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Ectodomain Mutations Alter The Proteolysis Of The Amyloid-Β Precursor Protein (App), Michael S. Mitsumori
Ectodomain Mutations Alter The Proteolysis Of The Amyloid-Β Precursor Protein (App), Michael S. Mitsumori
Dissertations, Masters Theses, Capstones, and Culminating Projects
Alzheimer’s disease (AD) is the most common form of dementia, affecting over 5 million Americans. In AD patients there is a buildup of amyloid plaque in the brain, which contributes to AD symptoms. The main component of plaques is Amyloid-β (Aβ), a 40-42 length peptide formed from Amyloid-β Precursor Protein (APP) proteolysis. APP proteolysis can result in either anti-trophic or trophic peptides. Several APP polymorphisms exist that cause or protect against AD by altering APP proteolysis. Recently, more polymorphisms in the APP ectodomain have been discovered in patients with late onset AD (LOAD). The proteolysis of APP may be affected …