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Life Sciences

Theses/Dissertations

1983

Gerbils

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The Role Of The Adrenal Cortex In Fat Metabolism Of Meriones Unguiculatus, The Mongolian Gerbil, Saffia Baggia Aug 1983

The Role Of The Adrenal Cortex In Fat Metabolism Of Meriones Unguiculatus, The Mongolian Gerbil, Saffia Baggia

Master's Theses

The effects of adrenalectomy and corticoid replacement therapies on survival, weight loss, depot fat and blood free fatty acid were studied in Meriones unguiculatus, the Mongolian gerbil. Adrenalectomized gerbils that received cortisol and aldosterone lived significantly longer and lost significantly more weight than the controls (adrenalectomized gerbils not receiving any treatment) and the sham-operated groups. Cortisol and aldosterone treatment were also effective in mobilizing significantly greater amounts of depot fat into free fatty acid. Cortisol and aldosterone treated groups had significantly less blood free fatty acid than the control and the sham-operated groups.


The Role Of Adrenomedullary Hormones In Survival Of The Adrenalectomized Mongolian Gerbil, Meriones Unguiculatus, Carol B. Ussery Aug 1983

The Role Of Adrenomedullary Hormones In Survival Of The Adrenalectomized Mongolian Gerbil, Meriones Unguiculatus, Carol B. Ussery

Master's Theses

Thee effects of adrenalectomy and catecholamine replacement therapy on survival were studied in Meriones unguiculatus, the Mongolian gerbil. Adrenalectomized gerbils that received epinephrine lived significantly longer than the controls untreated adrenalectomized gerbils) and animals that received either norepinephrine or a combination of epinephrine and norepinephrine. Results also indicated that these epinephrine-treated animals lost more depot fat that either controls or other groups receiving treatment. In spite of the short survival benefit given by epinephrine, the mechanisms governing the critical adrenal dependency in this species remain unknown.