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Articles 31 - 42 of 42
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The Role Of Reactive Oxygen Species In Cell Death Induced By Thymidylate Synthase Inhibitors, Ufuk Ozer
The Role Of Reactive Oxygen Species In Cell Death Induced By Thymidylate Synthase Inhibitors, Ufuk Ozer
Theses and Dissertations
Thymidylate synthase (TS) catalyzes the reductive transfer of a methyl group from N5,N10-methylenetetrahydrofolate (CH2-THF) to dUMP, forming dTMP and dihydrofolate (DHF). It is generally accepted that inhibition of the enzyme leads to a deficiency of dTMP, followed by genome damage and programmed cell death. As such, TS has long been viewed as an important target of anti-neoplastic agents, such as 5-fluorouracil (5-FU) and raltitrexed (RTX), which lead to inhibition of the enzyme. Oxidative stress is well-recognized as having a central role in cellular response to a number of DNA damaging agents, and may be a proximate cause of …
Doc Dynamics In Eddies Of The Sargasso Sea, Eric Matthew Lachenmyer
Doc Dynamics In Eddies Of The Sargasso Sea, Eric Matthew Lachenmyer
Theses and Dissertations
Bacterial productivity and size-fractioned rates of dissolved organic carbon (DOC) excretion from primary and secondary producers were measured in two eddy types, one anti-cyclonic (February 2012) and one cyclonic eddy (July 2012), in the Sargasso Sea. Bacterial productivity (BP) rates in the cyclonic eddy were highest in the center (9.2 mg C m-2d-1) and edge (10.4 mg C m-2d-1) of the eddy compared to the anti-cyclone center (2.2 mg C m-2d-1) and edge (5.1 mg C m-2d-1). Rates of DOC excretion from14C-tracer experiments were not significantly higher than background; lack of accumulation of labeled material indicated very fast uptake of …
Outsmarting The Brain: Augmenting Motor Training With Non-Invasive Brain Stimulation In Order To Facilitate Plasticity-Dependent, Functional Improvement Within The Motor Cortex, Raymond Joseph Butts
Outsmarting The Brain: Augmenting Motor Training With Non-Invasive Brain Stimulation In Order To Facilitate Plasticity-Dependent, Functional Improvement Within The Motor Cortex, Raymond Joseph Butts
Theses and Dissertations
Brain stimulation techniques capable of optimizing cortical plasticity may provide the key to improved therapeutic techniques and functional outcomes. The primary aim of this dissertation was to examine the potential of motor training (MT) augmented with intermittent theta burst stimulation (iTBS) and anodal transcranial direct current stimulation (a-tDCS). The secondary aim was to investigate whether the training would also be advantageous to older-adults. We hypothesized that right-handed, college-age students exposed to the treatment (n=17) would perform better short-term (directly following MT) and long-term (24 hours and 7 days following MT) on motor-skill retention tests than students receiving sham stimulation (n=14). …
Exploring The Role Of Culture And Race In Stroke Rehabilitation Disparities, Jennifaye Verdina Greene
Exploring The Role Of Culture And Race In Stroke Rehabilitation Disparities, Jennifaye Verdina Greene
Theses and Dissertations
A study found that racial differences exist in stroke rehabilitation care and outcomes between African Americans (AAs) and Caucasian Americans (CAs). In addition to health status, the rehabilitation care of AAs with stroke (AAwS) may be influenced by cultural and or racial similarities or differences that exist between themselves and their physical therapists (PTs). Distorted perceptions of culture and race in the patient-PT relationship may contribute to disparities in stroke rehabilitation care and outcomes for AAwS. Current stroke rehabilitation literature lacks qualitative research that examines racialized differences in treatment. The purpose of this qualitative exploratory research study was to investigate …
Classroom Exercise Breaks And Educational Outcomes In Elementary School Students, Erin Kaye Howie
Classroom Exercise Breaks And Educational Outcomes In Elementary School Students, Erin Kaye Howie
Theses and Dissertations
Previous research has shown that physical activity may have beneficial effects on cognitive performance and academic achievement in children, but the optimal type and dose are unknown. Classroom exercise breaks are one type of physical activity opportunity in schools, with the potential to reach a large number of children. The purpose of this dissertation was to describe the prevalence and characteristics of classroom exercise breaks in central South Carolina, and to determine the acute effects of classroom exercise breaks on executive functions, math performance, on-task behavior and affective responses in 9 to 12 year-old children. Additionally, the dissertation examined the …
Unique Perspectives And Struggles Of Parents Rearing Children With Phenylketonuria With Unaffected Siblings, Cassandra Nicole Hollinger
Unique Perspectives And Struggles Of Parents Rearing Children With Phenylketonuria With Unaffected Siblings, Cassandra Nicole Hollinger
Theses and Dissertations
Phenylketonuria (PKU) is an autosomal metabolic condition that is screened for via newborn screening. Individuals who are identified as having PKU require a protein-restricted diet to protect against neurological damage. Many parents who learn their child has PKU may already have children who are not affected, or may have children later who are not affected. This creates a unique situation in which parents are rearing children that require a strict protein-restricted diet with children who do not. Parents who are currently rearing children with and without PKU were surveyed to learn what unique perspectives and struggles they face, especially regarding …
Working With Patients At Risk For Hereditary Degenerative Brain Disorders, Stephen John White
Working With Patients At Risk For Hereditary Degenerative Brain Disorders, Stephen John White
Theses and Dissertations
Hereditary degenerative brain disorders (HDBDs) are a unique class of genetic conditions that result in progressive loss of function within the nervous system, many of which present during adulthood. Given this, the diagnosis of a HDBD can be daunting for both the patient and the genetic counselor assisting in medical care. The purpose of this study was to find themes among genetic counselors who see this patient population and help provide a framework to counselors entering this field by recognizing verified methods of HDBD counseling. Sixteen genetic counselors who routinely see patients at-risk for HDBDs were interviewed concerning how they …
Evaluating The Impact Of Fishery-Related Claw Removal On Diet, Consumption Rate, Energetics And Reproduction In The Florida Stone Crab (Menippe Spp.), Jessica Mary Hogan
Evaluating The Impact Of Fishery-Related Claw Removal On Diet, Consumption Rate, Energetics And Reproduction In The Florida Stone Crab (Menippe Spp.), Jessica Mary Hogan
Theses and Dissertations
Many global fisheries are overexploited and working towards the development of sustainable fishing methods. Claw based crab fisheries, such as the Florida stone crab (Menippe mercenaria, M. adina, and hybrids) fishery, use unique fishing techniques that reduce the overall mortality of harvested organisms. For example, the Florida stone crab fishery is regulated by requiring that fisherman only harvest crab claws and requires that fishermen return the live crab to the water following harvesting. This process takes advantage of the ability of crabs to autotomize and regenerate their claws, and enables crabs to re-enter the fishery in subsequent years if they …
Chemical Leaching Methods And Measurements Of Marine Labile Particulate [Fe] And Δ56fe, Brandi Nicole Revels
Chemical Leaching Methods And Measurements Of Marine Labile Particulate [Fe] And Δ56fe, Brandi Nicole Revels
Theses and Dissertations
Iron (Fe) is an essential nutrient for life. However its low solubility in the seawater limits primary productivity in many regions of the world's oceans. Dissolved phase Fe (<0.4μm) has traditionally been considered the most biologically accessible form, but, recent studies suggest the particulate phase (>0.4μm) may contain an important, labile reservoir of Fe that may also be available to phytoplankton. Although valuable, Fe concentrations of particles alone do not provide complete evidence about the sources of particulate Fe to the ocean, or the extent particulate iron may be accessed by phytoplankton. Fe isotopes may help to reveal the biogeochemical cycling of particulate Fe. This study aims to develop a chemical leaching technique that accesses the …
Executing And Teaching Science--The Breast Cancer Genetics And Technology-Rich Curriculum Professional Development Studies Of A Science Educator, Regina Evarn Wragg
Executing And Teaching Science--The Breast Cancer Genetics And Technology-Rich Curriculum Professional Development Studies Of A Science Educator, Regina Evarn Wragg
Theses and Dissertations
This dissertation presents my explorations in both molecular biology and science education research. In study one, we determined the ADIPOQ and ADIPORI genotypes of 364 White and 148 Black BrCa patients and used dominant model univariate logistic regression analyses to determine individual SNP and haplotype associations with tumor or patient characteristics in a case-case comparison. We found twelve associations between individual SNPs and patient or tumor characteristics that impact BrCa prognosis. For example, the ADIPOQ rs1501299 C allele was associated with ER+ tumors (OR=4.73, p=0.001) among White women >50 years of age at their time of diagnosis. Also, the A …
Nutrient Limitation Of Bioluminescent Dinoflagellates In Mangrove Lagoon, Salt River Bay, St. Croix, Usvi, Michelle Zimberlin
Nutrient Limitation Of Bioluminescent Dinoflagellates In Mangrove Lagoon, Salt River Bay, St. Croix, Usvi, Michelle Zimberlin
Theses and Dissertations
Bioluminescent bays resulting from dense concentrations of bioluminescent dinoflagellates are rare, with only 14 documented systems worldwide. One of these bays, Mangrove Lagoon, is located in Salt River Bay National Park in St. Croix, USVI. Very little is known about the environmental factors responsible for maintaining the high dinoflagellate densities in this lagoon. In order to assess the dynamics of the dinoflagellates, in situ nutrient addition bioassays were conducted to determine which nutrients regulate the phytoplankton community, which includes the bioluminescent dinoflagellate Pyrodinium bahamense. Bioassays were conducted in two different seasons, (January 2013 and May 2013) to examine seasonal responses …
Adverse Outcome Pathways: A Framework For Identifying Chemical Mode Of Action During Zebrafish Embryogenesis, Krystle Yozzo
Adverse Outcome Pathways: A Framework For Identifying Chemical Mode Of Action During Zebrafish Embryogenesis, Krystle Yozzo
Theses and Dissertations
Human health and ecological risk assessors are currently facing increased demands and public pressure to evaluate the potential risk of hundreds to thousands of chemicals based on limited toxicity data. Therefore, scientifically sound models are needed to predict toxicity without sole reliance on conventional whole-organism (vertebrate) bioassays. To help address this challenge, adverse outcome pathways (AOPs) have recently been proposed as conceptual tools to help link direct, molecular-level initiating events to adverse outcomes at higher levels of biological organization. Additionally, using AOPs as frameworks, high-throughput screening (HTS) and high-content screening (HCS) assays have been recently proposed as key components of …