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Ectodomain Mutations Alter The Proteolysis Of The Amyloid-Β Precursor Protein (App), Michael S. Mitsumori
Ectodomain Mutations Alter The Proteolysis Of The Amyloid-Β Precursor Protein (App), Michael S. Mitsumori
Dissertations, Masters Theses, Capstones, and Culminating Projects
Alzheimer’s disease (AD) is the most common form of dementia, affecting over 5 million Americans. In AD patients there is a buildup of amyloid plaque in the brain, which contributes to AD symptoms. The main component of plaques is Amyloid-β (Aβ), a 40-42 length peptide formed from Amyloid-β Precursor Protein (APP) proteolysis. APP proteolysis can result in either anti-trophic or trophic peptides. Several APP polymorphisms exist that cause or protect against AD by altering APP proteolysis. Recently, more polymorphisms in the APP ectodomain have been discovered in patients with late onset AD (LOAD). The proteolysis of APP may be affected …
Apolipoprotein E4 And Sirt1 Interaction In Alzheimer’S Disease, Brittany Ann Philpot
Apolipoprotein E4 And Sirt1 Interaction In Alzheimer’S Disease, Brittany Ann Philpot
Dissertations, Masters Theses, Capstones, and Culminating Projects
Alzheimer’s disease (AD) is a neurodegenerative disorder whose exact cause(s) are still unknown. Εpsilon 4, an allele of apolipoprotein E (ApoE4), is currently the most important risk factor for Alzheimer’s disease. Individuals that inherit two copies of the ApoE ε4 allele have an approximately ten to thirty times increased risk of developing AD in comparison to persons not carrying this allele. This association may relate to ApoE4’s susceptibility to proteolysis and neurotoxicity. Amyloid precursor protein (APP) is involved with neurite extension and neurite retraction, and has been shown to function as a molecular switch with two separate cleavage patterns. Cleavage …