities. Method planning integrated the Knowledge to Action Cycle. …

Implementation Of Provider-Made Follow-Up Appointments For Depression In Primary Care, Rebecca Vaughn

Epsilon Sigma at-Large Research Conference

Implementation of provider-made follow-up appointments for depression in primary care

Rebecca Vaughn

College of Nursing, East Tennessee State University; Whitson Hester School of Nursing, Tennessee Technological University

Author Note

Rebecca Vaughn https://orcid.org/0009-0007-0731-3316 College of Nursing, East Tennessee State University

There are no conflicts of interest to disclose.

Corresponding concerning this manuscript should be addressed to Rebecca Vaughn

108 Reed Mill Lane Monroe TN 38573

Zrev2@etsu.edu

Abstract

Depression is a common condition diagnosed and managed in primary care.

Follow-up is inconsistent and low in these settings, creating a gap in care that

impacts management, adherence to treatment, and patient outcomes. The …

Comparisons Of Spiritual Well-Being, Psychological Well-Being, And Suicidal Ideation Between Usa And Taiwanese College Students, Pi-Ming Yeh Associate Professor, Cheng-Huei Chiao Professor, Jennchang Liou Professor

Epsilon Sigma at-Large Research Conference

Background: In Taiwan, there were 7,038 reports of attempted suicide among people aged 24 or younger in 2018. Anxiety disorders are the most common mental illness in the U.S., affecting 40 million adults in the United States age 18 and older.

Purpose: In this study, we compared United States (US) and Taiwanese college students’ spiritual well-being, psychological well-being, and suicidal ideation.

Methods: A total of 661 college students (481 from the US and 180 from Taiwan) were recruited to complete the survey study. This was a cross-sectional comparative research design. SPSS 28.0 was used to do the data analysis. Chi-square …

Lingering Effects Of Covid-19 On Mental Health In College Students, Morgan Bodker

Scholars Week

This study examined whether severity of an individual’s COVID symptoms is predictive of a long-term risk for depression in college students. An online survey was completed by 123 students (M = 19.45; SD = 4.23) who had been diagnosed with COVID-19 at any time since the pandemic. Severity of COVID symptoms at the time of diagnosis was assessed using seven questions on a 4-point Likert scale. Current depressive symptoms were measured using the Patient Health Questionnaire (PHQ-9). Participants who had a COVID diagnosis reported significantly higher levels of depression than participants who have never had COVID. A linear regression restricted …