Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network

Open Access. Powered by Scholars. Published by Universities.®

Life Sciences

Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 1381 - 1410 of 253680

Full-Text Articles in Entire DC Network

Gamma Sigma Delta, Nebraska Chapter Newsletter, Issue #64 Spring 2024 Apr 2024

Gamma Sigma Delta, Nebraska Chapter Newsletter, Issue #64 Spring 2024

Gamma Sigma Delta, Nebraska Chapter: Newsletters

President-Elect's message, John R. Ruberson

Nominations form for Gamma Sigma Delta, Nebraska chapter

2023 Outstanding Graduate Student Award nominations solicitation

2023 Teaching Award nominations solicitation

2023 Research Award nomination solicitation

2023 Extension Award nomination solicitation

2023 Award of Merit nomination solicitation

Annual dues notice

List of active members with expiration terms

Membership renewal form

Outstanding Graduate and Undergraduate Student Award fund solicitation

In memoriam:

Raymond "Gene" White (October 10, 1930-May 28, 2021)

ΓΣΔ pledge


An Analysis On The Capacity Of Visual Art To Promote Conservation Efforts, Devi Bell Apr 2024

An Analysis On The Capacity Of Visual Art To Promote Conservation Efforts, Devi Bell

Honors Projects

In recent decades, we have become more aware of the ways in which anthropogenic actions are harming Earth’s climate, ecosystems, and overall stability. Scientists generally agree on the urgency of our situation, yet the public may find difficulty in comprehending the multitude of information on it. This study aims to educate the public on biodiversity loss and related ecological issues in Ohio by discussing these topics through the medium of visual art. Five pieces involving different scientific subject matter and art mediums were created and displayed for participants to view. Participants completed two surveys, one before viewing the art and …


Alfred Russel Wallace Notes 30. Wallace A Theist? Part I., Charles H. Smith Apr 2024

Alfred Russel Wallace Notes 30. Wallace A Theist? Part I., Charles H. Smith

Faculty/Staff Personal Papers

Alfred Russel Wallace (1823−1913) has been portrayed as a ‘theist’ on a large number of occasions from his own time on to the present. In this, the first of a two part work, this assessment is questioned. In part one, the matter of Wallace’s personal philosophy and spiritual orientation is explored, the conclusion being that Wallace was a lifelong agnostic who can hardly be aligned with theism.


3rd Place Contest Entry: Cultural Attitudes Towards Ethnic Cuisine In Italy, Rachel Berns Apr 2024

3rd Place Contest Entry: Cultural Attitudes Towards Ethnic Cuisine In Italy, Rachel Berns

Kevin and Tam Ross Undergraduate Research Prize

This is Rachel Berns' submission for the 2024 Kevin and Tam Ross Undergraduate Research Prize, which won third place. It contains their essay on using library resources, their bibliography, and a sample of their research project on cultural attitudes toward ethnic cuisine in Italy.

Rachel is a fourth-year student at Chapman University, majoring in Health Sciences. Their faculty mentors are Dr. Anuradha Prakash and Dr. Sara Mattavelli.


What Factors Within The Context Of A Romantic Relationship And The Couple’S Finances Are Related To The Level Of Religiosity Among Contemporary Emerging Adults?, Brandan E. Wheeler, Joe D. Wilmoth, Tommy M. Phillips, Cecilia Brooks Apr 2024

What Factors Within The Context Of A Romantic Relationship And The Couple’S Finances Are Related To The Level Of Religiosity Among Contemporary Emerging Adults?, Brandan E. Wheeler, Joe D. Wilmoth, Tommy M. Phillips, Cecilia Brooks

Journal of Human Sciences and Extension

Research has identified the beneficial nature of spirituality/religiosity towards people’s general, psychological, and relational well-being despite a decline in religiosity among Americans, particularly among the younger generations. Research also suggests religiosity influences important relational factors, such as entering cohabiting relationships, but that these relational factors may also influence participants’ level of religiosity in a reciprocal effect. Therefore, the purpose of the current study was to explore how demographic, relational, and financial factors influence young adults’ level of religiosity within the context of a romantic relationship and the couples’ finances. Results from the current study suggest the length of the relationship …


Short-Term Transformative Impacts Of A Service-Learning Study Abroad Program, Caroline Cully Garbers, Dale W. Pracht, T. Grady Roberts Apr 2024

Short-Term Transformative Impacts Of A Service-Learning Study Abroad Program, Caroline Cully Garbers, Dale W. Pracht, T. Grady Roberts

Journal of Human Sciences and Extension

Universities are increasingly working to better prepare students for success in the workforce and increasingly advocating high-impact learning experiences. This case study explores the short-term impacts on students who participated in a short-term service-learning study abroad program in Ireland through a lens of Transformative Learning Theory. Data collection consisted of (a) a pre-participation interview, (b) a follow-up interview, and (c) participant observation. We found evidence of all four tenets of Mezirow’s Transformative Learning Theory: (a) refining meaning schema, (b) learning new schema, (c) transforming schemes, and (d) transforming perspectives. Emergent subthemes related to service-learning or personal growth were discovered within …


Monophosphoryl Lipid A-Based Adjuvant To Promote The Immunogenicity Of Multivalent Meningococcal Polysaccharide Conjugate Vaccines, Kishore Alugupalli Apr 2024

Monophosphoryl Lipid A-Based Adjuvant To Promote The Immunogenicity Of Multivalent Meningococcal Polysaccharide Conjugate Vaccines, Kishore Alugupalli

Department of Microbiology and Immunology Faculty Papers

Activation of the adaptive immune system requires the engagement of costimulatory pathways in addition to B and T cell Ag receptor signaling, and adjuvants play a central role in this process. Many Gram-negative bacterial polysaccharide vaccines, including the tetravalent meningococcal conjugate vaccines (MCV4) and typhoid Vi polysaccharide vaccines, do not incorporate adjuvants. The immunogenicity of typhoid vaccines is due to the presence of associated TLR4 ligands in these vaccines. Because the immunogenicity of MCV4 is poor and requires boosters, I hypothesized that TLR4 ligands are absent in MCV4 and that incorporation of a TLR4 ligand-based adjuvant would improve their immunogenicity. …


Ecological Monitoring Program At Vims Esl: Annual Report 2023, Paige G. Ross, Richard A. Snyder Apr 2024

Ecological Monitoring Program At Vims Esl: Annual Report 2023, Paige G. Ross, Richard A. Snyder

Reports

An Ecological Monitoring Program (EMP) has been established at the Virginia Institute of Marine Science Eastern Shore Laboratory (VIMS ESL) for the coastal environment near the Wachapreague lab. The goals of the initiative are to 1) provide status and trends information to scientists who study and regulators who manage Virginia’s marine resources, 2) provide a scientific context for short-term research and grant proposals 3) provide pedagogical enrichment for educators to use in their classes, and 4) build capacity in staff expertise and training of interns and students at VIMS ESL.

The program formalizes and standardizes data collection for a long-term …


Post-Vaccination Sars-Cov-2 Igg Spike Antibody Responses Among Clinical And Non-Clinical Healthcare Workers At A Tertiary Facility In Kenya, Lucy Wangari, Geoffrey Omuse, Rodney Adam, George Ongete, Cyrus Matheka, Patrick Mugaine, Shahin Sayed, Daniel Maina Apr 2024

Post-Vaccination Sars-Cov-2 Igg Spike Antibody Responses Among Clinical And Non-Clinical Healthcare Workers At A Tertiary Facility In Kenya, Lucy Wangari, Geoffrey Omuse, Rodney Adam, George Ongete, Cyrus Matheka, Patrick Mugaine, Shahin Sayed, Daniel Maina

Pathology, East Africa

Introduction: Following the coronavirus disease 19 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, vaccination became the main strategy against disease severity and even death. Healthcare workers were considered high-risk for infection and, thus, were prioritised for vaccination.

Methods: A follow-up to a SARS-CoV-2 seroprevalence study among clinical and non-clinical HCWs at the Aga Khan University Hospital, Nairobi, we assessed how vaccination influenced SARS-CoV-2 anti-spike IgG antibody responses and kinetics. Blood samples were drawn at two points spanning 6 to 18 months post-vaccination, and SARS-CoV-2 spike antibody levels were determined by enzyme-linked immunosorbent assay.

Results: Almost all participants, …


Occupational Engagement In Recreational Sports For The Deaf And Hard Of Hearing: An Employee Guidebook, Colleen Mcerlean, Mary Ann Smith, Christopher Ebner Apr 2024

Occupational Engagement In Recreational Sports For The Deaf And Hard Of Hearing: An Employee Guidebook, Colleen Mcerlean, Mary Ann Smith, Christopher Ebner

Spring 2024 Virtual OTD Capstone Symposium

An employee guidebook to help increase occupational engagement within recreational sports for the Deaf and Hard of Hearing population in the Austin, TX area.


Pilot Study: Effects Of Whole Body Vibrational Therapy On Equine Epaxial Muscle Soreness, Riley Leibeck Apr 2024

Pilot Study: Effects Of Whole Body Vibrational Therapy On Equine Epaxial Muscle Soreness, Riley Leibeck

Undergraduate Honors Thesis Projects

Whole body vibrational therapy (WBV) is well-studied in people, but there is a paucity of research of its effect on horses. It is suggested that WBV use in horses increases performance, aids in recovery, and stimulates nerves, bones, and muscles in ways that normal exercise does not. The purpose of this pilot study was to determine if frequent WBV therapy sessions affect back soreness in horses using pressure algometry. Most sporthorses will experience back soreness in their careers, and it is regarded as one of the most common causes of poor performance in equine athletes. Five horses were measured for …


Non-Native Rhizophora Mangle As Sinks For Coastal Contamination On Moloka’I, Hawai’I, Geoffrey Szafranski, Elise F. Granek, Michelle L. Hladik, Mia Hackett Apr 2024

Non-Native Rhizophora Mangle As Sinks For Coastal Contamination On Moloka’I, Hawai’I, Geoffrey Szafranski, Elise F. Granek, Michelle L. Hladik, Mia Hackett

Environmental Science and Management Faculty Publications and Presentations

Coastal mangrove forests provide a suite of environmental services, including sequestration of anthropogenic contamination. Yet, research lags on the environmental fate and potential human health risks of mangrove-sequestered contaminants in the context of mangrove removal for development and range shifts due to climate change. To address this, we conducted a study on Moloka'i, Hawai'i, comparing microplastic and pesticide contamination in coastal compartments both at areas modified by non-native red mangroves (Rhizophora mangle) and unmodified, open coastline. Sediment, porewater, and mangrove plant tissues were collected to quantify microplastic and pesticide concentrations across ecosystem type. Average microplastics were similar between …


Long-Term Health Related Quality Of Life Following Uterine Fibroid Embolization In A Predominantly Black African Population: A Retrospective Cohort Study, Michael Kioko, Marleen Temmerman, Timona Obura, Adelaide Lusambili Apr 2024

Long-Term Health Related Quality Of Life Following Uterine Fibroid Embolization In A Predominantly Black African Population: A Retrospective Cohort Study, Michael Kioko, Marleen Temmerman, Timona Obura, Adelaide Lusambili

Obstetrics and Gynaecology, East Africa

Uterine Fibroid Embolization (UFE) is one of the effective options available for treatment of symptomatic uterine fibroids with documented improvement in the quality of life and reduction in symptoms. The study assessed long-term quality of life post-uterine fibroid embolization in a mostly black population, noting scanty local or African research on this topic despite evidence suggesting a higher fibroid burden among black women. This retrospective study examined patients who underwent UFE from 2009 to 2014. Participants completed online demographic and UFS-QOL surveys. Statistical tests included Wilcoxon signed rank tests for HRQOL score differences and Pearson correlation for associations between independent …


Distribution Of Shell-Boring Polychaetes At Shellfish Aquaculture Sites Along The Northeast Coast Of The Us, Samantha Silverbrand Apr 2024

Distribution Of Shell-Boring Polychaetes At Shellfish Aquaculture Sites Along The Northeast Coast Of The Us, Samantha Silverbrand

Honors College

Coastal shellfish aquaculture has expanded substantially in recent years in Maine and New England as traditional wild fishery stocks have declined. As shellfish aquaculture has expanded, producers have become more concerned about marine worm pests (i.e., polychaetes) that infest cultured bivalves. In particular, worms from the genus Polydora (also known as “polydorids”) burrow into oyster and scallop shells where they feed and deposit mud. Bivalves cover over the muddy burrows creating blisters that can decrease their market value and hinder growth. Farmers and researchers have identified methods to control infestations of P. websteri, one common species of shell-boring worm. However, …


Mean Flow And Dispersion In The Western Mediterranean Sea From Drifter Observations, Helga Huntley, James Turbett, A.D. Kirwan, Jr., Pierre-Marie Poulain Apr 2024

Mean Flow And Dispersion In The Western Mediterranean Sea From Drifter Observations, Helga Huntley, James Turbett, A.D. Kirwan, Jr., Pierre-Marie Poulain

Faculty Scholarship for the College of Science & Mathematics

Currents in the ocean distribute water masses and everything floating in them. To understand how fast the water (and its flotsam) travels and how effectively it mixes, we need to study the flow statistics. There are two types of measurements of ocean currents: Eulerian measurements that look at how the ocean velocities change at a stationary point on the Earth; and Lagrangian measurements that follow a water mass. Dispersion and mixing is generally best captured by Lagrangian measurements. At the submesoscale (~10-1 – 10 km), the observational tool of choice are drifters, or floating buoys, tethered to a drogue that …


Varecia Rubra (Red Ruffed Lemur) Diel Activity And Calling At Andranobe, Masoala National Park, Madagascar, Hannah Elena Hilden-Reid Apr 2024

Varecia Rubra (Red Ruffed Lemur) Diel Activity And Calling At Andranobe, Masoala National Park, Madagascar, Hannah Elena Hilden-Reid

Dissertations and Theses

With respect to the natural variation in abiotic and biotic conditions present between daytime and nighttime periods, many animal species show evolutionary adaptations specialized for diurnality, nocturnality, or crepuscularity. Biologists have traditionally viewed categorizations of this kind as fixed within taxonomic groups, emphasizing how intricately species’ survival is contingent on the ability to adapt to low light, high light, or twilight conditions. However, movement away from such distinct temporal niche categories began within chronobiological studies following the discovery of more flexible patterns of activity in numerous taxa during the late 1970s. This shift generated increased interest in elucidating the complex …


Agricultural Groundcover Update February 2024, Justin Laycock Apr 2024

Agricultural Groundcover Update February 2024, Justin Laycock

Natural resources published reports

  • About 92% of the grainbelt had adequate (more than 50%) vegetative groundcover to prevent wind erosion in February 2024.
  • Nearly 8% of the grainbelt (1,193,400 ha) had less than 50% groundcover, which is inadequate to prevent wind erosion.
  • The northern grainbelt had the highest risk of wind erosion and 16.5% of this farmland had inadequate groundcover.
  • Less than 0.7% of the grainbelt had a high to very high risk of wind erosion because groundcover was less than 30%.


Procedures For Rangeland Condition Assessment In The Pilbara And Southern Rangelands 2022, Department Of Primary Industries And Regional Development Apr 2024

Procedures For Rangeland Condition Assessment In The Pilbara And Southern Rangelands 2022, Department Of Primary Industries And Regional Development

Natural resources published reports

To define the procedures used in 2022 by the Department of Primary Industries and Regional Development (DPIRD) to complete rangeland condition assessment (RCA) in the Pilbara and southern rangelands region which has predominantly shrub-based pastures. For the rest of the pastoral estate, DPIRD uses the Procedures for RCA in the Kimberley which has grass pastures.

RCA is the process DPIRD uses to make systematic, lease level assessment of rangeland. Rangeland condition considers both the condition of pastures (as defined in the Pasture condition and management guide for the Pilbara rangelands or Southern rangelands pasture condition and management guides) and soils …


Ecology And Conservation Of Diamondback Terrapins In Virginia, Cypress Ambrose Apr 2024

Ecology And Conservation Of Diamondback Terrapins In Virginia, Cypress Ambrose

Undergraduate Honors Theses

The diamondback terrapin (Malaclemys terrapin) is the only turtle species native to North America with specific morphological and physiological adaptations to estuarine environments. Along with many other pressures contributing to population declines, terrapins frequently become trapped and drown as bycatch in crab pots used in the commercial and recreational blue crab (Callinectes sapidus) fishery. A wealth of evidence supports the use of inexpensive bycatch reduction devices (BRDs) that can be attached to the entrances of these traps, which leads to a marked decrease in terrapin bycatch while not reducing crab catch dramatically. Virginia is the only …


Using Exercise To Reduce The Physical Symptoms Of Parkinson's Disease., Isabella Granahan, Jason Hoffman, John Catapano, Emma Gillis, Aveleen Mcginn Unkauf Apr 2024

Using Exercise To Reduce The Physical Symptoms Of Parkinson's Disease., Isabella Granahan, Jason Hoffman, John Catapano, Emma Gillis, Aveleen Mcginn Unkauf

Transformations: Presentation Slides

Proper forms of exercise can be used by individuals with Parkinson's to reduce the effects of the disease. Our study utilized a unique eccentric lower body exercise program to improve gait, balance, mood, and movement initiation/control for people diagnosed with Parkinson's disease. The twice weekly, 12 week exercise regime was evaluated through a variety of biomechanical, physiological and psychological measurements conducted throughout each of the training sessions. An analysis of the measures indicated that the exercise protocol did provide positive outcomes related to gait, balance, mood, and movement initiation/control for individuals that participated in our study


3rd Place Research Paper: Cultural Attitudes Towards Ethnic Cuisine In Italy, Rachel Berns Apr 2024

3rd Place Research Paper: Cultural Attitudes Towards Ethnic Cuisine In Italy, Rachel Berns

Kevin and Tam Ross Undergraduate Research Prize

Italy has become a common “landing country” for many European and Asian immigrants, creating a perception of invasion that has led to cultural reactionism masked in the reinforcement of “traditional cuisine.” For so-called traditional foods to endure, they must continually be reinvented, bearing different meanings and social values throughout time and space while accumulating rich, cultural baggage that serves as a powerful marker of identity in a given society. This paper explores the role of traditional cuisine in Italian national identity and pride, and the subsequent historical culinary antagonism maintained in widespread attitudes toward ethnic cuisine in Italy. Through an …


Multigenerational Consequences Of Environment And Loss On Maternal Behavior, Anxiety, Boldness, And Memory In Rats, Alayna Palamar Apr 2024

Multigenerational Consequences Of Environment And Loss On Maternal Behavior, Anxiety, Boldness, And Memory In Rats, Alayna Palamar

Longwood Senior Theses

Maternal behavior has long been studied for the implications it presents for offspring outcomes. In the present study, we examined the interplay between the positive effects of environmental enrichment and the negative consequences of loss – defined as a 50% litter cull – on both mothers and their offspring. In this multigenerational study, maternal Sprague Dawley rats were separated into one of four of the following conditions: enriched/control, enriched/loss, standard/control, and standard/loss. Maternal rats (P generation) were assessed using the following behavioral assays: Elevated Plus Maze (EPM) for anxiety-like behavior and boldness, Object Location Maze (OLM) for spatial memory, and …


Cortisol Production In Female Soccer Players, Katelyn Seagraves Apr 2024

Cortisol Production In Female Soccer Players, Katelyn Seagraves

Honors Projects

Cortisol is released from the adrenal glands when there is an apparent stressor. Exercise, while beneficial, is seen as stress to the body and incites increased cortisol release. Cortisol is known to increase with exercise, and higher-intensity exercise tends to raise cortisol more compared to lower intensities. However, less is known about interval training and cortisol concentrations.

This review of literature dives into the background of cortisol: how it's produced, what systems it regulates, and differences in production based on gender, stressors, exercise intensity, and duration. This paper identifies some knowledge gaps and links training intensities in soccer to cortisol …


An Exploration Of The Genetics Of The Mutant Huntingtin (Mhtt) Gene In A Cohort Of Patients With Chorea From Different Ethnic Groups In Sub-Saharan Africa, Mendi J. Muthinja, Carlos Othon Guelngar, Maouly Fall, Fatumah Jama, Huda Aldeen Shuja, Jamila Nambafu, Daniel Gams Massi, Oluwadamilola Ojo, Juzar Hooker, Dilraj Sokhi Apr 2024

An Exploration Of The Genetics Of The Mutant Huntingtin (Mhtt) Gene In A Cohort Of Patients With Chorea From Different Ethnic Groups In Sub-Saharan Africa, Mendi J. Muthinja, Carlos Othon Guelngar, Maouly Fall, Fatumah Jama, Huda Aldeen Shuja, Jamila Nambafu, Daniel Gams Massi, Oluwadamilola Ojo, Juzar Hooker, Dilraj Sokhi

Internal Medicine, East Africa

Background: Africans are underrepresented in Huntington's disease (HD) research. A European ancestor was postulated to have introduced the mutant Huntingtin (mHtt) gene to the continent; however, recent work has shown the existence of a unique Htt haplotype in South-Africa specific to indigenous Africans.

Objective: We aimed to investigate the CAG trinucleotide repeats expansion in the Htt gene in a geographically diverse cohort of patients with chorea and unaffected controls from sub-Saharan Africa.

Methods: We evaluated 99 participants: 43 patients with chorea, 21 asymptomatic first-degree relatives of subjects with chorea, and 35 healthy controls for the presence of the mHtt. Participants …


Toward A Coordinated Understanding Of Hydro-Biogeochemical Root Functions In Tropical Forests For Application In Vegetation Models, Daniela F. Cusack, Bradley O. Christoffersen, Chris M. Smith-Martin, Kelly M. Andersen, Amanda L. Cordeiro, Katrin Fleischer, S. Joseph Wright, Nathaly R. Guerrero-Ramírez, Laynara F. Lugli, Lindsay A. Mcculloch Apr 2024

Toward A Coordinated Understanding Of Hydro-Biogeochemical Root Functions In Tropical Forests For Application In Vegetation Models, Daniela F. Cusack, Bradley O. Christoffersen, Chris M. Smith-Martin, Kelly M. Andersen, Amanda L. Cordeiro, Katrin Fleischer, S. Joseph Wright, Nathaly R. Guerrero-Ramírez, Laynara F. Lugli, Lindsay A. Mcculloch

School of Integrative Biological and Chemical Sciences Faculty Publications and Presentations

Tropical forest root characteristics and resource acquisition strategies are underrepresented in vegetation and global models, hampering the prediction of forest–climate feedbacks for these carbon-rich ecosystems. Lowland tropical forests often have globally unique combinations of high taxonomic and functional biodiversity, rainfall seasonality, and strongly weathered infertile soils, giving rise to distinct patterns in root traits and functions compared with higher latitude ecosystems. We provide a roadmap for integrating recent advances in our understanding of tropical forest belowground function into vegetation models, focusing on water and nutrient acquisition. We offer comparisons of recent advances in empirical and model understanding of root characteristics …


The Interaction Of Sodium Fluoride And Sodium Selenate On The Developmental Toxicity To Xenopus Laevis And Ambystoma Maculatum Embryos, Shelby Wolfram Apr 2024

The Interaction Of Sodium Fluoride And Sodium Selenate On The Developmental Toxicity To Xenopus Laevis And Ambystoma Maculatum Embryos, Shelby Wolfram

Theses

Amphibians play critical roles in the environment's wellness. Fluoride (F) is a widely existing environmental pollutant. It is commonly known for being added to drinking water and as a topical dose on teeth. Selenium (Se) can be found in organic and inorganic forms in nature. Many different fertilizers, pesticides, insecticides, and fungicides contain sodium selenate in them. The range selenium has between deficiency and toxicity is narrow, meaning excess exposure could cause various adverse effects in aquatic organisms. Xenopus laevis is a standard model for developmental toxicity due to being minimal maintenance, cost efficient, and having transparent embryos. Xenopus makes …


2024 Weed Management At A Glance, Hilary A. Sandler, Katherine Ghantous Apr 2024

2024 Weed Management At A Glance, Hilary A. Sandler, Katherine Ghantous

Cranberry Chart Book - Management Guide

No abstract provided.


Exploring The Potential Pathogenicity Of A Type 2 Diabetes Mellitus Associated Insr Missense Variant Of Uncertain Significance Through Daf-2 In The Caenorhabditis Elegans Model, Brittany White Apr 2024

Exploring The Potential Pathogenicity Of A Type 2 Diabetes Mellitus Associated Insr Missense Variant Of Uncertain Significance Through Daf-2 In The Caenorhabditis Elegans Model, Brittany White

Theses

Type 2 diabetes mellitus (T2DM) is hallmarked by insulin resistance, with the INSR gene identified as a key player in this condition in humans. This gene is known to harbor genetic variants with a wide range of clinical significance from pathogenic to variants of uncertain significance (VUS) to benign. This project investigates a VUS associated with T2DM identified through ClinVar. A gene mutational analysis, predictive amino acid substitution analysis, and protein modeling predict INSR c.1628C>T (p. Thr543Met) to be likely pathogenic or damaging. PolyPhen-2 predicts this variant to be probably damaging (HumDiv score of 1.000).

Evolutionary conservation of the …


Analyzing Trends In Ground-Level Ozone, Keily Hart Apr 2024

Analyzing Trends In Ground-Level Ozone, Keily Hart

Honors Program Theses and Research Projects

In the last few decades, concerns regarding air pollution have led to many new laws and regulations being put into place to mitigate the e↵ects of pollution on the environment and humanity as a whole. This paper analyzes several decades’ worth of ground-level ozone readings in six of the largest metropolitan areas in Texas, using data from the United States Environmental Protection Agency (EPA). These regions include the Austin-Round Rock area, Corpus Christi, the Dallas-Fort Worth-Arlington area, El Paso, the Houston-The Woodlands-Sugar Land area, and the San Antonio-New Braunfels area. We identify trends in these readings using the Jonckheere-Terpstra test. …


Exploration Of Cytotoxicity Of _Rabidosa Rabida_ Venom On Invertebrate And Vertebrate Cell Cultures, Martina Gooden Apr 2024

Exploration Of Cytotoxicity Of _Rabidosa Rabida_ Venom On Invertebrate And Vertebrate Cell Cultures, Martina Gooden

Honors Theses

Venom has been observed in thousands of species across different taxa. It can be adapted for different purposes, including prey capture or predator defense. Venom is found almost universally in spiders, but there has been little exploration of spiders that are not medically significant. Rabidosa rabida, the rabid wolf spider, is a common species whose venom has not been adequately investigated. Previous studies indicate that they do not require venom to apprehend easy prey in a laboratory setting, raising a question as to what their venom is adapted to do. To evaluate its effect on mammalian cells, L929 murine fibroblasts …