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Basal Signaling Through Death Receptor 5 And Caspase 3 Activates P38 Kinase To Regulate Serum Response Factor - Mediated Myod Transcription, Jason A. Ross
ETD Archive
The formation of functional skeletal muscle is the consequence of both the differentiation and apoptosis of skeletal myoblasts. Ex vivo culture of skeletal myoblasts provides a tractable model for the study of these two coordinately regulated processes. We have previously reported that 23A2 myoblasts stably expressing a dominant negative Death Receptor 5 (A2:dnDR5 myoblasts) exhibit decreased basal mRNA and protein expression of the master muscle regulatory transcription factor MyoD. This decrease at the mRNA level is not a consequence of altered stability. Binding of the transcription factor SRF to a non-canonical CArG box within a serum response element (SRE) in …
Characterization Of The Immune Response To Anti-Mullerian Hormone, Justin M. Johnson
Characterization Of The Immune Response To Anti-Mullerian Hormone, Justin M. Johnson
ETD Archive
Anti-Mullerian hormone (AMH) has been known since the mid-twentieth century as the substance secreted by the testes of the male fetus that is responsible for directing the proper development of the male reproductive organs from the primordial structures that would otherwise become the uterus and fallopian tubes. However, despite its longknown significance in male development, only recently has its importance in the adult female become evident. AMH is now considered to be not only a clinical indicator of the finite ovarian egg supply, but a vital regulator thereof throughout the reproductive life of the female. Dysfunctions in AMH regulation may …
Determinants Of Holliday Junction Formation And Resolution During Budding Yeast Meiosis, Marina Bykova
Determinants Of Holliday Junction Formation And Resolution During Budding Yeast Meiosis, Marina Bykova
ETD Archive
In the process of meiosis, 4 haploid cells are produced from 1 diploid cell in two rounds of division. During prophase I of meiosis I, double strand breaks (DSBs) are created by the Spo11 protein, some of which are later repaired by homologous recombination into crossovers. During homologous recombination, structures called Holliday Junctions are formed, which later are resolved into crossovers to allow homologous chromosomes to separate. Ifthey are not resolved, the cell arrests and cannot progress further in meiosis. I have investigated three proteins known or suspected to be involved in Holliday Junction formation and resolution: the transcription factor …
Functional Ecology And Ecosystem Services Of Urban Trees, Milos Simovic
Functional Ecology And Ecosystem Services Of Urban Trees, Milos Simovic
ETD Archive
Compared to their natural counterparts, trees in urban ecosystems experience distinctive environmental conditions which can be both beneficial and harmful to tree functions and fitness. Thus, the morphological, phenological, and physiological functions of trees in urban ecosystems can be unique and might not be predictable from patterns identified in natural forests where most research on tree ecology has occurred. To better understand how different tree species contribute to ecosystem services in urban environments, we estimated a number of key performance metrics and functional traits for species commonly planted in urban areas. Between April of 2017 and December of 2019, we …
Life Cycle And Morphological Characterization Of Colpodella Sp. (Atcc 50594) In Hay Medium, Troy A. Getty
Life Cycle And Morphological Characterization Of Colpodella Sp. (Atcc 50594) In Hay Medium, Troy A. Getty
ETD Archive
Colpodella species are free living biflagellated protists that prey on algae and bodonids in a process known as myzocytosis. Colpodella are phylogenetically closely related to Apicomplexa. Cyst and trophozoite stages have been identified in Colpodella species, however the mechanisms of encystation and excystation are unknown. The timing and transition of the life cycle stages are unknown. In the present study I investigated the life cycle of Colpodella sp. (ATCC 50594). Colpodella sp. were grown in diprotist cultures in tissue culture flasks containing Hay medium bacterized with Enterobacter aerogenes and containing Bodo caudatus as prey. I wanted to know the timing …