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The Effect Of Whole Body Vibration On Skin Blood Flow And Nitric Oxide Production, Paula K. Johnson
The Effect Of Whole Body Vibration On Skin Blood Flow And Nitric Oxide Production, Paula K. Johnson
Theses and Dissertations
Background: Vascular dysfunction due to hyperglycemia in individuals with diabetes is a factor contributing to distal symmetric polyneuropathy (DSP). Reactive oxygen species (ROS) reduce the bioavailability of nitric oxide (NO), a powerful vasodilator, resulting in reduced circulation and nerve ischemia. Increases in blood NO concentrations and circulation have been attributed to whole body vibration (WBV). The purpose of this study was to the determine the effects of low frequency, low amplitude WBV on whole blood NO concentration and skin blood flow (SBF) in individuals with symptoms of DSP. Research Design and Methods: Ten subjects with diabetes and impaired sensory perception …
The Effect Of Type Ii Diabetes Mellitus On Oxygen Uptake Kinetics During Heavy Exercise, Dustin R. Allen, Cory L. Butts, Davor Krnjajic, David Keller, Paul Mcdonough
The Effect Of Type Ii Diabetes Mellitus On Oxygen Uptake Kinetics During Heavy Exercise, Dustin R. Allen, Cory L. Butts, Davor Krnjajic, David Keller, Paul Mcdonough
International Journal of Exercise Science: Conference Proceedings
The kinetics of oxygen uptake (Vo2) during the rest to exercise transition are thought to be modulated by intracellular metabolic processes. Diabetes has been shown to slow Vo2 kinetics, likely due to the impact of diabetes upon microvascular oxygen exchange (Padilla et al, 2007). However, to date, recovery from exercise has yet to be studied in these patients. Thus, the purpose of this study was to test the hypothesis that the existence of diabetes would hamper Vo2 kinetics during transitions to and from heavy leg cycling (H: Supra-LT). Nine subjects (4 control, 5 diabetic) completed three …
Deptor Expression Correlates With Muscle Protein Synthesis, Kevin L. Shimkus, Elyse V. Wudeck, Yasaman Shirazi-Fard, Mats I. Nilsson, Nicholas P. Greene, Harry A. Hogan, James D. Fluckey
Deptor Expression Correlates With Muscle Protein Synthesis, Kevin L. Shimkus, Elyse V. Wudeck, Yasaman Shirazi-Fard, Mats I. Nilsson, Nicholas P. Greene, Harry A. Hogan, James D. Fluckey
International Journal of Exercise Science: Conference Proceedings
Mammalian target of rapamycin (mTOR) has long been declared a focal point of muscle protein synthesis. mTORC1 (an mTOR complex consisting of mTOR, raptor, PRAS40, and mLST8) has been associated with regulation of protein translation in muscle, altering expression and activity levels of key downstream targets S6K1 and eIF-4E-BP1. mTORC1 has been shown to be affected by various stimuli, including nutritional status, growth factors, and mechanical loading. But in past incidents we have found disconnects in muscle protein synthesis and mTOR signaling, stimulating discussions that mTOR content and activation alone may not be able to fully account for muscle protein …