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A Coupled Hydrodynamic Model Of The Cardiovascular And Cerebrospinal Fluid System, Bryn Martin, Philippe Reymond, Jan Reymond, Jan Novy, Olivier Baledent, Nikolaos Stergiopulos
A Coupled Hydrodynamic Model Of The Cardiovascular And Cerebrospinal Fluid System, Bryn Martin, Philippe Reymond, Jan Reymond, Jan Novy, Olivier Baledent, Nikolaos Stergiopulos
Dr. Bryn Martin
Coupling of the cardiovascular and cerebrospinal fluid (CSF) system is considered to be important to understand the pathophysiology of cerebrovascular and craniospinal disease and intrathecal drug delivery. A coupled cardiovascular and CSF system model was designed to examine the relation of spinal cord (SC) blood flow (SCBF) and CSF pulsations along the spinal subarachnoid space (SSS). A one-dimensional (1-D) cardiovascular tree model was constructed including a simplified SC arterial network. Connection between the cardiovascular and CSF system was accomplished by a transfer function based on in vivo measurements of CSF and cerebral blood flow. A 1-D tube model of the …