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Sective Deficits In The Sense Of Smell Caused By Chemical Modification Of Olfactory Epithelium, J Russell Mason, Larry Clark, Thomas Morton

Larry Clark

A chemically selective procedure for covalent modification of Schiff base-forming binding sites in proteins is demonstrated in vitro. In vivo studies show that the same procedure produces a selective anosmia ("odor blindness") when applied to the olfactory epithelia of experimental animals. Surgical experiments confirm that the sense of smell is specifically affected.