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Monoclonal Antibodies: A Powerful Tool For Selecting And Analyzing Mutations In Antigens And Antibodies, Roberta Pollock, Jean-Luc Teillaud, Matthew Scharff Dec 1983

Monoclonal Antibodies: A Powerful Tool For Selecting And Analyzing Mutations In Antigens And Antibodies, Roberta Pollock, Jean-Luc Teillaud, Matthew Scharff

Roberta Pollock

Antibodies have played an important role in microbiology. In addition to their uses in classifying microorganisms and studying evolutionary relationships, antibodies are useful for detecting the microheterogeneity of proteins that arises from recombination and somatic mutation. However, the usefulness of im­ munological assays has been complicated by the difficulty of repeatedly gener­ ating large amounts of antibodies with restricted reactivity, and the heter­ ogeneity of all antisera obtained by conventional methods. These problems reflect the fact that antisera contain antibodies secreted by many antibody­ producing B cell clones; hence such antibodies are termed polyclonal anti­ bodies. Even if the same …


The Role Of Biogenic Amines In The Regulation Of Exocrine Gland Function: A Possible Mechanism For The Pathogenesis Of Cystic Fibrosis, A. Tenenhouse, E. Yu Dec 1983

The Role Of Biogenic Amines In The Regulation Of Exocrine Gland Function: A Possible Mechanism For The Pathogenesis Of Cystic Fibrosis, A. Tenenhouse, E. Yu

Edward Yu

No abstract provided.