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Influence Of Rooting On Stolon Branching In White Clover, M Jones, N R. Sackville Hamilton Aug 2024

Influence Of Rooting On Stolon Branching In White Clover, M Jones, N R. Sackville Hamilton

IGC Proceedings (1993-2023)

The relationship between rooting and branching in stolons of white clover (Trifolium repens L.) was investigated in a field experiment, Half of a group of stolons was allowed to develop roots naturally, while for the other half root establishment was prevented by severing young roots before they made contact with the soil. Prevention of root establishment did not affect the numbers of branches which developed on nodes produced during the experiment, and it stimulated of branching on nodes which were already present. This result was unexpected on the basis of earlier observations of stolon growth and suggests that the …


Accumulation Of Dry Matter, Protein And Total Available Carbohydrate In Berseem Under Different Cutting Regimes, P Martinello, G De Santis, A Iannucci, N Di Fonzo Aug 2024

Accumulation Of Dry Matter, Protein And Total Available Carbohydrate In Berseem Under Different Cutting Regimes, P Martinello, G De Santis, A Iannucci, N Di Fonzo

IGC Proceedings (1993-2023)

The effect of different cutting regimes on physiology and morphology of aerial parts and roots in 6 bcrseem (Trifolium alexadrium L.) genotypes was evaluated. Observations were carried out on individual plants at 4 stages of development: fourth and eighth internode elongation, early flowering and physiological seed maturity. The results showed that the genotypes were characterised by highest values of dry matter in the aerial and root parts at the early flowering stage. Variability among genotypes was observed.


Seasonal Growth Rhythms In Lucerne, C Poisson, G Genier, A Canal, P Guy, A Porcheron Aug 2024

Seasonal Growth Rhythms In Lucerne, C Poisson, G Genier, A Canal, P Guy, A Porcheron

IGC Proceedings (1993-2023)

The repartition of dry matter production of lilcerne (Medicago saliva) through the year is of great interest. A 3-year experiment began in 1990 to distinguish different rhythms of regrowth. Eighteen genotypes of very diverse geographic origins exhibiting great differences of winter dormancy were studied in a multisite experiment. Two different non-destructive methods were used to describe accurately leaf area index evolution: red far/red light ratio (660 nm/730 nm), and indirect measurement of LAI {LI-COR 2000); stem height and dry matter yield were regularly recorded. Important differences in summer and autumn behaviour leading to different sigmoid growth curves wece …


Inherent And Realized Potential Of Axillary Buds Of White Clover In Field Populations, P.C D. Newton, M.J M. Hay Aug 2024

Inherent And Realized Potential Of Axillary Buds Of White Clover In Field Populations, P.C D. Newton, M.J M. Hay

IGC Proceedings (1993-2023)

Fewer than 10% of while clover (Trifolium repens L.) axillary buds form established branches in grazed swards. In order to understand the mechanisms controlling his large loss of growth potential we have charted the potential fates a bud may meet. Each step in this flow chart offers the possibility for a loss of branching potential. We consider the factors that may be important in determining the fates of buds and highlight in particular the heavy losses of viable buds at a young age and propose that different factors may control branch initiation and branch establishment.


Prediction Of Plant Mortality Under Grazing- A Conceptual Approach, J J. Mott, G K. Mckeon, K A. Day Aug 2024

Prediction Of Plant Mortality Under Grazing- A Conceptual Approach, J J. Mott, G K. Mckeon, K A. Day

IGC Proceedings (1993-2023)

Based on the concept of biological thresholds, there is growing acceptance 0£ the importance o£ episodic events in the determination of rangeland condition trend. The variable rainfall occurring within Australian rangelands means that overstocking during droughts is a major cause of these Australian rangeland vegetation complexes exceeding these thresholds. Recently plant production models and simplistic estimates of the relationship between animal utilisation and plant mortality became available. Accurate estimates will be developed only with the incorporation of a sound mechanistic understanding of the relationship between utilisation of forage and plant mortality for different conditions of species and soils. Detailed studies …


Canopy Structure And Forage Production Of Lolium Rididum Gaudin As Influenced By The Frequency Of Defoliation, P P. Roggero, A Franca, M Sitzia, S Caredda Aug 2024

Canopy Structure And Forage Production Of Lolium Rididum Gaudin As Influenced By The Frequency Of Defoliation, P P. Roggero, A Franca, M Sitzia, S Caredda

IGC Proceedings (1993-2023)

An experiment was conducted in Sardinia to develop an appropriate rotational grazing management regime in spring for an ecotype of annual ryegrass (Lolium rigidum Gaudin). Three intermittent defoliation treatments were compared using sward surface height (10, 15 or 20 cm) to determine time of cutting. Forage dry matter yield, tiller population density, LAI, vertical distribution of plant tissues and other related characteristics were measured. Cutting when sward reached 10 cm resulted In significantly lower yields but a better canopy structure (denser sward, higher percentage of leaves in the bottom layers, higher leaf: sheath ratio) than the other treatments. The …


Physiological Response And Leaf Production Of Two C4 Grasses After Small Rainfall Events, A J. Norman, T L. Thurow, C A. Taylor Jr Aug 2024

Physiological Response And Leaf Production Of Two C4 Grasses After Small Rainfall Events, A J. Norman, T L. Thurow, C A. Taylor Jr

IGC Proceedings (1993-2023)

The response of plant water status and leaf production of sideoats grama (Bouteloua curtipendula Michx.) and curly mesquite (Hilaria belangeri Steud.) to application of 10 mm of water were studied in 6 continuous weighing lysimeters near Sonora, Texas, USA.: Transpiration, stomata! conductance, xylem water potentials and leaf production were measured foe both species. Soil water content was monitored in each lysimeter. The 10-mm simulated rainfall events improved plant water status regardless of prior soil water· content.' The transpiration rate for both species was similar. Stomata! conductance' of B. c1irtipe11d11/a responded faster after the simulated rainfall events. More favorable …


Effects Of Cutting Dates In Primary Growth, Water Soluble Carbohydrate Content And Nitrogen Fertilization On Regrowth Of Perennial Ryegrass, W Pohlmann, U Simon Aug 2024

Effects Of Cutting Dates In Primary Growth, Water Soluble Carbohydrate Content And Nitrogen Fertilization On Regrowth Of Perennial Ryegrass, W Pohlmann, U Simon

IGC Proceedings (1993-2023)

In a field experiment, an early• and a late-maturing cultivar of perennial ryegrass were cut during the primary growth in 6-weekly intervals starting when the early cultivar (Lolium perenne L.) reached stage of growth 31 (Simon & Park 1983, Proceedings XIV IGC), at 2 levels of nitrogen fertilisation. Dry mailer yield (DMY) in the regrowth was determined 4 weeks after defoliation in the primary growth. DMY in the regrowth decreased with delayed cutting in the primary growth. No significant correlation existed between the content of water soluble carbohydrates (WSC) in 1he stubble at the time of defoliation in the …


Effect Of Row Spacing And Sowing Rate On Establishment Of Lucerne Cv. Grasslands Oranga, M Askarian, J G. Hampton Aug 2024

Effect Of Row Spacing And Sowing Rate On Establishment Of Lucerne Cv. Grasslands Oranga, M Askarian, J G. Hampton

IGC Proceedings (1993-2023)

Studies on the effects of various row spacings and sowing rates on the establishment of autumn-sown lucerne (Medicago saliva L) cv. Grasslands Oranga were carried out in a split-plot experiment at Massey University Palmerston North, New Zealand. Seed was sown on 15 March 1991 at 1, 3, 6 and 12 kwha at row spacings of 15, 30, 45 and 60 cm. Seedling establishment increased as sowing rate and row spacing increased, but numbers of seedlings were not directly proportional to the number of seeds sown. The percentage establishment 6 months after sowing was significantly higher atthe lowest sowing rate. …


Cefiderocol Heteroresistance Associated With Mutations In Tonb-Dependent Receptor Genes In Pseudomonas Aeruginosa Of Clinical Origin, Stephanie L Egge, Samie A Rizvi, Shelby R Simar, Manuel Alcalde, Jose R W Martinez, Blake M Hanson, An Q Dinh, Rodrigo P Baptista, Truc T Tran, Samuel A Shelburne, Jose M Munita, Cesar A Arias, Morgan Hakki, William R Miller Aug 2024

Cefiderocol Heteroresistance Associated With Mutations In Tonb-Dependent Receptor Genes In Pseudomonas Aeruginosa Of Clinical Origin, Stephanie L Egge, Samie A Rizvi, Shelby R Simar, Manuel Alcalde, Jose R W Martinez, Blake M Hanson, An Q Dinh, Rodrigo P Baptista, Truc T Tran, Samuel A Shelburne, Jose M Munita, Cesar A Arias, Morgan Hakki, William R Miller

Student and Faculty Publications

The siderophore-cephalosporin cefiderocol (FDC) presents a promising treatment option for carbapenem-resistant (CR) P. aeruginosa (PA). FDC circumvents traditional porin and efflux-mediated resistance by utilizing TonB-dependent receptors (TBDRs) to access the periplasmic space. Emerging FDC resistance has been associated with loss of function mutations within TBDR genes or the regulatory genes controlling TBDR expression. Further, difficulties with antimicrobial susceptibility testing (AST) and unexpected negative clinical treatment outcomes have prompted concerns for heteroresistance, where a single lineage isolate contains resistant subpopulations not detectable by standard AST. This study aimed to evaluate the prevalence of TBDR mutations among clinical isolates of P. aeruginosa …


Video And Phone Visit Use Differed By Language Preference Among Us Latino And Chinese Adults During The First 9 Months Of The Covid-19 Pandemic: A Cross-Sectional Electronic Health Record Study, Nancy P Gordon, Teresa Y Lin, Antonia Torreblanca, Mary E Reed Aug 2024

Video And Phone Visit Use Differed By Language Preference Among Us Latino And Chinese Adults During The First 9 Months Of The Covid-19 Pandemic: A Cross-Sectional Electronic Health Record Study, Nancy P Gordon, Teresa Y Lin, Antonia Torreblanca, Mary E Reed

Student and Faculty Publications

BACKGROUND: During the first nine months of the COVID-19 emergency, patients were encouraged to use virtual versus clinic visits if in-person care was not deemed necessary by clinical staff. This study examined the association of spoken language preference and ethnicity with use of video versus phone virtual visits by US Latino and Chinese adult patients who got care in the same healthcare system.

METHODS: We analyzed electronic health record data for four groups of adults aged 26-85y who had ≥ 1 primary or specialty care outpatient clinician visits during April-December 2020: 80,869 Latino adults preferring Spanish (LEP Latino); 214,765 Latino …


Connecting Hiv-1 Viral Protein R Polymorphisms To Changes In Inflammatory Signals And Efficacy Testing Of Essential Oils As Disinfectants Against Sars-Cov-2, J. Brandon Lopez Aug 2024

Connecting Hiv-1 Viral Protein R Polymorphisms To Changes In Inflammatory Signals And Efficacy Testing Of Essential Oils As Disinfectants Against Sars-Cov-2, J. Brandon Lopez

Theses and Dissertations

Human Immunodeficiency Virus (HIV-1) is the causative agent for acquired immunodeficiency syndrome (AIDS). Different strains of HIV-1 have been linked to a long term non-progressor (LTNP) or rapid progressor (RP) form of disease depending on rate of AIDS progression. Viral protein R (Vpr) is a viral protein that has been linked to varying rates of AIDS progression depending on the sequence. In this work, the effects of two polymorphisms, a LTNP and a RP, on different cells are studied. The LTNP virus was linked to lower release of pro-inflammatory cytokines, such as TNF and IL-6, and an increase in apoptotic …


Conservation Decision Making And Agricultural Land Leasing - An Experimental Investigation Of The Role Of Gender, Diya Ganguly, Simanti Banerjee, Christopher Gustafson Aug 2024

Conservation Decision Making And Agricultural Land Leasing - An Experimental Investigation Of The Role Of Gender, Diya Ganguly, Simanti Banerjee, Christopher Gustafson

Cornhusker Economics

This research investigated the impact of landowner gender and of the different types of contract leases offered by them to a male tenant, on the conservation (or non-conservation) choice made by the tenant. Specifically, we investigate if a) female and male landowners offer different rental contracts and b) whether tenants choose different actions based on the landowner’s gender. For this purpose, we implemented a controlled, gender-context-loaded economic experiment with university students, in which we tested contract and land use choice under different treatments for three types of rental contracts – fixed rent, fixed rent with penalty, and fixed rent with …


Laying Framework For A Novel In Vitro Eukaryotic System To Measure Rate Of Transcription Elongation, John Lucas Ramirez Aug 2024

Laying Framework For A Novel In Vitro Eukaryotic System To Measure Rate Of Transcription Elongation, John Lucas Ramirez

Theses and Dissertations

Within each cell, genetic material is stored in the form of DNA. This DNA is compacted around proteins to form higher order structures called chromatin. The basic unit of chromatin is a histone protein octamer bound with DNA called a nucleosome. A nucleosome consists of eight core proteins, four pairs of histone proteins H2A, H2B, H3, and H4, wrapped by DNA. The DNA wraps around the histone protein roughly 1.7 times, helping facilitate the compaction of DNA within the nucleus of the cell. The location of nucleosomes makes genetic material that encodes various elements, such as promoters or enhancers, accessible …


Stem-Loop And Circle-Loop Tads Generated By Directional Pairing Of Boundary Elements Have Distinct Physical And Regulatory Properties, Wenfan Ke, Miki Fujioka, Paul Schedl, James Jaynes Aug 2024

Stem-Loop And Circle-Loop Tads Generated By Directional Pairing Of Boundary Elements Have Distinct Physical And Regulatory Properties, Wenfan Ke, Miki Fujioka, Paul Schedl, James Jaynes

Department of Biochemistry and Molecular Biology Faculty Papers

The chromosomes in multicellular eukaryotes are organized into a series of topologically independent loops called TADs. In flies, TADs are formed by physical interactions between neighboring boundaries. Fly boundaries exhibit distinct partner preferences, and pairing interactions between boundaries are typically orientation-dependent. Pairing can be head-to-tail or head-to-head. The former generates a stem-loop TAD, while the latter gives a circle-loop TAD. The TAD that encompasses the Drosophila even skipped (eve) gene is formed by the head-to-tail pairing of the nhomie and homie boundaries. To explore the relationship between loop topology and the physical and regulatory landscape, we flanked the nhomie boundary …


The Effects Of Simulated Predation And Nursery Structure On Post-Outplant Survival And Growth Of Sexual Juveniles Of Six Caribbean Coral Species, Jarrod Little Aug 2024

The Effects Of Simulated Predation And Nursery Structure On Post-Outplant Survival And Growth Of Sexual Juveniles Of Six Caribbean Coral Species, Jarrod Little

All HCAS Student Capstones, Theses, and Dissertations

Over the past few decades, increasing frequency and severity of direct and indirect anthropogenic stressors have resulted in reef degradation and decreased coral cover and diversity. In South Florida, coral propagation ex situ has gained popularity as a means to restore coral cover. Outplanting sexually propagated corals on the reef is particularly important as it contributes to greater genetic diversity and potentially overall reef resilience. However, these corals typically experience high levels of predation following outplanting, significantly reducing coral survival, and thus constitute a major bottleneck to the success of restoration efforts. This study assessed if simulated predation events on …


Seroprevalence And Associated Risk Factors Of Toxoplasma Gondii Infections In Dogs In Egypt, Abdelfattah Selim, Mohamed Marzok, Hattan S. Gattan, Omar A. Aljabr, Mohammed H. Alruhaili, Mohamed Salem Aug 2024

Seroprevalence And Associated Risk Factors Of Toxoplasma Gondii Infections In Dogs In Egypt, Abdelfattah Selim, Mohamed Marzok, Hattan S. Gattan, Omar A. Aljabr, Mohammed H. Alruhaili, Mohamed Salem

The Thai Journal of Veterinary Medicine

Toxoplasma gondii is a parasite that is found all over the world and has significant importance in veterinary medicine and public health. Dogs are considered as a final host for the parasite and play an important role in spreading of infection via contamination of environment by oocysts. The study aimed to determine the seroprevalence of T. gondii and analysis risk factors associated with the infections in dogs. A total of 430 blood samples were collected from dogs from three governorates situated at northern Egypt and analyzed using commercial ELISA kit. The overall seroprevalence of T. gondii in dogs was 24% …


The Cadet Athlete Physical Training Intervention (Capti): A 16-Week Periodized Program To Remediate Underdeveloped Tactical Athletes At A Senior Military College, Margaret T. Thornton, Amy S. Welch, Scott Caulfield, Rachele M. Pojednic Aug 2024

The Cadet Athlete Physical Training Intervention (Capti): A 16-Week Periodized Program To Remediate Underdeveloped Tactical Athletes At A Senior Military College, Margaret T. Thornton, Amy S. Welch, Scott Caulfield, Rachele M. Pojednic

International Journal of Exercise Science

International Journal of Exercise Science 17(4): 1083-1091, 2024. Approximately half of military recruits fail the Army Physical Fitness Test (APFT), and 70% of all injuries in the US military are musculoskeletal in nature. The purpose of this study was to investigate whether underdeveloped musculoskeletal and cardiovascular fitness levels and subsequent APFT scores of senior military college cadets could be improved by a novel, evidence-based Cadet Athlete Physical Training Intervention (CAPTI) compared to the current Remedial Physical Training program (RPT). Cadets failing the APFT (total score < 180, or < 60 in scored sit-ups, pushups or run time, respectively) participated in a 16-week remedial training program including either CAPTI (periodized full body calisthenic and varied-technique cardiovascular training, along with mobility training and mental health and wellbeing sessions), or a traditional, event-specific remedial training program (RPT). CAPTI was randomly assigned to one of three battalions, while the others received RPT. One hundred and thirty-eight cadets (n = 70 CAPTI, n = 68 RPT) participated in the study. After training, 82.9% …


Science Of Hemp: Production And Pest Management Meeting Proceedings (2023) Aug 2024

Science Of Hemp: Production And Pest Management Meeting Proceedings (2023)

Science of Hemp Annual Meeting

The fourth meeting of the Science of Hemp: Production and Pest Management Conference was held on November 13-15, 2023 at Auburn University in Auburn, AL. Agricultural scientists from 13 different universities across the United States attended a series of scientific presentations. Topics included agronomy, entomology, plant pathology, weed science, and controlled environment production. The abstracts for presentations and posters are included within this publication.


Living Dead Forests: Assessing Detrital Services In Puget Sound Pseudotsuga Menziesii Ecosystems, Forrest Becker Aug 2024

Living Dead Forests: Assessing Detrital Services In Puget Sound Pseudotsuga Menziesii Ecosystems, Forrest Becker

Capstone Collection

Coarse woody debris (CWD), the detrital result of down wood recruitment, contributes to wildlife habitat, nutrient cycling, morphological processes like soil formation, and each forest’s sense of place but if undermanaged can fuel wildfires or obstruct stakeholder use. Despite its ubiquity in Puget Sound Douglas fir (Pseudotsuga menziesii) forests in Washington, USA, few studies quantify the exact ecosystem services which down wood provides. This study seeks to understand how forest managers can estimate the ecosystem services of down wood and how human communities perceive down wood management between community, public, and private Douglas fir (P. menziesii) …


Investigating The Stability Of Different Sizes Of Gold Nanoparticles In Physiological Environments And Different Gold Nanoclusters In Water., Narges Hajighasemi Aug 2024

Investigating The Stability Of Different Sizes Of Gold Nanoparticles In Physiological Environments And Different Gold Nanoclusters In Water., Narges Hajighasemi

Electronic Thesis and Dissertation Repository

Gold nanoparticles (AuNPs) have become promising candidates for various biomedical applications due to their unique physicochemical properties and biocompatibility. Nevertheless, the efficacy of AuNPs in these applications highly relies on their stability and ability to maintain their desired properties within the complex environment of the human body. This thesis investigates the stability and aggregation behavior of citrate-coated AuNPs in in-vitro physiological environments and nitrogen heterocyclic carbene (NHC)-coated gold nanoclusters (AuNCs) in water over time. Analytical techniques such as electrophoretic mobility, dynamic light scattering, and inductively coupled plasma mass spectrometry were employed. It was shown that cell media (in contrast to …


A ‘Nuclear Bomb’ Or Just ‘A Joke’? Groundwater Models May Help Communicate Nuanced Risks To The Great Salt Lake, Matthew D. Laplante, Piyush Dahal, Shih-Yu Simon Wang, Kirsti Hakala, Avik Mukherjee Aug 2024

A ‘Nuclear Bomb’ Or Just ‘A Joke’? Groundwater Models May Help Communicate Nuanced Risks To The Great Salt Lake, Matthew D. Laplante, Piyush Dahal, Shih-Yu Simon Wang, Kirsti Hakala, Avik Mukherjee

Plants, Soils, and Climate Faculty Publications

The Great Salt Lake entered the zeitgeist of environmental concern in 2022 when a coalition of scientists and activists warned in a highly publicized report that the lake might be just five years away from complete desiccation, a possibility one state official warned was tantamount to an “environmental nuclear bomb”. Shortly thereafter, an unpredicted and unprecedented pluvial winter resulted in an increase in inflow, temporarily halting the lake’s decline and prompting Utah’s governor to mock the dire prediction as “a joke”, an outcome that speaks to the tension between agenda-setting and trust-building that researchers face when sharing worst-case warnings, particularly …


Stanniocalcin 2 Governs Cancer Cell Adaptation To Nutrient Insufficiency Through Alleviation Of Oxidative Stress, Shuo Qie, Haijuan Xiong, Yaqi Liu, Chenhui Yan, Yalei Wang, Lifeng Tian, Chenguang Wang, Nianli Sang Aug 2024

Stanniocalcin 2 Governs Cancer Cell Adaptation To Nutrient Insufficiency Through Alleviation Of Oxidative Stress, Shuo Qie, Haijuan Xiong, Yaqi Liu, Chenhui Yan, Yalei Wang, Lifeng Tian, Chenguang Wang, Nianli Sang

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Solid tumours often endure nutrient insufficiency during progression. How tumour cells adapt to temporal and spatial nutrient insufficiency remains unclear. We previously identified STC2 as one of the most upregulated genes in cells exposed to nutrient insufficiency by transcriptome screening, indicating the potential of STC2 in cellular adaptation to nutrient insufficiency. However, the molecular mechanisms underlying STC2 induction by nutrient insufficiency and subsequent adaptation remain elusive. Here, we report that STC2 protein is dramatically increased and secreted into the culture media by Gln-/Glc- deprivation. STC2 promoter contains cis-elements that are activated by ATF4 and p65/RelA, two transcription factors activated by …


Stress Granule Formation Helps To Mitigate Neurodegeneration, M. Rebecca Glineburg, Evrim Yildirim, Nicolas Gomez, Genesis Rodriguez, Jaclyn Pak, Xingli Li, Christopher Altheim, Jacob Waksmacki, Gerald M. Mcinerney, Sami J. Barmada, Peter K. Todd Aug 2024

Stress Granule Formation Helps To Mitigate Neurodegeneration, M. Rebecca Glineburg, Evrim Yildirim, Nicolas Gomez, Genesis Rodriguez, Jaclyn Pak, Xingli Li, Christopher Altheim, Jacob Waksmacki, Gerald M. Mcinerney, Sami J. Barmada, Peter K. Todd

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Cellular stress pathways that inhibit translation initiation lead to transient formation of cytoplasmic RNA/protein complexes known as stress granules. Many of the proteins found within stress granules and the dynamics of stress granule formation and dissolution are implicated in neurodegenerative disease. Whether stress granule formation is protective or harmful in neurodegenerative conditions is not known. To address this, we took advantage of the alphavirus protein nsP3, which selectively binds dimers of the central stress granule nucleator protein G3BP and markedly reduces stress granule formation without directly impacting the protein translational inhibitory pathways that trigger stress granule formation. In Drosophila and …


Friend Social Network Size Moderates The Association Between Age And Physical Activity Across Adulthood, Ashley Kuzmik, Yin Liu, Yendelela Cuffee, Lan Kong, Christopher N. Sciamanna, Liza S. Rovniak Aug 2024

Friend Social Network Size Moderates The Association Between Age And Physical Activity Across Adulthood, Ashley Kuzmik, Yin Liu, Yendelela Cuffee, Lan Kong, Christopher N. Sciamanna, Liza S. Rovniak

International Journal of Exercise Science

International Journal of Exercise Science 17(5): 1068-1082, 2024. Both physical activity and social network size decline as people age. However, limited research has examined if social network size and contact frequency differentially influence physical activity across the adult lifespan. This study aimed to assess if these social network characteristics moderated the relationship between age and physical activity level across adulthood. Multiple regression analyses were conducted to examine the main-effect association between age, past-week physical activity, and past-year physical activity, as well as the moderating effect of social network characteristics (i.e., friend network size, friend contact frequency, relative network size, and …


The Oncolytic Adenovirus Delta-24-Rgd In Combination With Onc201 Induces A Potent Antitumor Response In Pediatric High-Grade And Diffuse Midline Glioma Models, Daniel De La Nava, Iker Ausejo-Mauleon, Virginia Laspidea, Marisol Gonzalez-Huarriz, Andrea Lacalle, Noelia Casares, Marta Zalacain, Lucía Marrodan, Marc García-Moure, Maria C Ochoa, Antonio Carlos Tallon-Cobos, Reyes Hernandez-Osuna, Javier Marco-Sanz, Laasya Dhandapani, Irati Hervás-Corpión, Oren J Becher, Javad Nazarian, Sabine Mueller, Timothy N Phoenix, Jasper Van Der Lugt, Mikel Hernaez, Elizabeth Guruceaga, Carl Koschmann, Sriram Venneti, Joshua E Allen, Matthew D Dun, Juan Fueyo, Candelaria Gomez-Manzano, Jaime Gallego Perez-Larraya, Ana Patiño-García, Sara Labiano, Marta M Alonso Aug 2024

The Oncolytic Adenovirus Delta-24-Rgd In Combination With Onc201 Induces A Potent Antitumor Response In Pediatric High-Grade And Diffuse Midline Glioma Models, Daniel De La Nava, Iker Ausejo-Mauleon, Virginia Laspidea, Marisol Gonzalez-Huarriz, Andrea Lacalle, Noelia Casares, Marta Zalacain, Lucía Marrodan, Marc García-Moure, Maria C Ochoa, Antonio Carlos Tallon-Cobos, Reyes Hernandez-Osuna, Javier Marco-Sanz, Laasya Dhandapani, Irati Hervás-Corpión, Oren J Becher, Javad Nazarian, Sabine Mueller, Timothy N Phoenix, Jasper Van Der Lugt, Mikel Hernaez, Elizabeth Guruceaga, Carl Koschmann, Sriram Venneti, Joshua E Allen, Matthew D Dun, Juan Fueyo, Candelaria Gomez-Manzano, Jaime Gallego Perez-Larraya, Ana Patiño-García, Sara Labiano, Marta M Alonso

Student and Faculty Publications

BACKGROUND: Pediatric high-grade gliomas (pHGGs), including diffuse midline gliomas (DMGs), are aggressive pediatric tumors with one of the poorest prognoses. Delta-24-RGD and ONC201 have shown promising efficacy as single agents for these tumors. However, the combination of both agents has not been evaluated.

METHODS: The production of functional viruses was assessed by immunoblotting and replication assays. The antitumor effect was evaluated in a panel of human and murine pHGG and DMG cell lines. RNAseq, the seahorse stress test, mitochondrial DNA content, and γH2A.X immunofluorescence were used to perform mechanistic studies. Mouse models of both diseases were used to assess the …


Disability In Cluster Headache Is More Than Attack Frequency – Results From And Validation Of The English Version Of The Cluster Headache Impact Questionnaire (Chiq), Katharina Kamm, Andreas Straube, Mark Burish, Ruth Ruscheweyh Aug 2024

Disability In Cluster Headache Is More Than Attack Frequency – Results From And Validation Of The English Version Of The Cluster Headache Impact Questionnaire (Chiq), Katharina Kamm, Andreas Straube, Mark Burish, Ruth Ruscheweyh

Student and Faculty Publications

BACKGROUND: Cluster headache (CH) is associated with high disability. The Cluster Headache Impact Questionnaire (CHIQ) is a short, disease-specific disability questionnaire first developed and validated in German. Here, we validated the English version of this questionnaire.

METHODS: The CHIQ was assessed together with nonspecific headache-related disability questionnaires in CH patients from a tertiary headache center and an American self-help group.

RESULTS: 155 active episodic and chronic CH patients were included. The CHIQ showed good internal consistency (Cronbach's α = 0.91) and test-retest reliability (ICC = 0.93, n = 44). Factor analysis identified a single factor. Convergent validity was shown by …


08-05--2024 Orsp Newsletter, Liz Williamson Aug 2024

08-05--2024 Orsp Newsletter, Liz Williamson

ORSP Newsletter

Dr. John C. Higginbotham, Federal Demonstration Partnership (FDP), COPE (Clinic for Outreach and Personal Enrichment)


Exploring The Interaction Between Klebsiella Pneumoniae And Clostridioides Difficile At The Mucosal Interface, Taylor D. Ticer Aug 2024

Exploring The Interaction Between Klebsiella Pneumoniae And Clostridioides Difficile At The Mucosal Interface, Taylor D. Ticer

MUSC Theses and Dissertations

The gut microbiota plays a major role in human diseases. The impact of these microbes on human health comes not only from individual microbes but also from their interactions with each other. A prime example of this is Clostridioides difficile, an intestinal pathobiont that causes severe gastrointestinal illness. C. difficile works cooperatively with other gut bacteria, including Klebsiella pneumoniae. We hypothesized that K. pneumoniae would work synergistically with C. difficile and promote its pathogenesis. We screened over 40 K. pneumoniae strains to assess their interaction with the intestinal mucus layer, a key colonization site for C. difficile. …


Acceptability Of Heart Rate-Based Remote Monitoring Of Smoking Status., Matthew Mitnick, Shelby Goodwin, Mikaela Bubna, Justin S White, Bethany Raiff Aug 2024

Acceptability Of Heart Rate-Based Remote Monitoring Of Smoking Status., Matthew Mitnick, Shelby Goodwin, Mikaela Bubna, Justin S White, Bethany Raiff

College of Science & Mathematics Departmental Research

INTRODUCTION: Digital interventions present a scalable solution to overcome barriers to smoking cessation treatment, and changes in resting heart rate (HR) may offer a viable option for monitoring smoking status remotely. The goal of this study was to explore the acceptability of using smartphone cameras and activity trackers to measure heart rate for use in a smoking cessation intervention.

METHODS: Participants (N=410), most of whom identified as female (75.8 %) with mean age 38.3 years (SD 11.4), were recruited via the Smoke Free app. They rated the perceived comfort, convenience, and likelihood of using smartphone cameras and wrist-worn devices for …